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| 1 | Comparison of the effects of bevacizumab and ranibizumab injection on corneal angiogenesis in an alkali burn induced model显示文摘·AIM:To investigate the effects of bevacizumab and ranibizumab on corneal neovascularization in an alkali burn-induced model of corneal angiogenesis. ·METHODS:Fifteen Wistar-Albino rats were divided randomly into 3 groups after chemical cauterization of the cornea. The first group received a single dose of 0.1mL saline solution as a control group whereas second and third groups received a single dose of 2.5mg bevacizumab or 1mg ranibizumab by subconjunctival injection, respectively. After three weeks, the rat corneas were evaluated by biomicroscopy and corneal photographs were taken. The percentage of neovascularization area, length of the longest new vessel, corneal oedema and corneal opacity scores were assessed. ·RESULTS:The analysis of digital photographs showed that the percentage of neovascularization area to the total corneal area, the length of the longest new vessel, corneal oedema and opacity scores were significantly lower in both study groups compared to the control group (P <0.05). Additionally, the percentage of corneal neovascularization area, the length of the longest new vessel and corneal opacity score were less with bevacizumab than ranibizumab. ·CONCLUSION:Subconjunctival bevacizumab and ranibizumab treatments may be effective methods in reducing corneal neovascularization. Furthermore, bevacizumab is more effective than ranibizumab in the inhibition of corneal neovascularization. | Ayhan Dursun Mustafa Kemal Arici Feyza Dursun Ayse Vural Ozec Mustafa Ilker Toker Haydar Erdogan Aysen Topalkara | 2012 | International Journal of Ophthalmology(English edition)2012，5，4： | 10 |
| 2 | Performance evaluation of hybrid constructed wetlands for the treatment of municipal wastewater in developing countries显示文摘In developing countries,high cost of conventional wastewater treatment is a major hindrance in its application.Constructed wetlands(CWs)offer low-cost and effective solution to this issue.The current study aimed to evaluate an innovative maneuver of CWs i.e.hybrid flow constructed wetlands(HCWs)for municipal wastewater(MWW).The HCWs included two lab scale CWs;one horizontal and one vertical,in series.Local plant species were used.HCWs were operated in both,batch and continuous mode.Batch mode was used to(1)optimize detention time and(2)find pollutants removal efficiency.Continuous operation(at batch optimized retention time)was carried out for the evaluation of mass removal rate,r(g·m-2·d-1),volumetric rate constant,Kv(per day)and areal rate constant,Ka(m·d-1).Among two local plants tested,Pistia stratiotes gave better removal efficiency than Typha.Optimum detention time in HCWs was found to be 8 days(4+4 each).The optimum COD,BOD,TSS,TKN and P removal observed for Pistia stratiotes planted HCWs was 80%,84%,82%,71%and88%respectively.Effluent standards for COD,BOD and TSS were met at optimum conditions.The values of Kaand Kv demonstrated that more removal occurred in vertical flow as compared to horizontal flow CW. | Sajjad Haydar Mehwish Anis Misbah Afaq | 2020 | Chinese Journal of Chemical Engineering2020，28，6： | 4 |
| 3 | Comparison of pre-treatment and post-treatment use of selenium in retinal ischemia reperfusion injury显示文摘AIM: To investigate the effects of selenium in rat retinal ischemia reperfusion(IR) model and compare pretreatment and post-treatment use.METHODS: Selenium pre-treatment group(n =8) was treated with intraperitoneal(i.p.) selenium 0.5 mg/kg for7 d and terminated 24 h after the IR injury. Selenium posttreatment group( n = 8) was treated with i. p. selenium0.5 mg/kg for 7d after the IR injury with termination at the end of the 7d period. Sham group(n =8) received i.p.saline injections identical to the selenium volume for 7d with termination 24 h after the IR injury. Control group(n =8) received no intervention. Main outcome measures were retina superoxide dismutase(SOD), glutathione(GSH),total antioxidant status(TAS), malondialdehyde(MDA),DNA fragmentation levels, and immunohistological apoptosis evaluation.RESULTS: Compared to the Sham group, selenium pre-treatment had a statistical difference in all parameters except SOD. Post-treatment selenium also resulted in statistical differences in all parameters except the MDA levels. When comparing selenium groups, the pre-treatment selenium group had a statistically higher success in reduction of markers of cell damage such as MDA and DNA fragmentation. In contrast, the post-selenium treatment group had resulted in statisticallyhigher levels of GSH. Histologically both selenium groups succeeded to limit retinal thickening and apoptosis. Pre-treatment use was statistically more successful in decreasing apoptosis in ganglion cell layer compared to post-treatment use.CONCLUSION: Selenium was successful in retinal protection in IR injuries. Pre-treatment efficacy was superior in terms of prevention of tissue damage and apoptosis. | Alper Yazici Hasan Aksit Esin Sogutlu Sari Arzu Yay Haydar Ali Erken Dilek Aksit Harun Cakmak Kamil Seyrek Sitki Samet Ermis | 2015 | International Journal of Ophthalmology(English edition)2015，8，2： | 3 |
| 4 | Total oxidative stress, paraoxonase and arylesterase levels at patients with pseudoexfoliation syndrome and pseudoexfoliative glaucoma显示文摘AIM: To investigate the oxidative stress status of the aqueous humor and serum of patients with pseudoexfoliation(PEX) syndrome and pseudoexfoliative glaucoma(PEG) and to measure paraoxonase(PON) and arylesterase(ARE) levels.·METHODS: A total of 78 patients were enrolled in the study, with 26 patients in each separate group. The patients were divided into three groups: the first group entailed PEX syndrome patients, while the second group consisted of patients with PEG and the third group involved patients with no additional systemic diseases,other than the diagnosis of cataract as control. Total oxidative stress(TOS), total antioxidant capacity(TAC),PON, and ARE levels in aqueous humor and serum were measured.·RESULTS: TAC, PON and arylesterase levels in aqueous humor and serum of the PEX syndrome and PEG patients were significantly decreased compared with control group(P <0.05). TOS values were higher in patients with PEX syndrome and PEG than controls(P <0.05). TAC, PON and ARE levels of aqueous humor did not differ significantly between the PEX syndrome and PEG groups·CONCLUSION: These findings are potentially of significance and add to the growing body of evidence for oxidative stress in PEX syndrome and PEG. Decreased antioxidant defense and increased oxidative stress system may play an important role in the pathogenesis of PEX syndrome and PEG. | Feyza Dursun Ayse Vural Ozec Huseyin Aydin Aysen Topalkara Ayhan Dursun Mustafa Ilker Toker Haydar Erdogan Mustafa Kemal Arici | 2015 | International Journal of Ophthalmology(English edition)2015，8，5： | 2 |
| 5 | Can ischemia and dyssynchrony be detected during early stages of dobutamine stress echocardiography by 2-dimensional speckle tracking echocardiography?显示文摘 | Yang Yu Hector R. Villarraga Haydar K. Saleh Stephen S. Cha Patricia A. Pellikka | 2013 | The International Journal of Cardiovascular Imaging2013，，1： | 2 |
| 6 | Aortic pulse wave velocity and arterial wave reflections predict the extent and severity of coronary artery disease in chronic kidney disease patients 显示文摘 | Covic A Haydar AA Bhamra-Ariza P | 2005 | J Nephrol2005，18，4： | 1 |
| 7 | Complement-mediated injury reversibly disrupts glomerular epithelial cell actin microfilaments and focal adhesions Experimental membranous 显示文摘 | Topharn PS Haydar SA Kuphal R | 1999 | Kidney Int1999，55，5： | 1 |
| 8 | Changes in the alveolar bone thickness due to retraction of anterior teeth 显示文摘 | Sarikaya S Haydar B Ciger S | 2002 | Am J Orthod Dentofacial Orthop2002，122，1： | 1 |
| 9 | Effect of latanoprost/timolol and dorzolamide/tiomolol on intraocular pressure after phacoemulsification surgery显示文摘·AIM:To evalaute the effect of fixed-combination latanoprost 0.005%/timolol maleate 0.5% and dorzolamide hydrochloride 2%/timolol maleate 0.5% on postoperative intraocular pressure after phacoemulsification cataract surgery.·METHODS:This study is a prospective,randomized,double-masked and placebo-controlled.The study included 90 eyes of 90 patients which were scheduled to have phacoemulsification surgery.Patients were randomly assigned preoperatively to 1 of 3 groups (30 eyes of 30 patients).Two hour before surgery,the patients received one drop latanoprost/timolol (group 1),dorzolamide/timolol (group 2) and placebo (group 3,control group).The IOPs were measured at preoperative and postoperative 4,8,and 24 hours.·RESULTS:The preoperative mean intraocular pressure was not statistically significant between both drug groups and control group.In group 1 and 2,the postoperative mean IOP [group1:(14.03?à3.15)mmHg and group 2:(14.16?à4.43)mmHg] at 24 hours were significantly lower than the control group [(16.93?à3.70)mmHg,(P <0.05)].In addition,the postoperative mean IOP of group 1 [(14.90±3.69)mmHg] at 8 hours was significantly lower than the control group [(17.70?à3.89)mmHg,(P <0.05)],but there was no significant difference between group 2 [(16.16?à5.23)mmHg] and control group at 8 hours (P >0.05).·CONCLUSION:When compared with placebo,the use of preoperative fixed combination of latanoprost/timolol and dorzolamide/timolol is an effective method for preventing intraocular pressure elevation in 24 hours after phacoemulsification surgery,but did not completely prevent IOP spikes.· | Haydar Erdogan Ayse Vural Ozec Cengiz Caner Mustafa Ilker Toker Mustafa Kemal Arici Aysen Topalkara | 2011 | International Journal of Ophthalmology(English edition)2011，4，2： | 1 |
| 10 | Nephritogenic mAb 5-1-6 alters expression of ZO-1 in rat nephrin显示文摘 | Topham PS Kawachi H Haydar SA | 1999 | J Clin Invest1999，104，11： | 1 |
| 11 | Leachate recirculation using horizontal trenches in bioreactor landfills显示文摘 | HAYDAR M KHIRE M | 2005 | Journal of Geotechnical and Geoenvir0nmental Engineering ASCE2005，131，7： | 1 |
| 12 | Changes in alveolar bone thickess due to retraction of anterior teeth 显示文摘 | Sarikaya S Haydar B Cier S | 2002 | Am J Orthod Dentofacial Orthop2002，122，1： | 1 |
| 13 | SAR and biological evaluation of SEN12333/WAY- 317538 : novel alpha 7 nicotinic acetylcholine receptor agonist 显示文摘 | HAYDAR S N GHIRON C BETTINETTI L | 2009 | Bioorg Med Chem2009，17，14： | 1 |
| 14 | Coagulation-flocculation studies of tannery wastewater using combination of alum with cationic and anionic polymers 显示文摘 | Sajjad Haydar Javed Anwar Aziz | 2009 | Joumal of Hazardous Materials2009，168，23： | 1 |
| 15 | Comparison of Jones jig molar distalization appliance with extraoral traction显示文摘 | Haydar S Uner O | 2000 | Am J Orthod Dentofacial Orthop2000，117，： | 1 |
| 16 | Adsorption ofp-nitrophenol on an activated carbon with different oxidations显示文摘 | Haydar S Ferro-Garcla M A Rivera-Utrilla J | 2003 | Carbon2003，41，3： | 1 |
| 17 | The inci- dence of spinal cord ischaemia following thoracic and thoracoabdominal aortic endovascular intervention显示文摘 | Drinkwater SL Goebells A Haydar A | 2010 | Eur J Vasc Endovasc Surg2010，40，6： | 1 |
| 18 | Experimental simulation of tensile behavior of lunar soil simulant JSC-1显示文摘 | Haydar Arslan Stein Sture Susan Batiste | 2007 | Materials Science & Engineering A2007，，1： | 1 |
| 19 | Beneficial effects of statins on the kidney:the evidence moves from mouse to man 显示文摘 | Afzali B Haydar AA Vinen K | 2004 | Nephrol Dial Transplant2004，19，： | 1 |
| 20 | Epiatatic and independent functions of caspase-3 Bcl-X (L) in developmental programmed cell death显示文摘 | Roth KA Kuan C Haydar TF | 2000 | Proc Natl Acad Sci U S A2000，97，1： | 1 |
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