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1Gastrointestinal motility disorders in inflammatory bowel diseases显示文摘The relationship between motility and inflammatory gastrointestinal disorders is at the same time complex and intriguing since these conditions might share some genetic,environmental,immunological and microbial predisposing factors.In addition,significant symptom overlapping may occur,muddling the waters within the clinical context.Although on one hand this represents a challenge for the clinician for a potential under-or over-treatment and diagnostic delay,on the other hand it possibly represents an opportunity for the researcher to better disclose the intimate relationship between chronic(often low-grade)inflammation,motor disorders and deranged sensory function.The best example is probably represented by Crohn’s disease and ulcerative colitis.In fact,a number of gastrointestinal motor disorders have been described in association with these diseases,disorders which span from the esophagus to the anorectum,and which will be extensively covered in this review.It is conceivable that at least part of this derangement is strictly related to inflammatory cytokine trafficking and neuromuscular changes;however,given the high prevalence of functional gastrointestinal disorders in the general population,this overlap might also be serendipitous.However,it is worth noting that literature data on this topic are relatively scarce,sometimes quite outdated,and mostly focused on the interplay between irritable bowel syndrome and inflammatory bowel disease.Nevertheless,both researchers and clinicians must be aware that symptoms related to gastrointestinal motility disorders may be highly prevalent in both active and inactive inflammatory bowel disease,correlate with greater psychological comorbidity and poorer quality of life,and may negatively influence the therapeutic approaches.Gabrio Bassotti Elisabetta Antonelli Vincenzo Villanacci Marianna Salemme Manuela Coppola Vito Annese 2014World Journal of Gastroenterology2014,20,1:11
2溃疡性结肠炎肠黏膜愈合后的显微结构研究显示文摘目的探讨溃疡性结肠炎(ulcerative colitis,UC)患者肠黏膜愈合后的显微结构特征。方法以UC临床缓解期患者为研究对象,用甲醛制作UC的愈合肠黏膜标本,与同等数量正常肠黏膜标本对照,光镜下观察肠黏膜显微结构的炎症及结构改变。对比实验组与对照组实验室指标差异。结果 UC组结构改变及慢性炎症比率高于对照组,原UC病灶愈合处更易发生结构改变。基底层淋巴细胞浸润是慢性炎症最突出的特征。两组CRP、ESR值比较差异无统计学意义(P>0.05),ALB、BMI、Hb水平比较差异有统计学意义(P<0.05)。结论 UC内镜下观察到的愈合黏膜仍有不同程度持续慢性炎症改变。以显微镜下慢性炎症缓解作为治疗目标可能更利于控制UC复发。王萍 黄敏 陈峰 姚晓红 2016胃肠病学和肝病学杂志2016,25,10:7
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