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| 1 | Role of pentoxifylline in non-alcoholic fatty liver disease in high-fat diet-induced obesity in mice显示文摘AIM:To study pentoxifylline effects in liver and adipose tissue inflammation in obese mice induced by high-fat diet(HFD).METHODS: Male swiss mice(6-wk old) were fed a highfat diet(HFD; 60% kcal from fat) or AIN-93(control diet; 15% kcal from fat) for 12 wk and received pentoxifylline intraperitoneally(100 mg/kg per day) for the last 14 d. Glucose homeostasis was evaluated by measurements of basal glucose blood levels and insulin tolerance test two days before the end of the protocol. Final body weight was assessed. Epididymal adipose tissue was collected and weighted for adiposity evaluation. Liver and adipose tissue biopsies were homogenized in solubilization buffer and cytokines were measured in supernatant by enzyme immunoassay or multiplex kit, respectively. Hepatic histopathologic analyses were performed in sections of paraformaldehyde-fixed, paraffin-embedded liver specimens stained with hematoxylin-eosin by an independent pathologist. Steatosis(macrovesicular and microvesicular), ballooning degeneration and inflammation were histopathologically determined. Triglycerides measurements were performed after lipid extraction in liver tissue. RESULTS: Pentoxifylline treatment reduced microsteatosis and tumor necrosis factor(TNF)-α in liver(156.3 ± 17.2 and 62.6 ± 7.6 pg/mL of TNF-α for non-treated and treated obese mice, respectively; P < 0.05). Serum aspartate aminotransferase levels were also reduced(23.2 ± 6.9 and 12.1 ± 1.6 U/L for nontreated and treated obese mice, respectively; P < 0.05) but had no effect on glucose homeostasis. In obese adipose tissue, pentoxifylline reduced TNF-α(106.1 ± 17.6 and 51.1 ± 9.6 pg/mL for non-treated and treated obese mice, respectively; P < 0.05) and interleukin-6(340.8 ± 51.3 and 166.6 ± 22.5 pg/mL for non-treated and treated obese mice, respectively; P < 0.05) levels; however, leptin(8.1 ± 0.7 and 23.1 ± 2.9 ng/mL for non-treated and treated lean mice, respectively; P < 0.05) and plasminogen activator inhibitor-1(600.2 ± 32.3 and 1508.6 ± 210.4 pg/mL for non-treated and treated lean mice, respectively; P < 0.05) levels increased in lean adipose tissue. TNF-α level in the liver of lean mice also increased(29.6 ± 6.6 and 75.4 ± 12.6 pg/mL for non-treated and treated lean mice, respectively; P < 0.05) while triglycerides presented a tendency to reduction.CONCLUSION: Pentoxifylline was beneficial in obese mice improving liver and adipose tissue inflammation. Unexpectedly, pentoxifylline increased pro-inflammatory markers in the liver and adipose tissue of lean mice. | Simone Coghetto Acedo Cintia Rabelo e Paiva Caria érica Martins Ferreira Gotardo José Aires Pereira José Pedrazzoli Marcelo Lima Ribeiro Alessandra Gambero | 2015 | World Journal of Hepatology2015，7，24： | 2 |
| 2 | Characterization of cis-acting sequences regtflating root-specific gene expression in to- bacco 显示文摘 | Yamamoto YT Taylor CG Acedo GN | 1991 | Plant Cell1991，3，： | 1 |
| 3 | Iterative methods for strict pseudo-contractions in Hilbert spaces显示文摘 | ACEDO G L XU H K | 2007 | Nonlinear Analysis2007，67，： | 1 |
| 4 | In vitro Conservation of yam germplasm 显示文摘 | Acedo V Z Arradoza C | 2005 | Philippine Journal of Crop Science2005，30，1： | 1 |
| 5 | The effect of water treeing on the electric field distribution of XLPE显示文摘 | Radu I Acedo M Filippini J C | 2000 | IEEE Trans on Dielectrics and Electrical Insulation2000，7，6： | 1 |
| 6 | An implicit method for funding common solutions of variational inequalities and systems of equilibrium problems and fixed points of infinite family of nonexpansive mappings显示文摘 | Colao V Acedo G L Marino G | 2009 | Nonlinear Anal2009，71，78： | 1 |
| 7 | The danger of water trees in polymer insulated cables evaluated from calculations of electric field in the presence of water trees显示文摘 | Radu I Acedo M Notingher P | 1997 | Journal of Electrostatics1997，4041，： | 1 |
| 8 | Conservation of yam germplasm 显示文摘 | Acedo V Z Arradoza C | 2005 | Philippine Journal of Crop Science2005，30，1： | 1 |
| 9 | Effects of methotrexate on inflammatory alterations induced by obesity: An in vivo and in vitro study显示文摘 | Caroline Candida DeOliveira Simone Coghetto Acedo érica Martins Ferreira Gotardo Patricia de Oliveira Carvalho Thalita Rocha José Pedrazzoli Alessandra Gambero | 2012 | 2012 (1-2)2012，，1： | 1 |
| 10 | Banana fruit response to ethylene at different concentration of oxygen and carbon dioxide 显示文摘 | Acedo A L Bautista O K | 1993 | Aseen Food Journal1993，8，2： | 1 |
| 11 | Curriculum Reforms: In Search of Innova- tive Models for Dynamic Education Systems显示文摘 | ACEDO C | 2013 | Pros- pects2013，43，： | 1 |
| 12 | An entrepreneurial cognition perspective on the internationalization of SMEs显示文摘 | Francisco Jose Acedo & Juan Florin | 2006 | Springer Business Media2006，2006，： | 1 |
| 13 | The danger of water trees in polymer insulated power cables evaluated from calculations of electric field in the presence of water trees of different shapes and permittivity distributions 显示文摘 | Radu I Acedo M Notingher P | 1997 | Journal of Electrostatics1997，，4041： | 1 |
| 14 | An explicit finite difference method and a new von Neumann-type stability analysis for fractional diffusion equations显示文摘 | Yuste S B Acedo L | 2005 | SIAM Journal on Numerical Analysis2005，42，5： | 1 |
| 15 | In vitro conservation of yam germplasnl 显示文摘 | Acedo V Z Arradoza C | 2005 | Phihppine Journal of Crop Science2005，30，1： | 1 |
| 16 | Water treeing in underground power cables: modelling of the trees and calculation of the electric field perturbation显示文摘 | Acedo M Radu I Frutos F | 2001 | Journal of Electrostatics2001，53，4： | 1 |
| 17 | Determination of neutral and cationic herbicides in water by micellar electrokinetic capillary chromatography显示文摘 | ACEDO -VALENZUELA M I TERESA G D NIELENE M D ANTONIO S R | 2004 | Anal Chim Acta2004，519，： | 1 |
| 18 | In vitro conservation of yam germplasm显示文摘 | Acedo V Z Arradoza C | 2005 | Philippine Journal of Crop Science2005，30，1： | 1 |
| 19 | The effect of water treeing on the electric field distribution of XLPE- consequences for the dielectric strength显示文摘 | Radu I Acedo M Filippini J C | 2000 | IEEE Transactions on Dielectrics and Electrical Insulation2000，7，6： | 1 |
| 20 | Relationship between the structure of Ru/CeO2 catalysts and their activity in the catalytic ozonation of succinic acid aqueous solution显示文摘 | Acedo B Karpel N V L | 2001 | Appl Catal B:Environ2001，29，： | 1 |
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