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| 1 | COVID-19: An overview and a clinical update显示文摘The outbreak of coronavirus disease-2019(COVID-19,previously known as 2019 nCoV)caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection in Wuhan City,China,has spread rapidly around the world.Most patients from the first cluster had an epidemiological connection to the Wuhan's Huanan Seafood Wholesale Market.Available evidence has shown that SARSCoV-2 can be easily transmitted from person to person through close contact and respiratory droplets,posing a substantial challenge to public health.At present,the research on SARS-CoV-2 is still in the primary stages.However,dexamethasone and remdesivir are appeared to be promising medical therapies.Still,there is no definite specific treatment,and the mainstay of treatment is still focused on supportive therapies.Currently,over 150 vaccines are under investigation.It is necessary to understand the nature of the virus and its clinical characteristics in order to find effectively manage the disease.The knowledge about this virus is rapidly evolving,and clinicians must update themselves regularly.The present review comprehensively summarizes the epidemiology,pathogenesis,clinical characteristics,and management of COVID-19 based on the current evidence. | Arunkumar Krishnan James P Hamilton Saleh A Alqahtani Tinsay A Woreta | 2021 | World Journal of Clinical Cases2021，9，1： | 5 |
| 2 | Abnormal liver chemistries as a predictor of COVID-19 severity and clinical outcomes in hospitalized patients显示文摘BACKGROUND Abnormal liver chemistries are common findings in patients with Coronavirus Disease 2019(COVID-19).However,the association of these abnormalities with the severity of COVID-19 and clinical outcomes is poorly understood AIM We aimed to assess the prevalence of elevated liver chemistries in hospitalized patients with COVID-19 and compare the serum liver chemistries to predict the severity and in-hospital mortality.METHODS This retrospective,observational study included 3380 patients with COVID-19 who were hospitalized in the Johns Hopkins Health System(Baltimore,MD,United States).Demographic data,clinical characteristics,laboratory findings,treatment measures,and outcome data were collected.Cox regression modeling was used to explore variables associated with abnormal liver chemistries on admission with disease severity and prognosis RESULTS A total of 2698(70.4%)had abnormal alanine aminotransferase(ALT)at the time of admission.Other more prevalent abnormal liver chemistries were aspartate aminotransferase(AST)(44.4%),alkaline phosphatase(ALP)(16.1%),and total bilirubin(T-Bil)(5.9%).Factors associated with liver injury were older age,Asian ethnicity,other race,being overweight,and obesity.Higher ALT,AST,T-Bil,and ALP levels were more commonly associated with disease severity.Multivariable adjusted Cox regression analysis revealed that abnormal AST and T-Bil were associated with the highest mortality risk than other liver injury indicators during hospitalization.Abnormal AST,T-Bil,and ALP were associated with a need for vasopressor drugs,whereas higher levels of AST,T-Bil,and a decreased albumin levels were associated with mechanical ventilation CONCLUSION Abnormal liver chemistries are common at the time of hospital admission in COVID-19 patients and can be closely related to the patient’s severity and prognosis.Elevated liver chemistries,specifically ALT,AST,ALP,and T-Bil levels,can be used to stratify risk and predict the need for advanced therapies in these patients. | Arunkumar Krishnan Laura Prichett Xueting Tao Saleh A Alqahtani James P Hamilton Esteban Mezey Alexandra T Strauss Ahyoung Kim James J Potter Po-Hung Chen Tinsay A Woreta | 2022 | World Journal of Gastroenterology2022，28，5： | 2 |
| 3 | Quercetin downregulates matrix metalloproteinases 2 and 9 proteins expression in prostate cancer cells ( PC-3 ) 显示文摘 | VIJAYABABU M R ARUNKUMAR A KANAGA- RAJ P | 2006 | Mol Cell Biochem2006，287，12： | 1 |
| 4 | Garlic compound, diallyl disulfide induces cell cycle arrest in prostate cancer cell line PC-3 显示文摘 | Arunkumar A Vijayababu MR Srinivasan N | 2006 | Mol Cell Biochem2006，288，12： | 1 |
| 5 | Robust state estimation for discrete-time BAM neural networks with time-varying delay 显示文摘 | ARUNKUMAR A SAKTHIVEL R MATHIYALAGN K | 2014 | Neuroco-mputing2014，131，5： | 1 |
| 6 | Effects of quercetin on insulin-like growth factors (IGFs) and their binding protein-3 (IGFBP-3) secretion and induction of apoptosis in human prostate cancer cells显示文摘 | VIJAYABABU M R ARUNKUMAR A KANAGARAJ P | 2006 | J Carcinog2006，5，： | 1 |
| 7 | Chemical and structural instability of the chemically delithiated(1-z) Li O2 · (z) Li O2 (0≤y≤1 and 0≤z≤1) solid solution cathodes显示文摘 | Arunkumar T A Alvarez E Manthiram A | 2008 | J Mater Chem2008，18，2： | 1 |
| 8 | Quercetin downregulates matrix metalloproteinases 2 and 9 proteins expression in prostate cancer cells (PC-3) 显示文摘 | Vijayababu M R Arunkumar A Kanag-araj P | 2006 | Mol Cell Biochem2006，287，12： | 1 |
| 9 | Quercetin-induced growth inhibition and cell death in prostatic carcinoma cells(PC-3)are associated with increase in p21 and hypophosphorylated retinoblastoma proteins expression显示文摘 | Vijayababu MR Kanagaraj P Arunkumar A | | 0，，11： | 1 |
| 10 | 显示文摘 | Arunkumar T A Manthiram A | 2005 | Electrochimica Acta2005，50，： | 1 |
| 11 | Antiproliferative effect of diallyl disulfide (DADS) on prostate cancer cell line LNCaP显示文摘 | Gunadharin DN Arunkumar A Krishnamoorthy G | 2006 | Cell Bioche Funct2006，24，5： | 1 |
| 12 | Antiproli-ferative effect of diallyl disulfide (DADS)on prostate cancer cell line LNCaP显示文摘 | Gunadharin DN Arunkumar A Krishnamoorthy G | 2006 | Cell Biochem Funct2006，24，5： | 1 |
| 13 | Quercetin downregulates matrix metalloproteinases 2 and 9 proteins expression in prostate cancer cells(PC-3)显示文摘 | Vijayababu MR Arunkumar A Kanagaraj P | | 0，，： | 1 |
| 14 | Effects of quercetin on insulin-like growth factors (IG- Fs) and their binding protein 3 (IGFBP 3) secretion of apoptosis in human prostate cancer cells显示文摘 | Vijayababu M R Arunkumar A Kanagaraj P | | J Car cinog0，510，： | 1 |
| 15 | Quercetin downregulates matrix metalloproteinases 2 and 9 proteins expression in prostate-194-cancer cells (PC- 3) 显示文摘 | Vijayababu M R Arunkumar A Kanagaraj P | 2006 | Mol Cell Bioehem2006，287，2： | 1 |
| 16 | Fluorescent bispyrroles new building blocks for novel p-conjugated polymers显示文摘 | Arunkumar E Ajiayaghosh A | 2000 | Tetrahedron Letters2000，41，： | 1 |
| 17 | Quercetin downregulates matrix Metalloproteinases 2 and 9 proteins expression in prostate cancer cells (PC-3)显示文摘 | Vijayababu M R Arunkumar A Kanagaraj P | 2006 | Mol Cell Biochem2006，287，12： | 1 |
| 18 | Quercetin-induced growth inhibition and cell death in prostatic carcinoma cells (PC-3) are associated with increase in p21 and hypophosphorylated retinoblastoma proteins expression显示文摘 | Vijayababu MR Kanagaraj P Arunkumar A | 2005 | J Cancer Res Clin Oncol2005，131，11： | 1 |
| 19 | Chemopreventive effect of quercetin, a natural dietary flavonoid on prostate cancer in in?vivo model显示文摘 | Sharmila G Bhat F A Arunkumar R | 2014 | Clin Nutr2014，33，4： | 1 |
| 20 | Quercetin downregulates matrix metalloproteinases 2 and 9 proteins expression in prostate cancer cells (PC-3) 显示文摘 | Vijayababu M R Arunkumar A Kanagaraj P | 2006 | Mol Cell Biochem2006，287，12： | 1 |
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