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| 1 | Risk factors for Barrett’s oesophagus and oesophageal adenocarcinoma:Results from the FINBAR study显示文摘AIM:To investigate risk factors associated with Barrett's oesophagus and oesophageal adenocarcinoma.METHODS:This all-Ireland population-based case-control study recruited 224 Barrett's oesophagus patients,227 oesophageal adenocarcinoma patients and 260 controls.All participants underwent a structured interview with information obtained about potential lifestyle and environmental risk factors.RESULTS:Gastro-oesophageal reflux was associated with Barrett's [OR 12.0(95% CI 7.64-18.7)] and oesophageal adenocarcinoma [OR 3.48(95% CI 2.25-5.41)].Oesophageal adenocarcinoma patients were more likely than controls to be ex-or current smokers [OR 1.72(95% CI 1.06-2.81)and OR 4.84(95% CI 2.72-8.61)respectively] and to have a high body mass index [OR 2.69(95% CI 1.62-4.46)].No significant associations were observed between these risk factors and Barrett's oesophagus.Fruit but not vegetables were negatively associated with oesophageal adenocarcinoma [OR 0.50(95% CI 0.30-0.86)].CONCLUSION:A high body mass index,a diet low in fruit and cigarette smoking may be involved in the progression from Barrett's oesophagus to oesophageal adenocarcinoma. | Lesley A Anderson RG Peter Watson Seamus J Murphy Brian T Johnston Harry Comber Jim Mc Guigan John V Reynolds Liam J Murray | 2007 | World Journal of Gastroenterology2007，13，10： | 5 |
| 2 | Have patients with esophagitis got an increased risk of adenocarcinoma? Results from a population-based study显示文摘AIM: To examine an increased risk of esophageal adenocarcinoma is restricted to patients who develop Barrett's esophagus or whether esophagitis per se is a risk factor for adenocarcinoma.METHODS: A population-based cohort of patients with histological evidence of esophagitis without Barrett's esophagus was constructed using electronic pathology reports relating to all esophageal biopsies in Northern Ireland between 1993 and 1996. Person-years of followup and incident cases of esophageal cancer were calculated by linking the cohort to death files and the Northern Ireland Cancer Registry records. Standardized incidence ratios (SIR) were calculated for esophageal cancers (adenocarcinoma, squamous cell carcinoma (SCC), and histologically unspecified cancers).RESULTS: A total of 2 013 patients in the cohort provided 13 559 patient-years of follow-up (mean follow-up 6.7 years). None of the patients developed adenocarcinoma. Three patients developed SCC, and six developed histologically unspecified cancers. The SIR for all esophageal cancers and for SCC were 2.73 (95%CI 1.25-5.19) and 2.93 (95%CI 0.61-8.59), respectively. In a sensitivity analysis in which all unspecified esophageal cancers were treated as adenocarcinomas, the SIR for adenocarcinoma was 2.64 (0.97-5.75).CONCLUSION: The risk of adenocarcinoma is not elevated in patients with histological evidence of esophagitis without Barrett's esophagus; however, these patients may have a moderately increased risk of SCC.Further studies are required to confirm these findings,which suggest that Barrett's esophagus, not esophagitis,is the key precursor lesion in the development of adenocarcinoma. | Seamus J Murphy Lesley A Anderson Brian T Johnston Deirdre A Fitzpatrick Peter RG Watson Pauline Monaghan Liam J Murray | 2005 | World Journal of Gastroenterology2005，11，46： | 4 |
| 3 | Safety and efficacy of postoperative epidural analgesia显示文摘 | Wheatley RG Schug SA Watson D | 2001 | Br J Anaesth2001，87，： | 1 |
| 4 | Safety and efficacy of post-operative epidural analgesia显示文摘 | Wheatley RG Schug SA Watson D | 2001 | Br J Anaesth2001，87，： | 1 |
| 5 | Diagnosis of Coeliac disease显示文摘 | Watson RG | 2005 | BMJ2005，330，： | 1 |
| 6 | Satson and efficacy of postoperative epidural analgesia显示文摘 | Wheatley RG Schug SA Watson D | 2001 | Br J Anaesth2001，87，： | 1 |
| 7 | Non-steroidal anti-inflammatory drugs and the esophageal inflammation-metaplasia-adenocarcinoma sequence显示文摘 | Anderson LA Johnston BT Watson RG | 2006 | Cancer Res2006，66，9： | 1 |
| 8 | Safety and efficacy of postoperative epidural analgesia显示文摘 | Whaetley RG Schug SA Watson D | | 0，，： | 1 |
| 9 | Safety and efficacy of postoperative epidural analgesia Watson显示文摘 | Wheatley RG Schug SA Watson D | 2001 | Br J Anaesth2001，87，7： | 1 |
| 10 | Safety and efficacy of postoperative epidural analgesia显示文摘 | Whaetley RG Schug SA Watson D | 2001 | Br J Anaesth2001，7，： | 1 |
| 11 | Intestinal permeability tests in coeliac disease显示文摘 | Simon D Johnson Mike Smye Rg Peter Watson | 2001 | Clin Lab2001，47，34： | 1 |
| 12 | Racial differences in risk factors for atherosclerosis显示文摘 | Hutchinson RG Romm F Watson RL | 1997 | Angiology1997，48，4： | 1 |
| 13 | Circulating astrointestihal hormones in patients with flatulent dyspepsia,with and without gall - bladder disease 显示文摘 | Watson RG Shaw C Buchanan KD | 1986 | Digestion1986，35，4： | 1 |
| 14 | Safety and efficacy of postoperative epidural analgesia显示文摘 | Wheatley RG Schug SA Watson D | 2001 | Br J Anaesth2001，87，1： | 1 |
| 15 | Low prevalence of pri- mary biliary cirrhosis in Victoria, Australia显示文摘 | Watson RG Angus PW Dewar M | 1995 | Gut1995，36，： | 1 |
| 16 | Racial differences in risk factors for atherosclerosis显示文摘 | Hutchinson RG Romm F Watson RL | 1997 | Angiology1997，48，4： | 1 |
| 17 | Safety and efficacy of postoperative epidural analgesia显示文摘 | Wheatley RG Schug SA Watson D | 2001 | Br J Anaesth2001，87，1： | 1 |
| 18 | Effect of ovary holding temperature and time on equine granulosa cell apoptosis,oocyte chromatin configuration and cumulus morphology显示文摘 | Pedersen RG Watson ED Telfer EE | 2004 | Theriogenology2004，62，34： | 1 |
| 19 | Racial differences in risk factors for atherosclerosis显示文摘 | Hutchinson RG Romm F Watson RL | 1997 | Angiology1997，48，： | 1 |
| 20 | Racial differences in risk factors for atherosclerosis 显示文摘 | Hutchinson RG Romm F Watson RL | 1997 | Angiology1997，48，： | 1 |
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