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| 1 | Genetics of coronary artery disease and myocardial infarction显示文摘Atherosclerotic coronary artery disease(CAD) comprises a broad spectrum of clinical entities that include asymptomatic subclinical atherosclerosis and its clinical complications, such as angina pectoris, myocardial infarction(MI) and sudden cardiac death. CAD continues to be the leading cause of death in industrialized society. The long-recognized familial clustering of CAD suggests that genetics plays a central role in its development, with the heritability of CAD and MI estimated at approximately 50% to 60%. Understanding the genetic architecture of CAD and MI has proven to be difficult and costly due to the heterogeneity of clinical CAD and the underlying multi-decade complex pathophysiological processes that involve both genetic and environmental interactions. This review describes the clinical heterogeneity of CAD and MI to clarify the disease spectrum in genetic studies, provides a brief overview of the historical understanding and estimation of the heritability of CAD and MI, recounts major gene discoveries of potential causal mutations in familial CAD and MI, summarizes CAD and MIassociated genetic variants identified using candidate gene approaches and genome-wide association studies(GWAS), and summarizes the current status of the construction and validations of genetic risk scores for lifetime risk prediction and guidance for preventive strategies. Potential protective genetic factors against the development of CAD and MI are also discussed. Finally, GWAS have identified multiple genetic factors associated with an increased risk of in-stent restenosis following stent placement for obstructive CAD. This review will also address genetic factors associated with in-stent restenosis, which may ultimately guide clinical decision-making regarding revascularization strategies for patients with CAD and MI. | Xuming Dai Szymon Wiernek James P Evans Marschall S Runge | 2016 | World Journal of Cardiology2016，8，1： | 15 |
| 2 | Acute coronary syndrome in the older adults显示文摘1 Introduction Coronary heart disease remains the leading cause of death in the developed world.Advanced age is the single strongest risk factor for coronary artery disease (CAD) and independent predictor for poor outcomes following an acute coronary syndrome (ACS).ACS refers to a spectrum of conditions compatible with acute myocardial ischemia and/or infarction due to various degrees of reduction in coronary blood flow as a result of plaque rupture/erosion and thrombosis formation or supply and demand mismatch. | Xuming DAI Jan Busby-Whitehead Karen P Alexander | 2016 | Journal of Geriatric Cardiology2016，13，2： | 5 |
| 3 | Stable ischemic heart disease in the older adults显示文摘1 Introduction Ischemic heart disease is caused by atherosclerotic and/or thrombotic obstruction of coronary arteries.Clinical spectrum of ischemic heart disease expands from asymptomatic atherosclerosis of coronary arteries to acute coronary syndromes (ACS) including unstable angina,acute myocardial infarction (non-ST elevation myocardial infarction and ST elevation myocardial infarction). | Xuming DAI Jan Busby-Whitehead Daniel E Forman Karen P Alexander | 2016 | Journal of Geriatric Cardiology2016，13，2： | 5 |
| 4 | Interaction Between Variations in Dopamine D2 and Serotonin 2A Receptor is Associated with Short-Term Response to Antipsychotics in Schizophrenia显示文摘Dear Editor,Schizophrenia is a chronic and debilitating brain disorder,which has a strong genetic component with heritability ranging from 66%to 85%[1,2].Currently,antipsychotic drugs remain the most effective treatment for the psychotic symptoms of schizophrenia[3].Because of the severe sideeffects of first-generation antipsychotics(FGAs),secondgeneration antipsychotics(SGAs)have become more widely used in the treatment of schizophrenia. | Liansheng Zhao Huijuan Wang Yamin Zhang Jinxue Wei Peiyan Ni Hongyan Ren Gang Li Qiang Wang Gavin P Reynolds Weihua Yue Wei Deng Hao Yan Liwen Tan Qi Chen Guigang Yang Tianlan Lu Lifang Wang Fuquan Zhang Jianli Yang Keqing Li Luxian Lv Qingrong Tan Yinfei Li Hua Yu Hongyan Zhang Xin Ma Fude Yang Lingjiang Li Chuanyue Wang Huiyao Wang Xiaojing Li Wanjun Guo Xun Hu Yang Tian Xiaohong Ma Jeremy Coid Dai Zhang Chao Chen Tao Li Chinese Antipsychotics Pharmacogenomics Consortium | 2019 | Neuroscience Bulletin2019，35，6： | 3 |
| 5 | Fen1 mutations that specifically disrupt its interaction ~vith PCNA cause aneuploidy-associated cancer显示文摘 | Li Zheng Huifang Dai Muralidhar L Hegde Mian Zhou Zhigang Guo Xiwei Wu Jun Wu Lei Su Xueyan Zhong Sankar Mitra Qin Huang Kemp H Kernstine Gerd P Pfeifer Binghui Shen | 2011 | Cell Research2011，21，7： | 3 |
| 6 | Linear matrix equations from an inverse problem of vibration theory显示文摘 | Dai H P Lancaster | 1996 | Linear Algebra Appl1996，246，： | 2 |
| 7 | 显示文摘 | Zhao B Cheng P Dai Y | 2003 | Angew Chem Int Ed2003，42，8： | 1 |
| 8 | Targeting tumours by adoptive transfer of immune cells显示文摘 | Macary P A Too C T Dai X | 2006 | Clin Exp Pharmacol Physiol2006，33，56： | 1 |
| 9 | Dual effects of intrathecal BAM22 on nociceptive responses in acute and persistent pain-potential function of a novel receptor 显示文摘 | Hong Y Dai P Jiang J Zeng X | 2004 | Br J Pharmacol2004，141，： | 1 |
| 10 | The transcription factors GATA-4 and dHAND physically interact to synergistically activate cardiac gene expression through a p300-dependent mechanism显示文摘 | Dai YS Cserjesi P Markham BE | 2006 | J Biol Chem2006，277，27： | 1 |
| 11 | Moment Resistance of Steel Ⅰ-Beam to CFT Column Connection显示文摘 | Chiew S P Lie S T Dai C W | 2001 | Journal of Structural Engineering2001，，： | 1 |
| 12 | Immobilized baker’s yeastreduction of ketones in an ionic liquid, PF6,and watermix显示文摘 | Howarth J James P Dai J F | 2001 | Tetrahedron Letters2001，42，42： | 1 |
| 13 | Spatiotemporal changes of NGF, BDNF and NT -3 in the developing spinal cords of em- bryonic chicken 显示文摘 | Ba YC Dai P Zhou HL | 2010 | Neurochem Res2010，35，2： | 1 |
| 14 | Mechanical properties and microstructure of nanocrystalline nickel-carbon nanotube composites produced by electrodeposition 显示文摘 | DAI P Q XU W C HUANG Q Y | 2008 | Materials Science and Engineering: A2008，，： | 1 |
| 15 | TNFalpha and PTH utilize distinct mechanisms to induce IL-6 and RANKL expression with markedly different kinetics显示文摘 | Dai JC He P Chen X | | 0，，04： | 1 |
| 16 | Parametric optimiza -tion and comparative study of organic Rankine cyce (ORC) for low grade waste heat recovery显示文摘 | Dai Y P Wang J F Gao L | 2009 | Energy Conversion and Management2009，50，4： | 1 |
| 17 | Synthesis of Bi6Mo2015sub-microwires via a molten salt method and enhancing thephotocatalytic reduction of CO2 into solar fuel through tuning the surface oxide vacancies by simple post-heating treatment显示文摘 | Li P Zhou Y Tu W Wang R Zhang C Liu Q Li H Li Z Dai H Wang J Yan S Zou Z | 2013 | CrystEngComm2013，15，46： | 1 |
| 18 | Potential biomarkers in the urine of myocardial infarction rats:ametabolomic method and its application显示文摘 | Jiang P Dai WX Yan SK | 2011 | Mol Bio Syst2011，7，： | 1 |
| 19 | First report of twig canker on peach caused by Phomopsis amygdale in China显示文摘 | DAI F M ZENG R LU J P | 2012 | Plant disease2012，96，2： | 1 |
| 20 | Microstructure and property evolution of Cr-DLC films with different Cr content deposited by a hybrid beam technique 显示文摘 | DAI W KE P L WANG A Y | 2006 | Thin Solid Films2006，514，： | 1 |
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