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| 1 | Cytokines,cytokine gene polymorphisms and Helicobacter pylori infection:Friend or foe?显示文摘Helicobacter pylori(H.pylori)is a flagellated,spiralshaped,microaerophilic Gram-negative bacillus that colonises the gastric mucosa of more than 50%of the human population.Infection is a risk factor for gastritis,ulcer disease and stomach cancer.Immunity against H.pylori is mainly related to Th1/Th17 skewing,and the activation of regulatory T cells is the main strategy used to limit inflammatory responses,which can result in the pathogen persistence and can lead to chronic gastrointestinal diseases,including cancer.Furthermore,host genetic factors that affect cytokines may determine differences in the susceptibility to many diseases.In this review,we present the cytokine profiles and the main cytokine gene polymorphisms associated with resistance/susceptibility to H.pylori and discuss how such polymorphisms may influence infection/disease outcomes. | Camila A Figueiredo Cintia Rodrigues Marques Ryan dos Santos Costa Hugo Bernardino F da Silva Neuza M Alcantara-Neves | 2014 | World Journal of Gastroenterology2014，20，18： | 11 |
| 2 | 血浆游离DNA水平增高可作为预测重型颅脑损伤患者死亡率的独立指标(英文)显示文摘Trauma is the leading cause of death under 45 years worldwide and up to 50% of trauma fatalities are due to brain injury.Prediction of outcome is one of the major problems associated with severe TBI and research efforts have focused on the investigation of biomarkers with prognostic value following TBI. Therefore,our aim was to investigate whether cell-free DNA concentrations correlated to short-term primary outcome( survivor or death) and GCS scores following severe TBI. A total of 188 victims of severe TBI were enrolled in this prospective study,outcome variables comprised: survival and neurological assessment using the GCS at ICU discharge. Control blood samples were obtained from 25 healthy volunteers. Peripheral venous blood was collected at admission in the ICU. Plasma DNA was measured using a real-time quantitative PCR assay for the β-globin gene. There was correlation between higher DNA levels and both fatal outcome and lower hospital admission GCS scores. Plasma DNA concentrations at the chosen cut- off point( ≥171,381 kilogenomesequivalents /L) predicted mortality with a specificity of 90% and a sensitivity of 43%. Logistic regression analysis showed that elevated plasma DNA levels were independently associated with death( P < 0. 001). In conclusion,high cell-free DNA concentration was a predictor of short-term mortality following severe TBI. | Rodrigues Filho EM1 Simon D Ikuta N Klovan C Dannebrock F de Oliveira CO Regner A | 2014 | 中华神经外科疾病研究杂志2014，13，3： | 6 |
| 3 | Molecular approaches for spinal cord injury treatment显示文摘Injuries to the spinal cord result in permanent disabilities that limit daily life activities.The main reasons for these poor outcomes are the limited regenerative capacity of central neurons and the inhibitory milieu that is established upon traumatic injuries.Despite decades of research,there is still no efficient treatment for spinal cord injury.Many strategies are tested in preclinical studies that focus on ameliorating the functional outcomes after spinal cord injury.Among these,molecular compounds are currently being used for neurological recovery,with promising results.These molecules target the axon collapsed growth cone,the inhibitory microenvironment,the survival of neurons and glial cells,and the re-establishment of lost connections.In this review we focused on molecules that are being used,either in preclinical or clinical studies,to treat spinal cord injuries,such as drugs,growth and neurotrophic factors,enzymes,and purines.The mechanisms of action of these molecules are discussed,considering traumatic spinal cord injury in rodents and humans. | Fernanda Martins de Almeida Suelen Adriani Marques Anne Caroline Rodrigues dos Santos Caio Andrade Prins Fellipe Soares dos Santos Cardoso Luiza dos Santos Heringer Henrique Rocha Mendonça Ana Maria Blanco Martinez | 2023 | Neural Regeneration Research2023，18，1： | 3 |
| 4 | Embryonal rhabdomyosarcoma in the maxillary sinus with orbital involvement in a pediatric patient:Case report显示文摘This report presents a case of embryonal rhabdomyosarcoma(e RMS) located in the left maxillary sinus and invading the orbital cavity in a ten-year-old male patient who was treated at a referral hospital.The images provided from the computed tomography showed a heterogeneous mass with soft-tissue density,occupying part of the left half of the face inside the maxillary sinus,and infiltrating and destroying the bone structure of the maxillary sinus,left orbit,ethmoidal cells,nasal cavity,and sphenoid sinus.An analysis of the histological sections revealed an undifferentiated malignant neoplasm infiltrating the skeletal muscle tissue.The immunohistochemical analysis was positive for the antigens:MyoD 1,myogenin,desmin,and Ki67(100% positivity in neoplastic cells),allowing the identification of the tumour as an eR MS.The treatment protocol included initial chemotherapy followed by radiotherapy and finally surgery.The total time of the treatment was nine months,and in 18-mo of follow-up period did not show no local recurrences and a lack of visual impairment. | Ana Carolina Rodrigues de Melo Tácio Candeia Lyra Isabella Lima Arrais Ribeiro Alexandre Rolim da Paz Paulo Rogério Ferreti Bonan Ricardo Dias de Castro Ana Maria Gondim Valen?a | 2017 | World Journal of Clinical Cases2017，5，12： | 3 |
| 5 | Acute kidney injury and electrolyte disorders in COVID-19显示文摘Acute kidney injury(AKI)and electrolyte disorders are important complications of hospitalized coronavirus disease 2019(COVID-19)patients.AKI is thought to occur due to multiple pathophysiological mechanisms,such as multiple organ dysfunction(mainly cardiac and respiratory),direct viral entry in the renal tubules,and cytokine release syndrome.AKI is present in approximately one in every ten hospitalized COVID-19 patients.The incidence rates of AKI increase in patients who are admitted to the intensive care unit(ICU),with levels higher than 50%.Additionally,renal replacement therapy(RRT)is used in 7%of all AKI cases,but in nearly 20%of patients admitted to an ICU.COVID-19 patients with AKI are considered moderate-to-severe cases and are managed with multiple interdisciplinary conducts.AKI acts as a risk factor for mortality in severe acute respiratory syndrome coronavirus 2 infection,especially when RRT is needed.Electrolyte disorders are also common manifestations in hospitalized COVID-19 patients,mainly hyponatremia,hypokalemia,and hypocalcemia.Hyponatremia occurs due to a combination of syndrome of inappropriate secretion of antidiuretic hormone and gastrointestinal fluid loss from vomiting and diarrhea.When it comes to hypokalemia,its mechanism is not fully understood but may derive from hyperaldosteronism due to renin angiotensin aldosterone system overstimulation and gastrointestinal fluid loss as well.The clinical features of hypokalemia in COVID-19 are similar to those in other conditions.Hypocalcemia is the most common electrolyte disorder in COVID-19 and seems to occur because of vitamin D deficiency and parathyroid imbalance.It is also highly associated with longer hospital and ICU stay. | Gabriel Martins Nogueira Noel Lucas Oliveira Rodrigues Silva Ana Flávia Moura Marcelo Augusto Duarte Silveira JoséA Moura-Neto | 2022 | World Journal of Virology2022，11，5： | 2 |
| 6 | Adjuvant vinorelbine plus cisplatin versus observation in patients with completely resected stage IB–IIIA non-small-cell lung cancer (Adjuvant Navelbine International Trialist Association [ANITA]): a randomised controlled trial显示文摘 | Jean-Yves Douillard Rafael Rosell Mario De Lena Francesco Carpagnano Rodryg Ramlau Jose Luis Gonzáles-Larriba Tomasz Grodzki Jose Rodrigues Pereira Alain Le Groumellec Vito Lorusso Claude Clary Antonio J Torres Jabrail Dahabreh Pierre-Jean Souquet Julio A | 2006 | Lancet Oncology2006，，9： | 2 |
| 7 | Catalytic oxidation of isophorone to ketoisophorone over ruthenium supported MgAl-hydrotalcite 显示文摘 | Kishore D Rodrigues A E | 2007 | Catalysis Communications2007，8，7： | 1 |
| 8 | Neural mechanisms involved in the delay of gastric emptying and gastrointestinal transit of liquid after thoracic spinal cord transection in awake rats 显示文摘 | Gondim F A Rodrigues C L da-Graca J R | 2001 | Auton Neurosci2001，87，1： | 1 |
| 9 | Adsorption of propane and propylene in pellets and crystals of 5A zeolite显示文摘 | GIGOLA C RODRIGUES A E | 2002 | Ind Eng Chem Res2002，41，1： | 1 |
| 10 | Abscisic acid inhibits type 2C protein phosphatases via the PYR/ PYL family of START proteins显示文摘 | PARK S Y FUNG P NISHIMURA N JENSEN D R FFUJII ZHAO Y LUMBA S SANTIAGO J RODRIGUES A CHOW T F | 2009 | Science2009，324，： | 1 |
| 11 | Modeling natural convection in a heated vertical channel for room ventilation 显示文摘 | Rodrigues A M Piedade A Lahellec A | 2000 | Building and Environment2000，35，5： | 1 |
| 12 | Comparative study of the adsorption of phenol and salicylic acid from aqueous solution onto nonionic polymeric resins显示文摘 | Otero M Zabkova M Rodrigues A E | 2005 | Separation and Purification Technology2005，45，2： | 1 |
| 13 | Blood pressure response to physical exertion in adolescents: influence of overweight and obesity显示文摘 | Carletti L Rodrigues AN Perez A J | 2008 | Arq Bras Cardiol2008，91，1： | 1 |
| 14 | Production and characterisation of alginate microparticles incorporating Aero- monas hydrophila designed for fish oral vaccination 显示文摘 | Rodrigues A P Hirsch D Figueiredo H C P | 2006 | Process Biochem2006，41，： | 1 |
| 15 | Crane scheduling with spatial constraints显示文摘 | Lim A Rodrigues B Xiao F | 2004 | Naval Research Logistics2004，51，： | 1 |
| 16 | lmmunophenotypic characterization of peripheral T lymphocytes in Mycobacterium tuberculo- sis infection and disease显示文摘 | Rodrigues D S Medeiros E A Weckx L Y | 2002 | Clin Exp Immunol2002，128，1： | 1 |
| 17 | A General Theory of Prediction in Finite Populations 显示文摘 | RODRIGUES J BOLFARINE H ROGAKTO A | 1995 | International Statistical Review1995，53，： | 1 |
| 18 | Three-Dimensional Modeling of Vertical-Horizontal Rolling Process显示文摘 | XIONG Shang-wu Rodrigues J M C Martins P A F | 2003 | Finite Elements in Analysis and Design2003，39，： | 1 |
| 19 | Efficacy and safety of apretinin use for reoperative valvular surgery 显示文摘 | Rodrigues AJ Evora PR Bassetto S a al | 2007 | Ann Thorac Surg2007，83，6： | 1 |
| 20 | Viscoelasticdamping technologies, part I: Modeling and finite elementimplementation 显示文摘 | Vasques C M A * Moreira R A S Rodrigues J D | 2010 | Journal of Advanced Research inMechanical Engineering2010，1，2： | 1 |
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