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| 1 | Impact of poly chlorinated biphenyl (Aroclor 1254) and vitamin C on antioxidant system of rat ventral prostate显示文摘Aim:To evaluate the effect of polychlorinated biphenyls (PCB) and vitamin C on ventral prostatic antioxidant system in adult male rats.Methods:A group of 20 adult male rats were administered ip Aroclor 1254 in corn oil at a dose of 2 mg.kg^-1·day^-1 for 30 days.Ten control rats were administered only the vehicle.After 30 days the treated rats were divided at random into 2 sub-groups of 10 animals each.One sub-group received vitamin C at a dose of 500 mg.kg^-1·day^-1 for 10 days.The other group was maintained as Aroclor 1254 control.Twenty-four hours after the last treatment the rats were killed by decapitation.Ventral prostatic homogenate was prepared and used for the estimation of enzymatic antioxidants,including superoxide dismutase (SOD),catalase (CAT) and glutathione-S-transferase (GST) and hydrogen peroxide (H2O2),lipid peroxidation (LPO) and prostatic acid phosphatase.The serum levels of total T3,total T4,TSH,testosterone and estradiol were also assayed.Results:The body weight and ventral prostatic weight were reduced in PCB treated rats.The activities of SOD,CAT,GST and acid phosphatase were decreased while the levels of H2O2 and lipid peroxidation were increased in the ventral prostate of PCB treated rats.Administration of vitamin C restored these parameters.Serum levels of thyroid hormones,estradiol and testosteron ewere decreased in PCB treated animals.Administration of vitamin C restored the thyroid hormone levels.Conclusion:PCB induces oxidative stress and decreases the antioxidant enzymes in the ventral prostate of adult male rats;the effects could be reversed by the administration of vitamin C.(Asian J Androl 2004 Mar;6:19-22) | M. Sridhar P. Venkataraman S. Dhanammal A. Arunkumar M.M. Aruldhas N. Srinivasan J. Arunakaran | 2004 | Asian Journal of Andrology2004，6，1： | 5 |
| 2 | Garlic Compound, Diallyl Disulfide Induces Cell Cycle Arrest in Prostate Cancer Cell Line PC-3显示文摘 | Arumugam Arunkumar Marati Radhakrishnan Vijayababu Narasimman Srinivasan Maria Michael Aruldhas Jagedeesan Arunakaran | 2006 | Molecular and Cellular Biochemistry (-)2006，，1： | 1 |
| 3 | Testosterone and estradiol up-regulate androgen and estrogen receptors in immature and adult rat thyroid glands in vivo显示文摘 | Sakhila K Banu P Govindarajulu Michael M Aruldhas | 2002 | Steroids2002，，13： | 1 |
| 4 | Raman and Infrared Studies of NaLa(MoO4)2 :Nd3+ 显示文摘 | Ramakishnan V Aruldhas G | 1986 | Spectrochimica Acta1986，42，： | 1 |
| 5 | Testosterone and estradiol up-regulate angrogen and estrogen receptors in immature and adult rat thyroid gland in vivo显示文摘 | Banu SK Govindarajulu P Aruldhas MM | 2002 | Steroids2002，67，： | 1 |
| 6 | Testosterone and estradiol upregulate and rogen and estrogen receptors in immature and adult rat thyroid glands in vivo 显示文摘 | Banu SK Govindarajulu P Aruldhas MM | 2002 | Steroids2002，67，13： | 1 |
| 7 | Combustion Synthesis of Oxide Materials for Nuclear Waste Immobilization显示文摘 | Muthuraman M Aruldhas N Patil K C | 1994 | Bull Mater Sci1994，17，6： | 1 |
| 8 | Testosterone and estradiol have specific differential modulatory effecton the proliferation of human thyroid papillary andfollicular carcinoma cell lines independent of TSH action显示文摘 | Banu KS Govindarajulu P Aruldhas MM | 2002 | PolJ Pathol2002，53，2： | 1 |
| 9 | Vibrational and surface-enhanced Raman-scattering spectra of sulfamic acid显示文摘 | Philip D Eapen A Aruldhas G | 1995 | J Solid State Chem1995，116，2： | 1 |
| 10 | Differential response of rat skeletal muscle glycogen metabolism to testosterone and estradiol 显示文摘 | Ramamani A Aruldhas M M Govindarajulu P | 1999 | Can J Physiol Pharmacol1999，77，： | 1 |
| 11 | Differential response of rat skeletal muscle glycogen metabolism to testosterone and oestradiol 显示文摘 | RAMAMAMI A ARULDHAS M M GOVINDARAJULU P | 1999 | Can J Physiol Pharmacol1999，77，： | 1 |
| 12 | Androgen receptor expression in human thyroid cancer tissues: a potential mechanism underlying the gender bias in the incidence of thyroid cancers 显示文摘 | Stanley J A Aruldhas M M Chandrasekaran M | 2012 | J Steroid Biochem Mol Biol2012，130，12： | 1 |
| 13 | Estimating Safety Effects of Cross-section Design for Various 16 Expressway Types Using Negative Binomial Regression 显示文摘 | HADI M A ARULDHAS J CHOW L F | 1995 | Journal of Transportation Research Record1995，1550，： | 1 |
| 14 | Testosterone and estradiol have specific differential modulatory effect on the proliferation of human thyroid papillary and follicular carcinoma cell lines independent of TSH action显示文摘 | Banu KS Govindarajulu P Aruldhas MM | 2001 | Endocr Pathol2001，12，3： | 1 |
| 15 | Testosterone and estradiol have specific differential modulatory effect on the proliferation of human thyroid papillary and follicular carcinoma cell lines independent of TSH action显示文摘 | Banu KS Govindarajulu P Aruldhas MM | 2002 | Pol J Pathol2002，53，2： | 1 |
| 16 | Testosterone and estradiol have specific differential modulatory effect on the proliferation of human thyroid papillary and follicular carcino a cell lines independent of TSH action显示文摘 | Banu KS Govindarajulu P Aruldhas MM | 2001 | Endocr Pathol2001，12，3： | 1 |
| 17 | Modulatory effect of estradiol and testosterone on the development of Nnitrosodiisopropano-lamine induced thyroid tumors in female rats显示文摘 | Thiruvengadam A Govindarajulu P Aruldhas MM | 2003 | Endocr Res2003，29，1： | 1 |
| 18 | Combustion Synthesis of Oxide Materials for Nuclear Waste Immobilization显示文摘 | Muthuraman M Aruldhas N Patil K C | 1994 | Bull Mater Sci1994，17，6： | 1 |
| 19 | Chronic chromium exposure-induced changes in testicular histoarchitecture are associated with oxidative stress: study in a non-human primate (Macaca radiata Geoffrey) 显示文摘 | Aruldhas M Subramaniam S Sekar P | 2005 | Human Reprod2005，20，： | 1 |
| 20 | Developmental profiles of TSH, Sex steroids,and their receptors in the thyroid and their relevance to thyroid growth in immature rats显示文摘 | Banu SK Govindarajulu P Aruldhas MM | 2002 | Steroids2002，67，2： | 1 |
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