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| 1 | Photodynamic therapy vs radiofrequency ablation for Barrett's dysplasia: Efficacy,safety and cost-comparison显示文摘AIM:To compare effectiveness,safety,and cost of photodynamic therapy(PDT)and radiofrequency ablation(RFA)in treatment of Barrett’s dysplasia(BD).METHODS:Consecutive case series of patients undergoing either PDT or RFA treatment at single center by a single investigator were compared.Thirty-three patients with high-grade dysplasia(HGD)had treatment with porfimer sodium photosensitzer and 630 nm laser(130 J/cm),with maximum of 3 treatment sessions.Fifty-three patients with BD(47 with low-grade dysplasia-LGD,6 with HGD)had step-wise circumferential and focal ablation using the HALO system with maximum of 4 treatment sessions.Both groups received proton pump inhibitors twice daily.Endoscopic biopsies were acquired at 2 and 12 mo after enrollment,with 4-quadrant biopsies every 1 cm of the original BE extent.A complete histological resolution response of BD(CR-D)was defined as all biopsies at the last endoscopy session negative for BD.Fisher’s exact test was used to assess differences between the two study groups for primary outcomes.For all outcomes,a two-sided P value of less than 0.05 was considered to indicate statistical significance.RESULTS:Thirty(91%)PDT patients and 39(74%)RFA were men(P=0.05).The mean age was 70.7±12.2 and 65.4±12.7(P=0.10)year and mean length of BE was 5.4±3.2 cm and 5.7±3.2 cm(P=0.53)for PDT and RFA patients,respectively.The CR-D was(18/33)54.5%with PDT vs(47/53)88.7%with RFA(P=0.001).One patient with PDT had an esophageal perforation and was managed with non-surgical measures and no perforation was seen with RFA.PDT was five times more costly than RFA at our institution.The two groups were not randomized and had different BD grading are the limitations of the study.CONCLUSION:In our experience,RFA had higher rate of CR-D without any serious adverse events and was less costly than PDT for endoscopic treatment of BD. | Atilla Ertan Irum Zaheer Arlene M Correa Nirav Thosani Shanda H Blackmon | 2013 | World Journal of Gastroenterology2013，19，41： | 7 |
| 2 | The function of pro-grammed cell death 1 and its ligands in regulating autoim-munity and infection显示文摘 | Sharpe Arlene H Wherry E | 2007 | Nature Immunology2007，8，3： | 1 |
| 3 | Progeny analysis of glyphosate selected transgenic soybeans derived from Agrobacterium-mediated transformation显示文摘 | Clemente T Bradley J L Arlene R H | 2000 | Crop Sci2000，40，： | 1 |
| 4 | Predictors of Serological Cure and Serofast State After Treatment in HIV-Negative Persons With Earl Syphilis 显示文摘 | Se a Arlene C Wolff Mark Martin David H | 2011 | Clinical Infectious Diseases2011，53，11： | 1 |
| 5 | Rapid and reproducible Agrobacterium--Mediated transformation of sorghum 显示文摘 | Arlene H Shirley S Ismail D | 2006 | Plant Cell Reports2006，25，： | 1 |
| 6 | Field production and Junctional evaluation of chloroplast derived interferon-alpha2 b显示文摘 | ARLEN P A FALCONER R CHERUKUMILLI S COLE A COLE A M OISHI K K DANIELL H | 2007 | Plant Biotechnology J ournal2007，5，4： | 1 |
| 7 | Effective plague vaccination via oral delivery of plant cells expressing F1-V antigens in chloroplasts显示文摘 | ARLEN P A SINGLETON M ADAMOVICZ J J DING Y DAVOODI SEMIROMI D DANIELL H | 2008 | Infection and Immunity2008，76，8： | 1 |
| 8 | T cell costimulation and coinhibition inatherosclerosis显示文摘 | Arlene H Andrew H | 2008 | Circ Res2008，103，11： | 1 |
| 9 | Differential effects of oligomeric and fibrillar amyloid-B1-42 on astrocyte-mediated inflammation显示文摘 | Jill A White Arlene M Manelli Kristina H Holmberg | 2005 | Neurobiol Dis2005，18，3： | 1 |
| 10 | 显示文摘 | Jacobs J D Arlen M J Wang D H | 2010 | Polymer2010，51，14： | 1 |
| 11 | 显示文摘 | Jacobs J D Arlen M J Wang D H | 2010 | Polymer2010，51，14： | 1 |
| 12 | T cell costimulation and coinhibition inatherosclerosis显示文摘 | Arlene H Andrew H | 2008 | Circ Res2008，103，11： | 1 |
| 13 | The C-S lyases of higher plants显示文摘 | Arlene H Mazelis M | 1986 | Plant Physiol1986，80，： | 1 |
| 14 | The Use of immu- nofluoreseenee microscopy(IFM) and enzyme-linked immu- nosorbent assay (ELISA) as complementary techniques for protein identification in artists' materials显示文摘 | ARLEN H VICTORIA M MICHAEL Q | 2006 | Journal of the American Institute for Conservation2006，45，2： | 1 |
| 15 | Glyphosate as a selective agent for the production of fertile transgenle maize (Zea mays L)显示文摘 | Arlene R H Charles S G Sherri M B | 2002 | Mol Breed2002，10，： | 1 |
| 16 | The use of immunofluorescence microscopy ( IFM ) and enzyme linked immunosorbent assay (ELISA) as complementary techniques for protein identification in artists' materials显示文摘 | Arlen H Victoria M Michael Q | 2006 | J Am Inst Conserv2006，，2： | 1 |
| 17 | Molecular characterization,reactivation,and depletion of latent HIV显示文摘 | Brooks D G Hamer D H Arlen P A | 2003 | Immunity2003，19，： | 1 |
| 18 | HPV-associated head and neck cancer: a virus-related cancer epidemic显示文摘 | Shanthi Marur Gypsyamber D’Souza William H Westra Arlene A Forastiere | 2010 | Lancet Oncology2010，，8： | 1 |
| 19 | CD28 ligation increases macrophage suppression of T-cell proliferation显示文摘什么时候与怒气或淋巴节点房间相比,居民腹洞房间在 vitro 对 T 房间激活糟糕作出回应。在这房间来源的巨噬细胞的更伟大的比例的表示被显示了活跃地压制 T 房间反应。腹巨噬细胞展出不成熟的显型(MHC 班 II lo , B7 作为介绍抗原的房间减少他们的功效的 lo ) 。而且,这些房间乐意地表示可诱导的氮的氧化物 synthase (iNOS ) ,由限制氨基酸精氨酸的分解代谢支持 T 房间忍耐的酶。这里,我们调查外长的 T 房间 costimulation 的能力恢复腹 T 房间反应。我们证明 CD28 结扎没能恢复腹 T 房间反应并且实际上压制了被禁止 iNOS 恢复了的回答。是由 cytokine ELISpot 和抵销的 monoclonal 显示了抗体(mAb ) 处理,这 ‘ cosuppression’反应由于增加干扰素(IFN ) 的数字的 CD28 结扎是 -γ-secreting 房间。我们的结果说明那篇细胞的作文和 cytokine 周围影响 T 房间 costimulation 生物学。 | Daniel Silberman Amanda Bucknum Thomas Bartlett Gabriella Composto Megan Kozlowskil Amanda Walker Amy Werda Jackelyn Cua Arlene H Sharpe John E Somerville James E Riggs | 2012 | Cellular & Molecular Immunology2012，9，4： | 0 |
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