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| 1 | Panitumumab and irinotecan versus irinotecan alone for patients with KRAS wild-type, fluorouracil-resistant advanced colorectal cancer (PICCOLO): a prospectively stratified randomised trial显示文摘 | Matthew T Seymour Sarah R Brown Gary Middleton Timothy Maughan Susan Richman Stephen Gwyther Catherine Lowe Jennifer F Seligmann Jonathan Wadsley Nick Maisey Ian Chau Mark Hill Lesley Dawson Stephen Falk Ann O’Callaghan Kim Benstead Philip Chambers Alfred | 2013 | Lancet Oncology2013，，8： | 6 |
| 2 | In vivo anti-tumor activity of murine hematopoietic stem cells expressing a p185HER2-specific chimeric T-cell receptor gene显示文摘We have confirmed efficient anti-tumor activities of the peripheral lymphocytes transduced with a p185HER2-specific chimeric T-cell receptor gene both in murine and in human in our previous studies. To further test the feasibility of chimeric T-cell receptor in a bone marrow transplantation model, we first, made two murine tumor cell lines: MT901 and MCA-205, to express human p185HER2 by retroviral gene transduction. Murine bone marrow cells were retrovirally transduced to express the chimeric T-cell receptor and gene-modified bone marrow cells were transplanted into lethally irradiated mouse. Six months post transplantation, p185HER2-positive tumor cells:MT-901/HER2 or MCA-205/ HER2 was subcutaneously or intravenously injected to make mouse models simulating primary breast cancer or pulmonary metastasis. The in vivo anti-tumor effects were monitored by the size of the subcutaneous tumor or counting the tumor nodules in the lungs after India ink staining. The size of the subcutaneous tumor was significantly inhibited and the number of pulmonary nodules were significantly decreased in mouse recipients transplanted with chimeric T-cell receptor modified bone marrow cells compared with the control group. Our results suggest the efficient in vivo anti-tumor activities of chimeric T-cell receptor gene modified bone marrow cells. | JIAN MIN YANG MICHAEL S FRIEDMAN MARIANNE T HUBEN JENNIFER FULLER QIAO LI ALFRED E CHANG JAMES J MULE KEVIN T MCDONAGH | 2006 | Journal of Microbiology and Immunology2006，4，2： | 3 |
| 3 | 转染嵌合性T细胞受体基因小鼠T淋巴细胞的体外抗肿瘤作用显示文摘目的:研究小鼠T淋巴细胞在转染嵌合性T细胞受体基因后的体外抗肿瘤作用。方法:应用重组DNA技术,将HER2特异性嵌合性T-细胞受体构建入逆转录病毒载体;转入包装细胞后,收集病毒上清,转染小鼠T淋巴细胞,转基因后的小鼠T淋巴细胞分别与HER2阳性(SK-OV-3)或阴性(MCF-7)的肿瘤细胞系共培养,检测其细胞因子γ干扰素释放,51Cr释放法检测CTL评价其抗肿瘤效应。结果:所构建载体经酶切鉴定符合要求,乒乓法转染包装细胞系GP+E86,检测病毒滴度为1.2×106,Retronectin结合离心法转染经抗CD3/CD28单抗活化的小鼠T淋巴细胞,转染效率可达50%以上;转染嵌合性T细胞受体基因的T淋巴细胞与HER2阳性或阴性的肿瘤细胞系共培养后可检测到HER2特异性的细胞因子γ干扰素释放,51Cr释放法测CTL可见转染嵌合性T细胞受体基因T淋巴细胞对HER2阳性的肿瘤细胞具显著杀伤效应。结论:转染嵌合性T细胞受体基因的小鼠T淋巴细胞在体外可通过细胞因子释放和CTL效应发挥显著的抗肿瘤作用。 | 杨建民 Michael S Friedman 李峤 James J Mule Alfred E Chang Kevin T McDonagh | 2006 | 中国肿瘤生物治疗杂志2006，13，4： | 2 |
| 4 | Determination of Thin Metal Film Thickness by x-Ray Diffractometry Using the Scherrer Equation,Atomic Absorption Analysis and Transmission/Reflection Visible Spectroscopy显示文摘 | Agostino D | 1992 | Analytica Chimica Acta1992，262，2： | 1 |
| 5 | The degrada- tion of arginine by Clostridium perfringens (BP6K) 显示文摘 | GILBERT C S MILAN A L ALFRED A T | 1952 | Journal of Biological Chemisty1952，198，2： | 1 |
| 6 | Determinants of angle closure in older Singa- poreans显示文摘 | LAVANYA R WONG TY FRIEDMAN DS AUNG HT ALFRED T GAO H | | Arch Ophthalmol0，126，5： | 1 |
| 7 | Circadian rhythm in cardiac arrest:the Singapore experience显示文摘 | LATEEF F ONG M E ALFRED T | 2008 | Singapore Med J2008，49，9： | 1 |
| 8 | Insulin-like growth factor-I liposomal gene transfer and systemic growth hormone stimulate wound healing显示文摘 | PIERRE EJ REGINO PEREZ-POLO J ALFRED T | 1997 | J Burn Care Rehabil1997，18，： | 1 |
| 9 | Delayed neurologic sequelae resulting from epidemic diethylene glycol poisoning显示文摘 | Alfred S Coleman P Harris D Wigmore T Stachowski E Graudins A | 2005 | Clin Toxicol ( Phila )2005，43，3： | 1 |
| 10 | Mondelli Advance in Modeling and Simulation of Vacuum Electronic Devices显示文摘 | ANTONSEN T M JR ALFRED A | 1999 | Proceedings Of the IEEE1999，87，5： | 1 |
| 11 | Distribution of trace elements in the environment and the occurrence of heart disease in Georgia显示文摘 | Hansford T S Herbert I S Alfred T M | 1972 | Geol Soci Amer Bull1972，83，4： | 1 |
| 12 | Determinants of angle closure in older Singaporeans 显示文摘 | Lavanya R Wong TY Friedman DS Aung T Alfred T Gao H et a/ | 2008 | Arch Ophthalmol2008，126，5： | 1 |
| 13 | An optimization technique for protocol conformance test generation based on UIO sequence and rural Chinese postman tours显示文摘 | Alfred V Aho Anton T Dahbura David Lee | 1991 | IEEE transactions on communications1991，39，11： | 1 |
| 14 | Snow load effect on the Earth's Rotation and Gravitational Field, 1979 ~ 1985 显示文摘 | Chao B F William P O'Connor Alfred T C Chang | 1987 | Journal of Geophysical Research1987，92，9： | 1 |
| 15 | Indoor Chemistry:ozone,volatile organic compounds,and carpets显示文摘 | Weschler C J Alfred T | 1992 | Environmental Science and Technology1992，26，： | 1 |
| 16 | Nuttall Disorders of cochlear blood flow显示文摘 | Nakashima T Shinji Naganawa Alfred L | 2003 | Brain Research Reviews2003，43，： | 1 |
| 17 | Cold- indueed repression of the rice anther-speeifie cell wall invertase gene OSINV4 is correlated with sucrose accumulation and pollen sterility 显示文摘 | OLIVER S N VAN DONGEN J T ALFRED S C | 2005 | Plant Cell and Environment2005，28，： | 1 |
| 18 | $pirodiclofen and Spiromesifen 显示文摘 | Ralf N Thomas B Alfred E Reiner F and Ralf T | 2003 | Pestic Outlook2003，14，： | 1 |
| 19 | Abscisic acid inhibits type 2C protein phosphatases via the PYR/PYL family of START proteins 显示文摘 | Park S Y Fung P Nishimura N Jensen D R Fujii H Zhao Y Santiago J Rodrigues A Chow T F Alfred S E Bonetta D Finkelstein R Provart N J Desveaux D Rodriguez P L McCourt P Zhu J K Schroeder J I Volkman B F Cutler S R | 2009 | Science2009，324，5930： | 1 |
| 20 | Scalable multiresolution color image segmentation显示文摘 | T Akhlaghian N Golshah M Alfred | 2006 | Signal Processing2006，86，7： | 1 |
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