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| 1 | Bone mineral density in lifelong trained male football players compared with young and elderly untrained men显示文摘Purpose: The purpose of the present controlled cross-sectional study was to investigate proximal femur and whole-body bone mineral density(BMD), as well as bone turnover profile, in lifelong trained elderly male football players and young elite football players compared with untrained age-matched men.Methods: One hundred and forty healthy, non-smoking men participated in the study, including lifelong trained football players(FTE, n = 35)aged 65—80 years, elite football players(FTY, n = 35) aged 18—30 years, as well as untrained age-matched elderly(UE, n = 35) and young(UY,n = 35) men. All participants underwent a regional dual-energy X-ray Absorptiometry(DXA) scan of the proximal femur and a whole-body DXA scan to determine BMD. From a resting blood sample, the bone turnover markers(BTMs) osteocalcin, carboxy-terminal type-1 collagen crosslinks(CTX-1), procollagen type-1 amino-terminal propeptide(P1NP), and sclerostin were measured.Results: FTE had 7.3%—12.9% higher(p < 0.05) BMD of the femoral neck, wards, shaft, and total proximal femur in both legs compared to UE,and 9.3%—9.7% higher(p < 0.05) BMD in femoral trochanter in both legs compared to UY. FTY had 24.3%—37.4% higher(p < 0.001) BMD in all femoral regions and total proximal femur in both legs compared to UY. The whole-body DXA scan confirmed these results, with FTE showing similar whole-body BMD and 7.9% higher(p < 0.05) leg BMD compared to UY, and with FTY having 9.6% higher(p < 0.001) wholebody BMD and 18.2% higher(p < 0.001) leg BMD compared to UY. The plasma concentration of osteocalcin, CTX-1, and P1NP were 29%,53%, and 52% higher(p < 0.01), respectively, in FTY compared to UY.Conclusion: BMD of the proximal femur and whole-body BMD are markedly higher in lifelong trained male football players aged 65—80 years and young elite football players aged 18—30 years compared to age-matched untrained men. Elderly football players even show higher BMD in femoral trochanter and leg BMD than untrained young despite an age difference of 47 years. | Marie Hagman Eva Wulff Helge Therese Hornstrup Bjorn Fristrup Jens Jung Nielsen Niklas Rye Jorgensen Jesper Lovind Andersen Jorn Wulff Helge Peter Krustrup | 2018 | Journal of Sport and Health Science2018，7，2： | 5 |
| 2 | Effects of insulin and pathway inhibitors on the PI3K-Akt- mTOR phosphorylation profile in acute myeloid leukemia cells显示文摘The phosphatidylinositol 3-kinase(PI3K)-Akt-mechanistic target of rapamycin(mTOR)pathway is constitutively activated in human acute myeloid leukemia(AML)cells and is regarded as a possible therapeutic target.Insulin is an agonist of this pathway and a growth factor for AML cells.We characterized the effect of insulin on the phosphorylation of 10 mediators in the main track of the PI3K-Akt-mTOR pathway in AML cells from 76 consecutive patients.The overall results showed that insulin significantly increased the phosphorylation of all investigated mediators.However,insulin effects on the pathway activation profile varied among patients,and increased phosphorylation in all mediators was observed only in a minority of patients;in other patients,insulin had divergent effects.Global gene expression profiling and proteomic/phosphoproteomic comparisons suggested that AML cells from these two patient subsets differed with regard to AML cell differentiation,transcriptional regulation,RNA metabolism,and cellular metabolism.Strong insulin-induced phosphorylation was associated with weakened antiproliferative effects of metabolic inhibitors.PI3K,Akt,and mTOR inhibitors also caused divergent effects on the overall pathway phosphorylation profile in the presence of insulin,although PI3K and Akt inhibition caused a general reduction in Akt pT308 and 4EBP1 pT36/pT45 phosphorylation.For Akt inhibition,the phosphorylation of upstream mediators was generally increased or unaltered.In contrast,mTOR inhibition reduced mTOR pS2448 and S6 pS244 phosphorylation but increased Akt pT308 phosphorylation.In conclusion,the effects of both insulin and PI3K-Akt-mTOR inhibitors differ between AML patient subsets,and differences in insulin responsiveness are associated with differential susceptibility to metabolic targeting. | Ina Nepstad Kimberley Joanne Hatfield Ida Sofie Grønningsæter Elise Aasebø Maria Hernandez-Valladares Karen Marie Hagen Kristin Paulsen Rye Frode SBerven Frode Selheim Håkon Reikvam Øystein Bruserud | 2019 | Signal Transduction and Targeted Therapy2019，4，1： | 4 |
| 3 | OBSERVATION ON THE EFFECTS OF CHINESE MEDICINE ZHENXUANYIN FOR IMPROVING CEREBRAL BLOOD FLOW IN RATS WITH CEREBRAL ISCHEMIA显示文摘Zhenxuanyin (镇眩饮) is composed of pure Chinese medicinal herbs, such as gastrodia tuber, poria cocos, ligusticum wallichii etc. 4-verssel occlusion (4VO) model rats were reperfused after 30 minutes’ complete occlusion, and Zhenxuanyin was administered 3 times a day. 24 hours later, 123I-IMP uptake in the brain was evaluated as an index of cerebral blood flow (CBF). The results show that Zhenxuanyin (0.03g kg, 0.3g kg, Ig kg, or 3g/ kg a day) can greatly improve the blood flow in the main cerebral regions, and 0.3g/ kg can increase cerebral blood flow (CBF) to the normal level. | 王静怡 Yasuhiro Magata Naoya Hattori Yoshiharu Yonekura Nagara Tamaki Fumiko Tanaka Junji Konishi Seok Rye Choi Shigeru Matsuzaki | 1997 | Journal of Traditional Chinese Medicine1997，17，4： | 2 |
| 4 | Variable structure methods in servo system control显示文摘 | BONCHIS A CORKE P I RYE D C | 2001 | Automatica2001，37，4： | 2 |
| 5 | Antiinflammatory Properties of HDL显示文摘 | Philip J. Barter Stephen Nicholls Kerry-Anne Rye G M. Anantharamaiah Mohamad Navab Alan M. Fogelman | 2004 | Circulation Research2004，，8： | 2 |
| 6 | ABCA1 and ABCG1 synergize to mediate cholesterol export to apoA-1 显示文摘 | Gelissen IC Harris M Rye KA | 2006 | Arterioscler Thromb Vasc Biol2006，26，3： | 1 |
| 7 | Coarsening of Precipitates and Dispersoids in Aluminum Alloy Materials显示文摘 | Rylands L M Rye R L Rayhould D | 1994 | Journal of Material Science1994，29，： | 1 |
| 8 | Formation and metabolism of prebeta-migrating,lipidpoor apolipoprotein A-I 显示文摘 | Rye KA Barter PJ | 2004 | Arterioscler Thromb Vasc Biol2004，24，3： | 1 |
| 9 | Biochemical and structural studies of a L-haloacid dehalogenase from the thermophilic archaeon Sulfolobus tokodaii显示文摘 | Rye C A Isupov M N Lebedev A A | 2009 | Extremophiles2009，13，1： | 1 |
| 10 | Geology and geochemistry of paleosols developed on the Hekpoort Basalt, Pretoria Group, South Africa显示文摘 | Rye R Holland H D | 2000 | Am J Sci2000，300，2： | 1 |
| 11 | Impedance Control of a Hydraulically Actuated Robotic Excavator 显示文摘 | NGUYEN Q HA Q RYE D DURRANT-WHYTE H | 2000 | Automation in Construction2000，9，： | 1 |
| 12 | Lignin inhibits autoxidative degradation of cellulose 显示文摘 | Schmidt J A Rye C S Gumagul N | 1995 | Polymer Degradation and Stability1995，49，： | 1 |
| 13 | Dispersion strengthened Al-Fe-V-Si alloy显示文摘 | Skinner D J Rye R L Rayhould D | 1986 | Scripta Metallurgical1986，20，6： | 1 |
| 14 | Force/position Tracking for Electrohydraulic Systems of a Robotic Excavator显示文摘 | NGUYEN Q HA Q RYE D DURRANT-WHYTE H | 2000 | IEEE Conference on Decision and Control2000，，： | 1 |
| 15 | Interfering with cancer: a brief outline of advances in RNA interference in oncology显示文摘 | Rye PD Stigbrand T | 2004 | Tumour Biol2004，25，56： | 1 |
| 16 | Impedance control of a hydraulically actuated robotic excavator显示文摘 | HA Q P NAGUYEN Q H RYE D C | | 0，，5： | 1 |
| 17 | Fuzzy sliding-mode controllers with applications显示文摘 | HA Q P NGUYEN Q H RYE D C | | 0，，： | 1 |
| 18 | Fuzzy sliding-mode controllers with applications显示文摘 | Ha Q P Nguyen Q H Rye D C | 2001 | IEEE Transactions on Industrial Electronics2001，48，1： | 1 |
| 19 | Frequency fidelity of a compact CO2Doppler lidar transmitter 显示文摘 | RYE B J | 1992 | Appl Opt1992，31，30： | 1 |
| 20 | Effective of topotecan with carboplatin in relapsed ovar ian cancer:A phase Ⅰ/Ⅱ study显示文摘 | Bowm an A Rye T Ross G | 2001 | J Clin Oncol2001，19，： | 1 |
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