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| 1 | Ly49 receptors activate angiogenic mouse DBA+ uterine natural killer cells显示文摘 | Patricia DA Lima Megan M Tu Mir Munir A Rahim Annie R Peng B Anne Croy Andrew P Makrigiannis | 2014 | Cellular & Molecular Immunology2014，11，5： | 3 |
| 2 | Disseminated intravascular coagulation associated with massive brain injury显示文摘 | Keimowitz R M Annis B L | 1973 | J Neurosurg1973，39，2： | 2 |
| 3 | High omega arachidonic acid/docosahexaenoic acid ratio induces mitochondrial dysfunction and altered lipid metabolism in human hepatoma cells显示文摘BACKGROUND Non-alcoholic fatty liver disease(NAFLD) is a common cause of liver disease worldwide and is a growing epidemic. A high ratio of omega-6 fatty acids to omega-3 fatty acids in the diet has been implicated in the development of NAFLD. However, the inflicted cellular pathology remains unknown. A high ratio may promote lipogenic pathways and contribute to reactive oxygen species(ROS)-mediated damage, perhaps leading to mitochondrial dysfunction.Therefore, these parameters were investigated to understand their contribution to NAFLD development.AIM To examine the effect of increasing ratios of omega-6:3 fatty acids on mitochondrial function and lipid metabolism mediators.METHODS Hep G2-derived VL-17 A cells were treated with normal(1:1, 4:1) and high(15:1,25:1) ratios of omega-6: omega-3 fatty acids [arachidonic acid(AA):docosahexaenoic acid(DHA)] at various time points. Mitochondrial activity and function were examined via MTT assay and Seahorse XF24 analyzer, respectively.Triglyceride accumulation was determined by using Enzy Chrom? and levels of ROS were measured by fluorescence intensity. Protein expression of the mediators of lipogenic, lipolytic and endocannabinoid pathways was assessed by Western blotting.RESULTS High AA:DHA ratio decreased mitochondrial activity(P < 0.01;up to 80%) and promoted intracellular triglyceride accumulation(P < 0.05;40%-70%).Mechanistically, it altered the mediators of lipid metabolism;increased the expression of stearoyl-Co A desaturase(P < 0.05;22%-35%), decreased the expression of peroxisome proliferator-activated receptor-alpha(P < 0.05;30%-40%) and increased the expression of cannabinoid receptor 1(P < 0.05;31%).Furthermore, the high ratio increased ROS production(P < 0.01;74%-115%) and reduced mitochondrial respiratory functions such as basal and maximal respiration, ATP production, spare respiratory capacity and proton leak(P < 0.01;35%-68%).CONCLUSION High AA:DHA ratio induced triglyceride accumulation, increased oxidative stress and disrupted mitochondrial functions. Stimulation of lipogenic and steroidal transcription factors may partly mediate these effects and contribute to NAFLD development. | Reem Ghazali Kosha J Mehta SW Annie Bligh Ihab Tewfik Dahn Clemens Vinood B Patel | 2020 | World Journal of Hepatology2020，12，3： | 2 |
| 4 | The response of skin disease to stress:changes in the severity of acne vulgaris as affected by examination stress显示文摘 | Susna Y chon Alexa B | 2003 | J Arch Dematol2003，139，： | 1 |
| 5 | Pulse pressure and cardiovascular mortality in normotensive and hypertensive subjects显示文摘 | Annie R Michel S Louis G | 1998 | Hypertension1998，32，： | 1 |
| 6 | Quantitative analysis offlavour precursors and pyruvate levels in different tissues and cultivars ofonion(Allium cepa)显示文摘 | JAMES R B GRAHAM K M ANNIE N | 1999 | Food Chemistry1999，64，2： | 1 |
| 7 | Column test investigation on the performance of monolayer covers made of desulphurized tailings to prevent acid mine drainage 显示文摘 | Demers I Bussiere B Benzaazoua M Mamert M Annie B | 2008 | Minerals Engineering2008，21，4： | 1 |
| 8 | Schizophrenia: Etiology and course显示文摘 | Elaine W Lisa K Annie B | 2004 | Annual Review Psychology2004，55，： | 1 |
| 9 | There is more to life and death than mitochondria:Bcl-2 proteins at the endoplasmic reticulum显示文摘 | Annis MG Yethon JA Leber B | 2004 | Iochimica et BioPhysica Acta(BBA)-Molecular Cell Research2004，1644，： | 1 |
| 10 | Fluoroquinolone resistance associated with target mutation and active effiux in oropharyngeal isolates of viridans group Streptococci 显示文摘 | FRANCOIS G EMMANUELLE V ANNIE B H | 2000 | Antimicro Agents Chemother2000，44，8： | 1 |
| 11 | First struc- tural characterisation of an amino phosphonate monoes- ter metal complex 显示文摘 | ANNIE B S W CHOI N FAILLA S | 1994 | Journal of the chemical soci- ety-dalton transactions1994，，22： | 1 |
| 12 | Biochemical and cellular effects of roscovitine,a potent and selective inhibitor of the cyclin- dependent kinesis,cdk2 and cdk5 显示文摘 | Laurent M Annie B Odile M | 1997 | Eur J Biochem1997，243，： | 1 |
| 13 | Novel Bacillus thuringiensis Insecticidal crystal protein with a silent activity against Coleopteran larvae显示文摘 | Lambert B He H Annys K | 1992 | Appl Envir Microbiol1992，58，8： | 1 |
| 14 | Knowledge and attitudesabout cancer pain management : A national survey of Italian on-cologY nurses 显示文摘 | Matteo B Gianluca C Annie L et (27 | 2007 | European Journal of Oncology Nursing2007，11，： | 1 |
| 15 | Infection of human B lym- phocytes with lymphocryptoviruses related to Epstein-Barr virus 显示文摘 | Moghaddam A Koch J Annis B | 1998 | J Virol1998，72，4： | 1 |
| 16 | Effects of self-disclosure on relational intimacy in Facebook显示文摘 | Park N Jin B Annie Jin S.A | | 0，，05： | 1 |
| 17 | Alkaline phosphatase activity in symbiotic dinoflagellates(zooxanthellae)as a biological indicator of environmental phosphate exposure显示文摘 | Annis E R Cook C B | | 0，，： | 1 |
| 18 | Infection of human B lymphocytes with lymphocryptoviruses related to Epstein- Ban: virus 显示文摘 | Moghaddam A Koch J Annis B | 1998 | J Virol1998，72，4： | 1 |
| 19 | Treatment with granulocyte colony-stimulating factor prevents diabetes in NOD mice by recruiting plasmacytiod dendritic cells and functional CD24+,CD25+ regulatory T-cells显示文摘 | Hassen K Annie Masson Home A B | 2005 | Diabetes2005，54，： | 1 |
| 20 | New bidentate as full inhibitors of enkephalin-degrading enzymes: synthesis and analgesic properties 显示文摘 | Marie C F Annie C Romaine B | 1985 | J Med Chem1985，28，： | 1 |
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