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| 1 | 细胞移植治疗脊髓损伤(英文)显示文摘Spinal cord injury can lead to severe motor,sensory and autonomic dysfunction.Currently,there is no effective treatment for the injured spinalcord.The transplantation of Schwann cells,neural stem cells or progenitor cells,olfactory ensheathing cells,oligodendrocyte precursor cells and mesenchymal stem cells has been investigated as potential therapies for spinal cord injury.However,little is known about the mechanisms through which these individual cell types promote repair and functional improvements.The five most commonly proposed mechanisms include neuroprotection,immunomodulation,axon regeneration,neuronal relay formation and myelin regeneration.A better understanding of the mechanisms whereby these cells promote functional improvements,as well as an appreciation of the obstacles in implementing these therapies and effectively modeling spinal cord injury,will be important to make cell transplantation a viable clinical option and may lead to the development of more targeted therapies. | Assinck P Duncan GJ Hilton BJ Plemel JR Tetzlaff W | 2017 | 中华神经外科疾病研究杂志2017，16，3： | 54 |
| 2 | Notch signaling controls chondrocyte hypertrophy via indirect regulation of Sox9显示文摘RBPjk-dependent Notch signaling regulates both the onset of chondrocyte hypertrophy and the progression to terminal chondrocyte maturation during endochondral ossification. It has been suggested that Notch signaling can regulate Sox9 transcription, although how this occurs at the molecular level in chondrocytes and whether this transcriptional regulation mediates Notch control of chondrocyte hypertrophy and cartilage development is unknown or controversial. Here we have provided conclusive genetic evidence linking RBPjk-dependent Notch signaling to the regulation of Sox9 expression and chondrocyte hypertrophy by examining tissuespecific Rbpjk mutant(Prx1Cre;Rbpjkf/f), Rbpjk mutant/Sox9 haploinsufficient(Prx1Cre;Rbpjkf/f;Sox9f/1),and control embryos for alterations in SOX9 expression and chondrocyte hypertrophy during cartilage development. These studies demonstrate that Notch signaling regulates the onset of chondrocyte maturation in a SOX9-dependent manner, while Notch-mediated regulation of terminal chondrocyte maturation likely functions independently of SOX9. Furthermore, our in vitro molecular analyses of the Sox9 promoter and Notch-mediated regulation of Sox9 gene expression in chondrogenic cells identified the ability of Notch to induce Sox9 expression directly in the acute setting, but suppresses Sox9 transcription with prolonged Notch signaling that requires protein synthesis of secondary effectors. | Anat Kohn Timothy P Rutkowski Zhaoyang Liu Anthony J Mirando Michael J Zuscik Regis J O'Keefe Matthew J Hilton | 2015 | Bone Research2015，3，3： | 8 |
| 3 | Depositional Model for Peat Swamp and Coal Facies Evolution Using Sedimentology, Coal Macerals, Geochemistry and Sequence Stratigraphy显示文摘As one of the most important source rocks and reservoirs of unconventional natural gas, the sedimentary environment and mode of peat swamp(the predecessor of coal seam) is important to the coal seam's spatial distribution, material composition, hydrocarbon generation potential, reservoir physical properties, etc. To reveal the depositional characteristics and history of environmental change in a terrestrial basin during a period of peat accumulation, the Middle Jurassic aged #7 coal from Gaoquan in the Qaidam Basin(NW China) was investigated using sedimentology, maceral composition, geochemistry and sequence stratigraphy. Based on identification of the sedimentary shoreline break belt, wave energy depletion point and position of wave base, the peat swamp system can be subdivided into(1) lakeside plain,(2) low energy lakeshore,(3) high energy lakeshore, and(4) shallow lake subfacies. A new method for determining coal facies is proposed based on the combination of environmental parameters including oxidation-reduction levels, energy conditions and the influence of terrigneous sediments. The evolution of the coal seam shows that peat was deposited mainly in the low energy lakeshore and lakeside plain subfacies. Five types of sequence stratigrpahic surface and two types of parasequence were identified. Forced lake regressions and normal lake regressions are attributed as the causes of sequence boundaries. The sequence stratigraphic framework comprises six sequences and corresponding system tracts, and the curve of base-level for each demonstrates a characteristic initial period of slow rising followed by fast rising and then returning to slow rising. A model indicating the relationship among base-level changes, coal facies evolution, and the environmental features in the swamp is proposed that shows the environmental features of the swamp were controlled by both base-level changes and coal facies. Accompanying depositional environment changes from a lakeside plain to lakeshore and shallow lake caused by increasing rate of base-level rise, water paleosalinity, acidity and the percentage of woody plants decrease, and the bog type alters from the low marsh to raised bog. | Jing Lu Longyi Shao Minfang Yang Kai Zhou James R.Wheeley Hao Wang Jason Hilton | 2017 | Journal of Earth Science2017，28，6： | 5 |
| 4 | 龙门山北段平通河流域地貌演化过程显示文摘龙门山位于青藏高原东缘,是青藏高原周缘山脉中陡度变化最大的山脉,也是全球气候和构造活动最为强烈的地区之一,因此成为研究构造、气候如何影响山脉地貌演化过程这一科学问题的良好素材。在位于龙门山北段的平通河流域,汶川地震导致该区强烈的隆升、剥蚀作用,对研究该区地貌演化过程具有重要的启示意义。通过对平通河流域基于DEM数据的地形坡度、水系分布、河流发育程度等的分析,并综合研究区构造特征和岩性特征,获得该流域不同区域的地貌演化方向,其中两个区域的地貌演化最为剧烈:1.平通河流域位于北川-映秀断裂和彭灌断裂之间的地区,未来将发生较快的隆升,地貌向高、陡的方向演化,河流下切作用使河谷两岸形成更加陡峭的地形;2.在北川-映秀断裂上盘附近地区,在构造和气候作用下侵蚀、搬运作用强烈,山体将被快速剥蚀削低,但在河谷两岸也会形成更加陡峭的地形。 | 颜照坤 李勇 黄润秋 李奋生 闫亮 赵国华 张自力 张威 Densmore A L Hilton R G | 2012 | 山地学报2012，30，2： | 5 |
| 5 | The SOCS proteins:A new family of negative regulators of signal transduction 显示文摘 | Nicholson S E Hilton D J | 1998 | J Leukoc Biol1998，63，6： | 3 |
| 6 | 实验性海洛因依赖所致肌病与肾损害显示文摘目的 :了解海洛因对大鼠所致肌病与肾损害。方法 :采用海洛因腹腔注射方法 ,建立不同时期实验大鼠海洛因成瘾模型 ;应用光镜及电镜研究方法 ,观察腿部横纹肌及肾脏病理组织学和超微病理学结构变化 ;应用免疫组化方法 ,对不同时期实验大鼠肾脏进行相关形态学研究。结果 :(1)横纹肌和肾组织有不同程度损伤 ,部分动物肾组织中检出了肌红蛋白成分 ;(2 )肾脏病理组织学改变与海洛因成瘾时间有一定的关系。结论 :海洛因依赖对横纹肌和肾组织具有一定的损害作用。 | 李桢 徐汝昌 姚凤升 赵永和 韩晓华 杨真 王旭 Hilton JMN | 2004 | 中国药物依赖性杂志2004，13，4： | 3 |
| 7 | Wood density and carbon concentration of coarse woody debris in native forests,Brazil显示文摘Background: With the objective of increasing knowledge on biomass and carbon stocks, and thus improving the accuracy of published estimates, the present study explored wood density and carbon concentration of coarse woody debris (diameter≥10) by decay class in a Seasonal Semi-deciduous Forest (SSF) area in the Atlantic Rain Forest and in a Cerrado sensu-stricto (CSS) area (Brazilian savanna), in Brazil. Two strata were identified in each area and ten sampling units were systematic located in each stratum. Data were collected according to the line intersect sampling method. Each tallied element, the diameter, length, and perpendicular width were recorded at the transect intersection point. Each element was classified into a decay class, and the species was identified when possible. Sample discs were cut from each element, from which cylindrical samples were extracted and oven-dried to determine density. These cylinders were milled and analyzed using a LECO-C632 to determine carbon concentration as percentage of mass. Results: In both areas, wood density decreased as the decay class increased. For SSF the mean carbon concentration of all analyzed samples was 49.8% with a standard deviation of 3.3, with a range of 27.9–57.0% across 506 observations. For CSS the general mean was 49.6% with a standard deviation of 2.6, with a range of 31.2–54.5% over 182 observations. Carbon concentration barely change between decay classes. Carbon stock was estimated at 3.3 and 0.7 MgC/ha for the SSF and the CSS, respectively. Similar results were obtained when using a 50% conversion constant. Conclusions: The present study concludes that wood density decreases as the woody debris becomes more decomposed, a pattern found in many previous studies. The carbon concentration, however, barely changes between decay classes, and that result is consistent with most of the literature reviewed. Our carbon concentrations are very close to the 50% used most commonly as a conversion factor. We strongly recommend that future studies of CWD evaluate wood density and carbon concentration by decay class to address the uncertainty still found in the literature. | Andrea B.Moreira Timothy G.Gregoire Hilton Thadeu Z.do Couto | 2019 | Forest Ecosystems2019，6，2： | 3 |
| 8 | 汶川地震对龙门山地区平通河河流系统沉积物输移的影响显示文摘通过对龙门山地区2008年9月和2010年8月发生的大规模的滑坡和泥石流地质灾害的实地考察,并在详细分析龙门山北段平通河地震前后输沙率变化情况的基础上,对龙门山地区2008年汶川地震驱动的地质灾害空间分布情况、龙门山地区地形地貌特征和龙门山地区降水空间分布情况作对比分析,获得以下认识:①汶川地震对该区地质灾害的影响将是持续的,震后地质灾害形成的松散物源将以河流为载体,被输送到下游,并对下游水利建设、防洪防涝等产生较大影响;②构造因素(汶川地震)和地形地貌因素为地质灾害发生的根本原因,气候(降水量和降水强度)则为直接诱发因素。 | 颜照坤 李勇 黄润秋 林伟 李奋生 DENSMORE Alexander L HILTON Robert G | 2011 | 自然杂志2011，33，6： | 3 |
| 9 | 断念:犯罪预防语境下的基础构造显示文摘断念是行为主体(特别是青少年越轨者或犯罪人)在一段稳定的时期内对犯罪偏好明显与确定的拒绝。青少年在成年前后的关键转型期普遍出现了与犯罪行为断绝往来的人生状态与行为过程。从原因到断念的重心转向是犯罪预防的战略选择,犯罪断念的逻辑进路更适合犯罪预防功能的有效发挥。个人发展、外部社会环境、政策介入是断念塑造与促进的积极元素,以犯罪预防的视角评估断念生成与演进流程中凸现的本质特征与基础构造,有助于指导青少年沿着稳定的人生轨迹前行,防患于未然。 | 谢思军 Paris Hilton 李鹏 | 2007 | 江西公安专科学校学报2007，，1： | 2 |
| 10 | Aflatoxin Exposure and Viral Hepatitis in the Etiology of Liver Cirrhosis in The Gambia, West Africa显示文摘 | Kuniholm Mark H Lesi Olufunmilayo A Mendy Maimuna Akano Aliu O Sam Omar Hall Andrew J Whittle Hilton Bah Ebrima Goedert James J Hainaut Pierre Kirk Gregory D | 2008 | Environmental Health Perspectives2008，，11： | 2 |
| 11 | Twenty proteins containing a C terminal SOCS box form five structural classes 显示文摘 | Hilton D J Richardson R T Alexander W S | 1998 | Proc Natl Acad Sci1998，95，1： | 2 |
| 12 | Effects of quantitative feed restriction and sex on carcass traits,meat quality and meat lipid profile of Morada Nova lambs显示文摘Background: An experiment was conducted to evaluate the effects of feed restriction(FR) and sex on the quantitative and qualitative carcass traits of Morada Nova lambs. Thirty-five animals with an initial body weight of 14.5 ± 0.89 kg and age of 120 d were used in a completely randomized study with a 3 × 3 factorial scheme consisting of three sexes(11 entire males, 12 castrated males and 12 females) and three levels of feeding(ad libitum – AL and 30% and 60% FR).Results: Entire males presented greater hot and cold carcass weights(P < 0.05), followed by castrated males and females. However, the hot carcass yield was higher for females and castrated males than for entire males. Luminosity values were influenced(P < 0.05) by sex, with entire males presenting higher values than castrated males and females.Females showed higher(P < 0.05) concentrations of linoleic acid and arachidonic acid in the meat of the longissimus thoracis muscle. The meat of animals submitted to AL intake and 30% FR showed similar(P > 0.05) concentrations, and the concentrations of palmitic acid, palmitoleic acid, stearic acid, oleic acid and conjugated linoleic acid were higher(P < 0.05) than those of animals with 60% FR. The meat of females had a higher ω6/ω3 ratio and lower h/H ratio, and females had greater levels of feeding. The meat of animals on the 60% FR diet had a greater ω6/ω3 ratio, lower h/H ratio and lower concentration of desirable fatty acids in addition to a greater atherogenicity index(AI) and thrombogenicity index(TI).Conclusion: Lambs of different sexes had carcasses with different quantitative traits without total influence on the chemical and physical meat characteristics. The lipid profile of the meat was less favorable to consumer health when the animals were female or submitted to 60% feed restriction. | Thiago L.A.C.de Araújo Elzania S.Pereira Ivone Y.Mizubuti Ana C.N.Campos Marília W.F.Pereira Eduardo L.Heinzen Hilton C.R.Magalhaes Leilson R.Bezerra Luciano P da Silva Ronaldo L.Oliveira | 2017 | Journal of Animal Science and Biotechnology2017，8，4： | 2 |
| 13 | Extreme 3He/4He ratios in northwest Iceland:constratining the common component in mantle plumes 显示文摘 | Hilton D R Gronvold K Macpherson C G | 1999 | Earth Planet Sci Lett1999，173，： | 2 |
| 14 | UK and Ireland TVT trial group:tension- free vaginal tape versus colposuspension for primary urodynamic stress incontinence : 5-year follow up 显示文摘 | Ward KL Hilton P | 2008 | BJOG2008，115，2： | 1 |
| 15 | Novel 1xN and NxN Integrated Optical Switches Using Self-lmaging Multimode GaAs/Al-GaAs Waveguides显示文摘 | Jenkins R M Heaton J M Wright D R Parker J T Birbeck J C H Smith G W Hilton K P | 1994 | Appl Phys Lett 71994，64，： | 1 |
| 16 | A mathematical model for analysis of sediment core date: im- plications for enrichment factor calculations and trace metal transport mechanism 显示文摘 | HILTON J | 1985 | Chemical Geology1985，8，： | 1 |
| 17 | Minimum Weight Analysis Based on Structural Reliability 显示文摘 | Hilton H & Feigen M | 1960 | Journal of Aerospace Sciences1960，27，9： | 1 |
| 18 | Central demyelination of the Vth nerve root in trigeminal neuralgia associated with vascular compression显示文摘 | Love S Hilton DA Coakham HB | 1998 | Brain Pathol1998，8，： | 1 |
| 19 | Efficacy of lactobacillus GG as a diarrheal preventive in travelers显示文摘 | Hilton E Kolakowski P Singer C | 1997 | Travel Med1997，4，： | 1 |
| 20 | Identification of a second murine interleukin-11 receptor-chain gene (IL11Ra2)with a restricted pattern of expression显示文摘 | Robb L Hilton DJ Brook-Carter PT | 1997 | Genomics1997，，： | 1 |
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