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| 1 | One-day versus two-day cleansing for colon capsule endoscopy: a prospective randomized pilot study显示文摘 | Laura Ramos Onofre Alarcón Zaida Adrian Antonio Z. Gimeno-García David Nicolás-Pérez Alejandro Jiménez-Sosa Enrique Quintero | 2013 | Gastroenterologia y Hepatologia2013，，： | 2 |
| 2 | Synthesis of Ambrox from Communic Acids显示文摘 | Alejandro FB Joaquin A Enrique J Alvarez Manzaneda JM Ramos Sofia S | 1993 | Tetrahedron1993，49，： | 1 |
| 3 | Highlights of ASS234: a novel and promising therapeutic agent for Alzheimer’s disease therapy显示文摘There is no effective treatment to face Alzheimer’s disease complexity.Multitarget molecules are a good approach against the multiple physiopathological events associated with its development and progression.In this context,N-((5-(3-(1-benzylpiperidin-4-yl)propoxy)-1-methyl-1H-indol-2-yl)methyl)-N-methylprop-2-yn-1-amine(ASS234)has been tested achieving promising results.ASS234 has demonstrated to cross the blood-brain barrier in vivo,and a good in silico safety profile being less toxic than donepezil.Besides,ASS234 reversibly inhibits human acetyl-and butyryl-cholinesterase,and irreversibly inhibits human monoamine oxidase A and B.Moreover,this multitarget molecule has antioxidant and neuroprotective properties,and inhibitsΑβ1–42 andΑβ1–40 self-aggregation.Inquiring about the mechanism of action,several signaling pathways related to Alzheimer’s disease had been explored showing that ASS234 induces the wingless-type MMTV integration site(Wnt)family and several members of the heat shock proteins family and moreover counteracts neuroinflammatory and oxidative stress-related genes promoting the induction of several key antioxidant genes.Finally,in vivo experiments with ASS234 in C57BL/6J mice displayed its ability to reduce amyloid plaque burden and gliosis in the cortex and hippocampus,ameliorating scopolamine-induced learning deficits.Here we gather the information regarding ASS234 evaluated so far,showing its ability to face different targets,necessary to counteract a neurodegenerative disease as complex as the Alzheimer’s disease. | Alejandro Romero JoséMarco-Contelles Eva Ramos | 2020 | Neural Regeneration Research2020，15，1： | 1 |
| 4 | Toxicity induced by chemical warfare agents: Insights on the protective role of melatonin显示文摘 | René Pita José Marco-Contelles Eva Ramos Javier del Pino Alejandro Romero | 2013 | Chemico-Biological Interactions2013，，2： | 1 |
| 5 | Omega-3 Fatty Acids for the Prevention of Recurrent Symptomatic Atrial Fibrillation显示文摘 | Alejandro Macchia Hugo Grancelli Sergio Varini Daniel Nul Nicolás Laffaye Javier Mariani Daniel Ferrante Raúl Badra Julio Figal Silvina Ramos Gianni Tognoni Hernán C. Doval | 2013 | Journal of the American College of Cardiology2013，，： | 1 |
| 6 | Melatonin:a multitasking indoleamine to modulate hippocampal neurogenesis显示文摘Neurodegeneration affects a large number of cell types including neurons,astrocytes or oligodendrocytes,and neural stem cells.Neural stem cells can generate new neuronal populations through proliferation,migration,and differentiation.This neurogenic potential may be a relevant factor to fight neurodegeneration and aging.In the last years,we can find growing evidence suggesting that melatonin may be a potential modulator of adult hippocampal neurogenesis.The lack of therapeutic strategies targeting neurogenesis led researchers to explore new molecules.Numerous preclinical studies with melatonin observed how melatonin can modulate and enhance molecular and signaling pathways involved in neurogenesis.We made a special focus on the connection between these modulation mechanisms and their implication in neurodegeneration,to summarize the current knowledge and highlight the therapeutic potential of melatonin. | Alejandro Romero JoséÁngel Morales-García Eva Ramos | 2023 | Neural Regeneration Research2023，18，3： | 1 |
| 7 | 赫尔辛基古根海姆博物馆显示文摘波罗的海的女儿——赫尔辛基是芬兰最大的港口城市,人口密集,有着地球上极少数城市所特有的活力与创造力,而这创造力,尤其体现在它的建筑和设计上。赫尔辛基一直鼓励和致力于现代化高科技的蓬勃发展。但是,尽管赫尔辛基这个城市现已具备大都会的魅力和高标准的生活条件,但实际上,芬兰整体上仍然处于农业社会, | Peru Caada Xabler Arranz Alejandro Iturbe Julen Quevedo Jon Andonl Iparragulrre Ubay Calle Alvaro Arbina Igor Gonzalez Iigo Salaburu Nagila Ramos Martín García 姜敏华 | 2015 | 现代装饰2015，0，3： | 0 |
| 8 | Study of High Efficiency Membrane Pilot Test for Membrane Design Optimisation in Order to Reduce the Electrical Consumption显示文摘 | Federico Antonio Leon Alejandro Ramos | 2016 | Journal of Energy and Power Engineering2016，10，10： | 0 |
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