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| 1 | Dietary advanced glycation end-products aggravate non-alcoholic fatty liver disease显示文摘AIM To determine if manipulation of dietary advanced glycation end product(AGE), intake affects nonalcoholic fatty liver disease(NAFLD) progression and whether these effects are mediated via RAGE. METHODS Male C57Bl6 mice were fed a high fat, high fructose, high cholesterol(HFHC) diet for 33 wk and compared with animals on normal chow. A third group were given a HFHC diet that was high in AGEs. Another group was given a HFHC diet that was marinated in vinegar to prevent the formation of AGEs. In a second experiment, RAGE KO animals were fed a HFHC diet or a high AGE HFHC diet and compared with wildtype controls. Hepatic biochemistry, histology, picrosirius red morphometry and hepatic mR NA were determined. RESULTS Long-term consumption of the HFHC diet generated significant steatohepatitis and fibrosis after 33 wk. In this model, hepatic 4-hydroxynonenal content(a marker of chronic oxidative stress), hepatocyte ballooning, picrosirius red staining, α-smooth muscle actin and collagen type 1A gene expression were all significantly increased. Increasing the AGE content of the HFHC diet by baking further increased these markers of liver damage, but this was abrogated by pre-marination in acetic acid. In response to the HFHC diet, RAGE-/-animals developed NASH of similar severity to RAGE+/+ animals but were protected from the additional harmful effects of the high AGE containing diet. Studies in isolated Kupffer cells showed that AGEs increase cell proliferation and oxidative stress, providing a likely mechanism through which these compounds contribute to liver injury. CONCLUSION In the HFHC model of NAFLD, manipulation of dietary AGEs modulates liver injury, inflammation, and liver fibrosis via a RAGE dependent pathway. This suggests that pharmacological and dietary strategies targeting the AGE/RAGE pathway could slow the progression of NAFLD. | Christopher Leung Chandana B Herath Zhiyuan Jia Sof Andrikopoulos Bronwyn E Brown Michael J Davies Leni R Rivera John B Furness Josephine M Forbes Peter W Angus | 2016 | World Journal of Gastroenterology2016，22，35： | 7 |
| 2 | The performance of a solar regenerated open cycle desiccant bed grain cooling system显示文摘 | Ismail M Z Angus D E Thorpe G R | 1991 | Solar Energy1991，46，2： | 1 |
| 3 | General Patterns of Tag Usage Among University Groups in Flickr 显示文摘 | Angus E Thelwall M Stuart D | 2008 | Online Information Re- view2008，32，1： | 1 |
| 4 | Glucose kinetics and exercise performance during phases of the menstrual cycle: Effect of glucose ingestion显示文摘 | Campbell S E Angus D J Febbraio M A | 2001 | Am J PhysiolEndocrinolMetab2001，281，4： | 1 |
| 5 | 2001 SCCM/ESICM/ACCP/ ATS/SIS International Sepsis Definitions Conference 显示文摘 | Levy M M Fink M P Marshall J C Abraham E Angus D Cook D | 2003 | Crit Care Med2003，31，： | 1 |
| 6 | General patterns of tag usage among university groups in Flickr显示文摘 | Angus E Thelwall M Stuart D | 2008 | Online Information Review2008，32，1： | 1 |
| 7 | Prognostic signifi- cance of immunohistochemistry-based markers and algorithms in immunochemotherapy-treated diffuse large B cell lymphoma pa- tients显示文摘 | Culpin R E Sieniawski M Angus B | 2013 | Histopathology2013，63，6： | 1 |
| 8 | Production of androgens by microbial transformation of progesterone in vitro: a model for androgen production in rivers receiving paper mill effluent 显示文摘 | Jenkins R L Wilson E M Angus R A | 2004 | Environmental Health Perspectives2004，112，15： | 1 |
| 9 | Androstenedione and progesterone in the sediment of a river receiving paper mill effluent 显示文摘 | Jenkins R L Wilson E M Angus R A | 2003 | Toxicological Sciences2003，73，1： | 1 |
| 10 | Identification of epithelial gaps in human small and large intestine by confocal endomi- croscopy显示文摘 | Kiesslich R Goetz M Angus E M | 2007 | Gastroenterology2007，133，6： | 1 |
| 11 | Activity of the renin-angio- tensin system in acute severe asthma and the effect of angiotensin 1: on lung function显示文摘 | Millar E A Angus R M Hulks G | 1994 | Thorax1994，49，5： | 1 |
| 12 | Up-regulation of components of therenin-angiotensin system in the bile duct-ligated rat liv-er显示文摘 | Paizis G Cooper M E Schembri J M?Tikellis C BurrellL M Angus P W | 2002 | Gastroenterology?2002，123，： | 1 |
| 13 | General patterns of tagusage among University groups in Flickr 显示文摘 | Angus E Thelwall M Stuart D | 2008 | online information review2008，32，1： | 1 |
| 14 | Prognostic signifi- cance of immunohistochemistry-based markers and algorithms in immunochemotherapy-treated diffuse large B-cell lymphoma pa- tients显示文摘 | Culpin R E Sieniawski M Angus B | 2013 | Histopathology2013，63，6： | 1 |
| 15 | General patterns of tag usage among university groups in flickr显示文摘 | Angus E Thelwall M Stuart D | 2008 | Online Information Review2008，32，1： | 1 |
| 16 | General Patterns of Tag Usage Among University Groups in Flickr显示文摘 | Angus E Thelwall M Stuart D | 2008 | Online Information Review2008，，1： | 1 |
| 17 | What is necessary to ensure natural justice in environmental impact assessment decision-making 显示文摘 | ANGUS M S GERARD E | 2008 | Impact Assessment and Project Appraisal2008，26，： | 1 |
| 18 | Nuclear to cytoplasmic compartment shift of the p33ING1b tumour suppressor protein is associated with malignancy in melanocytic lesions显示文摘 | Nouman G S Anderson J J Mathers M E Leonard N Crosier S Lunec J Angus B | 2002 | Histopathology2002，40，： | 1 |
| 19 | Modeling T-cell activationusing gene expression profiling and state-space models 显示文摘 | Rangel C Angus J Ghahramani Z Lioumi M Sotheran E Gaiba A | 2004 | Bio-information2004，，20： | 1 |
| 20 | Potential of squalene as a functional lipid in foods and conmetics显示文摘 | Laurence E John C Angus M N | 2002 | Lipid Technology2002，12，： | 1 |
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