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| 1 | Selection of patients with hepatocellular carcinoma for livertransplantation:Past and future显示文摘The aim of liver transplantation(LT) for hepatocellular carcinoma(HCC) is to ensure a rate of disease-free survival similar to that of patients transplanted due to benign disease. Therefore, we are forced to adopt strict criteria when selecting candidates for LT and prioritizing patients on the waiting list(WL), to have clarified indications for bridging therapy for groups at risk for progression or recurrence, and to establish certain limits for downstaging therapies. Although the Milan criteria(MC) remain the standard and most employed criteria for indication of HCC patients for LT by far, in the coming years, criteria will be consolidated that take into account not only data regarding the size/volume and number of tumors but also their biology. This criteria will mainly include the alpha fetoprotein(AFP) values and, in view of their wide variability, any of the published logarithmic models for the selection of candidates for LT. Bridging therapy is necessary for HCC patients on the WL who meet the MC and have the possibility of experiencing a delay for LT greater than 6 mo or any of the known risk factors for recurrence. It is difficult to define single AFP values that would indicate bridging therapy(200, 300 or 400 ng/m L); therefore, it is preferable to rely on the criteria of a French AFP model score > 2. Other single indications for bridging therapy include a tumor diameter greater than 3 cm, more than one tumor, and having an AFP slope greater than 15 ng/m L per month or > 50 ng/m L for three months during strict monitoring while on the WL. When considering the inclusion of patients on the WL who do not meet the MC, it is mandatory to determine their eligibility for downstaging therapy prior to inclusion. The upper limit for this therapy could be one lesion up to 8 cm, 2-3 lesions with a total tumor diameter up to 8 cm, or a total tumor volume of 115 cm^3. Lastly, liver allocation and the prioritization of patients with HCC onthe WL should take into account the recently described HCC model for end-stage liver disease, which considers hepatic function, HCC size and the number and the log of AFP values. This formula has been calibrated with the survival data of non-HCC patients and produces a dynamic and more accurate assessment model. | Arturo Soriano Aranzazu Varona Rajesh Gianchandani Modesto Enrique Moneva Javier Arranz Antonio Gonzalez Manuel Barrera | 2016 | World Journal of Hepatology2016，8，1： | 6 |
| 2 | Causes of isehemie stroke in young adults, and evolution of the etiological diagnosis over the long term显示文摘 | Varona J F Guerra J M Bermejo F | 2007 | Eur Neurol2007，57，4： | 1 |
| 3 | Malic enzyme 1 genotype is associated with backfat thickness and meat quality traits in pigs 显示文摘 | Vidal O Varona L Oliver M A | 2005 | Anim Genet2005，37，： | 1 |
| 4 | Stroke in young adults显示文摘 | Varona JF Guerra JM Bermejo F | 2004 | Med Clin2004，122，： | 1 |
| 5 | Effects of dry grinding on the structural changes of kaolinite powders 显示文摘 | Sanchez Soto P J Ignacio Varona Perez-Rodriguez J L | 2000 | JAm Ceram Sac2000，83，7： | 1 |
| 6 | Causes of ischemic stroke in young adults,and evolution of the etiological diagnosis over the long term显示文摘 | Varona JF Guerra JM Bermeje F | 2007 | Eur Neurol2007，57，： | 1 |
| 7 | Gait ataxia during omeprazole therapy显示文摘 | Varona L | 1996 | Ann Pharmacother1996，30，： | 1 |
| 8 | Molecular cloning, functional characterization and mRNA expression analysis of the murine chemokine receptor CCR6 and its specific ligand MIP- 3alpha显示文摘 | Varona R Zaballos A Gutierrez J | 1998 | FEBS Lett1998，440，12： | 1 |
| 9 | Pseudomyxoma peritonei:a clinicopathologic analysis and follow-up of 21 patients显示文摘 | Varona JF Guerra JM Salamanca J | 2005 | Hepatogastroenterology2005，52，63： | 1 |
| 10 | Causes of ischemic stroke in young adults, and evolution of the etiological diagnosis over the long term显示文摘 | Varona JF Guerra JM Berrnejo F | 2007 | Eur Neurol2007，57，： | 1 |
| 11 | Genetic analysis of growth curve parameters for male and female chickens resulting from selection on shape of curve显示文摘 | Mignon G S Piles M Varona L | 2000 | Journal of Animal Science2000，78，： | 1 |
| 12 | Low Temperature Direct Growth of Nanocrystalline Silicon Carbide Films显示文摘 | Kerdiles S Rizk R Gourbilleau F Perez-Rodriguez A Garrido B Gonzalez Varona O Morante J R | 2000 | Materials Science and Engineering:B2000，6970，： | 1 |
| 13 | CCR6-deficient mice have impaired leukocyte homeostasis and altered contact hypersensitivity and delayed-type hypersensitivity responses显示文摘 | VARONA R VILLARES R CARRAMOLINO L | 2001 | J Clin Invest2001，107，6： | 1 |
| 14 | Polymorphism of DECRI and its association with carcass and meat quality traits显示文摘 | Amills M Vidal O Varona L | 2005 | J Anita Sci2005，83，： | 1 |
| 15 | Changes in solution color during phenol oxidation by Fenton reagent显示文摘 | Mijangos F Varona F Villota N | 2006 | Environ SciTechnol2006，40，17： | 1 |
| 16 | Genetic analysis of growth curve parameters for male and female chickens resulting from selection on shape of growth curve显示文摘 | MIGNON G S PILEST M VARONA L | 2000 | Journal of Animal Science2000，78，： | 1 |
| 17 | Formulation of a natural biocide based on lavandin essential oil by emulsification using modified starches显示文摘 | Varona S Martin A Cocero M J | 2009 | Chemical Engineering and Processing: Process Intensification2009，48，： | 1 |
| 18 | Cutting edge:Identification of the orphan chemokine receptorGPR-9-6 as CCR9,the receptor for the chemokine TECK显示文摘 | Zaballos A Gutierrez J Varona R | 1999 | J Immunol1999，162，10： | 1 |
| 19 | Polymorphism of the pig 2,4-dienoyl CoA reductase 1 gene (DECRI) and its association with carcass and meat quality traits显示文摘 | Amills M Vidal O Varona L | 2005 | J Anita Sci2005，83，3： | 1 |
| 20 | Causes of ischemic stroke in young adults, and evolution of the etiological diagnosis over the long term显示文摘 | Varona JF Guerra JM t3ermejo F | 2007 | Eur Neurol2007，57，： | 1 |
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