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| 1 | Predictors of spine deformity progression in adolescent idiopathic scoliosis: A systematic review with meta-analysis显示文摘AIM: To evaluate published data on the predictors of progressive adolescent idiopathic scoliosis(AIS) in order to evaluate their efficacy and level of evidence. METHODS: Selection criteria:(1) study design: randomized controlled clinical trials, prospective cohort studies and case series, retrospective comparative and none comparative studies;(2) participants: adolescents with AIS aged from 10 to 20 years; and(3) treatment: observation, bracing, and other. Search method: Ovid MEDLINE, Embase, the Cochrane Library, Pub Medand patent data bases. All years through August 2014 were included. Data were collected that showed an association between the studied characteristics and the progression of AIS or the severity of the spine deformity. Odds ratio(OR), sensitivity, specificity, positive and negative predictive values were also collected. A metaanalysis was performed to evaluate the pooled OR and predictive values, if more than 1 study presented a result. The GRADE approach was applied to evaluate the level of evidence.RESULTS: The review included 25 studies. All studies showed statistically significant or borderline association between severity or progression of AIS with the following characteristics:(1) An increase of the Cobb angle or axial rotation during brace treatment;(2) decrease of the rib-vertebral angle at the apical level of the convex side during brace treatment;(3) initial Cobb angle severity(> 25o);(4) osteopenia;(5) patient age < 13 years at diagnosis;(6) premenarche status;(7) skeletal immaturity;(8) thoracic deformity;(9) brain stem vestibular dysfunction; and(10) multiple indices combining radiographic, demographic, and physiologic characteristics. Single nucleotide polymorphisms of the following genes:(1) calmodulin 1;(2) estrogen receptor 1;(3) tryptophan hydroxylase 1;(3) insulin-like growth factor 1;(5) neurotrophin 3;(6) interleukin-17 receptor C;(7) melatonin receptor 1B, and(8) Scoli Score test. Other predictors included:(1) impairment of melatonin signaling in osteoblasts and peripheral blood mononuclear cells(PBMC);(2) G-protein signaling dysfunction in PBMC; and(3) the level of platelet calmodulin. However, predictive values of all these findings were limited, and the levels of evidence were low. The pooled result of brace treatment outcomes demonstrated that around 27% of patents with AIS experienced exacerbation of the spine deformity during or after brace treatment, and 15% required surgical correction. However, the level of evidence is also low due to the limitations of the included studies.CONCLUSION: This review did not reveal any methods for the prediction of progression in AIS that could be recommended for clinical use as diagnostic criteria. | Andriy Noshchenko Lilian Hoffecker Emily M Lindley Evalina L Burger Christopher MJ Cain Vikas V Patel Andrew P Bradford | 2015 | World Journal of Orthopedics2015，6，7： | 4 |
| 2 | Terahertz inverse synthetic aperture radar (ISAR) imaging with a quantum cascade laser transmitter显示文摘 | Andriy A D Thomas M G Waldman J | 2010 | Optics Express2010，18，16： | 1 |
| 3 | The NbB 2 -phase revisited: Homogeneity range, defect structure, superconductivity显示文摘 | Carlos Angelo Nunes Dariusz Kaczorowski Peter Rogl Márcia Regina Baldissera Paulo Atsushi Suzuki Gilberto Carvalho Coelho Andriy Grytsiv Gilles André Francoise Boureé Shigeru Okada | 2005 | Acta Materialia2005，，： | 1 |
| 4 | Xylose and cellobiose fermentation to ethanol by the thermotolerant methylotrophie yeast Hansenula polymorpha显示文摘 | OLENA B M C ANDRII A S | 2003 | Yeast Research2003，，4： | 1 |
| 5 | Point set registration: coherent point drift显示文摘 | ANDRIY M XUBO S | 2010 | IEEE Transactions on Pattern Analysis and Machine Intelligence2010，32，12： | 1 |
| 6 | Supercritical water oxidation of o-dichlorobenzene:degradation studies and simulation insights显示文摘 | Igor M Svishchev Andriy Plugatyr | 2006 | Journal of Supereritical Fluids2006，37，1： | 1 |
| 7 | Probabilistic matrix factorization 显示文摘 | Ruslan S Andriy M | 2008 | Advances in Neural Information Processing Sys- tems2008，，20： | 1 |
| 8 | Using plasma matrix metalloproteinase-9 and monocyte chemoattractant protein-1 to predict future cardiovascular events in subjects with carotid atherosclerosis显示文摘 | Yonggang M Andriy Y Michael E | 2014 | Atherosclerosis2014，232，1： | 1 |
| 9 | Glucans from fruit bodies of cultivated mushrooms Pleurotus ostreatus and Pleurotus eryngii: structure and potential prebiotic activity显示文摘 | ANDRIY S KATEI~'NA M ALLA S | 2009 | Carbohydrate Polymers2009，76，4： | 1 |
| 10 | Determination of polydextrose as a fat replacer in butter 显示文摘 | Katerina M Jana C Andriy S | 2007 | Journal of Food Sciences2007，25，1： | 1 |
| 11 | Different types of mechanical complications after surgical correction of adult spine deformity with osteotomy显示文摘AIM To determine the incidence and risk factors for mechanical complications(MC) after surgical correction of adult spinal deformity(ASD) with osteotomy.METHODS A retrospective study was performed. Inclusion criteria: Surgical correction of ASD using osteotomy; male or female; > 20 years old; follow-up ≥ 24 mo or revision. The MC of spine and spinal instrumentation were studied separately. Risk analysis included assessment of the association between more than 50 different characteristics(demographic,clinical,radiographic,and instrumentation) with different types of MC.RESULTS The medical records of 94 operations in 88 subjects were analyzed: Female(68%),mean age 58.6(SD,12.7) years. Cumulative incidence of MC at 2 year follow-up was 43.6%. Of these,78% required revision(P < 0.001). The following characteristics had significant(P ≤ 0.05) association with MC:(1) Preoperative: osteoporosis,smoking,previous spinal operation,sagittal vertical axis(SVA) > 100 mm,lumbar lordosis(LL) < 34°;(2) postoperative: SVA > 75 mm; operative correction: SVA > 75 mm,LL > 30°,thoracic kyphosis > 25°,and pelvic tilt > 9°; a fall; pseudarthrosis; and(3) device and surgical technique: use of previously implanted instrumentation; use of domino and/or parallel connectors; type of osteotomy(PSO vs SPO) if preoperative SVA < 100 mm; lumbar osteotomy location; in-situ rod contouring > 60°; and fixation to sacrum/pelvis.CONCLUSION Risk of MC after surgical correction of ASD is substantial. To decrease this risk over-and/or insufficient correction of the sagittal imbalance should be avoided. | Cameron Barton Andriy Noshchenko Vikas V Patel Christopher M J Cain Christopher Kleck Evalina L Burger | 2017 | World Journal of Meta-Analysis2017，5，6： | 1 |
| 12 | Numerical modelling of the metal flow and stock bending during the rolling of unequal angle bar显示文摘 | Sebastian M Andriy M | 2006 | Journal of Materials Processing Technology2006，177，： | 1 |
| 13 | Frequency stabilization of a single mode terahertz quantum cascade laser to the kilohertz level 显示文摘 | ANDRIY A DANYLOV THOMAS M GOYETTE JERRY WALDMAN | 2009 | Optics Express2009，17，9： | 1 |
| 14 | Alcohol consumption as a risk factor for atrial fibrillation: a systematic review and meta-analysis 显示文摘 | ANDRIY V SAMOKHVALOV M D | 2010 | Eur J C ardiovasc Prey Rehabil2010，17，6： | 1 |
| 15 | Glucans from fruit bodies of cultivated mushrooms Pleurotus ostreatus and Pleurotus eryngii : Structure and potential prebiotic activity显示文摘 | Andriy Synytsya Kate?ina Mí?ková Alla Synytsya Ivan Jablonsky Ji?í Spěvá?ek Vladimír Erban Eli?ka Ková?íková Jana ?opíková | 2008 | Carbohydrate Polymers2008，，4： | 1 |
| 16 | Pharmacophore approaches in protein kinase inhibitors design显示文摘Protein kinases constitute a superfamily of therapeutic targets for a number of human and animal diseases that include more than 500 members accordingly to sequencing data of the human genome. The well characterized nature of protein kinases makes them excellent targets for drug development. Pharmacophore approaches have become one of the major tools in the area of drug discovery. Application of pharmacophore modeling approaches allows reducing of expensive overall cost associated with drug development project. Pharmacophore models are important functional groups of atoms in the proper spatial position for interaction with target protein. Various ligand-based and structurebased methods have been developed for pharmacophore model generation. Despite the successes in pharmacophore models generation these approaches have not reached their full capacity in application for drug discovery. In the following review, we summarize the published data on pharmacophore models for inhibitorsof tyrosine protein kinases(EGFR, HER2, VEGFR, JAK2, JAK3, Syk, ZAP-70, Tie2) and inhibitors of serine/threonine kinases(Clk, Dyrk, Chk1, IKK2, CDK1, CDK2, PLK, JNK3, GSK3, m TOR, p38 MAPK, PKB). Here, we have described the achievements of pharmacophore modeling for protein kinase inhibitors, which provide key points for further application of generated pharmacophore hypotheses in virtual screening, de novo design and lead optimization. | Sergiy A Starosyla Galyna P Volynets Volodymyr G Bdzhola Andriy G Golub Sergiy M Yarmoluk | 2014 | World Journal of Pharmacology2014，3，4： | 0 |
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