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| 1 | 帕博利珠单抗治疗伴脑转移NSCLC患者的一项非随机、开放Ⅱ期试验的长期随访结果和生物标志物分析显示文摘背景与目的我们开展了一项帕博利珠单抗用于伴未治疗脑转移的非小细胞肺癌(non-small cell lung cancer,NSCLC)或黑色素瘤患者的疗效和安全性的II期试验,旨在评估程序性死亡受体1(programmed cell death 1,PD-1)抑制剂在中枢神经系统(central nervous system,CNS)中的疗效。中期结果已发表,现报道对NSCLC队列的更新分析结果。方法这是一项开放性、单中心、II期试验。纳入标准:年龄≥18岁,诊断为晚期NSCLC并伴有≥1个5 mm-20 mm脑转移病灶,既往从未治疗或之前放疗后进展,无神经系统症状,不需要激素治疗且美国东部肿瘤协作组(Eastern Cooperative Oncology Group,ECOG)<2分。患者每2周接受一次帕博利珠单抗(10 mg/kg)治疗。队列1为程序性死亡配体1(programmed cell death ligand 1,PD-L1)≥1%的患者,队列2为PD-L1<1%或未评估的患者。主要终点是脑转移患者缓解比例。所有经治患者均纳入疗效与安全性终点的分析。该研究已结束入组,并于Clinicaltrials.gov登记注册,注册号为NCT02085070。结果2014年3月31日-2018年5月21日,共42例患者接受治疗。中位随访时间为8.3个月(IQR:4.5个月-26.2个月)。队列1的37例患者中11例有脑转移缓解[29.7%(95%CI:15.9%-47.0%)]。队列2未观察到缓解。治疗相关的3级-4级不良事件(adverse events,AEs)包括2例肺炎、1例全身症状、1例结肠炎、1例肾上腺皮质功能不全、1例高血糖症和1例低钾血症。6例(14%)患者发生了治疗相关的严重不良事件,包括肺炎、急性肾损伤、低钾血症和肾上腺皮质功能不全。没有观察到治疗相关死亡病例。结论帕博利珠单抗治疗PD-L1≥1%的NSCLC伴脑转移患者有效,且对所有纳入的未经治疗的脑转移患者安全。需要进一步探索免疫治疗用于NSCLC合并CNS转移。 | Sarah B GOLDBERG Kurt A SCHALPER Scott N GETTINGER Amit MAHAJAN Roy S HERBST Anne C CHANG Rogerio LILENBAUM Frederick H WILSON Sacit Bulent OMAY James B YU Lucia JILAVEANU Thuy TRAN Kira PAVLIK Elin ROWEN Heather GERRSH Annette KOMLO Richa GUPTA Hailey WYATT Matthew RIBEIRO Yuval KLUGER Geyu ZHOU Wei WEI Veronica L CHANG Harriet M KLUGER 董晓荣(翻译/校对) | 2021 | 中国肺癌杂志2021，24，9： | 34 |
| 2 | Predictors of suboptimal bowel preparation in asymptomatic patients undergoing average-risk screening colonoscopy显示文摘AIM To identify risk factors for a suboptimal preparation among a population undergoing screening or surveillance colonoscopy.METHODS Retrospective review of the University of Michigan and Veteran's Administration(VA) Hospital records from 2009 to identify patients age 50 and older who underwent screening or surveillance procedure and had resection of polyps less than 1 cm in size and no more than 2 polyps. Patients with inflammatory bowel disease or a family history of colorectal cancer were excluded. Suboptimal procedures were defined as procedure preparations categorized as fair, poor or inadequate by the endoscopist. Multivariable logistic regression was used to identify predictors of suboptimal preparation.RESULTS Of 4427 colonoscopies reviewed, 2401 met our inclusion criteria and were analyzed. Of our population, 16% had a suboptimal preparation. African Americans were 70% more likely to have a suboptimal preparation(95%CI: 1.2-2.4). Univariable analysis revealed that narcotic and tricyclic antidepressants(TCA) use, diabetes, prep type, site(VA vs non-VA), and presence of a gastroenterology(GI) fellow were associated with suboptimal prep quality. In a multivariable model controlling for gender, age, ethnicity, procedure site and presence of a GI fellow, diabetes [odds ratio(OR) = 2.3; 95%CI: 1.6-3.2], TCA use(OR = 2.5; 95%CI: 1.3-4.9), narcotic use(OR = 1.7; 95%CI: 1.2-2.5) and Miralax-Gatorade prep vs 4L polyethylene glycol 3350(OR = 0.6; 95%CI: 0.4-0.9) were associated with a suboptimal prep quality. CONCLUSION Diabetes, narcotics use and TCA use were identified as predictors of poor preparation in screening colonoscopies while Miralax-Gatorade preps were associated with better bowel preparation. | Shail M Govani Eric E Elliott Stacy B Menees Stephanie L Judd Sameer D Saini Constantinos P Anastassiades Annette L Urganus Suzanna J Boyce Philip S Schoenfeld | 2016 | World Journal of Gastrointestinal Endoscopy2016，8，17： | 7 |
| 3 | Immunisation against PCV2 structural protein by DNA vaccination of mice显示文摘 | Ren S K Annette M B Tine H F | 2004 | Vaccine2004，22，： | 1 |
| 4 | Determinants of life quality in school-age children with cerebral palsy显示文摘 | Annette M Micbeal S Peter R etal | 2007 | Journal of Pediatrics2007，151，5： | 1 |
| 5 | A PhaseⅠ dose-escalation study of regorafenib (BAY 73-4506),an inhibitor of oncogenic,angiogenic,and stromal kinases,in patients with advanced solid tumors显示文摘 | Klaus M Annette F Simone S | | 0，，09： | 1 |
| 6 | Functions and Clinical Implications of Autocrine VEGF Signaling in Colorectal Cancer显示文摘 | Annette K. Larsen Aimery Gramont Virginie Poindessous Ana?s Bouygues Mériam Ayadi Paul Mésange | 2013 | Current Colorectal Cancer Reports2013，，3： | 1 |
| 7 | The Top level Global Research System, 1997-1999: Centers, Net works and Nodality: An Analysis Based on Bibliomet ric Indicators显示文摘 | CHRISTIAN W M ANNETTE W S | 2002 | Urban Studies2002，39，56： | 1 |
| 8 | Bacterial diversity ofsoil assessed by DGGE,T-RFLP and SSCP fingerprints of PCRamplified16S rRNA gene fragments: Do the different methodsprovide similar results 显示文摘 | Kornelia S Miruna OS Annett M | 2007 | Journal of Microbiological Methods2007，69，3： | 1 |
| 9 | A PPAR',/- FGF1 axis is required for adaptive adipose remodelling and metabolic homeostasis 显示文摘 | JOHAN W J JAE M S ANNETTE R A | 2012 | Nature2012，485，7398： | 1 |
| 10 | A phase I dose- escalation study of regorafenib (BAY 73-4506), an inhibitor of oncogenic, angiogenic, and stromal kinases, in patients with advanced solid tumors 显示文摘 | Klaus M Annette F Simone S | 2012 | Clin Cancer Res2012，18，9： | 1 |
| 11 | Matrix effects in irnmunobiosensor determination of clenbuterol in urine and serum显示文摘 | JOHANSSON ANNETTE M HELLEN S | 2004 | Analyst2004，129，5： | 1 |
| 12 | Stability of water- in - oil - emulsions containing phosphatidylcholine- depleted lecithin 显示文摘 | Annett K Inta S Gerald M | 2005 | Food Hydrocolloids2005，19，： | 1 |
| 13 | Characterization of advanced glycation end products for biochemical studies:side chain modifications and fluorescence characteristics显示文摘 | ANNETT S JOHANNES M JOVANA G M | 2005 | Analytical Biochemistry2005，338，2： | 1 |
| 14 | Long- term use of solifenacin in pediatric patients with overactive blad- der: Extension of a prospective open - label study 显示文摘 | Genervieve N Annette S Katherine M | 2014 | Can Urol Assoe J2014，8，34： | 1 |
| 15 | Peptide surfactants (pepfactants) for switchable foams and emulsions 显示文摘 | Andrew S M Annette F D Anton P J | 2007 | Chem Eng2007，2，5： | 1 |
| 16 | Bacterial diversi- ty of soils assessed by DGGE,T- RFLP and SSCP finger- prints of PCR-amplified 16S rRNA gene fragments : Do the different methods provide similar results 显示文摘 | Kornelia S Miruna O S Annett M | 2007 | Journal of Microbiological Methods2007，69，3： | 1 |
| 17 | Modeling and validation of the thermal effects on gas turbine transients显示文摘 | Annette E N Christoph W M Stephan S | | 0，，03： | 1 |
| 18 | Fatal and severe codeine intoxication in 3-year-old twins—interpretation of drug and metabolite concentrations显示文摘 | Nerea Ferreirós Sebastian Dresen Maren Hermanns-Clausen Volker Auwaerter Annette Thierauf Christoph Müller Roland Hentschel Rainer Trittler Gisela Skopp Wolfgang Weinmann | 2009 | International Journal of Legal Medicine2009，，5： | 1 |
| 19 | Immunisation against PCV2 structural protein by DNA vaccination of mice 显示文摘 | SφREN K ANNETTE M B TINE H F | 2004 | Vaccine2004，22，： | 1 |
| 20 | Shape-memory polymer networks from oligo(ε-caprolactone) dimethacrylates显示文摘 | Lendlein A Annette M S Schroeter M | 2005 | Journal of Polymer Science (part A):Polymer Chemistry2005，43，7： | 1 |
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