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| 1 | Heterogeneity of aberrant immunoglobulin expression in cancer cells显示文摘Accumulating evidence has shown that immunoglobulin(Ig)is‘unexpectedly’expressed by epithelial cancer cells and that it can promote tumor growth.The main purpose of this study was to explore the components of the cancerous Ig and its possible function.The presence of cancerous Ig in the Golgi apparatus was confirmed by immunofluorescence,indirectly suggesting that the cancerous Ig was processed and packaged in cancer cells.Western blot analysis and ELISA results indicated that cancer cells produced membrane Ig and secreted Ig into the supernatant fraction.The cancerous Ig consists of an a heavy chain and a k light chain.Finally,by analyzing the Ig components pulled down by protein A beads,the cancerous Ig was found to be structurally distinct from normal Ig.The cancerous Ig was truncated or aberrant.Although the underlying mechanism that causes the abnormalities has not been determined,our current discoveries strengthen our previous findings and promise fruitful future explorations. | Duosha Hu Zhi Duan Ming Li Yiqun Jiang Haidan Liu Hui Zheng Lili Li Ann M Bode Zigang Dong Ya Cao | 2011 | Cellular & Molecular Immunology2011，8，6： | 5 |
| 2 | Meta‐analysis of insulin aspart versus regular human insulin used in a basal–bolus regimen for the treatment of diabetes mellitus (在基础—餐时糖尿病治疗方案中使用门冬胰岛素与使用常规人胰岛素对照研究的Meta分析)显示文摘 | Simon Heller Bruce Bode Plamen Kozlovski Anne Louise Svendsen | 2013 | Journal of Diabetes2013，，4： | 5 |
| 3 | Promotion of cell proliferation and inhibition of ADCC by cancerous immunoglobulin expressed in cancer cell lines显示文摘To explore the significance of cancerous immunoglobulin(Ig)in cancer cell growth,HeLa cervical cancer cells were stably transfected with small interfering RNA(siRNA)that specifically,efficiently and consistently silences the expression of heavy chain genes of all immunoglobulin isotypes.This stable cell line was used to examine cell viability,colony formation and tumor growth in athymic nude mice.The results of these experiments indicated that siRNA-mediated knockdown of cancerous Ig inhibited cell growth in vitro and suppressed tumor cell growth in immune-deficient nude mice in vivo.Similarly,this siRNA also inhibited the growth of MGC gastric cancer cells and MCF-7 breast cancer cells.Furthermore,the presence of cancerous Ig specifically reduced antibody-dependent cell-mediated cytotoxicity(ADCC)induced by an anti-human epithelial growth factor receptor(EGFR)antibody in a dose-dependent manner,suggesting that the cancerous Ig-Fc receptor interaction inhibits natural killer cell(or NK cell)effector function.The prevalent expression of Ig in human carcinomas and its capacity to promote growth and inhibit immunity might have important implications in growth regulation and targeted therapy for human cancers. | Ming Li Hui Zheng Zhi Duan Haidan Liu Duosha Hu Ann Bode Zigang Dong Ya Cao | 2012 | Cellular & Molecular Immunology2012，9，1： | 4 |
| 4 | Activation of the Ig la I promoter by the transcription factor Ets-1 triggers Ig lal-Cal germline transcription in epithelial cancer cells显示文摘 | Zhi Duan Hui Zheng San Xu Yiqun Jiang Haidan Liu Ming Li Duosha Hu Wei Li Ann M. Bode Zigang Dong Ya Cao | 2014 | Cellular & Molecular Immunology2014，11，2： | 3 |
| 5 | Insulin degludec, an ultra-longacting basal insulin, versus insulin glargine in basal-bolus treatment with mealtime insulin aspart in type 1 diabetes (BEGIN Basal-Bolus Type 1): a phase 3, randomised, open-label, treat-to-target non-inferiority trial显示文摘 | Simon Heller John Buse Miles Fisher Satish Garg Michel Marre Ludwig Merker Eric Renard David Russell-Jones Areti Philotheou Ann Marie Ocampo Francisco Huiling Pei Bruce Bode | 2012 | The Lancet2012，，9825： | 2 |
| 6 | The paradox of arsenic: molecular mechanisms of cell transformation and chemotherapeutic effects显示文摘 | Ann M. Bode Zigang Dong | 2002 | Critical Reviews in Oncology and Hematology2002，，： | 1 |
| 7 | Tumor suppressor p16INK4a inhibits cancer cell growth by downregulating eEF1A2 through a direct interaction显示文摘 | Mee-Hyun Lee Bu Young Choi Yong-Yeon Cho Sung-Young Lee Zunnan Huang Joydeb Kumar Kundu Myoung Ok Kim Dong Joon Kim Ann M. Bode Young-Joon Surh Zigang Dong | 2013 | Journal of Cell Science2013，，16： | 1 |
| 8 | Two novel glycosides from the fruits of Morinda citrifolia (noni) in- hibit AP-1 transactivation and cell transformation in the mouse epidermal JB6 cell line 显示文摘 | LIU Guang-ming Ann Bode Ma Wei-ya | 2001 | Cancer Research2001，61，1： | 1 |
| 9 | EBV encoded miR-BHRF1-1 potentiates viral lytic replication by downregulating host p53 in nasopharyngeal carcinoma显示文摘 | Zijian Li Xue Chen Lili Li Sufang Liu Lifang Yang Xiaoqian Ma Min Tang Ann M. Bode Zigang Dong Lunquan Sun Ya Cao | 2011 | International Journal of Biochemistry and Cell Biology2011，，2： | 1 |
| 10 | AID expression increased by TNF-α is associated with class switch recombination of Igα gene in cancers显示文摘 | Zhi Duan Hui Zheng Haidan Liu Ming Li Min Tang Xinxian Weng Wei Yi Ann M. Bode Ya Cao | 2016 | Cellular & Molecular Immunology2016，13，4： | 1 |
| 11 | Inhibition of 12- O -tetradecanoylphorbol-13-acetate-induced NF-κB activation by tea polyphenols, (–)-epigallocatechin gallate and theaflavins显示文摘 | Masaaki Nomura Wei-ya Ma Nanyue Chen Ann M. Bode | 2000 | Carcinogenesis2000，，： | 1 |
| 12 | The crystal structure of the novel snake venom plasminogen activator TSV-PA: a prototype structure for snake venom serine proteinases显示文摘 | Marina AA Parry Uwe Jacob Robert Huber Anne Wisner Cassian Bon Wolfram Bode | 1998 | Structure1998，，9： | 1 |
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