|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Targeted therapies in gastric cancer and future perspectives显示文摘Advanced gastric cancer(AGC) is associated with a high mortality rate and, despite multiple new chemotherapy options, the survival rates of patients with AGC remains poor. After the discovery of targeted therapies, research has focused on the new treatment options for AGC. In the last two decades, many targeted molecules were developed against AGC. Currently, two targeted therapy molecules have been approved for patients with AGC. In 2010, trastuzumab was the first molecule shown to improve survival in patients with HER2-positive AGC as part of a first-line combination regimen. In 2014, ramucirumab was the second targeted molecule to improve survival rates and was suggested as treatment for patients with AGC who had progressed after firstline platinum plus fluoropyrimidine with or without anthracycline chemotherapy. Ramucirumab was the first targeted therapy acting as a single agent in patients with advanced gastroesophageal cancers. Although these two molecules were introduced into clinical use, many other promising molecules have been tested in phase Ⅰ-Ⅱ trials. It is obvious that in the near future many different targeted therapies will be in use for treatment of AGC. In this review, the current status of targeted therapies in the treatment of AGC and gastroesophageal junction tumors, including HER(2-3) inhibitors, epidermal growth factor receptor inhibitors, tyrosine kinase inhibitors, antiangiogenic agents, c-MET inhibitors, mammalian target of rapamycin inhibitors, agents against other molecular pathways fibroblast growth factor, Claudins, insulin-like growth factor, heat shock proteins, and immunotherapy, will be discussed. | Ozan Yazici M Ali Nahit Sendur Nuriye Ozdemir Sercan Aksoy | 2016 | World Journal of Gastroenterology2016，22，2： | 11 |
| 2 | Evaluation of an erosion-sediment transport model for a hillslope using laboratory flume data显示文摘Climate change can escalate rainfall intensity and cause further increase in sediment transport in arid lands which in turn can adversely affect water quality. Hence, there is a strong need to predict the fate of sediments in order to provide measures for sound erosion control and water quality management. The presence of microtopography on hillslopes influences processes of runoff generation and erosion, which should be taken into account to achieve more accurate modelling results. This study presents a physically based mathematical model for erosion and sediment transport coupled to one-dimensional overland flow equations that simulate rainfall-runoff generation on the rill and interrill areas of a bare hillslope. Modelling effort at such a fine resolution considering the flow connection between interrill areas and rills is rarely verified. The developed model was applied on a set of data gathered from an experimental setup where a 650 cm×136 cm erosion flume was pre-formed with a longitudinal rill and interrill having a plane geometry and was equipped with a rainfall simulator that reproduces natural rainfall characteristics. The flume can be given both longitudinal and lateral slope directions. For calibration and validation, the model was applied on the experimental results obtained from the setup of the flume having 5% lateral and 10% longitudinal slope directions under rainfall intensities of 105 and 45 mm/h, respectively. Calibration showed that the model was able to produce good results based on the R2(0.84) and NSE(0.80) values. The model performance was further tested through validation which also produced good statistics(R2=0.83, NSE=0.72). Results in terms of the sedigraphs, cumulative mass curves and performance statistics suggest that the model can be a useful and an important step towards verifying and improving mathematical models of erosion and sediment transport. | Anya Catherine CARGUELLES MinJae JUNG Kristine Joy BMALLARI GiJung PAK Hafzullah AKSOY Levent M KAVVAS Ebru ERIS JaeYoung YOON YoungJoon LEE SeonHwa HONG | 2014 | Journal of Arid Land2014，6，6： | 3 |
| 3 | Diagnostic value of CRP and Lp(a) in coronary heart disease显示文摘 | ERBAGCI A B TARAKCIOGLU M AKSOY M | 2002 | Acta Cardiol2002，57，3： | 2 |
| 4 | The effect of manganese on the microstructure and mechanical properties of leaded-tin bronze显示文摘 | Hurhan T Aksoy M Kuzucu V | 2001 | Journal of Materials Processing Technology2001，114，： | 1 |
| 5 | QUAD: Quadrant-based relative location estimates for representative topologies in wireless sensor networks显示文摘 | WONG M AKSOY D | 2009 | Computer Networks2009，53，12： | 1 |
| 6 | Feature normalization and likehood-based similarity measure for image retrieval 显示文摘 | Aksoy S Haralick R M | 2001 | Pattern RecognitionLetters(SO167-8655)2001，22，5： | 1 |
| 7 | Bipositional MR imaging vs arthrography for the evaluation of femoral head sphericity and containment in Legg-Calve-Perthes disease显示文摘 | Yazici M Aydingoz U Aksoy MC | 2002 | Clin Imaging2002，26，5： | 1 |
| 8 | Investigation of the casting microstructure of a Fe-base, Cr Ni Mo du- plex alloy显示文摘 | Ceylan M Kuzucu V Aksoy M | 1997 | Journal of Materials Processing Technolo- gy1997，69，： | 1 |
| 9 | Relationship between mean platelet volume and m-itral annular calcification显示文摘 | Varol E Aksoy F Ozaydin M | 2013 | Blood Coagul Fibrinolysis2013，，2： | 1 |
| 10 | Economic assessment of geothermal district heating systems:a case study of Balcova-Narlidere,turkey显示文摘 | ERDOGMUS B TOKSOY M OZERDEM B AKSOY N | | 0，，： | 1 |
| 11 | Stress distribution associated with loaded acrylic-metal-cement crowns by using finite element method 显示文摘 | Toparli M Aykul H Aksoy T | 2002 | J Oral Rehabil2002，29，11： | 1 |
| 12 | Doppler velocimetry of the uterine arteries after hysteroscopic rollerball endometrial ablation显示文摘 | Babceci M Demirel LC Aksoy E | 1998 | Hum Reprod1998，13，： | 1 |
| 13 | Protective and thera- peutic effects of licorice in rats with acute tubular necrosis 显示文摘 | Aksoy N Dogan Y Iriadam M | 2012 | J Ren Nutr2012，22，3： | 1 |
| 14 | Protective and therapeutic effects of licorice in rats with acute tubular necrosis显示文摘 | Aksoy N Dogan Y Iriadam M | 2012 | J Ren Nutr2012，22，3： | 1 |
| 15 | Removing intranasal splints after septal surgery显示文摘 | AKSOY E SERIN G M POLAT S | 2011 | J Craniofac Surg2011，22，： | 1 |
| 16 | The Effect of Niobium on the Microst Ructure of Ferritic Stainless Steel 显示文摘 | Kuzucu V Aksoy M Korkut M H | 1997 | Mater Sci Eng1997，230，122： | 1 |
| 17 | Comparison of com- pression plate and flexible intramedullary nail fixation in pediatric femoral shaft fractures显示文摘 | CAGLAR O AKSOY M C YAZICI M | 2006 | J Pediatr Orthop B2006，15，3： | 1 |
| 18 | The effect ofniobium and homogenization on the wear resistance and somemechanical properties of ferritic stainless steel containingl7 - 18wt% chromium显示文摘 | Aksoy M Kuzucu V Korkut M H | 1999 | Journal of Materials Processing Technology1999，91，： | 1 |
| 19 | Immobilized Candida antarctica lipase-catalyzed alcoholysis of cotton seed oil in a solvent-free medium显示文摘 | KOSE O TUTER M AKSOY H A | 2002 | Bioresource Technology2002，83，： | 1 |
| 20 | Evolution of the miR -290 -295/miR - 371 - 373 cluster family seed repertoire 显示文摘 | Wu S Aksoy M Shi J | 2014 | PloS one2014，9，10： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员