|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Genetics of hepatocellular carcinoma显示文摘The completely assembled human genome has made it possible for modern medicine to step into an era rich in genetic information and high-throughput genomic analysis. These novel and readily available genetic resources and analytical tools may be the key to unravel the molecular basis of hepatocellular carcinoma (HCC). Moreover, since an efficient treatment for this disease is lacking, further understanding of the genetic background of HCC will be crucial in order to develop new therapies aimed at selected targets. We report on the current status and recent developments in HCC genetics. Special emphasis is given to the genetics and regulation of major signalling pathways involved in HCC such as p53, Wnt- signalling, TGFβ, Ras, and Rb pathways. Furthermore, we describe the influence of chromosomal aberrations as well as of DNA methylation. Finally, we report on the rapidly developing field of genomic expression profiling in HCC, mainly by microarray analysis. | Andreas Teufel Frank Staib Stephan Kanzler Arndt Weinmann Henning Schulze-Bergkamen Peter R Galle | 2007 | World Journal of Gastroenterology2007，13，16： | 21 |
| 2 | Hepatocellular carcinoma in patients with autoimmune hepatitis显示文摘AIM: To evaluate and confirm the low incidence of hepatocellular carcinoma (HCC) in patients with autoimmune hepatitis (AIH). At present only very few cases of HCC in patients with AIH and definite exclusion of chronic viral hepatitis have been published, suggesting that HCC due to AIH is rare. METHODS: In order to further investigate the incidence of HCC in patients with AIH, we reviewed our large cohort of 278 patients with AIH. RESULTS: Eighty-nine patients (32%) were diagnosed with liver cirrhosis, a preneoplastic condition for HCC. We studied a total of 431 patient years of cirrhosis in these patients, an average 4.8 years per patient. During this period none of the patients of our own study cohort developed HCC. However, three patients with HCC due to AIH associated liver cirrhosis were referred to our department for further treatment of HCC. In all three patients chronic viral hepatitis was excluded. CONCLUSION: We conclude that HCC may under rare circumstances develop due to chronic AIH dependent liver cirrhosis. Compared to other causes of liver cirrhosis such as chronic viral hepatitis, alcohol, or hemochromatosis, the incidence of HCC is significantly lower. Pathophysiological differences between AIH and chronic viral hepatitis responsible for differences in the incidence of HCC are yet to be further characterized and may lead to new therapeutic concepts in prevention and treatment of liver cancer. | Andreas Teufel Arndt Weinmann Catherine Centner Anja Piendl Ansgar W Lohse Peter R Galle Stephan Kanzler | 2009 | World Journal of Gastroenterology2009，15，5： | 5 |
| 3 | Liver transplantation and BCLC classification:Limitations impede optimum treatment显示文摘Background:The Barcelona Clinic Liver Cancer(BCLC)system has been endorsed by international guidelines as a staging algorithm of hepatocellular carcinoma.This analysis was performed to assess the outcome of liver transplantation in patients treated against the BCLC recommendations.Methods:The data of 198 patients who underwent liver transplantation for hepatocellular carcinoma were extracted from a prospectively maintained database to classify the patients according to the BCLC system.Results:BCLC staging was as follows:0,n=5;A,n=77;B,n=41;C,n=53;and D,n=22.Accordingly,liver transplantation was performed in the majority of patients against BCLC recommendations.Surgery(n=16),radiofrequency ablation(n=15)and transarterial chemoembolization(n=151)preceded liver transplantation in 182 patients.Sixteen patients were transplanted without pretreatment.The 1-,5-and 10-year survival rates were 83.8%,62.4%and 45.9%,and 1-,5-,and 10-year recurrence rates were 7.7%,22.7%and 26.7%.The BCLC classification did neither impact survival(P=0.796)nor recurrence(P=0.693).In the Cox analysis,RECIST tumor progression and initial alpha fetoprotein were independent predictors of outcome.Conclusions:Neither the oncological nor the functional stratification imposed by the BCLC system was of importance for outcome.Lack of flexibility and disregard of biological parameters hamper its clinical applicability in liver transplantation. | Gerd Otto Michael B Pitton Maria Hoppe-Lotichius Arndt Weinmann | 2021 | Hepatobiliary & Pancreatic Diseases International2021，20，1： | 4 |
| 4 | Adding pegylated interferon to a current nucleos(t)ide therapy leads to HBsAg seroconversion in a subgroup of patients with chronic hepatitis B显示文摘 | Jens M. Kittner Martin F. Sprinzl Annette Grambihler Arndt Weinmann J?rn M. Schattenberg Peter R. Galle Marcus Schuchmann | 2012 | Journal of Clinical Virology2012，，1： | 2 |
| 5 | 连续夺获阈值监测与自动调节起搏器刺激输出——MICRONY SR+起搏器多中心研究显示文摘目的:本研究评价具有心室自动夺获功能的 Microny 起搏器的安全性及功效。方法:自1994年11月至1996年9月欧洲国家的16个医学中心,共有113例植入 Microny 起搏器的患者进入了研究。所有植入的起搏器采用了 Pacesetter 的低极化、双极电极导线(Membrane 1402 T)。患者在出院时及出院后1、3、6、12个月分别进行随访。结果:在植入后1个月的随访中,动态心电图显示所有未夺获的心搏均有后备起搏脉冲(4.5 V/0.49 ms)出现。植入时测试自身 R 波高度为14.7±7.4 mV,刺激除极波高度(ER)为10.2±4.8 mV。这些数值随时间推移保持稳定,但二者无相关性(r=0.29),植入时,由VARIO 功能测试的起搏阈值为0.5±0.2 V,由自动夺获功能测试的阈值为0.6±0.3 V。两种方法测试的起搏阈值在各次随访中相关性较好(r=0.79),平均差异为0.11 V。后备起搏脉冲占起搏刺激的1.1%。发放后备起搏脉冲的原因为未能夺获(7.1%);(伪)融合波(87.0%);ER 感知低下(0.5%)和QRS 感知低下(4.1%)。在自动夺获功能打开时,起搏电流总消耗为1.4 A。结论:本研究证明了自动夺获功能根据当时的起搏阈值安全和可靠地调节起搏器的输出,为患者提供最大的安全性并延长起搏器的使用寿命。 | Malcolm Clarke Bo Liu Hans Schller Ludwig Binner Charles Kennergren Modesto Guerola Peter Weinmann Ole Jorgen Ohm | 1997 | 中华心律失常学杂志1997，1，2： | 2 |
| 6 | Weakly-Supervised Single-view Dense 3D Point Cloud Reconstruction via Differentiable Renderer显示文摘In recent years,addressing ill-posed problems by leveraging prior knowledge contained in databases on learning techniques has gained much attention.In this paper,we focus on complete three-dimensional(3D)point cloud reconstruction based on a single red-green-blue(RGB)image,a task that cannot be approached using classical reconstruction techniques.For this purpose,we used an encoder-decoder framework to encode the RGB information in latent space,and to predict the 3D structure of the considered object from different viewpoints.The individual predictions are combined to yield a common representation that is used in a module combining camera pose estimation and rendering,thereby achieving differentiability with respect to imaging process and the camera pose,and optimization of the two-dimensional prediction error of novel viewpoints.Thus,our method allows end-to-end training and does not require supervision based on additional ground-truth(GT)mask annotations or ground-truth camera pose annotations.Our evaluation of synthetic and real-world data demonstrates the robustness of our approach to appearance changes and self-occlusions,through outperformance of current state-of-the-art methods in terms of accuracy,density,and model completeness. | Peng Jin Shaoli Liu Jianhua Liu Hao Huang Linlin Yang Michael Weinmann Reinhard Klein | 2021 | Chinese Journal of Mechanical Engineering2021，34，5： | 2 |
| 7 | Genetic association of autoimmune hepatitis and human leucocyte antigen in German patients显示文摘AIM: To report on our large German collective and updated data of 142 patients with autoimmune hepatitis (AIH) type 1. METHODS: Key investigations performed were liver biopsy, serum autoantibodies as well as serum markers such as IgG and elevated transaminases. Antinuclear antigen (ANA) and smooth muscle antigen (SMA) autoantibodies characterized type 1 AIH. Type 3 (AIH) was solely characterized by the occurrence of soluble liver antigen/liver-pancreas antigen (SLA/LP) autoantibodies either with or without ANA or SMA autoantibodies. RESULTS: Most prevalent HLAs were A2 (68 patients, 48%), B8 (63 patients, 44%), C7 (90 patients, 63%), DR3 (49 patients, 38%), DR4 (49 patients, 38%) and DQ2 (42 patients, 30%). Compared to the Italian and North American patients, we found fewer patients with a DQ2 subtype. Furthermore, the B8-DR3-DQ2 human leucocyte antigen (HLA) was also less prominent compared to the North American patients. However, prevalences of B8, DR3, DR4, DR7, DR11 and DR13 were comparable to the Italian and North American patients. Furthermore, we report on an additional subgroup of patients with SLA/LP positive AIH. Generally, in this subgroup of patients the same HLA subtypes were favoured as the AIH type 1. CONCLUSION: Although HLA subtypes were comparable between these three collectives, the German patients were distinct from the Italian and North American patients with respect to DQ2 and from the North American patients with respect to B8-DR3-DQ2HLA. A clinical correlation, e.g. difference in severity or treatability of AIH type 1, has yet to be determined. | Andreas Teufel Markus Wrns Arndt Weinmann Catherine Centner Anja Piendl Ansgar W Lohse Peter R Galle Stephan Kanzler | 2006 | World Journal of Gastroenterology2006，12，34： | 2 |
| 8 | Silo- ranes in dental composites 显示文摘 | Wolfgang Weinmann Christoph Thalacker Rainer Guggenberger | 2005 | Dental Materials2005，21，： | 1 |
| 9 | Development of a multi-target screening analysis for 301 drugs using a QTrap liquid chromatography/tandem mass spectrometry system and automated library searching显示文摘 | Mueller C A Weinmann W Dresen S | 2005 | Rapid Comm Mass Spectrom2005，，19： | 1 |
| 10 | Coneurrent autoimmune diseases in patients with autoimmune hepatitis显示文摘 | Teufel A Weinmann A Kahaly G J | 2010 | J Clin Gastroen- terol2010，44，3： | 1 |
| 11 | Comparison of Magnetic Properties of MRI Contrast Media Solutions at Different Magnetic Field Strengths显示文摘 | Martin Rohrer Hans Bauer Jan Mintorovitch Martin Requardt Hanns-Joachim Weinmann | 2005 | Investigative Radiology2005，，11： | 1 |
| 12 | Nogo- A expressed in Schwann cells impairs axonal regeneration after peripheral nerve injury显示文摘 | Pot C Simonen M Weinmann O | 2002 | J Cell Siol2002，159，1： | 1 |
| 13 | Novel ways to sensitise gastrointestinal cancer to apopsis显示文摘 | Schulze-Bergkamen H Weinmann A Moehler M | 2009 | Gut2009，58，： | 1 |
| 14 | Physical and regulatory constraints for communication over the power supply grid显示文摘 | Gebhardt M Weinmann F Dostert K | 2003 | IEEE Communications Magazine2003，41，5： | 1 |
| 15 | Correlation of finite element analysis to superplastic forming experiments 显示文摘 | LUCKEY S G FRIEDMAN P A WEINMANN K J | 2009 | Journal of Materials Processing Technology2009，194，： | 1 |
| 16 | Patterns of Nogo Mrna and protein expression in the developing and adult rat and after CNS lesions显示文摘 | Huber AB Weinmann Q Brosamle C | 2002 | Neurosci2002，22，9： | 1 |
| 17 | Treatment of lung cancer in the elderly part Ⅱ: small cell lung cancer显示文摘 | Weinmann M Jeremic B Bamberg M | 2003 | Lung Cancer2003，40，1： | 1 |
| 18 | Reserve carbohydrates in South African grasses显示文摘 | Weinmann H Leonora R | 1946 | Journal of South African Botany1946，12，： | 1 |
| 19 | Effect of deformation-dependent material parameters on forming limits of thin sheets 显示文摘 | Xu S Weinmann K J | 2000 | IntJ Mech Sci2000，42，： | 1 |
| 20 | Delayed neu?trophil apoptosis in very early rheumatoid arthritis patients is ab?rogated by methotrexate therapy显示文摘 | Weinmann P Moura RA Caetano-LopesJR | 2007 | Clin Exp Rheumatol2007，25，6： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员