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| 1 | Dietary advanced glycation end-products aggravate non-alcoholic fatty liver disease显示文摘AIM To determine if manipulation of dietary advanced glycation end product(AGE), intake affects nonalcoholic fatty liver disease(NAFLD) progression and whether these effects are mediated via RAGE. METHODS Male C57Bl6 mice were fed a high fat, high fructose, high cholesterol(HFHC) diet for 33 wk and compared with animals on normal chow. A third group were given a HFHC diet that was high in AGEs. Another group was given a HFHC diet that was marinated in vinegar to prevent the formation of AGEs. In a second experiment, RAGE KO animals were fed a HFHC diet or a high AGE HFHC diet and compared with wildtype controls. Hepatic biochemistry, histology, picrosirius red morphometry and hepatic mR NA were determined. RESULTS Long-term consumption of the HFHC diet generated significant steatohepatitis and fibrosis after 33 wk. In this model, hepatic 4-hydroxynonenal content(a marker of chronic oxidative stress), hepatocyte ballooning, picrosirius red staining, α-smooth muscle actin and collagen type 1A gene expression were all significantly increased. Increasing the AGE content of the HFHC diet by baking further increased these markers of liver damage, but this was abrogated by pre-marination in acetic acid. In response to the HFHC diet, RAGE-/-animals developed NASH of similar severity to RAGE+/+ animals but were protected from the additional harmful effects of the high AGE containing diet. Studies in isolated Kupffer cells showed that AGEs increase cell proliferation and oxidative stress, providing a likely mechanism through which these compounds contribute to liver injury. CONCLUSION In the HFHC model of NAFLD, manipulation of dietary AGEs modulates liver injury, inflammation, and liver fibrosis via a RAGE dependent pathway. This suggests that pharmacological and dietary strategies targeting the AGE/RAGE pathway could slow the progression of NAFLD. | Christopher Leung Chandana B Herath Zhiyuan Jia Sof Andrikopoulos Bronwyn E Brown Michael J Davies Leni R Rivera John B Furness Josephine M Forbes Peter W Angus | 2016 | World Journal of Gastroenterology2016，22，35： | 7 |
| 2 | Parents' needs following identification of childhood hearing loss 显示文摘 | Fitzpatrick E Angus D Durieux-Smith A | 2008 | Am J Audiol2008，17，1： | 1 |
| 3 | Epidemiology of severe sepsis around the world显示文摘 | Angus DC Pereira CA Silva E | 2006 | Endocr Metab Immune Disord Drug Targets2006，6，2： | 1 |
| 4 | 'Diamond-like' Amorphous Carbon Films显示文摘 | Stultz J E Shiller P J | 1984 | Composition and Properties of the So Called Thin Solid Films1984，118，： | 1 |
| 5 | The performance of a solar regenerated open cycle desiccant bed grain cooling system显示文摘 | Ismail M Z Angus D E Thorpe G R | 1991 | Solar Energy1991，46，2： | 1 |
| 6 | Inrensive insulin therpy in critical illness 显示文摘 | Angus DC Abraham E | 2005 | Am J Respir Crit Care Med2005，172，11： | 1 |
| 7 | Developmental pathways in colon cancer: crosstalk between WNT, BMP, Hedgehog and Notch 显示文摘 | Bertrand F E Angus C W Partis W J | 2012 | Cell Cycle2012，11，23： | 1 |
| 8 | Use of inten sive care at the end of life in the United States: an epidemiologic study显示文摘 | Angus D C Barnato A E Linde-Zwirble W T | 2004 | Crit Care Med2004，32，3： | 1 |
| 9 | Perceived prevalence of peanut allergy in Great Britain and its saaociation with other atopic conditions and with peanut allergy in other household members显示文摘 | Emmett S E Angus F J Fry J S | 1999 | Allergy1999，54，4： | 1 |
| 10 | General Patterns of Tag Usage Among University Groups in Flickr 显示文摘 | Angus E Thelwall M Stuart D | 2008 | Online Information Re- view2008，32，1： | 1 |
| 11 | Lamivudine plus low-dose hep- atitis B immunoglobulin to prevent recurrent hepatitis B following liver transplantation 显示文摘 | Gane E J Angus PW Strasser S | 2007 | Gastroenterology2007，132，3： | 1 |
| 12 | Sulfur-doped n-type diamond:preparation and electrochemical properties显示文摘 | Eaton S C Evstefeeva Yu E Angus J C Anderson A B and Pleskov Yu V | 2003 | Russian Journal of Electrochemistry2003，39，2： | 1 |
| 13 | Glucose kinetics and exercise performance during phases of the menstrual cycle: Effect of glucose ingestion显示文摘 | Campbell S E Angus D J Febbraio M A | 2001 | Am J PhysiolEndocrinolMetab2001，281，4： | 1 |
| 14 | The probability integral transform and related results显示文摘 | Angus J E | | 0，，04： | 1 |
| 15 | Epidemiology of severe sepsis around the world显示文摘 | Angus D C Pereira C A Silva E | 2006 | Endocr Metab Immune Disord Drug Targets2006，6，2： | 1 |
| 16 | Use of intensive care at the end of life in the United States: an epidemiologic study显示文摘 | Angus D C Barnato A E Linde-Zwirble W T | 2004 | Crit Care Med2004，32，3： | 1 |
| 17 | Measurements of dew显示文摘 | | 1958 | Arid Zone Res1958，2，： | 1 |
| 18 | Lamivudine plus low- dose hepatitis B immunoglobulin to prevent recurrent hepatitis B following liver transplantation显示文摘 | Gane E J Angus PW Strasser S | 2007 | Gastroenterology2007，132，3： | 1 |
| 19 | Combination low-dose hepatitis B immune globulin and lamivudine therapy provides effective prophylaxis against posttransplantation hepatitis B 显示文摘 | ANGUS P W MCCAUGHAN G GANE E J | 2000 | Liver Transpl2000，6，4： | 1 |
| 20 | Combination low- dose hepatitis B immune globulin and lamivudine therapy prorides effective prophylaxis against posttransplantation hepatitis B显示文摘 | Angus PW Mccaughan G Gane E J | 2000 | Liver Transpl2000，6，4： | 1 |
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