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| 1 | Liver cancer:Targeted future options显示文摘Hepatocellular carcinoma(HCC)has a poor prognosis an d systemic chemotherapies have disappointing results.The increasing knowledge of the molecular biolog y of HCC has resulted in novel targets,with the vascular endothelial growth factor and epidermal growth factor receptor(EGFR)-related pathways being of special interest.New blood vessel formation(angiogenesis)is essential for the growth of solid tumors.Anti-angiogenic strategies have become an important therapeutic modality for solid tumors.Several agents targeting angiogenesis-related pathways have entered clinical trials or have been already approved for the treatment of solid tumors.These include monoclonal antibodies,receptor tyrosine kinase inhibitors and immunomodulatory drugs.HCC is a highly vascular tumor,and angiogenesis is be-lieved to play an important role in its development and progression.This review summarizes recent advances in the basic understanding of the role of angiogenesis in HCC as well as clinical trials with novel therapeutic approaches targeting angiogenesis and EGFR-related pathways. | Andreas Pircher Michael Medinger Joachim Drevs | 2011 | World Journal of Hepatology2011，3，2： | 6 |
| 2 | TLR3-dependent immune regulatory functions of human mesangial cells显示文摘在 glomerulonephritis,进血管小球的煽动性的房间的迁居是在疾病开始和前进的一个重要步骤。病毒的受体像使用费的受体(TLR3 ) 3 被知道在联系病毒的 glomerulonephritis 起一个作用。把知识基于这,这研究试图定义 TLR3 ligand polyriboinosinic:polyribocytidylic 酸的效果(poly (我: C )) 在粘附分子和巨噬细胞的表示上居民 glomerular 房间上的刺激殖民地的因素(M-CSF ) 。在 MC 的实验证明病毒的受体由的激活 poly (我: C ) 导致细胞间的粘附分子 1 的时间依赖者和剂量依赖者正式就职(ICAM-1 ) ,脉管的房间粘附分子 1 (VCAM-1 ) 并且在 mRNA 和蛋白质的 M-CSF 铺平;这些结果被与 HCV RNA 孵化 MC 证实。是出现在击倒的实验,这效果被 TLR3 明确地调停。有 proinflammatory cytokines 的 MC 的 prestimulation 增加效果 poly (我: C ) ,除了它 VCAM-1 的正式就职。肿瘤坏死因素(TNF )-α, 同样,导致 ICAM-1, VCAM-1 和 M-CSF,并且放大 mesangial 反应到 poly (我: C ) 。这些结果被与 HCV RNA 孵化 MC 证实。我们因此提供人的 MC 代表在病毒的联系疾病的 GN 渗入血管小球的白血球和单核白血球的一个潜在的目标的证据,加亮 MC 可以作为居民扮演介绍抗原的房间的可能性。 | Monika Merkle Andrea Ribeiro Simone Koppel Joachim Pircher Hanna Mannell Maximilian Roeder Markus Wornle | 2012 | Cellular & Molecular Immunology2012，9，4： | 3 |
| 3 | Complex memory T-cell phenotypes revealed by coexpression of CD62L and CCR7显示文摘 | Unsoeld H Pircher H | 2005 | J Virol2005，79，7： | 1 |
| 4 | Buckling of thin-walled silos and tanks under axial load-some new aspects显示文摘 | Pircher M Bridge R Q | 2001 | Journal of Structural Engineering ASCE2001，127，10： | 1 |
| 5 | Austria's Finstertal rockfill dam 显示文摘 | Pircher W Schwab H | 1980 | WaterPower and Dam Construction1980，32，6： | 1 |
| 6 | The effects of a computer assisted cognitive training on neuropsychological parameters,mood and dysfunctional cognitions in depressive patients显示文摘 | Trebo E Holzner B Pircher M | | 0，，03： | 1 |
| 7 | The influence of circumferential weld-induced imperfections on the buckling of silos and tanks 显示文摘 | Pircher Martin Bridge Russell Q | 2001 | Journal of Constructional Steel Research2001，57，： | 1 |
| 8 | Optimization of cable tensioning in cable-stayed bridges显示文摘 | Janjic D Pircher M Pircher H | 2003 | Journal of Bridge Engineering2003，8，： | 1 |
| 9 | Buckling of thin-walled silos and tanks under axial load-some new aspects 显示文摘 | Pircher Martin Bridge Russell Q | 2001 | Journal of Structural Engineering2001，127，10： | 1 |
| 10 | The shape of circumferential weld-induced imperfections in thin-walled steel silos and tanks 显示文摘 | Pircher M Berry P A Ding X Beidge | 2001 | Thin-Walled Structures2001，39，： | 1 |
| 11 | Three dimensional polarization sensitive OCT of human skin in vivo 显示文摘 | Pircher M Goetzinger E Leitgeb R | 2004 | Optics Express2004，12，14： | 1 |
| 12 | Preoperative stressand anxiety in day-care patients and inpatients undergoingfast-track surgery显示文摘 | Wetsch WA Pircher I Lederer W | 2009 | Br J Anaesth2009，103，2： | 1 |
| 13 | Inhibitory receptor expression depends more dominantly on differentiation and activation than“Exhaustion”of human CD8Tcells显示文摘 | Legat A Speiser D E Pircher H Zehn D Fuertes Marraco S A | 2013 | Front Immunol2013，4，： | 1 |
| 14 | ncreased numbers of endothelial progenitor cells in peripheral blood and tumor specimens in non-small cell lung cancer: a methodological challenge and an ongoing debate on the clinical relevance 显示文摘 | Pircher A Khler C M Skvortsov S | 2008 | Oncol Rep2008，19，2： | 1 |
| 15 | Retinal pigmentepithelium segmentation by polarization sensitive optical cohe-rence tomography 显示文摘 | Gtzinger E Pircher M Geitzenauer W | 2008 | Opt Express2008，16，16： | 1 |
| 16 | Molecular analysis of the antigen receptor of virus-specific cytotoxic T cells and identifiction of a new Vα family显示文摘 | Pircher H Michalopoulos E E Iwamoto A | 1987 | Eur J Immunol1987，17，12： | 1 |
| 17 | The influence of circum ferential weld-induced imperfections on the buckling of silos and tanks显示文摘 | PIRCHER M BRIDGE R Q | 2001 | Journal of Constructional Steel Re- search2001，57，56： | 1 |
| 18 | Buckling of thin-walled silos and tanks under axial load some new aspects显示文摘 | PIRCHER M BRIDGE R Q | 2001 | Journal of Structural Engineering ASCE2001，127，10： | 1 |
| 19 | Virus Persistence in Acutely Infected Immunocompetent Mice by Exhaustion of Antivirul Cytotoxic Effector T Cells 显示文摘 | Lechner F Pircher H | 1993 | Nature1993，362，： | 1 |
| 20 | Farnesoid X receptor regulates bile acid-amino acid conjugation 显示文摘 | Kitto JL Petrowski ML | 2003 | J Biol Chem2003，278，27： | 1 |
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