|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Ten years of sorafenib in hepatocellular carcinoma: Are there any predictive and/or prognostic markers?显示文摘Sorafenib has been considered the standard of care for patients with advanced unresectable hepatocellular carcinoma(HCC) since 2007 and numerous studieshave investigated the role of markers involved in the angiogenesis process at both the expression and genetic level and clinical aspect. What results have ten years of research produced? Several clinical and biological markers are associated with prognosis. The most interesting clinical parameters are adverse events, Barcelona Clinic Liver Cancer stage, and macroscopic vascular invasion, while several single nucleotide polymorphisms and plasma angiopoietin-2 levels represent the most promising biological biomarkers. A recent pooled analysis of two phase III randomized trials showed that the neutrophil-to-lymphocyte ratio, etiology and extra-hepatic spread are predictive factors of response to sorafenib, but did not identify any predictive biological markers. After 10 years of research into sorafenib there are still no validated prognostic or predictive factors of response to the drug in HCC. The aim of the present review was to summarize 10 years of research into sorafenib, looking in particular at the potential of associated clinical and biological markers to predict its efficacy in patients with advanced HCC. | Giorgia Marisi Alessandro Cucchetti Paola Ulivi Matteo Canale Giuseppe Cabibbo Leonardo Solaini Francesco G Foschi Serena De Matteis Giorgio Ercolani Martina Valgiusti Giovanni L Frassineti Mario Scartozzi Andrea Casadei Gardini | 2018 | World Journal of Gastroenterology2018，24，36： | 14 |
| 2 | Surveillance for early diagnosis of hepatocellular carcinoma: How best to do it?显示文摘Surveillance for hepatocellular carcinoma(HCC)is considered a standard of care for patients with chronic liver disease who are at risk of developing this malignancy.Several studies have shown that surveillance can improve the prognosis of patients diagnosed with HCC through an increased likelihood of application of curative or effective treatments.Repetition of liver ultrasonography(US)every 6 mo is the recommended surveillance program to detect early HCCs,and a positive US has to entrain a well-defined recall policy based on contrast-enhanced,dynamic radiological imaging or biopsy for the diagnosis of HCC.Although HCC fulfills the accepted criteria regarding cost-effective cancer screening and surveillance,the implementation of surveillance in clinical practice is defective and this has a negative impact on the cost-effectiveness of the procedure.Education of both physicians and patients is of paramount importance in order to improve the surveillance application and its benefits in patients at risk of HCC.The promotion of specific educational programs for practitioners,clinicians and patients is instrumental in order to expand the correct use of surveillance in clinical practice and eventually improve HCC prognosis. | Edoardo G Giannini Alessandro Cucchetti Virginia Erroi Francesca Garuti Federica Odaldi Franco Trevisani | 2013 | World Journal of Gastroenterology2013，19，47： | 10 |
| 3 | European evidence based consensus for endoscopy in inflammatory bowel disease显示文摘 | Vito Annese Marco Daperno Matthew D. Rutter Aurelien Amiot Peter Bossuyt James East Marc Ferrante Martin G?tz Konstantinos H. Katsanos Ralf Kie?lich Ingrid Ordás Alessandro Repici Bruno Rosa Shaji Sebastian Torsten Kucharzik Rami Eliakim | 2013 | Journal of Crohn’s and Colitis2013，，12： | 7 |
| 4 | Prediction of genetic value for sweet cherry fruit maturity among environments using a 6K SNP array显示文摘The timing of fruit maturity is an important trait in sweet cherry production and breeding.Phenotypic variation for phenology of fruit maturity in sweet cherry appears to be under strong genetic control,but that control might be complicated by phenotypic instability across environments.Although such genotype-by-environment interaction(G×E)is a common phenomenon in crop plants,knowledge about it is lacking for fruit maturity timing and other sweet cherry traits.In this study,1673 genome-wide SNP markers were used to estimate genomic relationships among 597 weakly pedigree-connected individuals evaluated over two seasons at three locations in Europe and one location in the USA,thus sampling eight‘environments’.The combined dataset enabled a single meta-analysis to investigate the environmental stability of genomic predictions.Linkage disequilibrium among marker loci declined rapidly with physical distance,and ordination of the relationship matrix suggested no strong structure among germplasm.The most parsimonious G×E model allowed heterogeneous genetic variance and pairwise covariances among environments.Narrow-sense genomic heritability was very high(0.60–0.83),as was accuracy of predicted breeding values(>0.62).Average correlation of additive effects among environments was high(0.96)and breeding values were highly correlated across locations.Results indicated that genomic models can be used in cherry to accurately predict date of fruit maturity for untested individuals in new environments.Limited G×E for this trait indicated that phenotypes of individuals will be stable across similar environments.Equivalent analyses for other sweet cherry traits,for which multiple years of data are commonly available among breeders and cultivar testers,would be informative for predicting performance of elite selections and cultivars in new environments. | Craig M.Hardner Ben J.Hayes Satish Kumar Stijn Vanderzande Lichun Cai Julia Piaskowski JoséQuero-Garcia JoséAntonio Campoy Teresa Barreneche Daniela Giovannini Alessandro Liverani Gérard Charlot Miguel Villamil-Castro Nnadozie Oraguzie Cameron P.Peace | 2019 | Horticulture Research2019，6，1： | 5 |
| 5 | Nerve growth factor control of neuronal expression of angiogenetic and vasoactive factors显示文摘 | Laura C Luciana G Alessandro G | 2001 | PNAS2001，98，11： | 1 |
| 6 | Mitochondrial diseases and the heart: an overview of molecular basis, diagnosis, treatment and clinical course 显示文摘 | Limongelli G Masarone D D' Alessandro R | 2012 | Future Cardiol2012，8，1： | 1 |
| 7 | The governance of university knowl- edge transfer: a critical review of the literature 显示文摘 | ALDO G ALESSANDRO M | 2009 | Minerva2009，，1： | 1 |
| 8 | An implicit Gain-scheduling controller for Cranes 显示文摘 | GIORGIO C ALESSANDRO G GIAMPAOLO U | 1998 | IEEE Trans on Control Systems Technology1998，6，1： | 1 |
| 9 | Polymers from ReneWable Resources:A Challenge for the Future of Macromolecular Materials显示文摘 | ALESSANDRO G | | 0，，： | 1 |
| 10 | Spontaneous hexagon formation in a nonlinear optical medium with feedback mirror 显示文摘 | Alessandro G D Firth W J | 1991 | Physical Review Letters1991，66，20： | 1 |
| 11 | Improving penetration testing through static and dynamic analysis显示文摘 | William G J Halfond Shauvik Roy Choudhary Alessandro Orso | 2011 | Software Testing Verifieation&Reliability2011，21，3： | 1 |
| 12 | Renal transplantation in adults with Henoch-Schonlein purpura:long-term outcome显示文摘 | Gabriella M Beniamina G Alessandro D | | 0，，09： | 1 |
| 13 | Quantification of the probability of lightning strikes to structures using a fractal approach显示文摘 | Petrov N I Petrova G N D~Alessandro F | 2003 | IEEE Transactions on Dielertrics and Electrical Insulation2003，10，4： | 1 |
| 14 | Neural Respiratory Drive and Neuromuscular Coupling in Patients with Chronic Obstructive Pulmonary Disease显示文摘 | Massimo G Alessandro S Roberta G | 1999 | Chest1999，98，： | 1 |
| 15 | Evaluation of a new rapid quantitative D-dimer assay in patients with clinically suspected deep vein thrombosis显示文摘 | D'Angelo A D'Alessandro G Tomassini L | | 0，，3： | 1 |
| 16 | Design and Construction of Arbritrary Waveform Generator显示文摘 | Daniele D C Alessandro D G Giuliano D | 1983 | IEEE Trans on Instrumentation and Measurement1983，32，3： | 1 |
| 17 | How the FSH/ LH ratio and dose numbers in the p-FSH administration treat- ment regime,and insemination schedule affect superovulatory re- sponse in ewes显示文摘 | Alessandro A G D Marternucci G Taibi L | 2004 | Theriogenology2004，286，45： | 1 |
| 18 | Quantification of the probability of lightning strikes to structures using a fractal approach显示文摘 | Petrov N I Petrova G N D'Alessandro F | | 0，，04： | 1 |
| 19 | Chromogranin A and biochemical progression-free survival in prostate adenocarcinomas submitted to radical prostatectomy 显示文摘 | Alessandro S Vincenzo G Gomez A | 2007 | Endocrine-Related Cancer2007，14，3： | 1 |
| 20 | Low- frequency current oscillations and maximum power point tracking in grid-connected fuel-cell-based systems 显示文摘 | Alessandro G Giovanni P Giovanni S | 2010 | IEEE Trans on Industry Electronics2010，57，6： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员