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| 1 | Chronic antiepileptic drug use and functional network efficiency: A functional magnetic resonance imaging study显示文摘AIM To increase our insight in the neuronal mechanisms underlying cognitive side-effects of antiepileptic drug(AED) treatment.METHODS The relation between functional magnetic resonance-acquired brain network measures, AED use, and cognitive function was investigated. Three groups of patients with epilepsy with a different risk profile for developing cognitive side effects were included: A 'low risk' category(lamotrigine or levetiracetam, n=16), an 'intermediate risk' category(carbamazepine, oxcarbazepine, phenytoin, or valproate, n=34) and a 'high risk' category(topiramate, n=5). Brain connectivity was assessed using resting state functional magnetic resonance imaging and graph theoretical network analysis. The Computerized Visual Searching Task was used to measure central information processing speed, a common cognitive side effect of AED treatment. RESULTS Central information processing speed was lower in patients taking AEDs from the intermediate and high risk categories, compared with patients from the low risk category. The effect of risk category on global efficiency was significant(P < 0.05, ANCOVA), with a significantly higher global efficiency for patient from the low category compared with the high risk category(P < 0.05, post-hoc test). Risk category had no significant effect on the clustering coefficient(ANCOVA, P > 0.2). Also no significant associations between information processing speed and global efficiency or the clustering coefficient(linear regression analysis, P > 0.15) were observed. CONCLUSION Only the four patients taking topiramate show aberrant network measures, suggesting that alterations in functional brain network organization may be only subtle and measureable in patients with more severe cognitive side effects. | Tamar M van Veenendaal Dominique M IJff Albert P Aldenkamp Richard H C Lazeron Paul A M Hofman Anton J A de Louw Walter H Backes Jacobus F A Jansen | 2017 | World Journal of Radiology2017，9，6： | 2 |
| 2 | Kontrastmittelsonografie bei B-Bild-morphologisch unklaren Leberraumforderungen – Diagnostische Treffsicherheit im klinischen Alltag (DEGUM-Multicenter – Studie)显示文摘 | D Strobel K Seitz W Blank A Schuler C Dietrich A Herbay M Friedrich-Rust G Kunze D Becker U Will W Kratzer F Albert C Pachmann K Dirks H Strunk C Greis T Bernatik | 2008 | Ultraschall in Med2008，，05： | 2 |
| 3 | Loss of glom erular function and tubulointerstitial fibrosis cause or effect显示文摘 | Albert C M O Leon G F | 1994 | Kidney Internationall1994，45，： | 1 |
| 4 | Extremophilic organisms as an unexplored source of antifungal compounds显示文摘 | Phoebe C H Combie J Albert F G | 2001 | J Antibiot2001，54，1： | 1 |
| 5 | Moisture absorption and hygrothermal aging in a bismaleirnide resin 显示文摘 | Li Rongbao Albert F Y Charles Y C | 2001 | Polymer2001，42，17： | 1 |
| 6 | 查看详情显示文摘 | Hill K O Malo B Bilodeau F Johnson D C Albert J | | 0，，： | 1 |
| 7 | Serotonin-prefrontalcortical circuitry in anxiety and depression phenotypes : pivotalrole of pre- and post-synaptic 5-HT1A receptor expression 显示文摘 | Albert PR Vahid-Ansari F Luckhart C | 2014 | Front Behav Neurosci2014，8，： | 1 |
| 8 | Intensive care adult patients with severe respiratory failure caused by influenza A(H1N1)v in Spain显示文摘 | Rello J Rodríguez A Ibaez P Socias L Cebrian J Marques A Guerrero J Ruiz-Santana S Marquez E Del Nogal-Saez F Alvarez-Lerma F Martínez S Ferrer M Avellanas M Granada R Maraví-Poma E Albert P SierraR Vidaur L Ortiz P Prieto del Portillo I Galván B León-Gil C H1N1SEMICYUC Working Group | 2009 | Crit Care2009，13，5： | 1 |
| 9 | The sensitivity of tropospheric methane to the interannual variability in stratospheric ozone 显示文摘 | Charles D C Roulston M S Albert F C | 2001 | Chemosphere: Global Change Science2001，3，： | 1 |
| 10 | Physical and chemical properties of eroded soil aggregate显示文摘 | Alberts E E Wendt R C Pierst R F | 1983 | Transactions of the ASAE1983，26，： | 1 |
| 11 | Acute coronary syndrome in young Caucasian: about 62 cases 显示文摘 | Hamadou B Thuaire C Range G Demicheli T Kane A Albert F | 2013 | The Pan African medical journal2013，27，14： | 1 |
| 12 | Surgical anatomy of the vertebral arteries显示文摘 | HEARY R F ALBERT T J LUDWIG S C | 1996 | Spine1996，21，： | 1 |
| 13 | Extremophilic organisms as an unexplored source of antifungal compounds显示文摘 | Phoebe C H J R Combie J Albert F G | 2001 | JAntibiot2001，54，1： | 1 |
| 14 | Developing a Performance Index for Relationship-Based Construction Projects in Australia: Delphi Study 显示文摘 | John F Y Yeung Albert P C Chan Daniel W M | 2009 | Journal of Management in Engineering2009，25，2： | 1 |
| 15 | Interaction of COP1 and UVR8 regulates UV-B-induced photomorphogenesis and stress acclimation in Arabidopsis显示文摘 | Favory J Stec A Gruber H Rizzini L Oravecz A Funk M Albert A Cloix C Jenkins G I Oakeley E J Seidlitz H K Nagy F Ulm R | | 0，，： | 1 |
| 16 | Development of a genetic linkage map and identification of homologous linkage groups in sweetpotato using muhiple-dose AFLP markers显示文摘 | Jim C C F Yencho G C Albert K | 2008 | Mol Breeding2008，21，： | 1 |
| 17 | Transforming growth factor 1 and o in chronic liver disease 显示文摘 | Albert C Jesus P Nelson F | 1991 | N Engl J Med1991，32，4： | 1 |
| 18 | Surgical anatomy of the vertebral arteries显示文摘 | Heary R F Albert T J Ludwig S C | 1996 | Spine1996，21，18： | 1 |
| 19 | Efficacy and safety of subcutane- ous immunotherapy with a biologically standardized extract of Am- brosia artemisiifolia pollen: a double-blind, placebo-controlled study 显示文摘 | Mirone C Albert F Tosi A | 2004 | Clin Exp Allergyn2004，34，9： | 1 |
| 20 | A nonlinear time - stepped finite - element simulation of a symmetrical short - circuit in a synchronous machine 显示文摘 | Silvio IN Albert F Jean - Louis C | 1995 | IEEE Transactions on Magnetics1995，31，3： | 1 |
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