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| 1 | Role of gut microbiota-immunity axis in patients undergoing surgery for colorectal cancer:Focus on short and long-term outcomes显示文摘Human body is colonized by a huge amount of microorganisms mostly located in the gastrointestinal tract.These dynamic communities,the environment and their metabolites constitute the microbiota.Growing data suggests a causal role of a dysbiotic microbiota in several pathologies,such as metabolic and neurological disorders,immunity dysregulations and cancer,especially the well-studied colorectal cancer development.However,many were preclinical studies and a complete knowledge of the pathogenetic mechanisms in humans is still absent.The gut microbiota can exert direct or indirect effects in different phases of colorectal cancer genesis.For example,Fusobacterium nucleatum promotes cancer through cellular proliferation and some strains of Escherichia coli and Bacteroides fragilis produce genotoxins.However,dysbiosis may also cause a proinflammatory state and the stimulation of a Th17 response with IL-17 and IL-22 secretion that have a pro-oncogenic activity,as demonstrated for Fusobacterium nucleatum.Microbiota has a crucial role in several stages of postoperative course;dysbiosis in fact seems related with surgical site infections and Enterococcus faecalis(and other collagenase-producers microbes)are suggested as a cause of anastomotic leak.Consequently,unbalanced presence of some species,together with altered immune response may also have a prognostic role.Microbiota has also a substantial role in effectiveness of chemotherapy,chemoresistance and in the related side effects.In other words,a complete knowledge of the fine pathological mechanisms of gut microbiota may provide a wide range of new diagnostic tools other than therapeutic targets in the light of tailored medicine. | Ilenia Bartolini Matteo Risaliti Maria Novella Ringressi Filippo Melli Giulia Nannini Amedeo Amedei Paolo Muiesan Antonio Taddei | 2020 | World Journal of Gastroenterology2020，26，20： | 6 |
| 2 | Methane production and small intestinal bacterial overgrowth in children living in a slum显示文摘AIM:To analyze small intestinal bacterial overgrowth in school-aged children and the relationship between hydrogen and methane production in breath tests.METHODS:This transversal study included 85 children residing in a slum and 43 children from a private school,all aged between 6 and 10 years,in Osasco,Brazil.For characterization of the groups,data regarding the socioeconomic status and basic housing sanitary conditions were collected.Anthropometric data was obtained in children from both groups.All children completed the hydrogen(H 2) and methane(CH 4) breath test in order to assess small intestinal bacterial overgrowth(SIBO).SIBO was diagnosed when there was an increase in H 2 ≥ 20 ppm or CH 4 ≥ 10 ppm with regard to the fasting value until 60 min after lactulose ingestion.RESULTS:Children from the slum group had worse living conditions and lower nutritional indices than children from the private school.SIBO was found in 30.9%(26/84) of the children from the slum group and in 2.4%(1/41) from the private school group(P = 0.0007).Greater hydrogen production in the small intestine was observed in children from the slum group when compared to children from the private school(P = 0.007).A higher concentration of hydrogen in the small intestine(P < 0.001) and in the colon(P < 0.001) was observed among the children from the slum group with SIBO when compared to children from the slum group without SIBO.Methane production was observed in 63.1%(53/84) of the children from the slum group and in 19.5%(8/41) of the children from the private school group(P < 0.0001).Methane production was observed in 38/58(65.5%) of the children without SIBO and in 15/26(57.7%) of the children with SIBO from the slum.Colonic production of hydrogen was lower in methaneproducing children(P = 0.017).CONCLUSION:Children who live in inadequate environmental conditions are at risk of bacterial overgrowth and methane production.Hydrogen is a substrate for methane production in the colon. | Carolina Santos Mello Soraia Tahan Lígia Cristina FL Melli Mirian Silva do Carmo Rodrigues Ricardo Martin Pereira de Mello Isabel Cristina Affonso Scaletsky Mauro Batista de Morais | 2012 | World Journal of Gastroenterology2012，18，41： | 3 |
| 3 | Enteral glutamine pretreatment does not decrease plasma endotoxin level induced by ischemia-reperfusion injury in rats显示文摘AIM:To investigate whether oral glutamine pretreatment prevents impairment of intestinal mucosal integrity during ischemia-reperfusion (I/R) in rats. METHODS: The study was performed as two series with 40 rats in each. Each series of animals was divided into four groups. The first group was used as a control. Animals in the second group were only pretreated with oral glutamine, 1 g/kg for 4 d. The third group received a normal diet, and underwent intestinal I/R, while the fourth group was pretreated with oral glutamine in the same way, and underwent intestinal I/R. Intestinal mucosal permeability to 51Cr-labeled EDTA was measured in urine in the first series of animals. In the second series, histopathological changes in intestinal tissue and plasma endotoxin levels were evaluated. RESULTS: Intestinal I/R produced a significant increase in intestinal permeability, plasma endotoxin level and worsened histopathological alterations. After intestinal I/R, permeability was significantly lower in glutamine- treated rats compared to those which received a normal diet. However, no significant change was observed in plasma endotoxin levels or histopathological findings. CONCLUSION: Although glutamine pretreatment seems to be protective of intestinal integrity, upon I/R injury, such an effect was not observable in the histopathological changes or plasma endotoxin level. | Arda Demirkan Erkin Orazakunov Berna Sava■ M Ayhan Kuzu Mehmet Melli | 2008 | World Journal of Gastroenterology2008，14，3： | 2 |
| 4 | Quorum sensing controls expression of the type Ⅲ secretion gene transcription and protein secretion in enterohemorrhagic and enteropathogenic Escherichia coli显示文摘 | Sperandio V Mellies JL Nguyen W | 1999 | Proc Natl Acad Sci USA1999，96，15： | 1 |
| 5 | The chicken Il-I receptor:differential evolution of the cytoplasmic and extracellular domains显示文摘 | GUIDA S HEGUY A MELLI M | 1992 | Gene1992，111，： | 1 |
| 6 | Properties of spores of Bacillus subtilis blocked at an intermediate stage of spore germination 显示文摘 | Setlow B Melly E Setlow P | 2001 | J Bacteriol2001，183，： | 1 |
| 7 | Rhabdomyolysis: an evaluation of 475 hospitalized patients显示文摘 | Melli G Chaudhry V Cornblath DR | 2005 | Medicine (Baltimore)2005，84，6： | 1 |
| 8 | Isolation of endogenous anti- coagulant N-sulfated glycosaminoglycans in human plasma from healthy subjects 显示文摘 | Ruggiero M Melli M Parma B | 2002 | Pathophysiol Haemost Thromb2002，32，： | 1 |
| 9 | Listening to action- related sentences modulates the activity of the motor system: a combined TMS and behavioral study显示文摘 | Buccino G Riggio L Melli G | 2005 | Brain Res Cogn Brain Res2005，24，： | 1 |
| 10 | Public-Private Sector Wage Differentials in Germany:Evidence from Quantile Regression显示文摘 | Melly B | 2005 | Empirical Economics2005，30，2： | 1 |
| 11 | Effect of a monoclonal antibody to PCSK9 on LDL cholesterol显示文摘 | Stein EA Mellis S Yancopoulos GD | | 0，，： | 1 |
| 12 | Properties of periodate oxidized starch显示文摘 | Sloan J W Hofreiter B T Mellies R T | 1960 | Industrial and Engineering Chem1960，48，： | 1 |
| 13 | A case-control analysis ofexposure to traffic and acute myocardial infarction显示文摘 | Tonne C Melly S Mittleman M | 2007 | Environ HealthPerspect2007，115，： | 1 |
| 14 | Effect of a monoclonal antibody to PCSK9 on LDL cholesterol显示文摘 | Stein EA Mellis S Yancopoulos GD | 2012 | N Engl J Med2012，366，12： | 1 |
| 15 | Comparison of platinum-based neoadjuvant chemotherapy and primary debulking surgery in patients with advanced ovarian cancer 显示文摘 | Sayyah- Melli M Zonoozi G K Hashemzadeh S et a1 | 2013 | J Obstet Gynaecol India2013，63，6： | 1 |
| 16 | Endotoxin level in is-chemia-reperfusion injury in rats:effect of glutamine pretreatment on endotoxin levels and gut morphology显示文摘 | Demirkan A Savas B Melli M | | 0，，01： | 1 |
| 17 | Develop- ment and validation of a novel diagnostic test for human bru- cellosis using a glyco-engineered antigen coupled to magnetic beads显示文摘 | Ciocchini A E Serantes D A R Melli L J | 2013 | PLoS Negl Trop Dis2013，7，2： | 1 |
| 18 | Effect of a monoclonal antibody to PCSK9 on LDL cholesterol 显示文摘 | Stein EA Mellis S Yancopoulos GD | 2012 | N Engl J Med2012，366，12： | 1 |
| 19 | Decomposition of Differences in Distribution UsingQuantile Regression 显示文摘 | Melly B | 2005 | Labour Economics2005，12，4： | 1 |
| 20 | Optimizing training: what clinicians have to offer and how to deliver it 显示文摘 | Mellis CM | 2008 | Paediatric Respiratory Reviews2008，9，2： | 1 |
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