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| 1 | Retrograde-viewing device improves adenoma detection rate in colonoscopies for surveillance and diagnostic workup显示文摘AIM:To determine which patients might benefit most from retrograde viewing during colonoscopy through subset analysis of randomized,controlled trial data.METHODS:The Third Eye Retroscope Randomized Clinical Evaluation(TERRACE) was a randomized,controlled,multicenter trial designed to evaluate the efficacy of a retrograde-viewing auxiliary imaging device that is used during colonoscopy to provide a second video image which allows viewing of areas on the proximal aspect of haustral folds and flexures that are difficult to see with the colonoscope's forward view.We performed a post-hoc analysis of the TERRACE data to determine whether certain subsets of the patient population would gain more benefit than others from use of the device.Subjects were patients scheduled for colonoscopy for screening,surveillance or diagnostic workup,and each underwent same-day tandem examinations with standard colonoscopy(SC) and Third Eye colonoscopy(TEC),randomized to SC followed by TEC or vice versa.RESULTS:Indication for colonoscopy was screening in 176/345 subjects(51.0%),surveillance after previous polypectomy in 87(25.2%) and diagnostic workup in 82(23.8%).In 4 subjects no indication was specified.Previously reported overall results had shown a net additional adenoma detection rate(ADR) with TEC of 23.2% compared to SC.Relative risk(RR) of missing adenomas with SC vs TEC as the initial procedure was 1.92(P = 0.029).Post-hoc subset analysis shows additional ADRs for TEC compared to SC were 4.4% for screening,35.7% for surveillance,55.4% for diagnostic and 40.7% for surveillance and diagnostic combined.The RR of missing adenomas with SC vs TEC was 1.11(P = 0.815) for screening,3.15(P = 0.014) for surveillance,8.64(P = 0.039) for diagnostic and 3.34(P = 0.003) for surveillance and diagnostic combined.Although a multivariate Poisson regression suggested gender as a possibly significant factor,subset analysis showed that the difference between genders was not statistically significant.Age,bowel prep quality and withdrawal time did not significantly affect the RR of missing adenomas with SC vs TEC.Mean sizes of adenomas detected with TEC and SC were similar at 0.59 cm and 0.56 cm,respectively(P = NS).CONCLUSION:TEC allows detection of significantly more adenomas compared to SC in patients undergoing surveillance or diagnostic workup,but not in screening patients(ClinicalTrials.gov Identifier:NCT01044732). | Peter D Siersema Amit Rastogi Anke M Leufkens Paul A Akerman Kassem Azzouzi Richard I Rothstein Frank P Vleggaar Alessandro Repici Giacomo Rando Patrick I Okolo Olivier Dewit Ana Ignjatovic Elizabeth Odstrcil James East Pierre H Deprez Brian P Saunders Anthony N Kalloo Bradley Creel Vikas Singh Anne Marie Lennon Daniel C DeMarco | 2012 | World Journal of Gastroenterology2012，18，26： | 6 |
| 2 | Seroma after axillary lymph node dissection in breast cancer 显示文摘 | Douay N Akerman G Clément D | 2008 | Gynecol Obstet Fertil2008，36，： | 1 |
| 3 | Seroma after axillary lymph node dissection in breast cancer显示文摘 | Douay N Akerman G Clement D | 2008 | Gynecol Obstet Fertil2008，36，2： | 1 |
| 4 | Isolation of a cDNA encoding human holocarboxylase synthetase by functional complementation of a biotin auxotroph of Escherichia coli显示文摘 | LEON-DEL-RIO A LECLERC D AKERMAN B | 1995 | Proceedings of the National Academy of Sciences USA1995，92，10： | 1 |
| 5 | In vivo variability of TMA oxidation is partially mediated by polymorphisms of the FMO3 gene显示文摘 | Lambert D M Mamer O A Akerman B R | 2001 | Mol Genet Metab2001，73，3： | 1 |
| 6 | Effect of aci- dic solutions and acidic prochloraz on the control of postharvest decay caused by Alternaria alternata in mango and persimmon fruit 显示文摘 | Prusky D Kobiler I Akerman M | 2006 | Postharvest Biology and Technology2006，42，2： | 1 |
| 7 | A phase Ⅰ study of docetaxel, oxaliplatin, and capecitabine in patients with metastatic gastroesophageal cancer 显示文摘 | Evans D Miner T Akerman P | 2007 | Am J Clin Oncol2007，30，4： | 1 |
| 8 | The level of quiescent infection of Alternaria alternata in mango fruits at harvest determines the postharvest treatment applied for the control of rots during storage显示文摘 | PRUSKY D SHALOM Y KOBILER I AKERMAN M FUCHS Y | 2002 | Postharvest Biology and Technology2002，25，3： | 1 |
| 9 | Visual experience before eye opening and the development of the retinogenic- ulate pathway显示文摘 | AKERMAN CJ SMYTH D Thompson ID | 2002 | Neuron2002，35，5： | 1 |
| 10 | A phase I study of docetaxel,oxaliplatin,and capecitabine in patients with metastatic gastroesophageal cancer显示文摘 | Evans D Miner T Akerman P | 2007 | Am J Clin Oncol2007，30，4： | 1 |
| 11 | Isolation of a cDNA encoding human holocarboxylase synthethase by functional comple mentation of a biotin auxotroph of Escherichia coli显示文摘 | Leorr Del- Rio A Leclerc D Akerman B | 1995 | Proc Natl Acad Sci USA1995，92，： | 1 |
| 12 | Seroma after axillary lymph node dissection in breast cancer显示文摘 | Douay N Akerman G C16ment D | 2008 | Gynecol Obstet Fertil2008，36，2： | 1 |
| 13 | A phase Ⅰ study of docetaxel, oxaliplatin, and eapecitabine in patients with metastatic gastroesophageal cancer显示文摘 | Evans D Miner T Akerman P | 2007 | Am J Clin Oncol2007，30，4： | 1 |
| 14 | Spiral enteroscopy:a novel method of enteroscopy by using the Endo-Ease Discovery SB overtube and a pediatric colonoscope显示文摘 | Akerman P Agrawal D Chen W | | Gastrointestinal Endoscopy0，，： | 1 |
| 15 | The level of quiescent infection ofAlternaria alternata in mango fruits at harvest determines the postharvest treatment applied for the control of rots during storage Postharvest Biology and Technology显示文摘 | D Prusky Y Shalom l Kobiler M Akerman Y Fuchs | 2002 | (25):339-3472002，，25： | 1 |
| 16 | Mitochondrial calcium transport显示文摘 | Nicholls D Akerman K | 1982 | Biochim Biophys Acta1982，683，： | 1 |
| 17 | Laparoscopic cholecystectomy versus minilaparotomy in cholelithiasis:systematic review and meta-analysis显示文摘 | Castro PM Akerman D Munhoz CB | 2014 | Arq Bras Cir Dig2014，27，2： | 1 |
| 18 | A phase I study of doeetaxel, oxaliplatin, and eapecitabine in patients with metastatic gastroesophageal cancer 显示文摘 | Evans D Miner T Akerman P | 2007 | Am J Clin Oncol2007，30，4： | 1 |
| 19 | Isolation of a cDNA encoding human holocarboxylase synthethase by functional comple mentation of a biotin auxotroph of Es-cherichia coli显示文摘 | Leorr Del-Rio A Leclerc D Akerman B | | 0，，： | 1 |
| 20 | Erlotinib and chemoradiation followed by maintenance erlotinib for locally advanced pancreatic cancer: a phase Ⅰ study显示文摘 | Iannitti D Dipetfillo T Akerman P | 2005 | Am J Clin Oneol2005，28，6： | 1 |
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