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| 1 | 有 CT 冠的 angiography 的匾成像: 匾类型分类上的 intra 脉管的变细的效果显示文摘 AIM:To assess the attenuation of non-calcified atherosclerotic coronary artery plaques with computed tomography coronary angiography(CTCA).METHODS:Four hundred consecutive patients underwent CTCA(Group 1:200 patients,Sensation 64 Cardiac,Siemens;Group 2:200 patients,VCT GE Healthcare,with either Iomeprol 400 or Iodixanol 320,respectively) for suspected coronary artery disease(CAD).CTCA was performed using standard protocols.Image quality(score 0-3),plaque(within the accessible non-calcified component of each non-calcified/mixed plaque) and coronary lumen attenuation were measured.Data were compared on a per-segment/perplaque basis.Plaques were classified as fibrous vs lipid rich based on different attenuation thresholds.A P < 0.05 was considered significant.RESULTS:In 468 atherosclerotic plaques in Group 1 and 644 in Group 2,average image quality was 2.96 ± 0.19 in Group 1 and 2.93 ± 0.25 in Group 2(P ≥ 0.05).Coronary lumen attenuation was 367 ± 85 Hounsfield units(HU) in Group 1 and 327 ± 73 HU in Group 2(P < 0.05);non-calcified plaque attenuation was 48 ± 23 HU in Group 1 and 39 ± 21 HU in Group 2(P < 0.05).Overall signal to noise ratio was 15.6 ± 4.7 in Group 1 and 21.2 ± 7.7 in Group 2(P < 0.01).CONCLUSION:Higher intra-vascular attenuation modifies significantly the attenuation of non-calcified coronary plaques.This results in a more difficult characterization between lipid rich vs fibrous type. | Erica Maffei Chiara Martini Teresa Arcadi Alberto Clemente Sara Seitun Alessandra Zuccarelli Tito Torri Nico R Mollet Alexia Rossi Onofrio Catalano Giancarlo Messalli Filippo Cademartiri | 2012 | World Journal of Radiology2012，4，6： | 3 |
| 2 | Anti-tumor necrosis factor α therapy associates to type 17 helper T lymphocytes immunological shift and significant microbial changes in dextran sodium sulphate colitis显示文摘BACKGROUND Anti-tumor necrosis factor α(TNFα) represents the best therapeutic option to induce mucosal healing and clinical remission in patients with moderate-severe ulcerative colitis. On the other side gut microbiota plays a crucial role in pathogenesis of ulcerative colitis but few information exists on how microbiota changes following anti-TNFα therapy and on microbiota role in mucosal healing.AIM To elucidate whether gut microbiota and immune system changes appear following anti TNFα therapy during dextran sulfate sodium(DSS) colitis.METHODS Eighty C57 BL/6 mice were divided into four groups: 'No DSS', 'No DSS + antiTNFα', 'DSS' and 'DSS + anti-TNFα'. 'DSS' and 'DSS + anti-TNFα' were treated for 5 d with 3% DSS. At day 3, mice whithin 'No DSS+anti-TNFα' and'DSS+anti-TNFα' group received 5 mg/kg of an anti-TNFα agent. Forty mice were sacrificed at day 5, forty at day 12, after one week of recovery post DSS. The severity of colitis was assessed by a clinical score(Disease Activity Index), colon length and histology. Bacteria such as Bacteroides, Clostridiaceae, Enterococcaceae and Fecalibacterium prausnitzii(F. prausnitzii) were evaluated by quantitative PCR.Type 1 helper T lymphocytes(Th1), type 17 helper T lymphocytes(Th17) and CD4+ regulatory T lymphocytes(Treg) distributions in the mesenteric lymph node(MLN) were studied by flow cytometry.RESULTS Bacteria associated with a healthy state(i.e., such as Bacteroides, Clostridiaceae and F. prausnitzii) decreased during colitis and increased in course of anti-TNFαtreatment. Conversely, microorganisms belonging to Enterococcaceae genera,which are linked to inflammatory processes, showed an opposite trend.Furthermore, in colitic mice treated with anti-TNFα microbial changes were associated with an initial increase(day 5 of the colitis) in Treg cells and a consequent decrease(day 12 post DSS) in Th1 and Th17 frequency cells. Healthy mice treated with anti-TNFα showed the same histological, microbial and immune features of untreated colitic mice. 'No DSS + anti-TNFα' group showed a lymphomononuclear infiltrate both at 5 th and 12 th d at hematoxylin and eosin staining, an increase of in Th1 and Th17 frequency at day 12, an increase of Enterococcaceae at day 5, a decrease of Bacteroides and Clostridiaceae at day 12.CONCLUSION Anti-TNFα treatment in experimental model of colitis improves disease activity but it is associated to an increase in Th17 pathway together with gut microbiota alteration. | Valentina Petito Cristina Graziani Loris R Lopetuso Marco Fossati Alessandra Battaglia Vincenzo Arena Domenico Scannone Gianluca Quaranta Andrea Quagliariello Federica Del Chierico Lorenza Putignani Luca Masucci Maurizio Sanguinetti Alessandro Sgambato Antonio Gasbarrini Franco Scaldaferri | 2019 | World Journal of Gastroenterology2019，25，12： | 2 |
| 3 | Regulation of microtubule stability and mitotic progression by survivin显示文摘 | Alessandra Giodini Marko JK Nathan R | 2002 | Cancer Research2002，62，9： | 1 |
| 4 | Multi-target strategy to address Alzheimer’s disease: Design, synthesis and biological evaluation of new tacrine-based dimmers显示文摘 | Stefano R Alessandra B Manuela B | 2011 | Eur J Med Chem2011，46，5： | 1 |
| 5 | Repartition effect of aromatic polyaniline coatings on the separation of bioactive peptides in capillary electrophoresis显示文摘 | ALESSANDRA B SERGEY A P ANTHONY P F T PIER G R | 2002 | Electrophoresis2002，23，2： | 1 |
| 6 | 显示文摘 | Eliangela M T Alessandra L D R Antonio J F C | 2005 | Macromol Symp2005，229，： | 1 |
| 7 | 3-(4-{{Benzyl(methyl)amino}methyl}phenyl)-6,7-dimethoxy-2H-2-chromenone (AP2238) inhibits both acetylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation: a dual function lead for Alzheimer′s disease therapy 显示文摘 | Lorna P Angela R Alessandra B | 2003 | J Med Chem2003，46，12： | 1 |
| 8 | Survivin exists in immunochemically distinct subcellular pools and is involved in spindle microtubule function显示文摘 | Paola Fortugno Nathan R Wall Alessandra Giodini | 2002 | Journal of Cell Science2002，115，3： | 1 |
| 9 | Synthesis of analogues of calicheamicin and neocarzinostatin chromophore显示文摘 | Alessandra C Angela R M John M | 2004 | Tetrahedron2004，60，： | 1 |
| 10 | Advanced oxidation of the pharmaceutical drug diclofenac with UV/H2O2 and ozone显示文摘 | V Davide M Raffaele N R Alessandra | 2004 | Water Res2004，38，2： | 1 |
| 11 | Mandibular advancement devices are an alternative and valid treatment for pediatric obstructivesleep apnea syndrome显示文摘 | Maria PV Silvia M Alessandra R | 2012 | Sleep Breath2012，16，4： | 1 |
| 12 | Trametes versicolor:A possible tool for aflatoxin control显示文摘 | Zjatic S Reverberi M Alessandra R | 2005 | International Journal of Food Microbiology2005，，： | 1 |
| 13 | Pulse high-volume hae- mofiltration for treatment of severe sepsis : effects on hemody namics and survival 显示文摘 | Ranistha R Alessandra B Pasquale P | 2005 | Critical Care2005，9，4： | 1 |
| 14 | Effect of prolonged application times on the durability of resin-dentin bonds显示文摘 | Alessandra R Paula De Vieira L C | | 0，，06： | 1 |
| 15 | Protein phosphatase 2A subunit PR70 interacts with pRb and mecliates its c/ephosphorylation 显示文摘 | Alessandra M Pasquale F Sveva R | 2008 | Mol Cell Biol2008，28，： | 1 |
| 16 | Continuous xylose fermentation by Clostridium acetobutylicum-Kinetics and energetics issues under acidogenesis conditions显示文摘 | Alessandra P Francesca R Giuseppe O | 2014 | Bioresource Technology2014，164，： | 1 |
| 17 | An In Vitro System to Model the Establishment and Reactivation of HIV-1 Latency显示文摘 | Alessandra M Jill MH Fabio R | 2008 | The Journal of Immunology2008，181，： | 1 |
| 18 | Expression of cell cycle-regulated proteins pRB2/p130, p107, E2F4, p27, and pCNA in salivary gland tumors: prognostic and diagnostic implications显示文摘 | Giuseppe R Alessandra Z Candace MH | 2005 | Clinical Cancer Research2005，11，5： | 1 |
| 19 | Endogenous and exogenous poly- amines in the organogenesis in Curcuma longa 显示文摘 | Alessandra F M Viu Marco A O Viu Armando R Tavares | 2009 | Sci Hortieulturae2009，121，4： | 1 |
| 20 | Vascular endothelial growth factor increase the migration and proliferation of smooth muscle cells through the mediation of growth factors released by endothelial cells显示文摘 | Alessandra C Valeria B Bruto R | 2003 | J Surg Res2003，109，： | 1 |
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