|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Utility of tissue microarrays for profiling prognostic biomarkers in clinically localized prostate cancer: the expression of BCL-2, E-cadherin, Ki-67 and p53 as predictors of biochemical failure after radical prostatectomy with nested control for clinical and pathological risk factors显示文摘痊愈不能与经历激进的治疗的临床上局部性的前列腺癌症为所有人被保证。如果他们能改进秘密变形疾病的预言,分子的标记将是无价的。这研究被执行在激进的前列腺切除术标本调查 BCL-2, Ki-67, p53 和 E-cadherin 的表示。我们寻求了估计他们的能力在一个特定的治疗学的背景预言早生物化学的恶化。包括 41 案例对的 82 个病人为病理学的舞台,格利森等级和外科手术前的前列腺特定的抗原(PSA ) 被匹配集中。在每对的一个病人有生物化学的复发(在 2 年外科以内定义为 PSA 0.2 ng mL-1 ) 并且其它没有疾病生物化学地留下了(至少 3 年在外科以后定义同样无法发现的 PSA ) 。Immunohistochemical 分析被执行在四上估计标记表示复制从每个激进的前列腺切除术标本与良性、恶意的织物构造的织物 microarrays。Ki-67, p53 和 BCL-2,然而并非 E-cadherin,显著地在前列腺腺癌的 upregulated 与良性的前列腺织物相比(P < 0.01 ) 。然而,当比较与没有生物化学的复发的病人一起开发了早生物化学的恶化的病人时,在任何标记的表示的重要差别都没被观察。这研究证明 p53, BCL-2 和 Ki-67 的那表情与良性的前列腺织物相比是在临床上局部性的前列腺癌症的 upregulated,没有在 E-cadherin 表示的改变。Biomarker upregulation 没在激进的前列腺切除术以后为生物化学的复发有预示的价值,甚至在考虑病理学的舞台,整个瘤格利森等级和外科手术前的浆液 PSA 水平以后。 | Joseph Nariculam Alex Freeman Simon Bott Phillipa Munson Noriko Cable Nicola Brookman-Amissah Magali Williamson Roger S. Kirby John Masters Mark Feneley | 2009 | Asian Journal of Andrology2009，11，1： | 5 |
| 2 | Pulmonary and Cardiovascular Complications of Obesity: An Autopsy Study of 76 Obese Subjects显示文摘 | Haque Abida K Gadre Swarupa Taylor Jerrod Haque Sajid A Freeman Daniel Duarte Alex | 2008 | Archives of Pathology & Laboratory Medicine2008，，9： | 2 |
| 3 | A biopsy simulation study to assess the accuracy of several transrectal ultrasonography (TRUS)‐biopsy strategies compared with template prostate mapping biopsies in patients who have undergone radical prostatectomy显示文摘 | Yipeng Hu Hashim U. Ahmed Tim Carter Nimalan Arumainayagam Emilie Lecornet Winston Barzell Alex Freeman Pierre Nevoux David J. Hawkes Arnauld Villers Mark Emberton Dean C. Barratt | 2012 | BJU International2012，，6： | 1 |
| 4 | Focal therapy for localised unifocal and multifocal prostate cancer: a prospective development study显示文摘 | Hashim U Ahmed Richard G Hindley Louise Dickinson Alex Freeman Alex P Kirkham Mahua Sahu Rebecca Scott Clare Allen Jan Van der Meulen Mark Emberton | 2012 | Lancet Oncology2012，，： | 1 |
| 5 | Sustainable strategies for Ebola virus disease outbreak preparedness in Africa:a case study on lessons learnt in countries neighbouring the Democratic Republic of the Congo显示文摘Background: From May 2018 to September 2022, the Democratic Republic of Congo (DRC) experienced seven Ebola virus disease (EVD) outbreaks within its borders. During the 10th EVD outbreak (2018–2020), the largest experienced in the DRC and the second largest and most prolonged EVD outbreak recorded globally, a WHO risk assessment identified nine countries bordering the DRC as moderate to high risk from cross border importation. These countries implemented varying levels of Ebola virus disease preparedness interventions. This case study highlights the gains and shortfalls with the Ebola virus disease preparedness interventions within the various contexts of these countries against the background of a renewed and growing commitment for global epidemic preparedness highlighted during recent World Health Assembly events.Main text: Several positive impacts from preparedness support to countries bordering the affected provinces in the DRC were identified, including development of sustained capacities which were leveraged upon to respond to the subsequent coronavirus disease 2019 (COVID-19) pandemic. Shortfalls such as lost opportunities for operationalizing cross-border regional preparedness collaboration and better integration of multidisciplinary perspectives, vertical approaches to response pillars such as surveillance, over dependence on external support and duplication of efforts especially in areas of capacity building were also identified. A recurrent theme that emerged from this case study is the propensity towards implementing short-term interventions during active Ebola virus disease outbreaks for preparedness rather than sustainable investment into strengthening systems for improved health security in alignment with IHR obligations, the Sustainable Development Goals and advocating global policy for addressing the larger structural determinants underscoring these outbreaks.Conclusions: Despite several international frameworks established at the global level for emergency preparedness, a shortfall exists between global policy and practice in countries at high risk of cross border transmission from persistent Ebola virus disease outbreaks in the Democratic Republic of Congo. With renewed global health commitment for country emergency preparedness resulting from the COVID-19 pandemic and cumulating in a resolution for a pandemic preparedness treaty, the time to review and address these gaps and provide recommendations for more sustainable and integrative approaches to emergency preparedness towards achieving global health security is now. | Caroline S.Ryan Marie‑Roseline D.Belizaire Miriam Nanyunja Olushayo Oluseun Olu Yahaya Ali Ahmed Anderson Latt Matthew Tut Kol Bertrand Bamuleke Jayne Tusiime Nadia Nsabimbona Ishata Conteh Shamiso Nyashanu Patrick Otim Ramadan Solomon Fisseha Woldetsadik Jean‑Pierre Mulunda Nkata Jim T.Ntwari Senya D.Nzeyimana Leopold Ouedraogo Georges Batona Vedaste Ndahindwa Elizabeth A.Mgamb Magdalene Armah Joseph Francis Wamala Argata Guracha Guyo Alex Yao Sokemawu Freeman Alexander Chimbaru Innocent Komakech Muhau Kuku Walter M.Firmino Grace E.Saguti Faraja Msemwa Shikanga O‑Tipo Precious C.Kalubula Ngoy Nsenga Ambrose Otau Talisuna | 2022 | Infectious Diseases of Poverty2022，11，6： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员