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| 1 | Dietary advanced glycation end-products aggravate non-alcoholic fatty liver disease显示文摘AIM To determine if manipulation of dietary advanced glycation end product(AGE), intake affects nonalcoholic fatty liver disease(NAFLD) progression and whether these effects are mediated via RAGE. METHODS Male C57Bl6 mice were fed a high fat, high fructose, high cholesterol(HFHC) diet for 33 wk and compared with animals on normal chow. A third group were given a HFHC diet that was high in AGEs. Another group was given a HFHC diet that was marinated in vinegar to prevent the formation of AGEs. In a second experiment, RAGE KO animals were fed a HFHC diet or a high AGE HFHC diet and compared with wildtype controls. Hepatic biochemistry, histology, picrosirius red morphometry and hepatic mR NA were determined. RESULTS Long-term consumption of the HFHC diet generated significant steatohepatitis and fibrosis after 33 wk. In this model, hepatic 4-hydroxynonenal content(a marker of chronic oxidative stress), hepatocyte ballooning, picrosirius red staining, α-smooth muscle actin and collagen type 1A gene expression were all significantly increased. Increasing the AGE content of the HFHC diet by baking further increased these markers of liver damage, but this was abrogated by pre-marination in acetic acid. In response to the HFHC diet, RAGE-/-animals developed NASH of similar severity to RAGE+/+ animals but were protected from the additional harmful effects of the high AGE containing diet. Studies in isolated Kupffer cells showed that AGEs increase cell proliferation and oxidative stress, providing a likely mechanism through which these compounds contribute to liver injury. CONCLUSION In the HFHC model of NAFLD, manipulation of dietary AGEs modulates liver injury, inflammation, and liver fibrosis via a RAGE dependent pathway. This suggests that pharmacological and dietary strategies targeting the AGE/RAGE pathway could slow the progression of NAFLD. | Christopher Leung Chandana B Herath Zhiyuan Jia Sof Andrikopoulos Bronwyn E Brown Michael J Davies Leni R Rivera John B Furness Josephine M Forbes Peter W Angus | 2016 | World Journal of Gastroenterology2016，22，35： | 7 |
| 2 | Assessment of eccentric exercise-induced muscle damage of the elbow flexors by tensiomyography 显示文摘 | Angus M Hunter Stuart D R Galloway Iain J S | 2012 | Journal of Electromyography and Kinesiology2012，22，3： | 1 |
| 3 | The performance of a solar regenerated open cycle desiccant bed grain cooling system显示文摘 | Ismail M Z Angus D E Thorpe G R | 1991 | Solar Energy1991，46，2： | 1 |
| 4 | Oral corticosteroids in patients admitted to hospital with AECOPD:a prospestive randomized controlled trial显示文摘 | Davies L Angus R M Calverley P M | 1999 | Lancet1999，354，： | 1 |
| 5 | Poly(p-phenyleneamineimine):Sythesis and compaeison to polyaniline显示文摘 | ANGUS F L Lu P M ALLEN | 1987 | J Am Chem Soc1987，109，： | 1 |
| 6 | Tandem free- radical addition/substitution chemistry and its application to the preparation of novel ATI receptor antagonists显示文摘 | Staples M K Grange R L Angus J A | 2011 | Org Biomol Chem2011，9，2： | 1 |
| 7 | Oralcorticosteroids in patients admitted to hospital with exacerbations of chrnic obstructive primonary disease: a prospeetive randomixed controlled trial 显示文摘 | Davies L Angus R M Calverley P M | 1999 | Lancet1999，354，9177： | 1 |
| 8 | Oral corticosteroids in patients admitted to hospital with exacerbations of chronic obstructive pulmonary disease:a prospective randomised controlled trial 显示文摘 | Davies L Angus R M Calverley P M | 1999 | Lancet1999，354，9177： | 1 |
| 9 | Identification of epithelial gaps in human small and large intestine by confocal endomicroscopy显示文摘 | Kiesslich R Goetz M Angus EM | 2007 | Gastroenterology2007，133，6： | 1 |
| 10 | Hepatitis B and C virus infections and anti-tumor necrosis factor a therapy: guidelines for clinical approach 显示文摘 | NATHAN D M ANGUS P W GIBSON P R | 2006 | J Gastroenterol Hepatol2006，21，9： | 1 |
| 11 | Phasic development in field crops: I ~ thermal response in the seedling phase显示文摘 | ANGUS J F Cunningham R B Moncur M W | 1981 | Field Crops Research1981，3，3： | 1 |
| 12 | Prognostic signifi- cance of immunohistochemistry-based markers and algorithms in immunochemotherapy-treated diffuse large B cell lymphoma pa- tients显示文摘 | Culpin R E Sieniawski M Angus B | 2013 | Histopathology2013，63，6： | 1 |
| 13 | Production of androgens by microbial transformation of progesterone in vitro: a model for androgen production in rivers receiving paper mill effluent 显示文摘 | Jenkins R L Wilson E M Angus R A | 2004 | Environmental Health Perspectives2004，112，15： | 1 |
| 14 | Androstenedione and progesterone in the sediment of a river receiving paper mill effluent 显示文摘 | Jenkins R L Wilson E M Angus R A | 2003 | Toxicological Sciences2003，73，1： | 1 |
| 15 | Feedback lineariza- tion - based position control of an electrohydraulic servo system with supply pressure uncertainty显示文摘 | Angue M H Venugopal R Kenn6 J P | 2012 | IEEE Transactions on Control Systems Technology2012，20，4： | 1 |
| 16 | Identification of epithelial gaps in human small and large intestine by confocal endomi- croscopy显示文摘 | Kiesslich R Goetz M Angus E M | 2007 | Gastroenterology2007，133，6： | 1 |
| 17 | Avoiding hospital admission through provision of hospital care at home: a systematic review and meta analysis of individual patient data显示文摘 | Shepperd S Doll H Angus R M | 2009 | CMAJ2009，180，2： | 1 |
| 18 | Identification of epithelial gaps in human small and large intestine by con- focal endomicroscopy 显示文摘 | Kiesslich R Goetz M Angus EM | 2007 | Gastroenterology2007，133，6： | 1 |
| 19 | Activity of the renin-angio- tensin system in acute severe asthma and the effect of angiotensin 1: on lung function显示文摘 | Millar E A Angus R M Hulks G | 1994 | Thorax1994，49，5： | 1 |
| 20 | Hyper- glycaemia as a predictor of outcome during non - invasive ventila- tion in decompensated COPD显示文摘 | CHAKRABARTI B ANGUS R M AGARWAL S | 2009 | Throx2009，64，10： | 1 |
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