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| 1 | Would integrated Western and traditional Chinese medicine have more benefits for stroke rehabilitation? A systematic review and meta-analysis显示文摘Background Stroke is a major cause of death or long-term disability worldwide.Many patients with stroke receive integrative therapy consisting of Western medicine(WM)and routine rehabilitation in conjunction with Chinese medicine(CM),such as acupuncture and Chinese herbal medicine.However,there is no available evidence on the effectiveness of the combined use of WM and CM interventions in stroke rehabilitation.Aims The purpose of this meta-analysis is to evaluate the results of all individual studies to assess the combined use of CM and WM in stroke rehabilitation compared with WM only.Methods The Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines were followed.MEDLINE,EMBASE,Cochrane and China National Knowledge Infrastructure(CNKI)were searched.The included outcomes were dependency,motor function,depression and swallowing function.Subgroup analysis was performed,and publication bias was assessed using funnel plots.Summary of review 58 studies and 6339 patients were included in the meta-analysis.Subgroup analysis revealed that combined therapy comprising both acupuncture and WM had a superior effect on improving dependency and swallowing function compared with standard WM therapy alone.Potential superiority of combined therapy comprising CM and WM in improving depression compared with standard WM therapy was also found.Conclusions Our results indicate that the combined use of CM and WM could be more efficacious in stroke rehabilitation compared with the use of WM therapy alone.However,most studies were short in duration(2 to 4 weeks)and prone to different types of biases,which prevents making any conclusion regarding the long-term effects and raises concerns regarding true efficacy in context of high likelihood of Hawthorn bias.So,more randomised controlled trials with more rigorous design and longer duration of treatment and follow-up need to be conducted to compare WM alone versus WM and CM combined. | Linda LD Zhong Ya Zheng Alexander Y Lau Norman Wong Liang Yao Xingyao Wu Tengteng Shao Zhenxing Lu Huijuan Li Chun Sum Yuen Jianwen Guo Suzanne Lo Janita Chau Kam Wa Chan Bacon Fung Leung Ng Zhaoxiang Bian Edwin Chau-leung Yu | 2022 | Stroke & Vascular Neurology2022，7，1： | 7 |
| 2 | Origins and character- isties of fear of dentistry显示文摘 | Kleinkneeht RA Klepac RK Alexander LD | 1973 | J Am Dent Assoe1973，86，4： | 1 |
| 3 | Macrocycles that inhibit the binding between heat shock protein 90 and TPR-containing proteins显示文摘 | Ardi VC Alexander LD Johnson VA | 2011 | ACS Chem Biol2011，6，12： | 1 |
| 4 | Association between gait asymmetry and brain lesion location in stroke patients显示文摘 | Alexander LD Black SE Patterson KK | | 0，，02： | 1 |
| 5 | Efficacy of surgical decompression in regard to motor recovery in the setting of conus medullaris inju- ry 显示文摘 | Vafa LD Alexander R | 2006 | Spinal Cord Med2006，29，： | 1 |
| 6 | Exposure to low amounts of ultrasound energy does not improve soft tissue shoulder pathology: a systematic review 显示文摘 | Alexander LD Gilman DR Brown DR | 2010 | Phys Ther2010，90，1： | 1 |
| 7 | Angiotensin Ⅱ stimulates Fibronectin pro-tein synthesis via a Gβγ/arachidonic acid-dependent pathway显示文摘 | Alexander LD Ding Y Alagarsamy S | 2014 | Am J Physiol Renal Physiol2014，307，3： | 1 |
| 8 | Inhibi- tion of X-linked inhibitor of apoptosis with embelin differential- ly affects male versus female behavioral outcome following neo- natal hypoxia-ischemia in rats 显示文摘 | HILL CA ALEXANDER ML MCCULLOUGH LD | 2011 | Dev Neurosci2011，33，6： | 1 |
| 9 | Antibody-Mediated Injury in the Renal Allograft显示文摘 | Cornell LD Alexander MP Stegall MD | | 0，，06： | 1 |
| 10 | Cyclic stretch-induced TGF-β1and fibronectin expression is mediated byβ1-integrin through c-Src-and STAT3-dependent pathways in renal epithelial cells显示文摘 | Hamzeh MT Sridhara R Alexander LD | 2015 | Am J Physiol Renal Physiol2015，308，5： | 1 |
| 11 | Origins and characteristics of fear of dentistry 显示文摘 | Kleinknecht RA Klepac RK Alexander LD | 1973 | J Am Dent Assoc1973，86，4： | 1 |
| 12 | Efficacy of surgical decompression in regard to motor recovery in the setting of conus medullaris injury 显示文摘 | Vafa LD Alexander R | 2006 | Spinal Cord Med2006，29，： | 1 |
| 13 | Management of thyroid dysfunction during pregnancy and pestpartum: an endocrine society clinical practice guideline 显示文摘 | Groot LD Abalovich M Alexander EK | 2012 | J Clin Endocrinol Metab2012，97，8： | 1 |
| 14 | Cyclic stretch-induced TGF-β1 and fibronectin expression is mediated by β 1-integrin through c-Src- and STAT3- dependent pathways in renal epithelial cells 显示文摘 | Hamzeh MT Sridhara R Alexander LD | 2015 | Am J Physiol Renal Physiol2015，308，5： | 1 |
| 15 | Management of thy- roid dysfunction during pregnancy and postpartum: an endocrine society clinical practice guideline 显示文摘 | Groot LD Abalovich M Alexander EK | 2012 | J Clin Endocrinol Metab2012，97，8： | 1 |
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