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| 1 | Review of small-bowel cleansing scales in capsule endoscopy: A panoply of choices显示文摘Evaluation of the quality of small-bowel cleansing is required to assess the reliability of findings in capsule endoscopy(CE). Moreover, consensus regarding the need of intestinal preparation for CE remains to be achieved. The presence of multiple grading scales for smallbowel preparation in CE, which are time-consuming and complicated, adds difficulty to the comparison of different small-bowel cleansing regimens and their application in clinical practice. Nowadays, a validated scale universally accepted for grading small-bowel cleansing is lacking. In fact, there are numerous grading systems with very different technical characteristics, namely, the parameters and the portion of the CE video that are analyzed, the objectivity of the analysis, the lesser or greater dependency on the operator, and the validation of the score. The authors performed a review which aims to systematize and summarize currently available smallbowel grading scales in CE. | Ana Ponte Rolando Pinho Adélia Rodrigues Joao Carvalho | 2016 | World Journal of Gastrointestinal Endoscopy2016，8，17： | 6 |
| 2 | Application of Bioinspired Superhydrophobic Surfaces in Two-phase Heat Transfer Experiments显示文摘 | Emanuele Teodori Ana Sofia Moita Miguel Moura Pedro Pontes Antonio Moreira Yuan Bai Xinlin Li Yan Liu | 2017 | Journal of Bionic Engineering2017，14，3： | 3 |
| 3 | Use of Recombinant Antigens for the Diagnosis of Invasive Candidiasis显示文摘 | Ana Laín Natalia Elguezabal Elena Amutio I?igo Fernández de Larrinoa María Dolores Moragues José Pontón C. Pauza | 2008 | Clinical and Developmental Immunology2008，，： | 1 |
| 4 | Biologic width changes around loaded im- plants inserted in different levels in relation to crestal bone: histometrie evaluation in canine mandible 显示文摘 | Ana Emi lia Farias Pontes Fernando Salimon Ribeiro Gio- vanna Iezzi | 2008 | Clinical Oral Implants Research2008，19，5： | 1 |
| 5 | Giant cell arteritis: Current treatment and management显示文摘Glucocorticoids remain the cornerstone of medicaltherapy in giant cell arteritis(GCA) and should be started immediately to prevent severe consequences of the disease, such as blindness. However, glucocorticoid therapy leads to significant toxicity in over 80% of the patients. Various steroid-sparing agents have been tried, but robust scientific evidence of their efficacy and safety is still lacking. Tocilizumab, a monoclonal IL-6 receptor blocker, has shown promising results in a number of case series and is now being tested in a multi-centre randomized controlled trial. Other targeted treatments, such as the use of abatacept, are also now under investigation in GCA. The need for surgical treatment is rare and should ideally be performed in a quiescent phase of the disease. Not all patients follow the same course, but there are no valid biomarkers to assess therapy response. Monitoring of disease progress still relies on assessing clinical features and measuring inflammatory markers(C-reactive protein and erythrocyte sedimentation rate). Imaging techniques(e.g., ultrasound) are clearly important screening tools for aortic aneurysms and assessing patients with largevessel involvement, but may also have an important role as biomarkers of disease activity over time or in response to therapy. Although GCA is the most common form of primary vasculitis, the optimal strategies for treatment and monitoring remain uncertain. | Cristina Ponte Ana Filipa Rodrigues Lorraine O'Neill Raashid Ahmed Luqmani | 2015 | World Journal of Clinical Cases2015，3，6： | 1 |
| 6 | Histologic studies on osseointegration: Soft tissues response to implant surfaces and components. A review显示文摘 | Adriano Piattelli Ana Emilia Farias Pontes Marco Degidi Giovanna Iezzi | 2010 | Dental Materials2010，，1： | 1 |
| 7 | Influence of frozen storageand defrosting on the chemical and nutritional quality of sardine(Clupea pilchardus)显示文摘 | ANA M CASTRILLON ESTHER ALVAREZ PONTES MARIA T GARCIA ARIAS | 1996 | J Sci Food Agric1996，，70： | 1 |
| 8 | Cardiac Monitoring in Stroke Units: Importance of Diagnosing Atrial Fibrillation in Acute Ischemic Stroke显示文摘 | Rosa María Vivanco Hidalgo Ana Rodríguez Campello ángel Ois Santiago Elisa Cuadrado Godia Claustre Pont Sunyer Jaume Roquer | 2009 | 2009，，5： | 1 |
| 9 | Bubble Dynamics and Heat Transfer on Biphilic Surfaces:Experiments and Numerical Simulation显示文摘Wettability is known to play a major role in enhancing pool boiling heat transfer.In this context bioinspired surfaces can bring significant advantages in pool boiling applications.This work addresses a numerical investigation of bubble growth and detachment on a biphilic surface pattern,namely in a superhydrophobic region surrounded by a hydrophilic region.Surface characteristics resemble bioinspired solutions explored in our research group,mainly considering the main topographical characteristics.This numerical approach is intended to provide additional information to an experimental approach,allowing to obtain temperature,pressure and velocity fields in and around the bubble,which help to describe bubble dynamics.The model was validated based on experimental data obtained with extensive image processing of synchronized high-speed video and high-speed thermographic images.The results obtained here clearly evidence that combining enhanced direct numerical simulations with high-resolution transient experimental measurements is a promising tool to describe the complex and intricate hydrodynamic and heat transfer phenomena governing pool boiling on heated biphilic surfaces. | Pedro Pontes Ricardo Cautela Emanuele Teodori Ana Sofia Moita Anastasios Georgoulas António Luís Nobre Moreira Moreira | 2020 | Journal of Bionic Engineering2020，17，4： | 1 |
| 10 | Impact of the timing of capsule endoscopy in overt obscure gastrointestinal bleeding on yield and rebleeding rate-is sooner than 14 d advisable?显示文摘AIM To evaluate the impact of the timing of capsule endoscopy(CE) in overt-obscure gastrointestinal bleeding(OGIB). METHODS Retrospective, single-center study, including patients submitted to CE in the setting of overt-OGIB between January 2005 and August 2017. Patients were divided into 3 groups according to the timing of CE(≤ 48 h; 48 h-14 d; ≥ 14 d). The diagnostic and therapeutic yield(DY and TY), the rebleeding rate and the time to rebleed were calculated and compared between groups. The outcomes of patients in whom CE was performed before(≤ 48 h) and after 48 h(> 48 h), and before(< 14 d) and after 14 d(≥ 14 d), were alsocompared.RESULTS One hundred and fifteen patients underwent CE for overt-OGIB. The DY was 80%, TY-46.1% and rebleeding rate-32.2%. At 1 year 17.8% of the patients had rebled. 33.9% of the patients performed CE in the first 48 h, 30.4% between 48 h-14 d and 35.7% after 14 d. The DY was similar between the 3 groups(P = 0.37). In the ≤ 48 h group, the TY was the highest(66.7% vs 40% vs 31.7%, P = 0.005) and the rebleeding rate was the lowest(15.4% vs 34.3% vs 46.3% P = 0.007). The time to rebleed was longer in the ≤ 48 h group when compared to the > 48 h groups(P = 0.03).CONCLUSION Performing CE within 48 h from overt-OGIB is associated to a higher TY and a lower rebleeding rate and longer time to rebleed. | Catarina Gomes Rolando Pinho Adélia Rodrigues Ana Ponte Joana Silva Jaime Pereira Rodrigues Mafalda Sousa Joao Carlos Silva Joao Carvalho | 2018 | World Journal of Gastrointestinal Endoscopy2018，10，4： | 1 |
| 11 | Appropriateness of the study of iron deficiency anemia prior to referral for small bowel evaluation at a tertiary center显示文摘AIM To evaluate the adequacy of the study of iron deficiency anemia(IDA)in real life practice prior to referral to a gastroenterology department for small bowel evaluation.METHODS All consecutive patients referred to a gastroenterology department for small bowel investigation due to iron deficiency anemia,between January 2013 and December2015 were included.Both patients referred from general practitioners or directly from different hospital departments were selected.Relevant clinical information regarding prior anemia workup was retrospectively collected from medical records.An appropriate pre-referral study was considered the execution of esophagogastroduodenoscopy(EGD)with Helicobacter pylori(H.pylori)investigation,colonoscopy with quality standards(recent,total and with adequate preparation)and celiac disease(CD)screening(through serologic testing and/or histopathological investigation).RESULTS A total of 77 patients(58.4% female,mean age 67.1±16.7 years)were included.Most(53.2%)patients were referred from general practitioners,41.6% from other hospital specialties and 5.2% directly from the emergency department.The mean pre-referral hemoglobin concentration was 8.8±2.0 g/d L and the majority of anemias had microcytic(71.4%)and hypochromic(72.7%)characteristics.77.9%of patients presented with an incomplete pre-referral study:EGD in 97.4%,with H.pylori investigation in 58.3%,colonoscopy with quality criteria in 63.6%,and CD screening in 24.7%.Patients with an appropriate study at the time of referral were younger(48.7±17.7 vs 72.3±12.3 years,P<0.001).Small bowel evaluation was ultimately undertaken in 72.7%of patients,with a more frequent evaluation in patients with a quality colonoscopy at referral(78.6%vs 23.8%);P<0.001(OR=11.7,95%CI:3.6-38.6).The most common diagnosis regarded as the likely cause of IDA was small bowel angioectasia(18.2%)but additional causes were also found in the upper and lower gastrointestinal tracts of near 20% of patients.Small bowel studies detected previously unknown non-small bowel findings in 7.7% of patients.CONCLUSION The study of anemia prior to referral to gastroenterology department is unsatisfactory.Only approximately a quarter of patients presented with an appropriate study. | Jaime Pereira Rodrigues Rolando Pinho Joana Silva Ana Ponte Mafalda Sousa Joao Carlos Silva Joao Carvalho | 2017 | World Journal of Gastroenterology2017，23，24： | 0 |
| 12 | Utility of the balloon-overtube-assisted modified over-thewire stenting technique to treat post-sleeve gastrectomy complications显示文摘AIM To describe a modified technique of deployment of stents using the overtube developed for balloonassisted enteroscopy in post-sleeve gastrectomy(SG) complications. METHODS Between January 2010 and December 2015, all patients submitted to an endoscopic stenting procedure to treat a post-SG stenosis or leakage were retrospectively collected. Procedures from patients in which the stent was deployed using the balloon-overtube-assisted modified over-the-wire(OTW) stenting technique were described. The technical success, corresponding to proper placement of the stent in the stomach resulting in exclusion of the SG leak or the stenosis, was evaluated. Complications related to stenting were also reported.RESULTS Five procedures were included to treat 2 staple line leaks and 3 stenoses. Two types of stents were used, including a fully covered self-expandable metal stent designed for the SG anatomy(Hanarostent, ECBB-30-240-090; M.I. Tech, Co., Ltd, Seoul, SouthKorea) in 4 procedures and a biodegradable stent(BD stent 019-10A-25/20/25-080, SX-ELLA, Hradec Kralove, Czech Republic) in the remaining procedure. In all cases, an overtube was advanced with the endoscope through the SG to the duodenum. After placement of the guidewire and removal of the endoscope, the stent was easily advanced through the overtube. The overtube was pulled back and the stent was successfully deployed under fluoroscopic guidance. Technical success was achieved in all patients.CONCLUSION The adoption of a modified technique of deployment of OTW stents using an overtube may represent an effective option in the approach of SG complications. | Ana Ponte Rolando Pinho Luísa Proenca Joana Silva Jaime Rodrigues Mafalda Sousa Joao Carlos Silva Joao Carvalho | 2017 | World Journal of Gastrointestinal Endoscopy2017，9，6： | 0 |
| 13 | Yield of capsule endoscopy in obscure gastrointestinal bleeding:A comparative study between premenopausal and menopausal women显示文摘AIM To evaluate differences in capsule endoscopy(CE) performed in the setting of obscure gastrointestinal bleeding(OGIB) among premenopausal women(PMW) and menopausal women(MW).METHODS Retrospective, single-center study, including female patients submitted to CE in the setting of OGIB between May 2011 and December 2016. Patients were divided into 2 groups according to age, considering fertile age as ≤ 55 years and postmenopausal age as > 55 years. The diagnostic yield(DY), the rebleeding rate and the time to rebleed were evaluated and compared between groups. Rebleeding was defined as a drop of Hb > 2 g/dL or need for transfusional support or presence of melena/hematochezia.RESULTS A hundred and eighty three female patients underwent CE for OGIB, of whom 30.6%(n = 56) were PMW and 69.4%(n = 127) were MW. The DY was 30.4% in PMW and 63.8% in MW. The most common findings were angiodysplasias in both groups(PMW: 21.4%, MW: 44.9%)(P = 0.003). In PMW, only 1.8% required therapeutic endoscopy. In 17.3% of MW, CE findingsled to additional endoscopic treatment. Rebleeding at 1, 3 and 5 years in PMW was 3.6%, 10.2%, 10.2% and 22.0%, 32.3% and 34.2% in MW. Postmenopausal status was significantly associated with higher DY(P < 0.001), TY(P = 0.003), rebleeding(P = 0.031) and lower time to rebleed(P = 0.001).CONCLUSION PMW with suspected OGIB are less likely to have significant findings in CE. In MW DY, need for endoscopic treatment and rebleeding were significantly higher while time to rebleed was lower. | Joao Carlos Silva Rolando Pinho Adélia Rodrigues Ana Ponte Jaime Pereira Rodrigues Mafalda Sousa Catarina Gomes Joao Carvalho | 2018 | World Journal of Gastrointestinal Endoscopy2018，10，10： | 0 |
| 14 | Punica granatum Leaf Lipophilic Fraction Favours Mortality by Attenuating Inflammation in Mice with Polymicrobial Sepsis显示文摘Punica granatum L.possesses known antimicrobial and anti-inflammatory actions.Preparations of different parts of this plant have been commonly used in the folk medicine to prevent and treat infections;and studies have supported the use of P.granatum extracts for this purpose.However,little is known of the effects of P.granatum-derived fractions in severe infectious diseases such as sepsis.Here,we investigated the actions of the hexane fraction(HF),rich in lipophilic compounds,obtained from the leaves of this plant,in a murine model of polymicrobial sepsis.Oral pre-treatment with HF increased mortality in septic mice.The same animals presented with lower levels of interleukin-6,nitric oxide and hydrogen peroxide in their peritoneal lavage samples than vehicle mice.HF also increased polymorphonuclear cell accumulation in to the peritoneum of mice with sepsis.Macrophage-derived nitric oxide upon lipopolysaccharide stimuli was markedly reduced by incubation with HF.Diterpenes,triterpenes,phytosterols,vitamin E and ascorbyl palmitate were detected in the HF.These results indicate that P.granatum leaf lipophilic fractions may worsen sepsis outcome.This effect may be associated with its bioactive compounds which act synergistically or not,increasing sepsis mortality in vivo. | Nagila Caroline Fialho Sousa Isabella Fernandes da Silva Figueiredo Mizael Calacio de Araujo Elaine Pereira de Andrade Thais Costa Alves Bruna Letícia Rosa da Silva Domingos Magno Santos Pereira Saulo JoseFigueiredo Mendes Joao Francisco Silva Rodrigues Jaqueline Pessoa Pontes Simone Aparecida Teixeira AndreAlvares Marques Vale Marcus Vinicius Dias-Souza Lidio Goncalves Lima-Neto Vera Lucia dos Santos Ana Paula Azevedo-Santos Marcelo Nicolas Muscara Valerio Monteiro-Neto Andrea de Souza Monteiro Luis Claudio Nascimento da Silva Elizabeth Soares Fernandes | 2019 | Journal of Pharmacy and Pharmacology2019，7，7： | 0 |
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