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| 1 | Microfabrication of Oxidation-Sharpened Silicon Tips on Silicon Nitride Cantilevers for Atomic Force Microscopy 显示文摘 | Albert Folch Mark S Wrighton and Martin A Schmidt | 1997 | Journal of Microelectromechanical Systems1997，6，4： | 1 |
| 2 | Large-scale microfluidic gradient arrays reveal axon guidance behaviors in hippocampal neurons显示文摘High-throughput quantitative approaches to study axon growth behaviors have remained a challenge.We have developed a 1024-chamber microfluidic gradient generator array that enables large-scale investigations of axon guidance and growth dynamics from individual primary mammalian neurons,which are exposed to gradients of diffusible molecules.Our microfluidic method(a)generates statistically rich data sets,(b)produces a stable,reproducible gradient with negligible shear stresses on the culture surface,(c)is amenable to the long-term culture of primary neurons without any unconventional protocol,and(d)eliminates the confounding influence of cell-secreted factors.Using this platform,we demonstrate that hippocampal axon guidance in response to a netrin-1 gradient is concentration-dependent—attractive at higher concentrations and repulsive at lower concentrations.We also show that the turning of the growth cone depends on the angle of incidence of the gradient.Our study highlights the potential of microfluidic devices in producing large amounts of data from morphogen and chemokine gradients that play essential roles not only in axonal navigation but also in stem cell differentiation,cell migration,and immune response. | Nirveek Bhattacharjee Albert Folch | 2017 | Microsystems & Nanoengineering2017，3，1： | 1 |
| 3 | Detection of QTL affecting fatty acid composition in the pig显示文摘 | Alex Clop Cristina Ovilo Miguel Perez-Enciso Albert Cercos Anna Tomas Ana Fernandez Agustina Coll Josep M. Folch Carmen Barragan Isabel Diaz Maria A. Oliver Luis Varona Luis Silio Armand Sanchez Jose L. Noguera | 2003 | Mammalian Genome2003，，9： | 1 |
| 4 | Detection of QTL affecting fatty acid composition in the pig显示文摘 | Alex Clop Cristina Ovilo Miguel Perez-Enciso Albert Cercos Anna Tomas Ana Fernandez Agustina Coll Josep M. Folch Carmen Barragan Isabel Diaz Maria A. Oliver Luis Varona Luis Silio Armand Sanchez Jose L. Noguera | 2003 | Mammalian Genome2003，，9： | 1 |
| 5 | Differen- tiation-on-a-chip : A microfluidic platform for long-term cellculture studies显示文摘 | Tourovskaia Anna Figueroa-Masot Xavier Folch Albert | 2005 | Lab on a Chip2005，5，： | 1 |
| 6 | Electron beam deposition of gold nanostructures in a reactive environment显示文摘 | ALBERT FOLCH JAVIER TEJADA CHRISTOPHER H | 1995 | Applied Physics Letters1995，66，16： | 1 |
| 7 | Microfluidics for interrogating live intact tissues显示文摘The intricate microarchitecture of tissues–the“tissue microenvironment”–is a strong determinant of tissue function.Microfluidics offers an invaluable tool to precisely stimulate,manipulate,and analyze the tissue microenvironment in live tissues and engineer mass transport around and into small tissue volumes.Such control is critical in clinical studies,especially where tissue samples are scarce,in analytical sensors,where testing smaller amounts of analytes results in faster,more portable sensors,and in biological experiments,where accurate control of the cellular microenvironment is needed.Microfluidics also provides inexpensive multiplexing strategies to address the pressing need to test large quantities of drugs and reagents on a single biopsy specimen,increasing testing accuracy,relevance,and speed while reducing overall diagnostic cost.Here,we review the use of microfluidics to study the physiology and pathophysiology of intact live tissues at sub-millimeter scales.We categorize uses as either in vitro studies–where a piece of an organism must be excised and introduced into the microfluidic device–or in vivo studies–where whole organisms are small enough to be introduced into microchannels or where a microfluidic device is interfaced with a live tissue surface(e.g.the skin or inside an internal organ or tumor)that forms part of an animal larger than the device.These microfluidic systems promise to deliver functional measurements obtained directly on intact tissue–such as the response of tissue to drugs or the analysis of tissue secretions–that cannot be obtained otherwise. | Lisa F.Horowitz Adan D.Rodriguez Tyler Ray Albert Folch | 2020 | Microsystems & Nanoengineering2020，6，1： | 0 |
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