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| 1 | The optimization of phenolic compounds extraction from cactus pear(Opuntia ficus-indica) skin in a reflux system using response surface methodology显示文摘Objective:To extract,quantify,and evaluate the phenolic content in Opuntia ficus-indica skin for their antioxidant capacity with three different methods(ABTS,DPPH,and lipid oxidation)and to optimize the extraction conditions[time,temperature and ethanol concentration)in a reflux system.Methods:The extraction process was done using a reflux system.A San CristobalⅡexperimental design with three variables and three levels was used.The variables evaluated were time of extraction(h),concentration of ethanol(%,v/v)and temperature(°C).The extraction process was optimized using a response surface methodology.Results:It was observed that at higher temperature more phenolic compounds were extracted,but the antioxidant capacity was decreased.The optimum conditions for phenolic compounds extraction and antioxidant capacity mixing the three methods were as Follows:45%of ethanol,80℃and 2 hours of extraction.Values obtained in our results are little higher that other previously reported.Conclusions:It can he concluded the by-products of Opuntia ficus-indica represent a good source of natural antioxidants with possible applications in food,cosmetics or drugs industries. | Aguirre Joya Jorge De La Garza Toledo Heliodoro Zugasti Cruz Alejandro Belmares Cerda Ruth Aguilar Cristóbal No | 2013 | Asian Pacific Journal of Tropical Biomedicine2013，3，6： | 1 |
| 2 | The Reno-Protective Effect of Hydration With Sodium Bicarbonate Plus N-Acetylcysteine in Patients Undergoing Emergency Percutaneous Coronary Intervention显示文摘 | Alejandro Recio-Mayoral Marinela Chaparro Belén Prado Rocío Cózar Irene Méndez Debasish Banerjee Juan C. Kaski José Cubero Jose M. Cruz | 2007 | Journal of the American College of Cardiology2007，，12： | 1 |
| 3 | Prevalence and Factors Associated With Circadian Blood Pressure Patterns in Hypertensive Patients显示文摘 | Alejandro de la Sierra Josep Redon José R. Banegas Julián Segura Gianfranco Parati Manuel Gorostidi Juan J. de la Cruz Javier Sobrino José L. Llisterri Javier Alonso Ernest Vinyoles Vicente Pallarés Antonio Sarría Pedro Aranda Luis M. Ruilope | 2009 | Hypertension2009，，3： | 1 |
| 4 | Mineralogical Phases Formed by Flux Glasses in Continuous Casting Mould显示文摘 | Alejandro Cruz Federico Chavez Antonio Romero | 2007 | Journal of Materials Processing Technology2007，358，： | 1 |
| 5 | Clinical Features of 8295 Patients With Resistant Hypertension Classified on the Basis of Ambulatory Blood Pressure Monitoring显示文摘 | Alejandro de la Sierra Julián Segura José R. Banegas Manuel Gorostidi Juan J. de la Cruz Pedro Armario Anna Oliveras Luis M. Ruilope | 2011 | Hypertension2011，，5： | 1 |
| 6 | Clinical Features of 8295 Patients With Resistant Hypertension Classified on the Basis of Ambulatory Blood Pressure Monitoring显示文摘 | Alejandro de la Sierra Julián Segura José R. Banegas Manuel Gorostidi Juan J. de la Cruz Pedro Armario Anna Oliveras Luis M. Ruilope | 2011 | Hypertension2011，，5： | 1 |
| 7 | Mineralogical phases formed by flux glasses in continuous casting mould 显示文摘 | Alejandro Cruz Federico Chavez | 2006 | Journal of Materials Processing Technology2006，10，6： | 1 |
| 8 | The previous use of digoxin does not worsen early outcome of acute coronary syndromes: an analysis of the ARIAM Registry显示文摘 | Juan Carlos Garcia-Rubira Manuel Calvo-Taracido Francisca Francisco-Aparicio Manuel Almendro-Delia Alejandro Recio-Mayoral Antonio Reina Toral Oscar Aramburu-Bodas Pastora Gallego García de Vinuesa José Maria Cruz Fernández Angel Garcia Alcántara Rafael H | 2014 | Internal and Emergency Medicine2014，，7： | 1 |
| 9 | Clinical Features of 8295 Patients With Resistant Hypertension Classified on the Basis of Ambulatory Blood Pressure Monitoring显示文摘 | Alejandro de la Sierra Julián Segura José R. Banegas Manuel Gorostidi Juan J. de la Cruz Pedro Armario Anna Oliveras Luis M. Ruilope | 2011 | Hypertension2011，，5： | 1 |
| 10 | Kentish Plover(Charadrius alexandrinus) and Little Tern(Sternula albifrons) prefer shells for nesting:A field experiment显示文摘Shorebird populations are declining worldwide,mainly due to human disturbances and loss of coastal wetlands.However,supratidal habitats as saltpans could play a role in buffering human impact.Saltpans have shown to be important as feeding or breeding sites of some shorebird species.A potential conservation strategy to increase shorebird populations in saltpans is to manipulate the cues that birds use to select optimal breeding habitat.Here it is hypothesized that shorebirds are attracted to bivalve shells due to the advantages they offer.Following this hypothesis,we supplemented a restored saltpan in 2019 and 2021 with bivalve shells,expecting an increase in the number of breeding birds’ nests.More than 75% of Kentish Plover(Charadrius alexandrinus) and Little Tern(Sternula albifrons) nests were found in patches with shells in both years.The best model for both species indicates that the presence of shells is the factor that most correlates with the location of nests.The probability of choosing one place over another to settle their nest increases in areas with an abundance of shells,double in the case of the Kentish Plover and triple in the case of the Little Tern.The result of this study may constitute a valuable tool for attracting birds to restored saltpans and could contribute to the success of expensive restoration projects where time is usually a constraint. | Macarena Castro Andrés De la Cruz Nuria Martin-Sanjuan Alejandro Pérez-Hurtado | 2024 | Avian Research2024，15，1： | 0 |
| 11 | Thinking outside the black box:are the brain endothelial cells the new main target in Alzheimer's disease?显示文摘The blood-brain barrier is the interface through which the brain interacts with the milieu and consists mainly of a sophisticated network of brain endothelial cells that forms blood vessels and selectively moves molecules inside and outside the brain through multiple mechanisms of transport.Although brain endothelial cell function is crucial for brain homeostasis,their role in neurodegenerative diseases has historically not been considered with the same importance as other brain cells such as microglia,astroglia,neurons,or even molecules such as amyloid beta,Tau,or alpha-synuclein.Alzheimer's disease is the most common neurodegenerative disease,and brain endothelial cell dysfunction has been reported by several groups.However,its impairment has barely been considered as a potential therapeutic target.Here we review the most recent advances in the relationship between Alzheimer's disease and brain endothelial cells commitment and analyze the possible mechanisms through which their alterations contribute to this neurodegenerative disease,highlighting their inflammatory phenotype and the possibility of an impaired secretory pattern of brain endothelial cells that could contribute to the progression of this ailment.Finally,we discuss why shall brain endothelial cells be appreciated as a therapeutic target instead of solely an obstacle for delivering treatments to the injured brain in Alzheimer's disease. | Enrique Estudillo Adolfo López-Ornelas Alejandro Rodríguez-Oviedo Neptali Gutiérrez de la Cruz Marco Antonio Vargas-Hernández Adriana Jiménez | 2023 | Neural Regeneration Research2023，18，12： | 0 |
| 12 | Rainfall Trend Analysis in the City of Villahermosa, Mexico显示文摘In this paper, a study by means of linear regression of rainfall in Villahermosa is proposed, within the study area 5 meteorological stations distributed in the city were analyzed because it is one of the most populated areas of the state, once estimated the data, the non-parametric Mann-Kendall test was used to determine increasing or decreasing linear trends in precipitation. To determine the usefulness of statistical inference, the linear correlation coefficient (r) was calculated, which was 0.86 on average. Statistical efficiency (E) was also calculated, which in all the cases analyzed suggests the viability of statistical inference. As a result of this analysis, a complete rainfall database is presented and evaluated for increasing or decreasing trends for the 1980-2010 period. | Ana Victoria Gómez Alejandro Heliodoro Daniel Cruz Suárez | 2019 | Journal of Geological Resource and Engineering2019，7，1： | 0 |
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