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| 1 | Intrahepatic cholestasis of pregnancy:When should you look further?显示文摘Pruritis with abnormal liver function tests is the classical presentation of intrahepatic cholestasis of pregnancy(ICP),a condition associated with significant fetal complications.Although the etiology of ICP is unclear in many cases,certain features of the clinical presentation should alert the practitioner to the possibility of an underlying metabolic defect, which may not only affect subsequent pregnancies, but may be an indicator of more serious subsequent liver disease.We report a kindred of Anglo-Celtic descent,among whom many members present with ICP,gallstones or cholestasis related to use of oral contraception.Genetic studies revealed a novel mutation in the ABCB4 gene,which codes for a phospholipid transport protein.The clinical significance of this mutation and the importance of identifying such patients are discussed. | Winita Hardikar Shivani Kansal Ronald P J Oude Elferink Peter Angus | 2009 | World Journal of Gastroenterology2009，15，9： | 22 |
| 2 | Dietary advanced glycation end-products aggravate non-alcoholic fatty liver disease显示文摘AIM To determine if manipulation of dietary advanced glycation end product(AGE), intake affects nonalcoholic fatty liver disease(NAFLD) progression and whether these effects are mediated via RAGE. METHODS Male C57Bl6 mice were fed a high fat, high fructose, high cholesterol(HFHC) diet for 33 wk and compared with animals on normal chow. A third group were given a HFHC diet that was high in AGEs. Another group was given a HFHC diet that was marinated in vinegar to prevent the formation of AGEs. In a second experiment, RAGE KO animals were fed a HFHC diet or a high AGE HFHC diet and compared with wildtype controls. Hepatic biochemistry, histology, picrosirius red morphometry and hepatic mR NA were determined. RESULTS Long-term consumption of the HFHC diet generated significant steatohepatitis and fibrosis after 33 wk. In this model, hepatic 4-hydroxynonenal content(a marker of chronic oxidative stress), hepatocyte ballooning, picrosirius red staining, α-smooth muscle actin and collagen type 1A gene expression were all significantly increased. Increasing the AGE content of the HFHC diet by baking further increased these markers of liver damage, but this was abrogated by pre-marination in acetic acid. In response to the HFHC diet, RAGE-/-animals developed NASH of similar severity to RAGE+/+ animals but were protected from the additional harmful effects of the high AGE containing diet. Studies in isolated Kupffer cells showed that AGEs increase cell proliferation and oxidative stress, providing a likely mechanism through which these compounds contribute to liver injury. CONCLUSION In the HFHC model of NAFLD, manipulation of dietary AGEs modulates liver injury, inflammation, and liver fibrosis via a RAGE dependent pathway. This suggests that pharmacological and dietary strategies targeting the AGE/RAGE pathway could slow the progression of NAFLD. | Christopher Leung Chandana B Herath Zhiyuan Jia Sof Andrikopoulos Bronwyn E Brown Michael J Davies Leni R Rivera John B Furness Josephine M Forbes Peter W Angus | 2016 | World Journal of Gastroenterology2016，22，35： | 7 |
| 3 | Epidemiology of severe sepsis in the United States:analysis of incidence,outcome,and associated costs of care显示文摘 | Angus DC Linde-Zwirble WT Lidicker J | 2001 | Crit Care Med2001，29，7： | 1 |
| 4 | Cryoprecipitate for the correction of co- agulopathy associated with liver disease 显示文摘 | French C J Bellomo R Angus P | 2003 | Anaesth Intensive Care2003，31，4： | 1 |
| 5 | Epidemiology of severe sepsis in the United States : analysis of incidence, out- come, and associated costs of care 显示文摘 | Angus DC Linde - Zwirble WT Lidicker J | 2001 | Crit Care Med2001，29，： | 1 |
| 6 | Comparative assessment of expression of the inhibitor of growth 1 gene (ING1) in normal and neoplastic tissnos显示文摘 | Nouman GS Angus B Lunec J | 2002 | Hybridoma2002，21，1： | 1 |
| 7 | Epiemiology of se- vere in the United States :analysis of incidence , outcome , and as- sociated costs of care显示文摘 | Angus DC Linde -Zwirblr WT Lidicker J | 2001 | Cirt Care Med2001，29，： | 1 |
| 8 | Epidemiology of severe sepsis in the united states:analysis of incidence,outcome,and associated costs of care显示文摘 | Angus DC Linde-Zwirble WT Lidicker J | 2001 | Crit Care Med2001，29，7： | 1 |
| 9 | Epidemi- ology of severe sepsis in the United States: analysis of inci- dence, out-come, and associated costs of care 显示文摘 | Angus DC Linde -Zwirble WT Lidicker J | 2001 | Crit Care Med2001，29，7： | 1 |
| 10 | Statistical Surface Roughness Checking Procedure Based on a Cutting Tool Wear Model 显示文摘 | Yang Kai J Angus | 2006 | Journal of Manufacturing System2006，23，1： | 1 |
| 11 | Epidemiology of severe sepsis in the United States:analysis of incidence,outcome,and associated costs of care显示文摘 | Angus DC Linde-Zwirble WT Lidicker J | 2001 | Crit Care Med2001，29，7： | 1 |
| 12 | Soil water extraction by dryland crops, annual pastures, and lucerne in south-eastern Australia 显示文摘 | Angus J F Stapper M Van Herwaarden A F | 2001 | Australian Journal of Agricultural Research2001，52，2： | 1 |
| 13 | Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care 显示文摘 | Angus DC Linde-Zwirble WT Lidicker J | 2001 | Crit Care Med2001，29，7： | 1 |
| 14 | Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care显示文摘 | Angus D C Linde-Zwirble W T Lidicker J | 2001 | Crit Care Med2001，29，7： | 1 |
| 15 | Epidemiology of severe sepsis in the United States:analysis of incidence,outcome,and associated costs of care显示文摘 | Angus DC Linde-Zwirble WT Lidickcr J | 2001 | Crit Care Med2001，29，7： | 1 |
| 16 | Epidemiology of severe sepsis in the United States : analysis of incidence, outcome, and associated costs of care 显示文摘 | Angus DC Linde-Zwirble WT Lidicker J | 2001 | Crit Care Med2001，29，7： | 1 |
| 17 | Islet encapsulation:strategies to enhance islet cell functions显示文摘 | Beck J Angus R Madsen B | 2007 | Tissue Eng2007，13，： | 1 |
| 18 | Epidemiology ofsevere sepsis in the United States:analysis of incidence, outcome,and associated costs of care 显示文摘 | Angus DC Linde-Zwirble WT Lidicker J | 2001 | Cnt Care Med2001，29，7： | 1 |
| 19 | Epidemiology of severe sepsis in the United States :analysis of incidence,outcome,and associated costs of care显示文摘 | Angus DC Linde-Zwirble WT Lidicker J | 2001 | Crit Care Med2001，29，： | 1 |
| 20 | A New Method for Determining Small Misorientation from Electron Back Scatter Diffraction Patterns显示文摘 | Angus J Wilkinson | 2001 | Scripta Mater2001，44，： | 1 |
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