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| 1 | Toll样受体与肝炎病毒相关性肾炎的研究进展显示文摘天然免疫是生物体感知并且抵抗病原微生物的第一道防线,但由于病原微生物分子的异质性以及快速进化的特征,使得宿主对病原体的监测成为一项艰巨的任务。然而,Toll样受体(Toll-like receptor,TLRs)家族作为最有代表性的模式识别受体(pattern recognition receptor,PRRs),可以识别病原体相关的分子模式(pathogen-associated molecular patterns,PAMPs)。 | 张桂玲 吕金雷 | 2017 | 华中科技大学学报(医学版)2017，46，1： | 1 |
| 2 | 丙肝相关肾病的诊疗方案研究显示文摘丙型肝炎病毒是一种常见的以引起肝脏损伤为主的黄病毒科病毒,是导致肝炎、肝硬化甚至原发性肝癌常见病因之一。丙肝相关肾病是由丙肝病毒侵入人体后引起的肾脏损伤,主要表现为肾病综合征、膜性肾病、膜增生性肾小球肾炎、Ig A相关肾病。对于丙肝相关肾病,目前还没有相关指南明确指出统一的治疗方案。本文综述了丙型肝炎的流行情况、丙肝相关肾病的研究概况和诊疗概况。 | 韩鹦赢 | 2016 | 中国处方药2016，14，4： | 1 |
| 3 | Arterial thrombosis in the context of HCV-associated vascular disease can be prevented by protein C显示文摘Hepatitis C virus(HCV)infection is a major problem worldwide.HCV is not limited to liver disease but is frequently complicated by immune-mediated extrahepatic manifestations such as glomerulonephritis or vasculitis.A fatal complication of HCV-associated vascular disease is thrombosis.Polyriboinosinic:polyribocytidylic acid(poly(I:C)),a synthetic analog of viral RNA,induces a Toll-like receptor 3(TLR3)-dependent arteriolar thrombosis without significant thrombus formation in venules in vivo.These procoagulant effects are caused by increased endothelial synthesis of tissue factor and PAI-1 without platelet activation.In addition to human umbilical endothelial cells(HUVEC),human mesangial cells(HMC)produce procoagulatory factors,cytokines and adhesion molecules after stimulation with poly(I:C)or HCV-containing cryoprecipitates from a patient with a HCV infection as well.Activated protein C(APC)is able to prevent the induction of procoagulatory factors in HUVEC and HMC in vitro and blocks the effects of poly(I:C)and HCV-RNA on the expression of cytokines and adhesion molecules in HMC but not in HUVEC.In vivo,protein C inhibits poly(I:C)-induced arteriolar thrombosis.Thus,endothelial cells are de facto able to actively participate in immune-mediated vascular thrombosis caused by viral infections.Finally,we provide evidence for the ability of protein C to inhibit TLR3-mediated arteriolar thrombosis caused by HCV infection. | Philipp Blüm Joachim Pircher Monika Merkle Thomas Czermak Andrea Ribeiro Hanna Mannell Florian Krötz Alexander Hennrich Michael Spannagl Simone Köppel Erik Gaitzsch Markus Wörnle | 2017 | Cellular & Molecular Immunology2017，14，12： | 0 |
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