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| 1 | Risk factors for Barrett’s oesophagus and oesophageal adenocarcinoma:Results from the FINBAR study显示文摘AIM:To investigate risk factors associated with Barrett's oesophagus and oesophageal adenocarcinoma.METHODS:This all-Ireland population-based case-control study recruited 224 Barrett's oesophagus patients,227 oesophageal adenocarcinoma patients and 260 controls.All participants underwent a structured interview with information obtained about potential lifestyle and environmental risk factors.RESULTS:Gastro-oesophageal reflux was associated with Barrett's [OR 12.0(95% CI 7.64-18.7)] and oesophageal adenocarcinoma [OR 3.48(95% CI 2.25-5.41)].Oesophageal adenocarcinoma patients were more likely than controls to be ex-or current smokers [OR 1.72(95% CI 1.06-2.81)and OR 4.84(95% CI 2.72-8.61)respectively] and to have a high body mass index [OR 2.69(95% CI 1.62-4.46)].No significant associations were observed between these risk factors and Barrett's oesophagus.Fruit but not vegetables were negatively associated with oesophageal adenocarcinoma [OR 0.50(95% CI 0.30-0.86)].CONCLUSION:A high body mass index,a diet low in fruit and cigarette smoking may be involved in the progression from Barrett's oesophagus to oesophageal adenocarcinoma. | Lesley A Anderson RG Peter Watson Seamus J Murphy Brian T Johnston Harry Comber Jim Mc Guigan John V Reynolds Liam J Murray | 2007 | World Journal of Gastroenterology2007，13，10： | 5 |
| 2 | Have patients with esophagitis got an increased risk of adenocarcinoma? Results from a population-based study显示文摘AIM: To examine an increased risk of esophageal adenocarcinoma is restricted to patients who develop Barrett's esophagus or whether esophagitis per se is a risk factor for adenocarcinoma.METHODS: A population-based cohort of patients with histological evidence of esophagitis without Barrett's esophagus was constructed using electronic pathology reports relating to all esophageal biopsies in Northern Ireland between 1993 and 1996. Person-years of followup and incident cases of esophageal cancer were calculated by linking the cohort to death files and the Northern Ireland Cancer Registry records. Standardized incidence ratios (SIR) were calculated for esophageal cancers (adenocarcinoma, squamous cell carcinoma (SCC), and histologically unspecified cancers).RESULTS: A total of 2 013 patients in the cohort provided 13 559 patient-years of follow-up (mean follow-up 6.7 years). None of the patients developed adenocarcinoma. Three patients developed SCC, and six developed histologically unspecified cancers. The SIR for all esophageal cancers and for SCC were 2.73 (95%CI 1.25-5.19) and 2.93 (95%CI 0.61-8.59), respectively. In a sensitivity analysis in which all unspecified esophageal cancers were treated as adenocarcinomas, the SIR for adenocarcinoma was 2.64 (0.97-5.75).CONCLUSION: The risk of adenocarcinoma is not elevated in patients with histological evidence of esophagitis without Barrett's esophagus; however, these patients may have a moderately increased risk of SCC.Further studies are required to confirm these findings,which suggest that Barrett's esophagus, not esophagitis,is the key precursor lesion in the development of adenocarcinoma. | Seamus J Murphy Lesley A Anderson Brian T Johnston Deirdre A Fitzpatrick Peter RG Watson Pauline Monaghan Liam J Murray | 2005 | World Journal of Gastroenterology2005，11，46： | 4 |
| 3 | Intracellularaccumulation of beta-amyloid(1-42) in neurons is facilitated by the alpha 7 nicotinic acetylcholine receptor in Alzheimer's dis- ease显示文摘 | Nagele RG D'Andrea MR Anderson WJ | 2002 | Neuroscience2002，110，2： | 1 |
| 4 | Increasing breast cancer incidence in China:the numbers add up显示文摘 | ZIEGLER RG ANDERSON WF GAIL MH | | 0，，19： | 1 |
| 5 | Multiplefunctions of caveolin-1显示文摘 | Liu P Rudick M Anderson RG | 2002 | J Biol Chem2002，277，41： | 1 |
| 6 | Non-steroidal anti-inflammatory drugs and the esophageal inflammation-metaplasia-adenocarcinoma sequence显示文摘 | Anderson LA Johnston BT Watson RG | 2006 | Cancer Res2006，66，9： | 1 |
| 7 | The caveolae membrane system显示文摘 | Anderson RG | 1998 | Ann Res Biochem1998，67，1： | 1 |
| 8 | Preglomerlar structural changges in the renal vascularature显示文摘 | Kett MM Evans RG | 1995 | Hypertension Blood Press1995，2，： | 1 |
| 9 | Multiple functions of caveolin-1 显示文摘 | Liu P Rudick M Anderson RG | 2002 | J Biol Chem2002，277，41： | 1 |
| 10 | A simple method for the determination of cholesterol and some plant sterols in fishery-based food products显示文摘 | Kovacs MIP Anderson WE Ackman RG | 1979 | Journal of Food Science1979，44，： | 1 |
| 11 | effects ofdrinking patterns on the relationship between alcohol and coro-nary-occlusion显示文摘 | Gruchow HW Hoffmann RG Anderson AS | 1982 | Atherosclerosis1982，43，3： | 1 |
| 12 | Structure of a bacterial quorum-sensing transcription factor complexed with pheromone and DNA显示文摘 | Zhang RG Pappas KM Brace JL Miller PC Oulmassov T Molyneaux JM Anderson JC Bashkin JK Winans SC Joachimiak A | 2002 | Nature2002，417，6892： | 1 |
| 13 | Increasing breast cancer incidence in China: the numbers add up显示文摘 | Ziegler RG Anderson WF Gail MH | 2008 | J Natl Cancer Inst2008，100，19： | 1 |
| 14 | Caveolin,a protein component of caveolae membrane coats显示文摘 | Heuser JE Donzell WC Ying YS Glenney JR Anderson RG | 1992 | Cell1992，68，4： | 1 |
| 15 | Calcium signal transduction from caveo- lae 显示文摘 | Isshiki M Anderson RG | 1999 | Cell Calcium1999，26，5： | 1 |
| 16 | The caveolae membrane system显示文摘 | Anderson RG | | 0，，： | 1 |
| 17 | The modular adaptor protein ARH is required for low density lipoprotein (LDL) binding and internalization but not for LDL receptor clustering incoated pits 显示文摘 | Michaely P Li WP Anderson RG | 2004 | J Biol Chem2004，279，34： | 1 |
| 18 | Regulated migration of epidermal growth factor receptor from caveolae显示文摘 | Wineo C Gill GN Anderson RG | 2009 | J Biol Chem2009，274，30： | 1 |
| 19 | Treatment of epidermal pigmented lesions with the frequency doubled Q-switched Nd: YAG laser: a single - impact, dose-response, multicenter trial显示文摘 | Kilmer SL Wheeland RG Goldberg DJ Anderson RR | 1994 | Arch Dermatol1994，130，12： | 1 |
| 20 | Multiple functions of caveolin - 1 显示文摘 | Liu P Rudick M Anderson RG | 2002 | J Biol Chem2002，277，41： | 1 |
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