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| 1 | Retrograde-viewing device improves adenoma detection rate in colonoscopies for surveillance and diagnostic workup显示文摘AIM:To determine which patients might benefit most from retrograde viewing during colonoscopy through subset analysis of randomized,controlled trial data.METHODS:The Third Eye Retroscope Randomized Clinical Evaluation(TERRACE) was a randomized,controlled,multicenter trial designed to evaluate the efficacy of a retrograde-viewing auxiliary imaging device that is used during colonoscopy to provide a second video image which allows viewing of areas on the proximal aspect of haustral folds and flexures that are difficult to see with the colonoscope's forward view.We performed a post-hoc analysis of the TERRACE data to determine whether certain subsets of the patient population would gain more benefit than others from use of the device.Subjects were patients scheduled for colonoscopy for screening,surveillance or diagnostic workup,and each underwent same-day tandem examinations with standard colonoscopy(SC) and Third Eye colonoscopy(TEC),randomized to SC followed by TEC or vice versa.RESULTS:Indication for colonoscopy was screening in 176/345 subjects(51.0%),surveillance after previous polypectomy in 87(25.2%) and diagnostic workup in 82(23.8%).In 4 subjects no indication was specified.Previously reported overall results had shown a net additional adenoma detection rate(ADR) with TEC of 23.2% compared to SC.Relative risk(RR) of missing adenomas with SC vs TEC as the initial procedure was 1.92(P = 0.029).Post-hoc subset analysis shows additional ADRs for TEC compared to SC were 4.4% for screening,35.7% for surveillance,55.4% for diagnostic and 40.7% for surveillance and diagnostic combined.The RR of missing adenomas with SC vs TEC was 1.11(P = 0.815) for screening,3.15(P = 0.014) for surveillance,8.64(P = 0.039) for diagnostic and 3.34(P = 0.003) for surveillance and diagnostic combined.Although a multivariate Poisson regression suggested gender as a possibly significant factor,subset analysis showed that the difference between genders was not statistically significant.Age,bowel prep quality and withdrawal time did not significantly affect the RR of missing adenomas with SC vs TEC.Mean sizes of adenomas detected with TEC and SC were similar at 0.59 cm and 0.56 cm,respectively(P = NS).CONCLUSION:TEC allows detection of significantly more adenomas compared to SC in patients undergoing surveillance or diagnostic workup,but not in screening patients(ClinicalTrials.gov Identifier:NCT01044732). | Peter D Siersema Amit Rastogi Anke M Leufkens Paul A Akerman Kassem Azzouzi Richard I Rothstein Frank P Vleggaar Alessandro Repici Giacomo Rando Patrick I Okolo Olivier Dewit Ana Ignjatovic Elizabeth Odstrcil James East Pierre H Deprez Brian P Saunders Anthony N Kalloo Bradley Creel Vikas Singh Anne Marie Lennon Daniel C DeMarco | 2012 | World Journal of Gastroenterology2012，18，26： | 6 |
| 2 | 3D additive manufactured composite scaffolds with antibiotic-loaded lamellar fillers for bone infection prevention and tissue regeneration显示文摘Bone infections following open bone fracture or implant surgery remain a challenge in the orthopedics field.In order to avoid high doses of systemic drug administration,optimized local antibiotic release from scaffolds is required.3D additive manufactured(AM)scaffolds made with biodegradable polymers are ideal to support bone healing in non-union scenarios and can be given antimicrobial properties by the incorporation of antibiotics.In this study,ciprofloxacin and gentamicin intercalated in the interlamellar spaces of magnesium aluminum layered double hydroxides(MgAl)andα-zirconium phosphates(ZrP),respectively,are dispersed within a thermoplastic polymer by melt compounding and subsequently processed via high temperature melt extrusion AM(~190◦C)into 3D scaffolds.The inorganic fillers enable a sustained antibiotics release through the polymer matrix,controlled by antibiotics counterions exchange or pH conditions.Importantly,both antibiotics retain their functionality after the manufacturing process at high temperatures,as verified by their activity against both Gram+and Gram-bacterial strains.Moreover,scaffolds loaded with filler-antibiotic do not impair human mesenchymal stromal cells osteogenic differentiation,allowing matrix mineralization and the expression of relevant osteogenic markers.Overall,these results suggest the possibility of fabricating dual functionality 3D scaffolds via high temperature melt extrusion for bone regeneration and infection prevention. | María C´amara-Torres Stacy Duarte Ravi Sinha Ainhoa Egizabal Noelia´Alvarez Maria Bastianini Michele Sisani Paolo Scopece Marco Scatto Alessandro Bonetto Antonio Marcomini Alberto Sanchez Alessandro Patelli Carlos Mota Lorenzo Moroni | 2021 | Bioactive Materials2021，6，4： | 2 |
| 3 | Polarization-independent low-power integrated acousto-optic tunable filter/switch using APE/Ti polarisation splitter on lithium niobate 显示文摘 | A d' Alessandro | 1993 | Electron Lett1993，29，20： | 1 |
| 4 | Slip locking in finite elements for composite beams with deformable shear connection显示文摘 | Dall'Asta A Alessandro Zona | 2004 | Finite Elenents is Analysis and Design2004，40，4： | 1 |
| 5 | Insight into p95HER2 in Breast Cancer: Molecular Mechanisms and Targeted Therapies显示文摘 | Ramon Andrade de Mello Alessandro de Vasconcelos Ronaldo A Ribeiro Ines Pousa Noemia Afonso Deolinda Pereira Helena Rodrigues | 2012 | Recent Patents on DNA and Gene Sequences2012，，1： | 1 |
| 6 | A re-weighting strategy for im- proving margins 显示文摘 | FABIO A ALESSANDRO S | 2002 | Artificial Intelligence2002，137，： | 1 |
| 7 | A Monte Carlo Investi gation of the Harniltonian Mean Field Model显示文摘 | Alessandro P Giuseppe A Andrea R | 2005 | Physica A Statistical Mechanics and its Applications2005，349，1： | 1 |
| 8 | 显示文摘 | Justin Kitzes Daniel Moran Alessandro Galli Yoshihiko Wada Mathis Wackernagel: Interpretation and application of the Ecological Footprint: A reply to Fiala (2008) | 2009 | Ecological Economics Volume 68 Issue 4 15 February 20092009，，： | 1 |
| 9 | Transstornal approach to closure of bronchopleural fistulas after pneumonectomy, A fifteen cases report 显示文摘 | Vanni B Alborto A Alessandro | 2000 | Lung Cancer2000，29，： | 1 |
| 10 | Dose-dependent cigarette smoking-related inflammatory response in healthy adults 显示文摘 | Kuschner WG Alessandro A Wang H | 1996 | Eur Respir J1996，9，10： | 1 |
| 11 | Characterization ofN-trimethyl chitosardalginate complexes andcurcumin release显示文摘 | Martins Alessandro F Bueno Pedro V A Almeida Elizangela A M S | 2013 | International Journal of Biological Macromolecules2013，57，： | 1 |
| 12 | Physical activity and exercise training:a relevant aspect of the dialysis patient's care 显示文摘 | Cupisti A D'Alessandro C Bottai A | 2013 | Intern Emerg Med2013，8，1： | 1 |
| 13 | Applications of Laccases and Tyrosinases (phenoloxidases) Immobilized on Different Supports:A Review显示文摘 | Nelson Durán Maria A Rosa Alessandro D'Annibale | 2002 | Enzyme and Microbial Technology2002，，31： | 1 |
| 14 | Bronchopulmonary kctinomycosis Associated With Hiatal Hernia显示文摘 | Alessandro A Alberto C Alessandro M | 2009 | Mayo Clinic Proceedings2009，84，2： | 1 |
| 15 | Nutrition knowledge and dietary composition in Italian adolescent female ath- letes and non-athletes显示文摘 | Cupisti A D'Alessandro C Castrogiovanni S | 2002 | International Journal of Sport Nutrition & Exercise Metabolism2002，12，2： | 1 |
| 16 | Proteomics of apheresis platelet supernatants during routine storage: Gender-related differences 显示文摘 | Dzieciatkowska M D' Alessandro A Burke TA | 2014 | J Proteomics2014，112，： | 1 |
| 17 | Geographic variation and environmental conditions as cofactors in Chlamydia psittaci association with ocular adnexal lymphomas:a comparison between Italian and African samples显示文摘 | Alessandro C Anna O Giuseppina A | 2010 | Hernatol Oncol2010，28，： | 1 |
| 18 | Severe aortic regurgitation and reduced left ventricular ejection fraction: Outcomes after isolated aortic valve replacement and combined surgery显示文摘 | Alessandro Sionis Ana García-Alvarez María ángeles Castel Marco Cordero Miguel Josa Félix Pérez-Villa Eulàlia Roig | 2010 | Journal of Heart and Lung Transplantation2010，，4： | 1 |
| 19 | Food intake and nutritional status in stable hemodialysis patients显示文摘 | Cupisti A D'Alessandro C Valeri A | 2010 | Ren Fail2010，32，： | 1 |
| 20 | Physical activity and exercise training:a relevant aspect of the dialysis patient’s care显示文摘 | Cupisti A D’alessandro C Bottai A | 2013 | Internal and Emergency Medicine2013，8，1： | 1 |
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