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| 1 | Assessment of interobserver variation in Garden classification and management of fresh intracapsular femoral neck fracture in adults显示文摘ObjectiveTo 在如果侧面的看法的增加改变整形外科的外科医生被要求仅仅在 AP 看法上分类 35 大腿骨的颈破裂并且建议管理的分类和管理 plan.MethodsTen ,骨折和管理计划基于 anteroposterior ( AP )看并且也估计的新鲜的大腿骨的颈的花园分类上估计 interobserver 协议计划。当时,一样的电影是在 10 天以后与他们的侧面的看法一起重新显示出。结果与到在二个组之间的分类和管理计划的尊重相比。Interobserver 同意用 Fleiss’ 被计算kappa.ResultsThere 仅仅仅仅在 AP 看法上的花园分类上是一个公平 interobserver 协议(kappa 价值 0.39 ) 它改善了在增加一个侧面的看法以后节制同意(kappa 价值 0.52 ) 。当仅仅在 AP 上的管理计划上的 interobserver 协议有细微改进时,仅仅看(kappa 价值 0.50 ) 并且 AP 与侧面的看法(kappa 价值 0.52 ) 结合了。侧面的看法的补充在 15.42% 盒子中改变了分类并且在 23.14% cases.ConclusionWe 改变了管理计划断定当它毫无疑问在计划大腿骨的颈骨折的治疗有一个角色,那个侧面的看法应该与怀疑的大腿骨的颈骨折在所有病人上习惯性地被获得。 | Amit Aggarwal Mahipal Singh Aditya N Aggarwal Shuchi Bhatt | 2014 | Chinese Journal of Traumatology2014，17，2： | 13 |
| 2 | Genomic alterations and molecular subtypes of gastric cancers in Asians显示文摘Gastric cancer(GC) is a highly heterogenic disease,and it is the second leading cause of cancer death in the world.Common chemotherapies are not very effective for GC,which often presents as an advanced or metastatic disease at diagnosis.Treatment options are limited,and the prognosis for advanced GCs is poor.The landscape of genomic alterations in GCs has recently been characterized by several international cancer genome programs,including studies that focused exclusively on GCs in Asians.These studies identified major recurrent driver mutations and provided new insights into the mutational heterogeneity and genetic profiles of GCs.An analysis of gene expression data by the Asian Cancer Research Group(ACRG) further uncovered four distinct molecular subtypes with well-defined clinical features and their intersections with actionable genetic alterations to which targeted therapeutic agents are either already available or under clinical development.In this article,we review the ACRG GC project.We also discuss the implications of the genetic and molecular findings from various GC genomic studies with respect to developing more precise diagnoses and treatment approaches for GCs. | Xiang S.Ye Chunping Yu Amit Aggarwal Christoph Reinhard | 2016 | Chinese Journal of Cancer2016，35，8： | 10 |
| 3 | Gut microbiota and liver disease显示文摘 | Amit Goel Mahesh Gupta Rakesh Aggarwal | 2014 | J Gastroenterol Hepatol2014，，6： | 4 |
| 4 | Recent advances in elucidating the genetics of common variable immunodeficiency显示文摘Common variable immunodeficiency disorders(CVID),a heterogeneous group of inborn errors of immunity,is the most common symptomatic primary immunodeficiency disorder.Patients with CVID have highly variable clinical presentation.With the advent of whole genome sequencing and genome wide association studies(GWAS),there has been a remarkable improvement in understanding the genetics of CVID.This has also helped in understanding the pathogenesis of CVID and has drastically improved the management of these patients.A multiomics approach integrating the DNA sequencing along with RNA sequencing,proteomics,epigenetic and metabolomics profile is the need of the hour to unravel specific CVID associated disease pathways and novel therapeutic targets.In this review,we elaborate various techniques that have helped in understanding the genetics of CVID. | Vaishali Aggarwal Aaqib Zaffar Banday Ankur Kumar Jindal Jhumki Das Amit Rawat | 2020 | Genes & Diseases2020，7，1： | 4 |
| 5 | Leukocyte adhesion defect:Where do we stand circa 2019?显示文摘Migration of polymorphonuclear leukocytes from bloodstream to the site of inflammation is an important event required for surveillance of foreign antigens.This trafficking of leukocytes from bloodstream to the tissue occurs in several distinct steps and involves several adhesion molecules.Defect in adhesion of leukocytes to vascular endothelium affecting their subsequent migration to extravascular space gives rise to a group of rare primary immunodeficiency diseases(PIDs)known as Leukocyte Adhesion Defects(LAD).Till date,four classes of LAD are discovered with LAD I being the most common form.LAD I is caused by loss of function of common chain,cluster of differentiation(CD)18 of β2 integrin family.These patients suffer from life-threatening bacterial infections and in its severe form death usually occurs in childhood without bone marrow transplantation.LAD II results from a general defect in fucose metabolism.These patients suffer from less severe bacterial infections and have growth and mental retardation.Bombay blood group phenotype is also observed in these patients.LAD III is caused by abnormal integrin activation.LAD III patients suffer from severe bacterial and fungal infections.Patients frequently show delayed detachment of umbilical cord,impaired wound healing and increased tendency to bleed.LAD IV is the most recently described class.It is caused by defects in β2 and α4β1 integrins which impairs lymphocyte adhesion.LAD IV patients have monogenic defect in cystic-fibrosis-transmembraneconductance-regulator(CFTR)gene,resulting in cystic fibrosis.Pathophysiology and genetic etiology of all LAD syndromes are discussed in detail in this paper. | Jhumki Das Avinash Sharma Ankur Jindal Vaishali Aggarwal Amit Rawat | 2020 | Genes & Diseases2020，7，1： | 2 |
| 6 | Comparison of efficacy of metformin and D-chiro-inositol on clinical biomarkers in patients with polycystic ovarian syndrome:an open label study显示文摘Objective:Polycystic ovary syndrome(Pcos)is a pathophysiological disorder affecting reproductive and metabolic indices in females.The present study was designed to compare the efficacy of metformin and D-chiroinositol in PcoS patients.Methods:In a tertiary care hospital in North India,prospective observational research was undertaken on 1o0 patients with PCOS,which was diagnosed based on European Society of Human Reproduction and Embryology Guidelines and ultrasound of lower abdomen.The study involves various clinical characteristics into consideration for the determination of statistical significance(P<0.05)in PCOS patients.Student's t-test along with the association between PCOS and patients taking metformin and D-chiro-inositol,as well as their impact on various biochemical parameters,were investigated finally using Pearson Correlation Analysis.Results:This study comprises 50 patients taking metformin and 50 patients taking D-chiro-inositol in women suffering from PCOS.Body mass index(BMI)and waist-to-hip ratio(WHR)were statistically significant(P<0.05)within the groups of both metformin and D-chiro-inositol.Biochemical parameters such as luteinizing hormone(LH),follicle stimulating hormone(FSH),anti-mullerian hormone(AMH)and glycated hemoglobin(HbA1c)were found to be statistically significant(P<0.05)in both groups.LH,FSH and AMH(14.40±0.52;14.28±0.53;1.99±0.10)were comparatively lower in patients taking D-chiro-inositol as compared to metformin group(14.17±0.42;19.88±1.01;2.61±0.04).HbA1c(3.71±0.08)with P<0.05 was found to be decreased more in metformin group as compared to patients taking D-chiro-inositol(4.90±0.09).A positive correlation was found between HbAlc and LH in metformin,&HbAlc and FSH in D-chiro-inositol groups,respectively.Conclusion:The results indicate that D-chiro-inositol shows better results in reducing clinical variables involved in causing PCOS as compared to metformin whereas metformin has better glycemic control in PCOS patients. | Gaurika Aggarwal Shikha Gupta Ojus Sardana Harleen Pratima Kumari Rupinder Kaur Thakur Gurjeet Singh Amit Sharma Ravinder Singh | 2023 | Global Health Journal2023，7，3： | 1 |
| 7 | Microencapsulation Processes and Applications in Textile Processing显示文摘 | AGGARWAL A K AMIT D NARESH K | 1998 | Colourage1998，，8： | 1 |
| 8 | Changes in gene expression in liver tissue from patients with fulminant hepatitis E显示文摘AIM: To study host gene expression and numberof immune cells in liver tissues from patients with fulminant hepatitis E(FH-E).METHODS: Microarray-based expression profiling was done using Illumina Human WG-6_v3_Bead Chip arrays on post-mortem liver tissue from 5 patients with FH-E,and compared with similar tissue from 6 patients with fulminant hepatitis B(FH-B; disease controls) and normal liver tissue from 6 persons.Differential expression was defined as ≥ 2.0-fold change with Benjamini-Hochberg false discovery rate below 0.05 using t-test in liver tissue from FH-B and FH-E,than healthy liver tissue.For some genes that showed differential expression in FH-E,microarray data were validated using quantitative reverse transcription PCR.Differentially expressed gene lists were then subjected to 'Gene Ontology' analysis for biological processes,and pathway analysis using Bio Carta database on the DAVID server.In addition,tissue sections were stained for CD4+,CD8+ and CD56+ cells using indirect immunohistochemistry; cells staining positive for each of these markers were counted and compared between groups.RESULTS: Compared to normal livers,those from patients with FH-E and FH-B showed differential expression of 3377 entities(up-regulated 1703,downregulated 1674) and 2572 entities(up 1164,down 1408),respectively.This included 2142(up 896,down 1246) entities that were common between the two sets; most of these belonged to metabolic,hemostatic and complement pathways,which are active in normal livers.Gene expression data from livers of patients with FH-E but not those of FH-B showed activation of several immune response pathways,particularly those involving cytotoxic T cells.The fold-change values of m RNA for selected genes in livers from FH-E than in normal liver tissue determined using quantitative reverse transcription PCR showed excellent concordance with microarray analysis.At immunohistochemistry,CD8+ T cells showed an increase in liver biopsies from both FH-E [median 53.4 per arbitrary unit area(range 31.2-99.9)] and FH-B [median 49.3(19.3-51.0); P = 0.005] compared to control liver tissue [median 6.9(3.1-14.9)].CONCLUSION: FH-E patients show CD8+ T cell infiltration and increased gene expression of cytotoxic T cell pathways in liver,suggesting a possible pathogenetic role for these cells. | Anshu Naik Amit Goel Vinita Agrawal Aditya N Sarangi Nanda Chhavi Vineeta Singh Shahid Jameel Rakesh Aggarwal | 2015 | World Journal of Gastroenterology2015，21，26： | 1 |
| 9 | Osteosynthesis of femoral-neck nonunion with angle blade plate and autogenous fibular graft显示文摘 | Ramesh Sen Sujit Tripathy Tarun Goyal Sameer Aggarwal Naveen Tahasildar Daljit Singh Amit Singh | 2012 | International Orthopaedics2012，，4： | 1 |
| 10 | Sonographic diagnosis of Ascaris lumbricoides infestation as a cause of intestinal obstruction显示文摘 | Vinod Mehta Sunder Goyal Sanjay Pandit Amit Mittal Amit Aggarwal | 2010 | The Indian Journal of Pediatrics2010，，7： | 1 |
| 11 | Microencapsulation processes and applications in textile processing显示文摘 | Aggarwal A K Amit D Naresh K | 1998 | Co- lourage1998，45，8： | 1 |
| 12 | 世界范围乙型肝炎和丙型肝炎的控制治疗费用昂贵且疗效有限,关键在于预防显示文摘乙型肝炎病毒(HBV)和丙型肝炎病毒(HCV)具有嗜肝细胞性,它们有许多共同特点,都可以经皮肤传染,例如通过输入血液制品或使用被病毒污染的注射器传染。身体长久被感染可导致肝硬化和肝细胞癌等严重后遗症。 | Rakesh Aggarwal Amit Goel 李晓惠(译) 杜军保(校) | 2010 | 英国医学杂志中文版2010，13，1： | 1 |
| 13 | 显示文摘 | Aggarwal A K Dayal Amit Kumar Naresh | 1998 | Colourage1998，，8： | 1 |
| 14 | Zinner syndrome:A unique triad of mesonephric duct abnormalities as an unusual cause of urinary symptoms in late adolescence显示文摘 | Nitin P Ghonge Bharat Aggarwal Amit Kumar Sahu | 2010 | Uroradiology2010，26，3： | 1 |
| 15 | 儿童眼外伤概况分析(英文)显示文摘目的:研究北印度三级转诊中心儿童眼外伤的临床特征。方法:基于医院的流行病学研究。包括所有年满16岁的眼外伤儿童。记录关于患者的社会经济状况,治疗手段和出院情况。随访3mo,记录初始和最终视力。眼部创伤分类指南和Birmingham眼部创伤术语用于眼外伤的定义和分类。社会经济地位是根据改良B.G.Prasad分类和Kuppuswamy社会经济级别分级的。结果:在42例儿童中,男女比例为3.6∶1。发生在11~16岁儿童眼外伤最多(50%)。大多数儿童(59.52%)属于较低的社会经济阶层,且均为农村背景。在家中发生眼外伤的儿童为20例(47.61%),其次在学校,游乐场和街道发生为6例(14.28%)。其中开放性眼外伤19例(45.24%),闭合性眼外伤23例(54.75%)。因木棍、石头、烟花、跌倒、玩具而受伤的儿童数量分别为12例(28.57%),5例(11.90%),3例(7.14%),3例(7.14%)和2例(4.76%)。17例(40.47%)儿童需要药物治疗,25名(59.53%)需要手术治疗。结论:农村地区和经济条件较差的男童更易患眼外伤。儿童在家里更易患眼外伤。木棍和石头是引起眼外伤最常见的因素。开放性眼外伤的患病率更高且视力不良增多。需要进一步的以人群为基础研究以补充本研究。基于此,人们可以计划在该地区实施一项长期的政策以预防儿童眼外伤。 | Kanishk Singh Amit Maitreya Pradeep Aggarwal Harsh Bahadur | 2017 | 国际眼科杂志2017，17，3： | 1 |
| 16 | Transcranial lateral perforating gunshot injury through skull base presenting without residual damage:A fortunate survivor显示文摘We reported a case of a 32 years old male presenting with a perforating gunshot injury in craniocerebral region 3 h after the assault.The bullet entered above the right zygomatic arch,travelling through the coronal plane,and exited from the left zygomatic arch.The patient was fully conscious at presentation and developed facial nerve palsy during his hospital stay.Non-contrast CT scan of the head revealed fractures of the right orbit,bilateral maxilla,bilateral pterygoid plates,ethmoid air cells,vomer and left zygoma,and without any cerebral damage.He was treated conservatively and the facial palsy was resolved.The patient survived without any complications.Such case has not been described in the available literature till date. | Amit Garg Abhishek Mandal Ipsita Aggarwal Anmol Galhotra Shouvik Das Sanjay Marwah | 2021 | Chinese Journal of Traumatology2021，24，3： | 1 |
| 17 | Clinical profile and outcomes of hepatocellular carcinoma in primary Budd-Chiari syndrome显示文摘BACKGROUND There is scant literature on hepatocellular carcinoma(HCC)in patients with Budd-Chiari syndrome(BCS).AIM To assess the magnitude,clinical characteristics,feasibility,and outcomes of treatment in BCS-HCC.METHODS A total of 904 BCS patients from New Delhi,India and 1140 from Mumbai,India were included.The prevalence and incidence of HCC were determined,and among patients with BCS-HCC,the viability and outcomes of interventional therapy were evaluated.RESULTS In the New Delhi cohort of 35 BCS-HCC patients,18 had HCC at index presentation(prevalence 1.99%),and 17 developed HCC over a follow-up of 4601 person-years,[incidence 0.36(0.22-0.57)per 100 person-years].BCS-HCC patients were older when compared to patients with BCS alone(P=0.001)and had a higher proportion of inferior vena cava block,cirrhosis,and long-segment vascular obstruction.The median alpha-fetoprotein level was higher in patients with BCS-HCC at first presentation than those who developed HCC at follow-up(13029 ng/mL vs 500 ng/mL,P=0.01).Of the 35 BCS-HCC,26(74.3%)underwent radiological interventions for BCS,and 22(62.8%)patients underwent treatment for HCC[transarterial chemoembolization in 18(81.8%),oral tyrosine kinase inhibitor in 3(13.6%),and transarterial radioembolization in 1(4.5%)].The median survival among patients who underwent interventions for HCC compared with those who did not was 3.5 years vs 3.1 mo(P=0.0001).In contrast to the New Delhi cohort,the Mumbai cohort of BCS-HCC patients were predominantly males,presented with a more advanced HCC[Barcelona Clinic Liver Cancer C and D],and 2 patients underwent liver transplantation.CONCLUSION HCC is not uncommon in patients with BCS.Radiological interventions and liver transplantation are feasible in select primary BCS-HCC patients and may improve outcomes. | Ankit Agarwal Sagnik Biswas Shekhar Swaroop Arnav Aggarwal Ayush Agarwal Gautam Jain Anshuman Elhence Arun Vaidya Amit Gupte Ravi Mohanka Ramesh Kumar Ashwani Kumar Mishra Shivanand Gamanagatti Shashi Bala Paul Subrat Kumar Acharya Akash Shukla Shalimar | 2024 | World Journal of Gastrointestinal Oncology2024，16，3： | 0 |
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