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| 1 | Photodynamic therapy vs radiofrequency ablation for Barrett's dysplasia: Efficacy,safety and cost-comparison显示文摘AIM:To compare effectiveness,safety,and cost of photodynamic therapy(PDT)and radiofrequency ablation(RFA)in treatment of Barrett’s dysplasia(BD).METHODS:Consecutive case series of patients undergoing either PDT or RFA treatment at single center by a single investigator were compared.Thirty-three patients with high-grade dysplasia(HGD)had treatment with porfimer sodium photosensitzer and 630 nm laser(130 J/cm),with maximum of 3 treatment sessions.Fifty-three patients with BD(47 with low-grade dysplasia-LGD,6 with HGD)had step-wise circumferential and focal ablation using the HALO system with maximum of 4 treatment sessions.Both groups received proton pump inhibitors twice daily.Endoscopic biopsies were acquired at 2 and 12 mo after enrollment,with 4-quadrant biopsies every 1 cm of the original BE extent.A complete histological resolution response of BD(CR-D)was defined as all biopsies at the last endoscopy session negative for BD.Fisher’s exact test was used to assess differences between the two study groups for primary outcomes.For all outcomes,a two-sided P value of less than 0.05 was considered to indicate statistical significance.RESULTS:Thirty(91%)PDT patients and 39(74%)RFA were men(P=0.05).The mean age was 70.7±12.2 and 65.4±12.7(P=0.10)year and mean length of BE was 5.4±3.2 cm and 5.7±3.2 cm(P=0.53)for PDT and RFA patients,respectively.The CR-D was(18/33)54.5%with PDT vs(47/53)88.7%with RFA(P=0.001).One patient with PDT had an esophageal perforation and was managed with non-surgical measures and no perforation was seen with RFA.PDT was five times more costly than RFA at our institution.The two groups were not randomized and had different BD grading are the limitations of the study.CONCLUSION:In our experience,RFA had higher rate of CR-D without any serious adverse events and was less costly than PDT for endoscopic treatment of BD. | Atilla Ertan Irum Zaheer Arlene M Correa Nirav Thosani Shanda H Blackmon | 2013 | World Journal of Gastroenterology2013，19，41： | 7 |
| 2 | Transformation of Arabidopsis thaliana with Agrobacterium tumefaciens 显示文摘 | Alan M Lloyd Arlene R Barnason Stephen O Rog- ers | 1986 | Science1986，234，： | 1 |
| 3 | CDC2/CDK1 Expression in Esophageal Adenocarcinoma and Precursor Lesions Serves as a Diagnostic and Cancer Progression Marker and Potential Novel Drug Target显示文摘 | Donna E Hansel Surajit Dhara RuChih C Huang Raheela Ashfaq Mari Deasel Yutaka Shimada Harold S Bernstein John Harmon Malcolm Brock Arlene Forastiere M Kay Washington Anirban Maitra Elizabeth Montgomery | 2005 | The American Journal of Surgical Pathology2005，，3： | 1 |
| 4 | A phase Ⅱ study of perifosine in androgen independent prostate cancer 显示文摘 | Posadas E M Gulley J Arlen P M | 2005 | Cancer Biol Ther2005，4，10： | 1 |
| 5 | A political theory of corporate tax- ation显示文摘 | Arlen J and Deborah M W | 1995 | Yale Law Journal1995，105，1： | 1 |
| 6 | Oligomeric and f ibrillar species of Amyloid-β peptides显示文摘 | Dahlgren Karie N Manelli Arlene M Stine W Blaine | 2002 | J Biol Chem2002，277，32： | 1 |
| 7 | The application of the psy-chological contract to workplace safety显示文摘 | | 2006 | Journal of Safety Re-search2006，36，5： | 1 |
| 8 | The impact of environmental change and human land use on alluvial valleys in the Loess Plateau of China during the Middle Holoeene 显示文摘 | Rosen M Arlene | 2008 | Geomorphology2008，101，： | 1 |
| 9 | Erbium, chromium :yttrium scandium gallium garnet laser for caries removal : influence on bond- ing of a self-etching adhesive system 显示文摘 | Arlene T Marcia MM Julia M | 2008 | Lasers Med Sci2008，23，4： | 1 |
| 10 | Phase I study of sequential vaccinations with fowlpox-CEA (6D)-TRICOM alone and sequentially with vaccinia- CEA(6D)-TRICOM, with and without granulocytemacrophage colony-stimulating factor, in patients with carcinoembryonic antigen-expressing carcinomas 显示文摘 | Marshall J L Gulley J L Arlen P M | 2005 | J Clin Oncol2005，23，： | 1 |
| 11 | The Clinical de- tection of pancreatic carcinoma: A companrison of the standard biomarkers to that of a newer class biomarkers used for both diagnosis and therapy显示文摘 | ARLEN M ARLEN P WANG X | 2013 | Pancreatic Dis T- her S2013，4，： | 1 |
| 12 | The impact of environmental change and hu- man land use on alluvial valleys in the Loess Plateau of China during the Middle Holoeene显示文摘 | Rosen M Arlene | 2008 | Ge-omorphology2008，，101： | 1 |
| 13 | The Clinical Detection of Pan creatic Carcinoma: A Comparison of the Standard Biomarkers to that of a Newer Class of Biomarkers used for both Diagnosis and Therapy显示文摘 | Arlen M Arlen P Wang X | 2013 | Pancreatic Dis Ther S2013，4，： | 1 |
| 14 | Proteasome inhibition ablates activation of NF-KB in myocardial reperfusion and reduces reperfusion injury 显示文摘 | Joseph P Farhad A Arlene M | 2003 | Am J Physiol Heart Circ Physiol2003，284，3： | 1 |
| 15 | Concurrent chemotherapy and radiotherapy for organ preservation in advanced laryngeal cancer显示文摘 | Arlene A F Helmuth G Moshe M M | 2003 | N Eng J Med2003，349，22： | 1 |
| 16 | Field production and Junctional evaluation of chloroplast derived interferon-alpha2 b显示文摘 | ARLEN P A FALCONER R CHERUKUMILLI S COLE A COLE A M OISHI K K DANIELL H | 2007 | Plant Biotechnology J ournal2007，5，4： | 1 |
| 17 | Barriers and facilitators to exercise among stroke surviors显示文摘 | Teresa M Laurie Plue Arlene Schmid | 2007 | Rehabilitation nursing2007，32，6： | 1 |
| 18 | Analysis and behavior of steel storage drive-in racks 显示文摘 | ARLENE M S F FLAVIO T S MARCILIO S R F | 2009 | Thin-Walled Structures2009，48，2： | 1 |
| 19 | Effective plague vaccination via oral delivery of plant cells expressing F1-V antigens in chloroplasts显示文摘 | ARLEN P A SINGLETON M ADAMOVICZ J J DING Y DAVOODI SEMIROMI D DANIELL H | 2008 | Infection and Immunity2008，76，8： | 1 |
| 20 | Effects of enhanced UV-B radiation on the growth of rice and its susceptibility to rice blast under glasshouse conditions显示文摘 | Finckh M R Arlene Q Chavez A | 1995 | Agriculture Ecosystems and Environment1995，52，： | 1 |
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