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| 1 | Predictors of spine deformity progression in adolescent idiopathic scoliosis: A systematic review with meta-analysis显示文摘AIM: To evaluate published data on the predictors of progressive adolescent idiopathic scoliosis(AIS) in order to evaluate their efficacy and level of evidence. METHODS: Selection criteria:(1) study design: randomized controlled clinical trials, prospective cohort studies and case series, retrospective comparative and none comparative studies;(2) participants: adolescents with AIS aged from 10 to 20 years; and(3) treatment: observation, bracing, and other. Search method: Ovid MEDLINE, Embase, the Cochrane Library, Pub Medand patent data bases. All years through August 2014 were included. Data were collected that showed an association between the studied characteristics and the progression of AIS or the severity of the spine deformity. Odds ratio(OR), sensitivity, specificity, positive and negative predictive values were also collected. A metaanalysis was performed to evaluate the pooled OR and predictive values, if more than 1 study presented a result. The GRADE approach was applied to evaluate the level of evidence.RESULTS: The review included 25 studies. All studies showed statistically significant or borderline association between severity or progression of AIS with the following characteristics:(1) An increase of the Cobb angle or axial rotation during brace treatment;(2) decrease of the rib-vertebral angle at the apical level of the convex side during brace treatment;(3) initial Cobb angle severity(> 25o);(4) osteopenia;(5) patient age < 13 years at diagnosis;(6) premenarche status;(7) skeletal immaturity;(8) thoracic deformity;(9) brain stem vestibular dysfunction; and(10) multiple indices combining radiographic, demographic, and physiologic characteristics. Single nucleotide polymorphisms of the following genes:(1) calmodulin 1;(2) estrogen receptor 1;(3) tryptophan hydroxylase 1;(3) insulin-like growth factor 1;(5) neurotrophin 3;(6) interleukin-17 receptor C;(7) melatonin receptor 1B, and(8) Scoli Score test. Other predictors included:(1) impairment of melatonin signaling in osteoblasts and peripheral blood mononuclear cells(PBMC);(2) G-protein signaling dysfunction in PBMC; and(3) the level of platelet calmodulin. However, predictive values of all these findings were limited, and the levels of evidence were low. The pooled result of brace treatment outcomes demonstrated that around 27% of patents with AIS experienced exacerbation of the spine deformity during or after brace treatment, and 15% required surgical correction. However, the level of evidence is also low due to the limitations of the included studies.CONCLUSION: This review did not reveal any methods for the prediction of progression in AIS that could be recommended for clinical use as diagnostic criteria. | Andriy Noshchenko Lilian Hoffecker Emily M Lindley Evalina L Burger Christopher MJ Cain Vikas V Patel Andrew P Bradford | 2015 | World Journal of Orthopedics2015，6，7： | 4 |
| 2 | The composition of un- recorded alcohol from eastern Ukraine: Is there a toxicological concern beyond ethanol alone?显示文摘 | DIRK W L ANDRIY V S JENNY | 2010 | Food Chem Toxicol2010，48，： | 1 |
| 3 | Room temperature tunneling magnetoresistance of electron beam deposited (Co60Fe50)x(Al2O3)1-x cermet granular films显示文摘 | Andriy Y V Wang J Q Zhou w L | 2002 | J Appl Phys2002，91，10： | 1 |
| 4 | Different types of mechanical complications after surgical correction of adult spine deformity with osteotomy显示文摘AIM To determine the incidence and risk factors for mechanical complications(MC) after surgical correction of adult spinal deformity(ASD) with osteotomy.METHODS A retrospective study was performed. Inclusion criteria: Surgical correction of ASD using osteotomy; male or female; > 20 years old; follow-up ≥ 24 mo or revision. The MC of spine and spinal instrumentation were studied separately. Risk analysis included assessment of the association between more than 50 different characteristics(demographic,clinical,radiographic,and instrumentation) with different types of MC.RESULTS The medical records of 94 operations in 88 subjects were analyzed: Female(68%),mean age 58.6(SD,12.7) years. Cumulative incidence of MC at 2 year follow-up was 43.6%. Of these,78% required revision(P < 0.001). The following characteristics had significant(P ≤ 0.05) association with MC:(1) Preoperative: osteoporosis,smoking,previous spinal operation,sagittal vertical axis(SVA) > 100 mm,lumbar lordosis(LL) < 34°;(2) postoperative: SVA > 75 mm; operative correction: SVA > 75 mm,LL > 30°,thoracic kyphosis > 25°,and pelvic tilt > 9°; a fall; pseudarthrosis; and(3) device and surgical technique: use of previously implanted instrumentation; use of domino and/or parallel connectors; type of osteotomy(PSO vs SPO) if preoperative SVA < 100 mm; lumbar osteotomy location; in-situ rod contouring > 60°; and fixation to sacrum/pelvis.CONCLUSION Risk of MC after surgical correction of ASD is substantial. To decrease this risk over-and/or insufficient correction of the sagittal imbalance should be avoided. | Cameron Barton Andriy Noshchenko Vikas V Patel Christopher M J Cain Christopher Kleck Evalina L Burger | 2017 | World Journal of Meta-Analysis2017，5，6： | 1 |
| 5 | Peptidases of pinworms Sypkac- ia muris and Passalurus ambitzuous 显示文摘 | Jaroslav V Andriy L | 2010 | Experimental Parasitology2010，126，15： | 1 |
| 6 | The JAK2/STAT3 signaling pathway is required for growth of CD44^sup +^CD24^sup -^ stem cell-like breast cancer cells in human tumors显示文摘 | Marotta Lauren L C Almendro Vanessa Marusyk Andriy Shipitsin Michail Schemme Janina Walker Sarah R Bloushtain-Qimron Noga Kim Jessica J Choudhury Sibgat A Maruyama Reo Wu Zhenhua G?nen Mithat Mulvey Laura A Bessarabova Marina O Huh Sung Jin | 2011 | Journal of Clinical Investigation2011，，： | 1 |
| 7 | A strategy for clo- ning glycosyltransferase genes involved in natural product biosynthesis显示文摘 | Andriy L Holger W Annette C | 2007 | Appl Microbiol Biotechnol2007，75，6： | 1 |
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