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| 1 | Comparative population dynamics of three species of cladocera in relation to different levels of chlorella vulgaris and microcystis aeruginosa显示文摘 | ALEJANDRO FEDERICO ALVA-MARTINEZ SARMA S S S NANDINI S | 2001 | Crustaceana2001，74，8： | 1 |
| 2 | Hilbert transform analysis of a time series of speckle interferograms with a temporal carrier显示文摘 | Fernando A Marengo Rodriguez Alejandro Federico Guillermo H Kaufmann | 2008 | Applied Optics2008，47，9： | 1 |
| 3 | Scintillation and beam-wander analysis in an optical ground station-satellite uplink显示文摘 | FEDERICO D JUAN A R ALEJANDRO R | 2004 | Appl Opt2004，43，19： | 1 |
| 4 | Mineralogical Phases Formed by Flux Glasses in Continuous Casting Mould显示文摘 | Alejandro Cruz Federico Chavez Antonio Romero | 2007 | Journal of Materials Processing Technology2007，358，： | 1 |
| 5 | Gastrointestinal manifestations in Parkinson’s disease: prevalence and occurrence before motor symptoms显示文摘 | Maria G. Cersosimo Gabriela B. Raina Cristina Pecci Alejandro Pellene Cristian R. Calandra Cristiam Gutiérrez Federico E. Micheli Eduardo E. Benarroch | 2013 | Journal of Neurology2013，，5： | 1 |
| 6 | Insights into induction of the immune response by the hepatitis B vaccine显示文摘After more than four decades of hepatitis B virus(HBV)vaccine implementation,its safety and efficacy in preventing HBV infection have been proven and several milestones have been achieved.Most countries have included HBV immunization schedules in their health policies and progress has been made regarding universalization of the first HBV vaccine dose at birth.All of these actions have significantly contributed to reducing both the incidence of HBV infection and its related complications.However,there are still many drawbacks to overcome.The main concerns are the deficient coverage rate of the dose at birth and the large adult population that has not been reached timely by universal immunization.Additionally,the current most widely used second-generation vaccines do not induce protective immunity in 5%to 10%of the population,particularly in people over 40-years-old,obese(body mass index>25 kg/m2),heavy smokers,and patients undergoing dialysis or infection with human immunodeficiency virus.Recently developed and approved novel vaccine formulations using more potent adjuvants or multiple antigens have shown better performance,particularly in difficult settings.These advances re-launch the expectations of achieving the World Health Organization’s objective of completing hepatitis control by 2030. | Federico Alejandro Di Lello Alfredo Pedro Martínez Diego Martín Flichman | 2022 | World Journal of Gastroenterology2022，28，31： | 1 |
| 7 | First-line cisplatin,docetaxel,and cetuximab for patients with recurrent or metastatic head and neck cancer:A multicenter cohort study显示文摘BACKGROUND The targeted therapy cetuximab[directed at the epidermal growth factor receptor(EGFR)]in combination with 5-fluorouracil and platinum-based chemotherapy(the EXTREME regimen)has shown substantial efficacy for patients with recurrent or metastatic squamous cell carcinoma of the head and neck(R/M SCCHN).Thus,this scheme has been established as the preferred first-line option for these patients.However,more recently,a new strategy combining platinum,taxanes,and cetuximab(the TPEx regimen)has demonstrated similar efficacy with a more favorable toxicity profile in clinical trials.AIM To evaluate the safety and efficacy of the TPEx scheme as first-line therapy in advanced SCCHN in a multicenter cohort study.METHODS This retrospective multicenter cohort study included patients with histologically confirmed recurrent or metastatic SCCHN treated with first-line TPEx at five medical centers in Argentina between January 1,2017 and April 31,2020.Chemotherapy consisted of four cycles of docetaxel,cisplatin,and cetuximab followed by cetuximab maintenance therapy.Clinical outcomes and toxicity profiles were collected from medical charts.Treatment response was assessed by the investigator in accordance with Response Evaluation Criteria in Solid Tumors(version 1.1).Adverse events were graded according to the National Cancer Institute Common Terminology Criteria for Adverse Events(version 4.0).RESULTS Twenty-four patients were included.The median age at diagnosis was 58 years(range:36-77 years).The majority of patients(83.3%)received at least four chemotherapy cycles in the initial phase.In the included group,the overall response rate was 62.5%,and 3 patients achieved a complete response(12.5%).The median time to response was 2.4 mo[95% confidence interval(CI):1.3-3.5].With a median follow-up of 12.7 mo(95%CI:8.8-16.6),the median progression-free survival(PFS)was 6.9 mo(95%CI:6.5-7.3),and the overall survival rate at 12 mo was 82.4%.Patients with documented tumor response showed a better PFS than those with disease stabilization or progression[8.5 mo(95%CI:5.5-11.5)and 4.5 mo(95%CI:2.5-6.6),respectively;P=0.042].Regarding the safety analysis,two-thirds of patients reported at least one treatment-related adverse event,and 25% presented grade 3 toxicities.Of note,no patient experienced grade 4 adverse events.CONCLUSION TPEx was an adequately tolerated regimen in our population,with low incidence of grade 3-4 adverse events.The median PFS were consistent with those in recent reports of clinical trials evaluating this treatment combination.This regimen may be considered an attractive therapeutic strategy due to its simplified administration,decreased total number of chemotherapy cycles,and treatment tolerability. | Agustin Falco Mariano Leiva Albano Blanco Guido Cefarelli Andres Rodriguez Juan Melo Federico Cayol Manglio Miguel Rizzo Alejandro Sola Hernan Rodriguez Montani Matias Chacon Diego Enrico Federico Waisberg | 2022 | World Journal of Clinical Oncology2022，13，2： | 1 |
| 8 | Comparative population dynamics of three species of cladocera in relation lo different levels of chlorella vulgaris and microcystis aeruginosa 显示文摘 | Alejandro Federico Alva-Martinez Sarma S S S Nandini S | 2001 | Crustaceana2001，74，8： | 1 |
| 9 | Effect of mixed diets (cyanobacteria and green algae) on the population growth of the cladocerans Ceriodaphnia dubia and Moina macrocopa显示文摘 | Alejandro Federico Alva-Martínez S. S. S. Sarma S. Nandini | 2007 | Aquatic Ecology2007，，4： | 1 |
| 10 | Mineralogical phases formed by flux glasses in continuous casting mould 显示文摘 | Alejandro Cruz Federico Chavez | 2006 | Journal of Materials Processing Technology2006，10，6： | 1 |
| 11 | The Casimir Effect in Microstructured Geometries 显示文摘 | Alejandro W Rodriguez Federico Capasso Steven G Johnson | 2011 | Nphoton2011，5，： | 1 |
| 12 | 麦德林克里克拉酒店显示文摘该酒店位于麦德林市埃尔珀布拉多的一个规整的街区内。新落成的建筑调整了原有街区结构,创造出一个便于人们通行的半公共空间,将步行通道、楼梯、庭院、裙楼、平台、露台和带顶广场融合在同一处场地内。建筑本身作为城市的十字路口,呈可穿透式布局,拥有多条出入口,并被本地植物环绕。建筑旨在将城市的日常生活与酒店及其客人的活动融合起来。其设计理念是打造多样化的文化活动中心,通过艺术、美食节、博览会、音乐会、戏剧、夜生活等各式各样的娱乐形式来激活当地的创意产业,让酒店生活与城市日常相互融合、相互补充。 | Felipe Mesa Federico Mesa Alejandro Arango(摄影) Carlos Vélez(摄影) | 2021 | 当代建筑2021，，6： | 0 |
| 13 | Implementation of a virtual multicenter gastrointestinal tumor board to reduce cancer disparities in Argentina显示文摘Given the increasing complexity of cancer care,multidisciplinary tumor boards have become essential in daily clinical oncology practice.The Project Extension for Community Healthcare Outcomes(ECHO)initiative developed an innovative telementoring model using a'hub and spoke'design consisting of a team of experts(hub)that offers a full service to multiple participants(the spokes)during regularly scheduled sessions discussing patients'clinical cases.The Alexander Fleming Cancer Institute in Buenos Aires was the first hub in Latin America to implement Project ECHO for gastrointestinal tumors.In our 3-year experience,80 patients from 37 centers were evaluated within Project ECHO and a range of three to five cases were discussed in each meeting.From our perspective,the impact of this novel approach was a remarkable strategy to reduce care disparities by equalizing access to high-quality medical knowledge in a multidisciplinary environment for medical discussions.Additionally,it was shown to have a cost-effective impact directly on the patients and the local health system,since relevant costs were saved after unnecessary treatments,studies and travel expenses were avoided. | Federico Esteso Natalia Soledad Tissera Juan Manuel O'Connor Romina Luca Eduardo Huertas Fernando Sánchez Loria Ivana Pedraza Alejandro Pairola Fernando Brancato Lisandro Paganini Mariana Kucharczyk Mora Amat Maria Teresa Pombo Mariana Galli Luisina Bruno Luis Caro Andrés Rodriguez Diego Enrico Federico Waisberg Matías Chacón | 2022 | World Journal of Clinical Oncology2022，13，6： | 0 |
| 14 | Hepatitis C virus treatment failure:Clinical utility for testing resistance-associated substitutions显示文摘The hepatitis C virus has a high mutation capacity that leads to the emergence of resistance-associated substitutions(RAS).However,the consequence of resistance selection during new direct-acting antiviral drug(DAA)treatment is not necessarily the therapeutic failure.In fact,DAA treatment has shown a high rate(>95%)of sustained virological response even when high baseline RAS prevalence has been reported.In the context of RAS emergence and high rates of sustained viral response,the clinical relevance of variants harboring RAS is still controversial.Therefore,in order to summarize the data available in international guidelines,we have reviewed the clinical utility of testing RAS in the era of new pangenotypic DAA drugs. | Ezequiel Ridruejo Matias Javier Pereson Diego M Flichman Federico Alejandro Di Lello | 2021 | World Journal of Hepatology2021，13，9： | 0 |
| 15 | Study of High Efficiency Membrane Pilot Test for Membrane Design Optimisation in Order to Reduce the Electrical Consumption显示文摘 | Federico Antonio Leon Alejandro Ramos | 2016 | Journal of Energy and Power Engineering2016，10，10： | 0 |
| 16 | Higher cardiovascular risk scores and liver fibrosis risk estimated by biomarkers in patients with metabolic-dysfunction-associated fatty liver disease显示文摘BACKGROUND The definition of metabolic-dysfunction-associated fatty liver disease(MAFLD)allows identification of metabolically complicated patients.Fibrosis risk scores are related to cardiovascular risk(CVR)scores and could be useful for the identification of patients at risk of systemic complications.AIM To evaluate the relationship between MAFLD and CVR using the Framingham risk score in a group of Mexican patients.METHODS Cross-sectional,observational and descriptive study carried out in a cohort of 585 volunteers in the state of Veracruz with MAFLD criteria.The risk of liver fibrosis was calculated with aspartate aminotransferase-to-platelet ratio index,nonalcoholic fatty liver disease score and fibrosis-4,as well as with transient hepatic elastography with Fibroscan~?.The CVR was determined by the Framingham system.RESULTS One hundred and twenty-five participants(21.4%)with MAFLD criteria were evaluated,average age 54.4 years,63.2%were women,body mass index 32.3 kg/m~2.The Framingham CVR was high in 43 patients(33.9%).Transient elastography was performed in 55.2%of volunteers;39.1%with high CVR and predominance in advanced fibrosis(F3–F4).The logistic regression analysis showed that liver fibrosis,diabetes and hypertension independently increased CVR.CONCLUSION One of every three patients with MAFLD had a high CVR,and in those with high fibrosis risk,the CVR risk was even greater. | Giovanni Alejandro Salgado Alvarez Samanta Mayanin Pinto Galvez Uriel Garcia Mora Ana Delfina Cano Contreras Cristina Durán Rosas Bryan Adrián Priego-Parra Arturo Triana Romero Mercedes Amieva Balmori Federico Roesch Dietlen Sophia Eugenia Martinez Vazquez Ines Osvely Mendez Guerrero Luis Alberto Chi-Cervera Raúl Bernal Reyes Leonardo Alberto Martinez Roriguez Maria Eugenia Icaza Chavez Jose Maria Remes Troche | 2022 | World Journal of Hepatology2022，14，8： | 0 |
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