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| 1 | Ameliorative effects of bombesin and neurotensin on trinitrobenzene sulphonic acid-induced colitis,oxidative damage and apoptosis in rats显示文摘AIM:To investigate the effects of bombesin (BBS) and neurotensin (NTS) on apoptosis and colitis in an ulcerative colitis model. METHODS:In this study, a total of 50 rats were divided equally into 5 groups. In the control group, no colitis induction or drug administration was performed. Colitis was induced in all other groups. Following the induction of colitis, BBS, NTS or both were applied to three groups of rats. The remaining group (colitis group) received no treatment. On the 11th d after induction of colitis and drug treatment, blood samples were collected for TNF-α and IL-6 level studies. Malondialdehyde (MDA), carbonyl, myeloperoxidase (MPO) and caspase-3 activities, as well as histopathological findings, evaluated in colonic tissues. RESULTS:According to the macroscopic and microscopic findings, the study groups treated with BBS, NTS and BBS + NTS showed significantly lower damage and inflammation compared with the colitis group (macroscopic score, 2.1 ± 0.87, 3.7 ± 0.94 and 2.1 ± 0.87 vs 7.3 ± 0.94;microscopic score, 2.0 ± 0.66, 3.3 ± 0.82 and 1.8 ± 0.63 vs 5.2 ± 0.78, P < 0.01). TNF-α and IL-6 levels were increased significantly in all groups compared with the control group. These increases were significantly smaller in the BBS, NTS and BBS + NTS groups compared with the colitis group (TNF-α levels, 169.69 ± 53.56, 245.86 ± 64.85 and 175.54 ± 42.19 vs 556.44 ± 49.82;IL-6 levels, 443.30 ± 53.99, 612.80 ± 70.39 and 396.80 ± 78.43 vs 1505.90 ± 222.23, P < 0.05). The colonic MPO and MDA levels were significantly lower in control, BBS, NTS and BBS + NTS groups than in the colitis group (MPO levels, 24.36 ± 8.10, 40.51 ± 8.67 and 25.83 ± 6.43 vs 161.47 ± 38.24;MDA levels, 4.70 ± 1.41, 6.55 ± 1.12 and 4.51 ± 0.54 vs 15.60 ± 1.88, P < 0.05). Carbonyl content and caspase-3 levels were higher in the colitis and NTS groups than in control, BBS and BBS + NTS groups (carbonyl levels, 553.99 ± 59.58 and 336.26 ± 35.72 vs 209.76 ± 30.92, 219.76 ± 25.77 and 220.34 ± 36.95;caspase-3 levels, 451.70 ± 68.27 and 216.20 ± 28.17 vs 28.60 ± 6.46, 170.50 ± 32.37 and 166.50 ± 30.95, P < 0.05). CONCLUSION:The results of this study suggest BBS and NTS, through their anti-inflammatory actions, support the maintenance of colonic integrity and merit consideration as potential agents for ameliorating colonic inflammation. | Alper Akcan Sebahattin Muhtaroglu Hulya Akgun Hizir Akyildiz Can Kucuk Erdogan Sozuer Alper Yurci Namik Yilmaz | 2008 | World Journal of Gastroenterology2008，14，8： | 14 |
| 2 | Large pedinculated antral hyperplastic gastric polyp traversed the bulbus causing outlet obstruction and iron deficiency anemia: endoscopic removal显示文摘We present here a large (3 cm) hyperplastic gastric polyp prolapsed into duodenum and caused outlet obstruction and iron deficiency anemia in 60 years old male patient.Endoscopic removal was performed successfully. | Murat Alper Yusuf Akcan Olcay Belenli | 2003 | World Journal of Gastroenterology2003，9，3： | 5 |
| 3 | Melatonin reduces bacterial translocation and apoptosis in trinitrobenzene sulphonic acid-induced colitis of rats显示文摘AIM: To investigate the effects of exogenous melatonin on bacterial translocation and apoptosis in a rat ulcerati-ve colitis model. METHODS: Rats were randomly assigned to three groups: groupⅠ: control, group Ⅱ: experimental colitis, group Ⅲ: colitis plus melatonin treatment. On d 11 after colitis, plasma tumor necrosis factor-α, portal blood endotoxin levels, colon tissue myeloperoxidase and caspase-3 activity were measured. Bacterial translocation was quantified by blood, lymph node, liver and spleen culture. RESULTS: We observed a significantly reduced inciden-ce of bacterial translocation to the liver, spleen, mesen-teric lymph nodes, portal and systemic blood in animals treated with melatonin. Treatment with melatonin signifi-cantly decreased the caspase-3 activity in colonic tissues compared to that in trinitrobenzene sulphonic acid-trea-ted rats (16.11 ± 2.46 vs 32.97 ± 3.91, P < 0.01). CONCLUSION: Melatonin has a protective effect on ba-cterial translocation and apoptosis. | Alper Akcan Can Kucuk Erdogan Sozuer Duygu Esel Hizir Akyildiz Hulya Akgun Sabahattin Muhtaroglu Yucel Aritas | 2008 | World Journal of Gastroenterology2008，14，6： | 5 |
| 4 | Predisposing factors and surgical outcome of complicated liver hydatid cysts显示文摘AIM: To evaluate the predisposing factors for peritoneal perforation and intrabiliary rupture and the effects of these complications on surgical outcome in liver hydatid disease.METHODS: A total of 372 patients with liver hydatid cysts who had undergone surgical treatment were evaluated retrospectively. Twenty eight patients with peritoneal perforation, 93 patients with spontaneous intrabiliary perforation, and 251 patients with noncomplicated hydatid cysts were treated in our clinics.RESULTS: When the predisposing factors for complications were evaluated, younger age, superf icial position, and larger cyst dimensions (P < 0.05; range, 0.0010.017) increased peritoneal perforation rates. It was shown that older age increased cyst dimensions, and presence of multiple and bilobar cysts increased intrabiliary rupture rates (P < 0.05; range, 0.0010.028). Partial pericystectomy and drainage was the most frequent surgical procedure in all groups (71.6%). The incidence of postoperative complications in the peritoneal perforated group, in the intrabiliary ruptured group, and in the noncomplicated group was 25%, 16.1% and 5.5%, respectively. When compared, complication rates were significantly different (P = 0.002). When length of hospital stay was compared, there was no signif icant difference between the groups (P > 0.05). The overall recurrence rate was 3.8% (14 patients), but there was not any statistical difference among the patient groups (P = 0.13). The early postoperative mortality rate was 1.1%. CONCLUSION: In peritoneally perforated and intrabiliary ruptured cases, the most important steps are irrigation of the peritoneal cavity and clearance of the cystic material from the biliary tree. | Alper Akcan Erdogan Sozuer Hizir Akyildiz Zeki Yilmaz Ahmet Ozturk Altay Atalay | 2010 | World Journal of Gastroenterology2010，16，24： | 4 |
| 5 | Granulomatous lobular mastitis: a complex diagnostic and therapeutic problem 显示文摘 | Akcan A Akyildiz H Deneme MA | 2006 | World J Surg2006，30，： | 1 |
| 6 | Granulomatous mastitis: radiological findings 显示文摘 | Ozturk M Mavili E Kahriman G Akcan AC Ozturk F | 2007 | Aeta Radiol2007，48，2： | 1 |
| 7 | A new determi-nistic data aggregation method for wireless sensor networks 显示文摘 | Akcan H Bronnimann H | 2007 | Signal Processing2007，87，12： | 1 |
| 8 | Two successive pregnancies after ursodeoxycholic acid therapy in a previously infertile woman with antimitochondriM antibody-negative primary biliary cirrhosis显示文摘 | Korkut E Kisacik B Akcan Y | 2005 | Fertil Steril2005，83，： | 1 |
| 9 | The correlation of the D-dimer test and biphasie eomputed tomography with mesenteric eomputed tomography angiography in the diag- nosis of acute mesenterie isehemia显示文摘 | Akyildiz H Akcan A Ozttirk A | 2009 | Am J Surg2009，197，4： | 1 |
| 10 | The effect of kangaroo care on pain in premature infants during invasive procedures 显示文摘 | Esma Akcan Rana Yigit Aytug Abel | 2009 | The Turkish Journal of Pediat6cs2009，51，： | 1 |
| 11 | Urinary calcium excretion in healthy Turkish children显示文摘 | S/Snmez F Akcanal B Altincik A | 2007 | Int Urol Nephrol2007，39，3： | 1 |
| 12 | Granulomatous lobularmas-titis : a complex diagnostic and therapeutic problem 显示文摘 | Akcan A Akyildiz H Deneme MA | 2006 | World JSurg2006，30，8： | 1 |
| 13 | Polychlorinated biphenyls andorganochlorine pesticides in amniotic fluids of pregnant women insouth-central Turkey显示文摘 | Daglioglu N Akcan R Efeoglu P | 2013 | Toxicological & Environmental Chemistry2013，95，6： | 1 |
| 14 | Granulomatouslobular mastitis : a complex diagnostic and therapeutic problem显示文摘 | Akcan A Akyildiz H Deneme MA | 2006 | World J Surg2006，30，8： | 1 |
| 15 | The value of D-dimer test in the diagnosis of patients with nontraumatic acute abdomen显示文摘 | Akyildiz HY S(o)züer E Akcan A | 2010 | Ulus Travma Acil Cerrahi Derg2010，16，1： | 1 |
| 16 | The correlation of the D-din- er test and biphasic computed tomography with mesenterie com- puted tomography angiography in the diagnosis of acute mesenteric ischemia显示文摘 | Akyildiz H Akcan A Oztrk A | 2009 | Am J Surg2009，197，4： | 1 |
| 17 | Ischemia-modified albumin levels in cerebrovascular accidents显示文摘 | Abdulkadir Gunduz Suleyman Turedi Ahmet Mentese Vildan Altunayoglu Ibrahim Turan Suleyman Caner Karahan Murat Topbas Murat Aydin Ismet Eraydin Buket Akcan | 2008 | American Journal of Emergency Medicine2008，，8： | 1 |
| 18 | Skeletal and dental stability after maxillary distraction with a rigid external device in adult cleft lip and palate patients显示文摘 | Aksu M Saglam-Aydinatay B Akcan CA El H Taner T Kocadereli I | | 0，，： | 1 |
| 19 | Factors Affecting the Shape of Lactation Curves of Holstein Cows from the Balikesir Province of Turkey显示文摘 | M. Tekerli Z. Akinci I. Dogan A. Akcan | 2000 | Journal of Dairy Science2000，，6： | 1 |
| 20 | Salmonella typhimurium infections in BALB/c mice: a comparison of tissue biolumi- nescence, tissue cultures and mice clinical scores 显示文摘 | Ozkaya H Akcan AB Aydemir G | 2012 | New Microbiol2012，35，1： | 1 |
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