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| 1 | Developmental Lead Exposure Alters the Distribution of Protein Kinase C Activity in the Rat Hippocampus显示文摘Chronic low-level lead (Pb) exposure in children is known to cause a deficit in learning and memory. In vitro studies have demonstrated that Pb altered protein kinase C (PKC) activityt Especially, hippocampal PKC has been correlated with performance in several learning tasks. The effects of Pb exposure on hippocampal PKC were investigated during development at various postnatal ages: postnatal day (PN) 7, 14, 28, and 56. Two-tenth % Pb acetate was administered to pregnant and lactating dams and then administered to weanling rats in drinking water. PKC activity was measured in both membrane and cytosolic fractions from the hippocampi of the controls and Pb-exposed animals. Pb-induced increase in PKC activity in the cytosolic fraction was obsereved in the PN56 rats. In contrast, PKC activity was decreased by Pb at PN7 in the membrane fraction. Furthermore, a significant decrease in the ratio of membrane to cytosolic PKC activity which is representative of PKC distribution was observed in the PN28 and PN56 Pb-exposed rats relative to the same-age controls. This study indicates that chronic Pb exposure during development influences hippocampal PKC activity and distribution. These changes may be involved in the subclinical neurotoxicity of chronic Pb exposure in young children. | HWEI-HSIEN CHEN TANGENG MA ARTHUR S. HUME AND ING K. HO(Deportment of Pharmacology and Toxicology, University ofMississippi Medical Center, 2500 North State Street,Jackson, MS 39216, USA) | 1998 | Biomedical and Environmental Sciences1998，11，1： | 7 |
| 2 | Alcohol and Mortaiity显示文摘 | Arthur L Armstrong MA Gary D | 1992 | AnnIntern Med1992，117，8： | 1 |
| 3 | Rib fracturepain and disability:can we do better显示文摘 | Kerr-Valentic MA Arthur M Mullins RJ | 2003 | J Trauma2003，54，6： | 1 |
| 4 | Intramolecular carbon isotopic analysis of aceticacid by direct injection of aqueous solution显示文摘 | THOM AS B FREEMAN K H ARTHUR MA | 2009 | Organic Geochemistry2009，40，2： | 1 |
| 5 | Cell-based therapies and tissue engineering显示文摘 | Rice MA Dodson BT Arthur JA | 2005 | Otolaryngol Clin North Am2005，38，2： | 1 |
| 6 | Developing Predictive Models of Health Literacy显示文摘 | Laurie T. Martin ScD MPH Teague Ruder MA José J. Escarce MD PhD Bonnie Ghosh-Dastidar PhD Daniel Sherman PhD Marc Elliott PhD Chloe E. Bird PhD Allen Fremont PhD Charles Gasper MA Arthur Culbert PhD Nicole Lurie MD MSPH | 2009 | Journal of General Internal Medicine2009，，11： | 1 |
| 7 | A trial of antioxidants N-acetylcysteine and procysteine in ARDS显示文摘 | Arthur PW Murray MA | 1997 | Chest1997，112，： | 1 |
| 8 | Energetics of heterotropic cooperativity between a-naphthoflavone and testosterone binding to CYP3A4显示文摘 | Arthur GR William MA | 2007 | Archives of Biochemistry and Biophysics2007，463，1： | 1 |
| 9 | Cell-based therapies and tissue engineering 显示文摘 | Rice MA Dodson BT Arthur JA | 2005 | Otolaryngol Clin North Am2005，38，： | 1 |
| 10 | Rib fracture pain and disability: can we do better 显示文摘 | Kerr-Valentic MA Arthur M Mullins RJ | 2003 | J Trauma2003，54，6： | 1 |
| 11 | Stand structure over 9 years in burned and fire-excluded oak stands on the Cumberland Plateau,Kentucky显示文摘 | Blankenship BA Arthur MA | | 0，，： | 1 |
| 12 | Necrotic death without mitochondrial dysfunction-delayed death of cardiac myocytes following oxidative stress显示文摘 | Casey TM Arthur PG Bogoyevitch MA | 2007 | Biochim Biophys Acta2007，1773，3： | 1 |
| 13 | Cell-based Therapies and Tissue Engineering显示文摘 | RICE MA DODSON BT ARTHUR JA | 2005 | Otolaryngol Clin North Am(S0030-6665)2005，38，2： | 1 |
| 14 | Glycoprotein VI is asso- ciated with GP I b-IX-V on the membrane of resting and activated platelets 显示文摘 | Arthur JF Gardiner EE Ma'Tzaris M | 2005 | Thromb Haemost2005，93，4： | 1 |
| 15 | Response of understory vegetation and tree regeneration to a single prescribed fire in oak-pine forests显示文摘 | Kuddes-Fischer LM Arthur MA | | 0，，： | 1 |
| 16 | Developing Predictive Models of Health Literacy显示文摘 | Laurie T. Martin ScD MPH Teague Ruder MA José J. Escarce MD PhD Bonnie Ghosh-Dastidar PhD Daniel Sherman PhD Marc Elliott PhD Chloe E. Bird PhD Allen Fremont PhD Charles Gasper MA Arthur Culbert PhD Nicole Lurie MD MSPH | 2009 | Journal of General Internal Medicine2009，，11： | 1 |
| 17 | Cell-based therapies and tissue engineering 显示文摘 | Rice MA Dodson BT Arthur JA | 2005 | Otolaryngol Clin North Am2005，38，2： | 1 |
| 18 | Excerpts From the United States Renal Data System 2002 Annual Data Report: Atlas of End-Stage Renal Disease in the United States显示文摘 | Allan J. Collins Bertram Kasiske Charles Herzog Shu-Cheng Chen Susan Everson Edward Constantini Richard Grimm Marshall McBean Jay Xue Blanche Chavers Arthur Matas Willard Manning Thomas Louis Jennie Ma Wei Pan Jiannong Liu Suying Li Tricia Roberts Frederi | 2003 | American Journal of Kidney Diseases2003，，4： | 1 |
| 19 | Further studies of root decomposition following harvest of a northern hardwoods forest 显示文摘 | Fahey TJ Arthur MA | 1994 | For Sci1994，40，4： | 1 |
| 20 | Irradiated vacuum-packed lamb meat stored under refrigeration :microbiology, physicochemical stability and sensory acceptance显示文摘 | Fregonesi V P Portes R G Aguiar A M M Figueira L C Gor^alves C B Arthur V Lima C G Fernandes A M Trindade MA | 2014 | Meat Science2014，97，2： | 1 |
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