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| 1 | Restoration of energy level in the early phase of acute pediatric pancreatitis显示文摘Acute pancreatitis (AP) is a serious inflammatory disease with rising incidence both in the adult and pediatric populations. It has been shown that mitochondrial injury and energy depletion are the earliest intracellular events in the early phase of AP. Moreover, it has been revealed that restoration of intracellular ATP level restores cellular functions and defends the cells from death. We have recently shown in a systematic review and meta-analysis that early enteral feeding is beneficial in adults; however, no reviews are available concerning the effect of early enteral feeding in pediatric AP. In this minireview, our aim was to systematically analyse the literature on the treatmentof acute pediatric pancreatitis. The preferred reporting items for systematic review(PRISMA-P) were followed, and the question was drafted based on participants, intervention, comparison and outcomes: P: patients under the age of twenty-one suffering from acute pancreatitis; I: early enteral nutrition (per os and nasogastric- or nasojejunal tube started within 48 h); C: nil per os therapy; O: length of hospitalization, need for treatment at an intensive care unit, development of severe AP, lung injury (including lung oedema and pleural effusion), white blood cell count and pain score on admission. Altogether, 632 articles (Pub Med: 131; EMBASE: 501) were found. After detailed screening of eligible papers, five of them met inclusion criteria. Only retrospective clinical trials were available. Due to insufficient information from the authors, it was only possible to address length of hospitalization as an outcome of the study. Our mini-meta-analysis showed that early enteral nutrition significantly(SD = 0.806, P = 0.034) decreases length of hospitalization compared with nil per os diet in acute pediatric pancreatitis. In this minireview, we clearly show that early enteral nutrition, started within 24-48 h, is beneficial in acute pediatric pancreatitis. Prospective studies and better presentation of research are crucially needed to achieve a higher level of evidence. | Dóra Mosztbacher Nelli Farkas Margit Solymár Gabriella Pár Judit Bajor ákos Szucs József Czimmer Katalin Márta Alexandra Mikó Zoltán Rumbus Péter Varjú Péter Hegyi Andrea Párniczky | 2017 | World Journal of Gastroenterology2017，23，6： | 8 |
| 2 | Aging related methylation influences the gene expression of key control genes in colorectal cancer and adenoma显示文摘AIM To analyze colorectal carcinogenesis and age-related DNA methylation alterations of gene sequences associated with epigenetic clock CpG sites. METHODS In silico DNA methylation analysis of 353 epigenetic clock Cp G sites published by Steve Horvath was performed using methylation array data for a set of 123 colonic tissue samples [64 colorectal cancer(CRC), 42 adenoma, 17 normal; GEO accession number: GSE48684]. Among the differentially methylated agerelated genes, secreted frizzled related protein 1(SFRP1) promoter methylation was further investigated in colonic tissue from 8 healthy adults, 19 normal children, 20 adenoma and 8 CRC patients using bisulfite-specific PCR followed by methylation-specific high resolution melting(MS-HRM) analysis. m RNA expression of age-related 'epigenetic clock' genes was studied using Affymetrix HGU133 Plus2.0 whole transcriptome data of 153 colonic biopsy samples(49 healthy adult, 49 adenoma, 49 CRC, 6 healthy children)(GEO accession numbers: GSE37364, GSE10714, GSE4183, GSE37267). Whole promoter methylation analysis of genes showing inverse DNA methylationgene expression data was performed on 30 colonic samples using methyl capture sequencing.RESULTS Fifty-seven age-related Cp G sites including hypermethylated PPP1R16 B, SFRP1, SYNE1 and hypomethylated MGP, PIPOX were differentially methylated between CRC and normal tissues(P < 0.05, ?β≥ 10%). In the adenoma vs normal comparison, 70 CpG sites differed significantly, including hypermethylated DKK3, SDC2, SFRP1, SYNE1 and hypomethylated CEMIP, SPATA18(P < 0.05, ?β≥ 10%). In MS-HRM analysis, the SFRP1 promoter region was significantly hypermethylated in CRC(55.0% ± 8.4 %) and adenoma tissue samples(49.9% ± 18.1%) compared to normal adult(5.2% ± 2.7%) and young(2.2% ± 0.7%) colonic tissue(P < 0.0001). DNA methylation of SFRP1 promoter was slightly, but significantly increased in healthy adults compared to normal young samples(P < 0.02). This correlated with significantly increased SFRP1 m RNA levels in children compared to normal adult samples(P < 0.05). In CRC tissue the mR NA expression of 117 agerelated genes were changed, while in adenoma samples 102 genes showed differential expression compared with normal colonic tissue(P < 0.05, logF C > 0.5). The change of expression for several genes including SYNE1, CLEC3 B, LTBP3 and SFRP1, followed the same pattern in aging and carcinogenesis, though not for all genes(e.g., MGP). CONCLUSION Several age-related DNA methylation alterations can be observed during CRC development and progression affecting the m RNA expression of certain CRC- and adenoma-related key control genes. | Orsolya Galamb Alexandra Kalmár Barbara Kinga Barták árpád V Patai Katalin Leiszter Bálint Péterfia Barnabás Wichmann Gábor Valcz Gábor Veres Zsolt Tulassay Béla Molnár | 2016 | World Journal of Gastroenterology2016，22，47： | 7 |
| 3 | Reduction of ischemia reperfusion injury after liver resection and hepatic inflow occlusion by α-lipoic acid in humans显示文摘AIM: To evaluate the protective effects of precondition- ing by α-lipoic acid (LA) in patients undergoing hepatic resection under inflow occlusion of the liver. METHODS: Twenty-four patients undergoing liver re- section for various reasons either received 600 mg LA or NaCl 15 min before transection performed under inflow occlusion of the liver. Blood samples and liver wedge bi- opsy samples were obtained after opening of the abdo- men immediately after inflow occlusion of the liver, and 30 min after the end of inflow occlusion of the liver. RESULTS: Serum levels of aspartate transferase and alanine transferase were reduced at all time points in patients who received LA in comparison to those who received NaCL. This was accompanied by reduced histo- morphological features of oncosis. We observed TUNEL- positive hepatocytes in the livers of the untreated patients, especially after 30 min of ischemia. LA attenu- ated this increase of TUNEL-positive hepatocytes. Under preconditioning with LA, ATP content was significantly enhanced after 30 min of ischemia and after 30 min of reperfusion. CONCLUSION: This is the first report on the poten- tial for LA reducing ischemia/reperfusion injury (IRI) of the liver in humans who were undergoing liver surgery. Beside its simple and rapid application, side effects did not occur. LA might therefore represent a new strategy against hepatic IRI in humans. | Fritz Dünschede Kirsten Erbes Achim Kircher Stefanie Westermann Joachim Seifert Arno Schad Kempski Oliver Alexandra K Kiemer Junginger Theodor | 2006 | World Journal of Gastroenterology2006，12，42： | 6 |
| 4 | Antidiabetic and antioxidant effects of Annona muricata (Annonaceae), aqueous extract on streptozotocin-induced diabetic rats显示文摘 | Ngueguim Tsofack Florence Massa Zibi Benoit Kouamouo Jonas Tchuidjang Alexandra Dzeufiet Djomeni Paul Désiré Kamtchouing Pierre Dimo Théophile | 2014 | Journal of Ethnopharmacology2014，，2： | 2 |
| 5 | Stereotactic body radiation therapy in patients with hepatocellular carcinoma: A mini-review显示文摘Stereotactic body radiation therapy(SBRT) is an emerging treatment for hepatocellular carcinoma. This technique results in excellent local control rates with favorable toxicity profile despite being predominantly used in heavily pretreated patients or those unsuitable for other local therapies. SBRT may be used as a sole treatment or in combination with other local therapies as well as a bridging strategy for patient awaiting liver transplants. This brief review describes current practice of SBRT with respect to radiation technique, patient selection and treatment concepts. It summarizes available evidence from retroand prospective studies evaluating SBRT alone, SBRT in combination with other treatments and SBRT compared to other local treatment approaches. | Sabine Gerum Alexandra D Jensen Falk Roeder | 2019 | World Journal of Gastrointestinal Oncology2019，11，5： | 2 |
| 6 | Novel trends in follicular development, atresia and cor- pusluteum regression: a role for apop- tosis 显示文摘 | Alexandra R Petros D | 2005 | Reproductive Biomedicine2005，11，1： | 1 |
| 7 | Wnt signaling in stem and cancer stem cells显示文摘 | Jane D Holland Alexandra Klaus Alistair N Garratt Walter Birchmeier | 2013 | Current Opinion in Cell Biology2013，，2： | 1 |
| 8 | Characterization of polyploid wheat genomic diversity using a high-density 90 000 single nucleotide polymorphism array 显示文摘 | Wang SC Debbie W Kerrie F Alexandra A Shiaoman C Bevan EH Marco M Silvio S Sara GM Luigi C Anna MM Alex W Stuart S Gary B Ralf W Joerg P International Wheat Genome Sequencing Consortium Morten L Diane M Rudi A Rudy D Gina BG Abraham K Alina RA Catherine F Jerome S Michele M Curtis P Luo MC Jan DMM Jorge D Martin G Roberto T Cindy L Ivan M Colin C Keith JE Matthew H Eduard A | 2014 | Plant Biotechnol J2014，12，： | 1 |
| 9 | Glutamine andα-ketoglutarate prevent the decrease in muscle free glutamine concentration and influence protein synthesis after total hip replacement显示文摘 | Britt I B Folke H Alexandra yon der D | 1995 | Metabolism1995，44，9： | 1 |
| 10 | Development of a method to produce freeze-dried cubes from 3 pacific salmon species 显示文摘 | Charles C Alexandra C M Olivera D N | 2010 | Journal of Food Science2010，75，5： | 1 |
| 11 | Substrate effect on bacterial communities from constructed wetlands planted with Typha latifolia treating industrial stewater显示文摘 | Cristina S C C Anouk F D Alexandra M | 2009 | Ecological Engineering2009，35，： | 1 |
| 12 | Activation of rat recombinant α1 β2δ2s GABAA receptor by the insecticide ivermectin 显示文摘 | Helmuth A Alexandra L Josef D | 2000 | European Journal of Pharmacology2000，394，： | 1 |
| 13 | Econ- omic evaluations of clinical pharmacy services: 2001-2005 显示文摘 | ALEXANDRA P FRED D HOTLMAN J M | 2008 | Pharmacotherapy2008，28，11： | 1 |
| 14 | A method for evaluating ink mileage in gravure printing显示文摘 | Renmei Xu Alexandra Pekarovicova Paul D | 2007 | Tappi Journal2007，，12： | 1 |
| 15 | Impact of chronic kidney disease on prognosis of patients with diabetes mellitus treated with percutaneous coronary intervention显示文摘 | Eugenia Nikolsky Roxana Mehran Diane Turcot Eve D Aymong Gary S Mintz Zoran Lasic Alexandra J Lansky Emmanouil Tsounias Jeffrey W Moses Gregg W Stone Martin B Leon George D Dangas | 2004 | The American Journal of Cardiology2004，，3： | 1 |
| 16 | Bilirubin toxicity to human erythrocytes : A review 显示文摘 | Alexandra Bfito M Silva RF Bfites D | 2006 | Clin Chim Acta2006，374，12： | 1 |
| 17 | Aneuploidies detection in miscarriages and fetal deaths using multiplex ligation-dependent probe amplification: an alternative for speeding up results?显示文摘 | Berta Carvalho Sofia Dória Carla Ramalho Otília Brand?o Mário Sousa Alexandra Matias Alberto Barros Filipa Carvalho | 2010 | European Journal of Obstetrics and Gynecology2010，，2： | 1 |
| 18 | Secondary organic aerasol formation from aromatic precursors 显示文摘 | Wipawee D Alexandra E Yosuke K | 2003 | Environmental Science and Technology2003，37，16： | 1 |
| 19 | Development and evaluation in vlvo of a long-term dilivery system for vapreotide, a somatostain analogue显示文摘 | ALEXANDRA R W KAMEL B YVES D Z | 1998 | Controlled rel1998，52，： | 1 |
| 20 | Molecular engineering of resveratrol in plants显示文摘 | Bertrand D Sylvain C Alexandra C | 2009 | Plant Bioteclmology Journal2009，7，1： | 1 |
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