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| 1 | 接受48周高效抗逆转录病毒治疗的艾滋病患者细胞内HIVDNA定量检测及其意义显示文摘目的观察中国艾滋病患者外周血T淋巴细胞及单核细胞作为HIV—1病毒储存库的情况,了解其在接受48周高效抗逆转录病毒治疗(HAART)中的动态变化及其临床意义。方法35例慢性HIV-1感染的成人在初治HAART的0、24、48周,使用流式细胞仪测定血T淋巴细胞亚群数量,使用磁珠分选法从外周血单个核细胞中分离T淋巴细胞和单核细胞并提取细胞DNA,采用实时荧光定量RT—PCR法检测血清HIVRNA、用SYBRGreen实时PCR对T淋巴细胞和单核细胞内的前病毒HIVDNA载量进行定量测定;使用SPSS18.0软件对收集的数据进行分析。结果35例艾滋病患者在HAART初次启动的0、24、48周,外周血HIVRNA水平分别为(4.12±1.41)、≤1.69、≤1.69lg拷贝/ml,CD4+T淋巴细胞数分别为(196±101)、(321±112)、(392±127)个/μl;在T淋巴细胞中HIVDNA水平分别为(4.03±0.53)、(2.74±1.16)、(2.45±0.41)lg拷贝/106细胞,在单核细胞中HIVDNA水平分别为(2.51±0.68)、(2.16±0.34)、(2.03±0.25)lg拷贝/106细胞。统计学分析显示,在48周HAART过程中,外周血HIVRNA水平与CD4T淋巴细胞数呈负相关,与T淋巴细胞及单核细胞中的前病毒HIVDNA水平均呈正相关;T淋巴细胞中的HIVDNA下降速度慢于单核细胞;外周血CD4+T淋巴细胞与T淋巴细胞前病毒HIVDNA载量呈负相关。结论HIV感染者T淋巴细胞和单核细胞均可作为HIV病毒储存库,而淋巴细胞是更主要的储存库细胞;细胞内HIVDNA水平与血HIVRNA水平变化正相关,与血CD4T淋巴细胞数呈负相关,T淋巴细胞内前病毒HIVDNA水平变化可能作为HAART中AIDS病程进展的观察指标之一。 | 郑煜煌 Diallo Mamadou Alius 陈霞 何艳 贺波 贺梅 王红艳 肖水灵 罗艳 姚运海 林一鹤 谌资 周华英 | 2012 | 中华内科杂志2012，51，9： | 8 |
| 2 | Consumer acceptability and sensory profiling of sesame oils obtained from different processes显示文摘This study aimed to investigate the effect of oil processing technologies on the sensory qualities of sesame oils and to identify drivers of liking.Using a check-all-that-apply(CATA)question and a hedonic scale,150 consumers evaluated the acceptability and sensory characteristics of 5 sesame oil samples including an aqueous extracted oil(S1),a cold-pressed oil(S2),two batches of screw-pressed oils(S3 and S5)and one crude sesame oil(S4).Solid-phase microextraction-gas chromatography-olfactometry-mass spectrometry(SPME-GC-O-MS)was used to identify odour-active compounds.The results showed that roasting,extraction techniques and filtration process influenced sensory perception and the acceptability of sesame oils.Consumers liked roasted sesame oils more than the cold-pressed sesame oil and liked the aqueous extracted sesame oil the most.Sensory attributes'sweet smell','mellow','roasted','nutty','persistent','high-intense flavour'and'cooked sesame seed flavour'were drivers of liking,while'green','raw sesame seed','rancid','woody'and'fishy'were drivers of disliking.'Burnt'flavour was liked by some while disliked by others.Pyrazines contributed to roasted flavour;2-acetylpyrrole,acetophenone and furfural contributed to nutty flavour;2-pentyl-furan,5-methyl-2-furancarboxaldehyde,and 2-phenyl-2-butenal contributed to sweet odour in the roasted sesame seeds.Nonanal,hexanal,1-hexanol and ocimene were responsible for the'green'flavour perceived in the cold-pressed oil.This study provides valuable information for sesame manufacturers on how to improve the sensory qualities of sesame oils through process manipulation to meet the needs of diverse consumers. | Wenting Yin Maradza Washington Xueting Ma Xi Yang Aliu Lu Rui Shi Renyong Zhao Xuede Wang | 2020 | Grain & Oil Science and Technology2020，3，2： | 5 |
| 3 | Aflatoxin Exposure and Viral Hepatitis in the Etiology of Liver Cirrhosis in The Gambia, West Africa显示文摘 | Kuniholm Mark H Lesi Olufunmilayo A Mendy Maimuna Akano Aliu O Sam Omar Hall Andrew J Whittle Hilton Bah Ebrima Goedert James J Hainaut Pierre Kirk Gregory D | 2008 | Environmental Health Perspectives2008，，11： | 2 |
| 4 | Variation on Wild Sunflower (Helianthus ruderalis L.) for Quantitative and Qualitative Parameters显示文摘 | S. A. Aliu S. Sh. Fetahu S. Xh. Kaqiu H. E. Bytyci | 2010 | Journal of Agricultural Science and Technology2010，4，3： | 2 |
| 5 | Meals and de-phytinization affect calcium and zinc absorption in Nigerian chil-dren with rickets显示文摘 | Thacher Tom D Aliu Oluseyi Griffin Ian J | 2009 | The Journal of Nutrition2009，139，5： | 1 |
| 6 | A Survey of Self Organisation in Future Cellular Networks显示文摘 | Aliu O G Imran A Imran M A | 2013 | IEEE Communications Surveys & Tutorials2013，15，1： | 1 |
| 7 | Open-access electronic case report journals: the rationale for case report guidelines显示文摘 | Sun GH Aliu O Hayward RA | 2013 | J Clin Epidemiol2013，66，10： | 1 |
| 8 | Intra-city polarization,residential type and attribute importance:a discrete choice study of Lagos显示文摘 | ALIU I R AJALA A O | 2014 | Habitat International2014，，42： | 1 |
| 9 | The effect of pre-affordable care Act (ACA) medicaid digibility expansion in new york state on Access to specialty surgical care 显示文摘 | Aliu O Auger KA Sun GH | 2014 | Med Care2014，6，30： | 1 |
| 10 | Pharmacoki-netics of diminazene in female Boran(Bos indicus)cattle显示文摘 | ALIU Y O MAMMSAN M PEREGRINE A S | 1993 | JVet Pharmacol Ther1993，16，3： | 1 |
| 11 | A surveyof self-organization in future cellular networks显示文摘 | ALIU 0 G IMRAN A IMARAN M A | 2013 | IEEECommunications Society2013，15，1： | 1 |
| 12 | Absorption, distribution and excretion of imidocarb显示文摘 | Aliu YO Davis RH Jr Camp BJ | 1977 | Am J Vet Res1977，38，12： | 1 |
| 13 | Pharmacokinetics of diminazene in plasma and lymph of goats显示文摘 | Mamman M Mckeever DJ Aliu YO | 1996 | AJVR1996，57，5： | 1 |
| 14 | Veritas Observations of a Very High Energy 3'--Ray Flare From the Blazar 3C 66A显示文摘 | ACCIARI V A ALIU E ARLEN T | 2009 | ApJ2009，693，： | 1 |
| 15 | Arsenic in Surface Soils Affected by Mining and Metallurgical Processing in K. Mitrovica Region, Kosovo显示文摘 | Stafilov Trajce Aliu Milihate Sajn Robert | 2010 | International Journal of Environmental Research and Public Health2010，，11： | 1 |
| 16 | Diminazene/be- renil: Bioavailability and disposition in dairy goats 显示文摘 | ALIU Y O ODEGAARD S SOGNEN E | 1984 | Acta Vet Scand1984，25，4： | 1 |
| 17 | Altered expression of miR-21 and YI'EI In human laryngeal and hypopharyngeal squamous cell carcinomas 显示文摘 | aLiu J Lei DP Jin T | 2011 | Asian Pae J Cancer Prey2011，12，10： | 1 |
| 18 | Absorption,distribution and excretion of imidocarb dipropionate in sheep显示文摘 | ALIU Y O DAVIS P H CAMP B J | | 0，，12： | 1 |
| 19 | The Effect of Medicaid Ex- pansion on Delivery of Finger and Thumb Replantation Care to Medicaid Beneficiaries and the Uninsured显示文摘 | Giladi A M Aliu O Chung K C | 2015 | Plast ReeonstrSurg2015，136，5： | 1 |
| 20 | Smart contract applications in the built environment: How prepared are Nigerian construction stakeholders?显示文摘Studies have demonstrated that advanced technology,such as smart contract applications,can enhance both pre-and post-contract administration within the built environment sector.Smart contract technology,exemplifying blockchain technologies,has the potential to improve transparency,trust,and the security of data transactions within this sector.However,there is a dearth of academic literature concerning smart contract applications within the construction industries of developing countries,with a specific focus on Nigeria.Consequently,this study seeks to explore the relevance of smart contract technology and address the challenges impeding its adoption,offering strategies to mitigate the obstacles faced by smart contract applications.To investigate the stakeholders,this research conducted 14 virtual interview sessions to achieve data saturation.The interviewees encompassed project management practitioners,senior management personnel from construction companies,experts in construction dispute resolution,professionals in construction software,and representatives from government construction agencies.The data obtained from these interviews underwent thorough analysis employing a thematic approach.The study duly recognizes the significance of smart contract applications within the sector.Among the 12 identified barriers,issues such as identity theft and data leakage,communication and synchronization challenges,high computational expenses,lack of driving impetus,excessive electricity consumption,intricate implementation processes,absence of a universally applicable legal framework,and the lack of a localized legal framework were recurrent impediments affecting the adoption of smart contract applications within the sector.The study also delves into comprehensive measures to mitigate these barriers.In conclusion,this study critically evaluates the relevance of smart contract applications within the built environment,with a specific focus on promoting their usage.It may serve as a pioneering effort,especially within the context of Nigeria. | Andrew EBEKOZIEN Clinton AIGBAVBOA Samuel Adeniyi ADEKUNLE Mohamad Shaharudin SAMSURIJAN John ALIU Bernard Martins ARTHUR-AIDOO Godpower Chinyeru AMADI | 2024 | Frontiers of Engineering Management2024，11，1： | 0 |
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