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您的检索式：作者名="Andreas Pircher"
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| 1 | Liver cancer:Targeted future options显示文摘Hepatocellular carcinoma(HCC)has a poor prognosis an d systemic chemotherapies have disappointing results.The increasing knowledge of the molecular biolog y of HCC has resulted in novel targets,with the vascular endothelial growth factor and epidermal growth factor receptor(EGFR)-related pathways being of special interest.New blood vessel formation(angiogenesis)is essential for the growth of solid tumors.Anti-angiogenic strategies have become an important therapeutic modality for solid tumors.Several agents targeting angiogenesis-related pathways have entered clinical trials or have been already approved for the treatment of solid tumors.These include monoclonal antibodies,receptor tyrosine kinase inhibitors and immunomodulatory drugs.HCC is a highly vascular tumor,and angiogenesis is be-lieved to play an important role in its development and progression.This review summarizes recent advances in the basic understanding of the role of angiogenesis in HCC as well as clinical trials with novel therapeutic approaches targeting angiogenesis and EGFR-related pathways. | Andreas Pircher Michael Medinger Joachim Drevs | 2011 | World Journal of Hepatology2011，3，2： | 6 |
| 2 | TLR3-dependent immune regulatory functions of human mesangial cells显示文摘在 glomerulonephritis,进血管小球的煽动性的房间的迁居是在疾病开始和前进的一个重要步骤。病毒的受体像使用费的受体(TLR3 ) 3 被知道在联系病毒的 glomerulonephritis 起一个作用。把知识基于这,这研究试图定义 TLR3 ligand polyriboinosinic:polyribocytidylic 酸的效果(poly (我: C )) 在粘附分子和巨噬细胞的表示上居民 glomerular 房间上的刺激殖民地的因素(M-CSF ) 。在 MC 的实验证明病毒的受体由的激活 poly (我: C ) 导致细胞间的粘附分子 1 的时间依赖者和剂量依赖者正式就职(ICAM-1 ) ,脉管的房间粘附分子 1 (VCAM-1 ) 并且在 mRNA 和蛋白质的 M-CSF 铺平;这些结果被与 HCV RNA 孵化 MC 证实。是出现在击倒的实验,这效果被 TLR3 明确地调停。有 proinflammatory cytokines 的 MC 的 prestimulation 增加效果 poly (我: C ) ,除了它 VCAM-1 的正式就职。肿瘤坏死因素(TNF )-α, 同样,导致 ICAM-1, VCAM-1 和 M-CSF,并且放大 mesangial 反应到 poly (我: C ) 。这些结果被与 HCV RNA 孵化 MC 证实。我们因此提供人的 MC 代表在病毒的联系疾病的 GN 渗入血管小球的白血球和单核白血球的一个潜在的目标的证据,加亮 MC 可以作为居民扮演介绍抗原的房间的可能性。 | Monika Merkle Andrea Ribeiro Simone Koppel Joachim Pircher Hanna Mannell Maximilian Roeder Markus Wornle | 2012 | Cellular & Molecular Immunology2012，9，4： | 3 |
| 3 | Neoadjuvant chemo-immunotherapy modifies CD4 + CD25 + regulatory T cells (Treg) in non-small cell lung cancer (NSCLC) patients显示文摘 | Andreas Pircher Gabriele Gamerith Arno Amann Susanne Reinold Helmut Popper Anneliese G?chter Georg Pall Ewald W?ll Herbert Jamnig Günther Gastl Anna Maria Wolf Wolfgang Hilbe Dominik Wolf | 2014 | Lung Cancer2014，，1： | 1 |
| 4 | Arterial thrombosis in the context of HCV-associated vascular disease can be prevented by protein C显示文摘Hepatitis C virus(HCV)infection is a major problem worldwide.HCV is not limited to liver disease but is frequently complicated by immune-mediated extrahepatic manifestations such as glomerulonephritis or vasculitis.A fatal complication of HCV-associated vascular disease is thrombosis.Polyriboinosinic:polyribocytidylic acid(poly(I:C)),a synthetic analog of viral RNA,induces a Toll-like receptor 3(TLR3)-dependent arteriolar thrombosis without significant thrombus formation in venules in vivo.These procoagulant effects are caused by increased endothelial synthesis of tissue factor and PAI-1 without platelet activation.In addition to human umbilical endothelial cells(HUVEC),human mesangial cells(HMC)produce procoagulatory factors,cytokines and adhesion molecules after stimulation with poly(I:C)or HCV-containing cryoprecipitates from a patient with a HCV infection as well.Activated protein C(APC)is able to prevent the induction of procoagulatory factors in HUVEC and HMC in vitro and blocks the effects of poly(I:C)and HCV-RNA on the expression of cytokines and adhesion molecules in HMC but not in HUVEC.In vivo,protein C inhibits poly(I:C)-induced arteriolar thrombosis.Thus,endothelial cells are de facto able to actively participate in immune-mediated vascular thrombosis caused by viral infections.Finally,we provide evidence for the ability of protein C to inhibit TLR3-mediated arteriolar thrombosis caused by HCV infection. | Philipp Blüm Joachim Pircher Monika Merkle Thomas Czermak Andrea Ribeiro Hanna Mannell Florian Krötz Alexander Hennrich Michael Spannagl Simone Köppel Erik Gaitzsch Markus Wörnle | 2017 | Cellular & Molecular Immunology2017，14，12： | 0 |
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