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| 1 | EGFR and HER2 expression in advanced biliary tract cancer显示文摘AIM:To analyze the pathogenetic role and potential clinical usefulness of the epidermal growth factor receptor(EGFR)and the human epidermal growth factor receptor 2(HER2)in patients with advanced biliary tract cancer(BTC). METHODS:EGFR and HER2 expression was studied in biopsy samples from 124 patients(51%women; median age 64.8 years),with advanced BTC diagnosed between 1997 and 2004.Five micrometers sections of paraffin embedded tissue were examined by standard, FDA approved immunohistochemistry.Tumors with scores of 2+or 3+for HER2 expression on immunochemistry were additionally tested for HER2 gene amplification by fluorescence in situ hybridisation(FISH).RESULTS:34/124 patients(27.4%)had gallbladder cancer,47(37.9%)had intrahepatic BTC and 43(34.7%)had extrahepatic or perihilar BTC.EGFR expression was examined in a subset of 56 samples. EGFR expression was absent in 22/56 tumors(39.3%). Of the remaining samples expression was scored as 1+in 12(21.5%),2+in 13(23.2%)and 3+in 9(16%), respectively.HER2 expression was as follows:score 0 73/124(58.8%),score 1+27/124(21.8%),score 2+ 21/124(17%)and score 3+4/124(3.2%).HER2 gene amplification was present in 6/124,resulting in an overall amplification rate of 5%. CONCLUSION:Our data suggest that routine testing and therapeutic targeting of HER2 does not seem to be useful in patients with BTC,while targeting EGFR may be promising. | Jan Harder Oliver Waiz Florian Otto Michael Geissler Manfred Olschewski Brigitte Weinhold Hubert E Blum Annette Schmitt-Graeff Oliver G Opitz | 2009 | World Journal of Gastroenterology2009，15，36： | 18 |
| 2 | Predictors of suboptimal bowel preparation in asymptomatic patients undergoing average-risk screening colonoscopy显示文摘AIM To identify risk factors for a suboptimal preparation among a population undergoing screening or surveillance colonoscopy.METHODS Retrospective review of the University of Michigan and Veteran's Administration(VA) Hospital records from 2009 to identify patients age 50 and older who underwent screening or surveillance procedure and had resection of polyps less than 1 cm in size and no more than 2 polyps. Patients with inflammatory bowel disease or a family history of colorectal cancer were excluded. Suboptimal procedures were defined as procedure preparations categorized as fair, poor or inadequate by the endoscopist. Multivariable logistic regression was used to identify predictors of suboptimal preparation.RESULTS Of 4427 colonoscopies reviewed, 2401 met our inclusion criteria and were analyzed. Of our population, 16% had a suboptimal preparation. African Americans were 70% more likely to have a suboptimal preparation(95%CI: 1.2-2.4). Univariable analysis revealed that narcotic and tricyclic antidepressants(TCA) use, diabetes, prep type, site(VA vs non-VA), and presence of a gastroenterology(GI) fellow were associated with suboptimal prep quality. In a multivariable model controlling for gender, age, ethnicity, procedure site and presence of a GI fellow, diabetes [odds ratio(OR) = 2.3; 95%CI: 1.6-3.2], TCA use(OR = 2.5; 95%CI: 1.3-4.9), narcotic use(OR = 1.7; 95%CI: 1.2-2.5) and Miralax-Gatorade prep vs 4L polyethylene glycol 3350(OR = 0.6; 95%CI: 0.4-0.9) were associated with a suboptimal prep quality. CONCLUSION Diabetes, narcotics use and TCA use were identified as predictors of poor preparation in screening colonoscopies while Miralax-Gatorade preps were associated with better bowel preparation. | Shail M Govani Eric E Elliott Stacy B Menees Stephanie L Judd Sameer D Saini Constantinos P Anastassiades Annette L Urganus Suzanna J Boyce Philip S Schoenfeld | 2016 | World Journal of Gastrointestinal Endoscopy2016，8，17： | 7 |
| 3 | Epidemiology of constipation (EPOC) study in the United States: relation of clinical subtypes to sociodemographic features显示文摘 | Walter F Stewart Joshua N Liberman Robert S Sandler Michael S Woods Annette Stemhagen Elsbeth Chee Richard B Lipton Christina E Farup | 1999 | The American Journal of Gastroenterology1999，，12： | 2 |
| 4 | Expectant management of severe preeclampsia at 27 0/7 to 33 6/7 weeks 'gestation: maternal and perinatal out- comes according to gestational age by weeks at onset of expect- ant management 显示文摘 | Annette E | 2009 | American journal of perinatology2009，26，6： | 1 |
| 5 | Predictors of survival for esophageal cancer patients with and without celiac axis lymphadenopathy: impact of staging endosonography显示文摘 | Mohamad A Eloubeidi Michael B Wallace Brenda J Hoffman Margaret B Leveen Annette Van Velse Robert H Hawes Carolyn E Reed | 2001 | The Annals of Thoracic Surgery2001，，1： | 1 |
| 6 | Inflammatory mechanisms in ischemic stroke:therapeutic approaches显示文摘 | Shaheen E Lakhan Annette Kirchgessner Magdalena Hofer | 2009 | Journal of Translational Medicine2009，97，7： | 1 |
| 7 | Characterization of Damaged Skin by Imedance Spec- troscopy: Mechanical Damage 显示文摘 | White Erick A Orazem Mark E Bunge Annette L | 2013 | Pharmaceutical Research2013，30，8： | 1 |
| 8 | Production of hepatic outflow block and ascites with an ameroid constrictor 显示文摘 | Sweat E R Musieant M E Annetts D L | 1966 | Surg Forum1966，17，： | 1 |
| 9 | IL-10, regulatory T cells, and Kupffer cells mediate tolerance in concanavalin A-induced liver injury in mice显示文摘 | Annette E Markus B Thomas P | 2007 | Hepatology2007，45，2： | 1 |
| 10 | Rsistance to α-amylase digestion in four native high-amylose maize stavches显示文摘 | Annette E Donald B | 2004 | Cereal Che2004，81，： | 1 |
| 11 | Acute myoglobinuria and heroin snorting显示文摘 | ANNETT E N | 1979 | JAMA1979，241，： | 1 |
| 12 | Modelling the spatial distribution of agricultural land use at the regional scale 显示文摘 | ROUNSEVELL M D A ANNETTS J E AUDSLEY E | 2003 | Agriculture Ecosystems and Environment2003，95，： | 1 |
| 13 | From soil to gut: Bacillus cereus and its food poisoning toxins 显示文摘 | LOTTE P STENFORS ARNESEN ANNETTE FAGERLUND PER E GRANUM | 2008 | FEMS Microbiol Rev2008，32，4： | 1 |
| 14 | EXPRESSION OF MAJOR HISTOCOMPATIBILITY COMPLEX ANTIGENS AND REPLACEMENT OF DONOR CELLS BY RECIPIENT ONES IN HUMAN LIVER GRAFTS显示文摘 | ANNETTE S. H. GOUW HENDRIK J. HOUTHOFF SIPPIE HUITEMA JOSéE M. BEELEN CHRIS H. GIPS SIBRAND POPPEMA | 1987 | Transplantation1987，，2： | 1 |
| 15 | Nigrostriatal alpha-synucleinopathy induced by viral vector-mediated overexpression of human alpha-synuclein : a new primate model of Parkinson's disease 显示文摘 | KIRIK D ANNETT L E BURGER C | 2003 | Proc Natl Acad Sci U S A2003，100，28： | 1 |
| 16 | Differentim effects of psychostimulants and related agents on dopaminergiC and serotonergic transporter function显示文摘 | Annette E Fleckenstein Haughey H M at el | 1999 | European Journal of Pharmacology1999，382，： | 1 |
| 17 | Racial/ethnic disparities in hepatocellular carcinoma treatment and survival in California, 1988-2012显示文摘AIM To describe racial/ethnic differences in treatment and survival among liver cancer patients in a populationbased cancer registry.METHODS Invasive cases of primary hepatocellular carcinoma, n = 33270, diagnosed between January 1, 1988-December 31, 2012 and reported to the California Cancer Registry were analyzed by race/ethnicity, age, gender, geographical region, socio-economic status, time period of diagnosis, stage, surgical treatment, and survival. Patients were classified into 15 racial/ethnic groups: non-Hispanic White(White, n = 12710), Hispanic(n = 8500), Chinese(n = 2723), non-Hispanic Black(Black, n = 2609), Vietnamese(n = 2063), Filipino(n = 1479), Korean(n = 1099), Japanese(n = 658), American Indian/Alaskan Native(AIAN, n = 281), Laotian/Hmong (n = 244), Cambodian(n = 233), South Asian(n = 190), Hawai`ian/Pacific Islander(n = 172), Thai(n = 95), and Other Asian(n = 214). The main outcome measures were receipt of surgical treatment, and cause-specific and all-cause mortality.RESULTS After adjustment for socio-demographic characteristics, time period, and stage of disease, compared to Whites, Laotian/Hmong [odds ratio(OR) = 0.30, 95%CI: 0.17-0.53], Cambodian(OR = 0.65, 95%CI: 0.45-0.96), AIAN(OR = 0.66, 95%CI: 0.46-0.93), Black(OR = 0.76, 95%CI: 0.67-0.86), and Hispanic(OR = 0.78, 95%CI: 0.72-0.84) patients were less likely, whereas Chinese(OR = 1.58, 95%CI: 1.42-1.77), Koreans(OR = 1.45, 95%CI: 1.24-1.70), Japanese(OR = 1.41, 95%CI: 1.15-1.72), and Vietnamese(OR = 1.26, 95%CI: 1.12-1.42) were more likely to receive surgical treatment. After adjustment for the same covariates and treatment, cause-specific mortality was higher for Laotian/Hmong [(hazard ratio(HR) = 1.50, 95%CI: 1.29-1.73)], Cambodians(HR = 1.35, 95%CI: 1.16-1.58), and Blacks(HR = 1.07, 95%CI: 1.01-1.13), and lower for Chinese(HR = 0.82, 95%CI: 0.77-0.86), Filipinos(HR = 0.84, 95%CI: 0.78-0.90), Vietnamese(HR = 0.85, 95%CI: 0.80-0.90), Koreans(HR = 0.90, 95%CI: 0.83-0.97), and Hispanics(HR = 0.91, 95%CI: 0.88-0.94); results were similar for all-cause mortality.CONCLUSION Disaggregated data revealed substantial racial/ethnic differences in liver cancer treatment and survival, demonstrating the need for development of targeted interventions to mitigate disparities. | Susan L Stewart Sandy L Kwong Christopher L Bowlus Tung T Nguyen Annette E Maxwell Roshan Bastani Eric W Chak Moon S Chen Jr | 2016 | World Journal of Gastroenterology2016，22，38： | 1 |
| 18 | Inflammatory mechanismsin ischemic stroke: therapeutic approaches 显示文摘 | Shaheen E Lakhan Annette Kirchgessner | 2009 | Journal of translationmedicine2009，7，97： | 1 |
| 19 | EGCG redirects amyloidogenic polypeptides into unstructured, off-pathway oligomers 显示文摘 | Dagmar E E Jan B Annett B | 2008 | Nature Structural & Molecular Biology2008，15，6： | 1 |
| 20 | Nigrostriatal alpha-synucleinopathyinduced by viral vector-mediated overexpression of human alpha-synuclein:A new primate model of Parkinson's disease显示文摘 | Kirik D Annett L E Burger C | 2002 | Proc Natl Acad Sci USA2002，100，5： | 1 |
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