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| 1 | Postoperative bile leakage managed successfully by intrahepatic biliary ablation with ethanol显示文摘我们报导手术后的倔强的胆汁漏的一个案例与乙醇由肝内的胆汁的脱离成功地设法。与肝细胞癌诊断的一个 75 岁的人包括有尾的脑叶和前面的片断的部分经历了扩大以后的 segmentectomy。纳入胆汁管的前面的分支的肝的肿瘤小心地被分开并且 resected。手术后地从肝表面排干的液体包含了全部的胆红素的高集中,在每天的 150 mL 的经常的体积。在 d 上 32 在外科以后,引流管的 fistulogram 表明了前面的胆汁管的改进。内视镜后退胆管造影术表明了近似前面的胆汁管和外部前面的胆汁管的没有改进的完全的阻塞。在 d 上 46 在外科以后,一后退 transhepatic 胆汁的排水(RTBD ) 试管在开的外科下面被插入到前面的胆汁管。然而,拿的 RTBD 的对比研究 7 瞬间外科以后表明尽管有延长保守管理,管仍然是专利,我们因此决定执行孤立的胆汁管的乙醇脱离。四 mL 纯乙醇被注入孤立的前面的胆汁管十分钟,过程一个星期正在被重复五次。追随者 23 尝试,胆汁果汁的体积每天到达了不到 10 mL。RTBD 二天以后被夹钳并且搬迁。在 RTBD 移动以后,病人没有抱怨或症状。没有肝脓肿形成,后续磁性的回声成像表明了注射乙醇的前面的片断的萎缩。 | Tetsuya Shimizu Hiroshi Yoshida Yasuhiro Mamada Nobuhiko Taniai Satoshi Matsumoto Yoshiaki Mizuguchi Shigeki Yokomuro Yasuo Arima Koho Akimaru Takashi Tajiri | 2006 | World Journal of Gastroenterology2006，12，21： | 9 |
| 2 | Long-term results of elective hepatectomy for the treatment of ruptured hepatocellular carcinoma显示文摘 | Hiroshi Yoshida Yasuhiro Mamada Nobuhiko Taniai Yoshiaki Mizuguchi Daisuke Kakinuma Yoshinori Ishikawa Tomohiro Kanda Satoshi Matsumoto Koich Bando Koho Akimaru Takashi Tajiri | 2008 | Journal of Hepato - Biliary - Pancreatic Surgery2008，，2： | 2 |
| 3 | Effect of transforming growth factor-β1 on human intrahepatic cholangiocarcinoma cell growth显示文摘AIM: To elucidate the biological effects of transforming growth factor-β1 (TGF-β1) on intrahepatic cholan- giocarcinoma (ICC). METHODS: We investigated the effects of TGF-β1 on human ICC cell lines (HuCCT1, MEC, and HuH-28) by monitoring the influence of TGF-β1 on tumor growth and interleukin-6 (IL-6) expression in ICC cells. RESULTS: All three human ICC cell lines produced TGF-β1 and demonstrated accelerated growth in the presence of TGF-β1 with no apoptotic effect. Studies on HuCCT1 revealed a TGF-β1-induced stimulation of the expression of TGF-β1, as well as a decrease in TGF-β1 mRNA expression induced by neutralizing anti-TGF-β1 antibody. These results indicate that TGF-β1 stimulates the production and function of TGF-β1 in an autocrine fashion. Further, IL-6 secretion was observed in all three cell lines and exhibited an inhibitory response to neutralizing anti-TGF-β1 antibody. Experiments using HuCCT1 revealed a TGF-β1-induced acceleration of IL-6 protein expression and mRNA levels. These findings demonstrate a functional interaction between TGF-β1 and IL-6. All three cell lines proliferated in the presence of IL-6. In contrast, TGF-β1 induced no growth effect in HuCCT1 in the presence of small interfering RNA against a specific cell surface receptor of IL-6 and signal transducer and activator of transcription-3. CONCLUSION: ICC cells produce TGF-β1 and confer a TGF-β1-induced growth effect in an autocrine fashion.TGF-β1 activates IL-6 production, and the functional interaction between TGF-β1 and IL-6 contributes to ICC cell growth by TGF-β1. | Tetsuya Shimizu Shigeki Yokomuro Yoshiaki Mizuguchi Yutaka Kawahigashi Yasuo Arima Nobuhiko Taniai Yasuhiro Mamada Hiroshi Yoshida Koho Akimaru Takashi Tajiri | 2006 | World Journal of Gastroenterology2006，12，39： | 2 |
| 4 | Reverse vesicles: counter structure of biological membranes 显示文摘 | KUNIEDA H AKIMARU M USHIO N | 1993 | Journal of Colloid and Interface Science1993，156，2： | 1 |
| 5 | Clinical and subclinical acute rejection ear ly after liver transplantation: contributing factors and relevance for the long-term course显示文摘 | Tippner C Nashan B Hoshino K Schmidt-Sandte E Akimaru K B/Sker K H | 2001 | Transplantation2001，72，： | 1 |
| 6 | jejunectomy can reduce excessively elevated portal pressure after major hepatectomy in beagle dogs显示文摘 | Kawano Y Akimaru K Takubo K | 2006 | J Surg Res2006，130，1： | 1 |
| 7 | Clinical and subclinical acute rejection early after liver transplantation:contributing factors and relevance for the long-term course显示文摘 | Tippner C Nashan B Hoshino K Schmidt-Sandte E Akimaru K B(o)ker K H | 2001 | Transplantation2001，72，： | 1 |
| 8 | Surgical treatment for better prognosis of patients with liver metastases from colorectal cancer 显示文摘 | Taniai N Akimaru K Yoshida H | 2007 | Hepatogastroenterology2007，54，78： | 1 |
| 9 | Dextran induces differentia- tion of circulating endothelial progenitor ceils 显示文摘 | Obi S Masuda H Akimaru H | 2014 | Physiol Rep2014，2，00： | 1 |
| 10 | Purification and properties of Bacillus coagulans cyclomaltodextrin glucanotransferase显示文摘 | Akimaru K Yagi T | 1991 | J Ferm Bioeng1991，，71： | 1 |
| 11 | Asynchronous expression and clocalization of Bsep and Mrp2 during development of rat liver显示文摘 | Zinchuk VS Okada T Akimaru K | 2002 | Am J Physiol Gastrointest Liver Physiol2002，282，3： | 1 |
| 12 | Asynchronous expressionand colocalization of Bsep and Mrp2 during development of rat liver显示文摘 | Vadim ZS Okada T Akimaru K | 2001 | Physiol Gastrointest Liver Physiol2001，282，3： | 1 |
| 13 | The effect of mixing of surfactants on solubilization in a microemulsion system 显示文摘 | Kunieda H Nakano A Akimaru M | 1995 | J Colloid Interface Sci1995，170，： | 1 |
| 14 | Combined neuroendocrine cell carcinoma and adenocarcinnoma of the gallbladder: report of a case显示文摘 | Shimizu T Tajiri T Akimaru K | 2006 | J Nippon Med Sch2006，73，2： | 1 |
| 15 | Cholecystitis caused by infiltration of immature myeloid cells:a case report显示文摘 | SHIMIZU T TAJIRI T AKIMARU K | 2006 | J Nippon Med Sch2006，73，： | 1 |
| 16 | Sonic Hedge- hog-induced activation of the Glil promoter is mediated by GLI3显示文摘 | DAI P AKIMARU H TANAKA Y | 1999 | J Biol Chem1999，274，： | 1 |
| 17 | Inhibition of the nuclear import of cubitus interruptus by roadkill in the presence of strong hedgehog signal显示文摘 | Seong K H Akimaru H Dai P | | 0，，12： | 1 |
| 18 | Exogenous interleukin-3 enhances IL-4 production by splenic CD4^+ cells during the early stages of a Trichinella spiralis infection显示文摘 | Korenaga M Akimaru Y ttashiguehi Y | 1998 | Int Arch Allergy Immunol1998，117，2： | 1 |
| 19 | CLINICAL AND SUBCLINICAL ACUTE REJECTION EARLY AFTER LIVER TRANSPLANTATION: CONTRIBUTING FACTORS AND RELEVANCE FOR THE LONG-TERM COURSE显示文摘 | Christa Tippner Bj?rn Nashan Ken Hoshino Elke Schmidt-Sandte Koho Akimaru Klaus H.W. B?ker Hans J. Schlitt | 2001 | Transplantation2001，，6： | 1 |
| 20 | Methodological development of a clonogenic assay to determine endothelial progenitor cell potential显示文摘 | Masuda H Alev C Akimaru H | 2011 | Circ Res2011，109，1： | 1 |
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