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| 1 | 动脉粥样硬化和基质金属蛋白酶:活体分子MR成像实验研究显示文摘目的评价以基质金属蛋白酶(MMPs)作为靶目标的分子MR成像对比剂P947检测和成像活体动脉粥样硬化病变中基质金属蛋白酶的能力:比较其与P1135的特异度:明确基质金属蛋白酶在动脉粥样硬化血管中的表达与分布:应用荧光标记P947(Eu—P947)在体内的分布和分子定位。方法动物保护与应用委员会批准进行所有实验。将钆螯合物(1,4,7,10-tetraazacvclododecane-N,N_,N_,N_—tetraaceticacidl与一能与MMPs特异结合的多肽黏附合成P947。 | V. Amirbekian J.G. Aguinaldo S. Amirbekian F. Hyafil E. Vucic M. Sirol 郭瑜(译) 葛夕洪(校) | 2009 | 国际医学放射学杂志2009，32，4： | 4 |
| 2 | A major Philippinensis Phytochemistry 显示文摘 | AGUINALDO A piperidine alkaloid M READ R from Microcos W | 1990 | Phytochemistry1990，29，： | 1 |
| 3 | Mem- brane processes显示文摘 | PELLEGRIN M L WILF M AGUINALDO J | 2010 | Water Environment Research2010，82，10： | 1 |
| 4 | Evidence for a clade of nematodes, arthropods and other moulting animals显示文摘 | Aguinaldo A M Turbeville J M Linford L S | 1997 | Nature1997，387，6632： | 1 |
| 5 | Non-invasive MRI of mouse models of atherosclerosis显示文摘 | Weinreh D B Aguinaldo J G Feig J E | 2007 | NMR Biomed2007，20，3： | 1 |
| 6 | Noninvasive In Vivo Human Coronary Artery Lumen and Wall Imaging Using Black-Blood Magnetic Resonance Imaging显示文摘 | Zahi A. Fayad Valentin Fuster John T. Fallon Timothy Jayasundera Stephen G. Worthley Gerard Helft J. Gilberto Aguinaldo Juan J. Badimon Samin K. Sharma | 2000 | Circulation: Journal of the American Heart Association2000，，5： | 1 |
| 7 | Atherosclerotic lesions in genetically modified mice quantified in vivo by non-invasive highresolution magnetic resonance microscopy显示文摘 | Aguinaldo JG Rong JX | 2002 | Atherosclerosis2002，162，： | 1 |
| 8 | Comprehensive analysis of HFE gene in hereditary hemochromatosis and in diseases associated with acquired iron overload显示文摘BACKGROUND Patients with hepatitis C virus(HCV) and hepatocellular carcinoma(HCC) may or not develop iron overload(IO),which is associated with worst prognosis,because can cause serious damage to organs.HFE gene controls the iron uptake from gut,particularly in patients with hereditary hemochromatosis(HH).AIM To identify associations between HFE coding region in patients exhibiting hereditary hemochromatosis and in diseases associated with acquired IO.METHODS We sequenced exons 2 to 5 and boundary introns of HFE gene,evaluating all polymorphic sites in patients presenting hereditary(hemochromatosis) or acquired iron overload HCV and HCC) and in healthy controls,using Sanger sequencing.We also determined the ensemble of extended haplotype in healthy control individuals,including several major histocompatibility complex loci,using sequence specific probes.Haplotype reconstruction was performed using the Arlequin and Phase softwares,and linkage disequilibrium(LD) between histocompatibility loci and HFE gene was performed using the Haploview software.RESULTS The HFE*003 allele was overrepresented(f = 71%) and HFE*001 allele was underrepresented(f = 14%) in HH patients compared to all groups.A strong linkage disequilibrium was observed among the H63 D-G,IVS2(+4)-C and C282 YG gene variants,particularly in HH;however,the mutation IVS2(+4)T>C was not directly associated with HH susceptibility.The HFE*001/HFE*002 genotype conferred susceptibility to HCC in HCV patients exhibiting IO(P = 0.02,OR =14.14).Although HFE is telomeric to other histocompatibility genes,the H63 DG/IVS2(+4)-C(P ≤ 0.00001/P ≤ 0.0057) combination was in LD with HLA-B*44 allele group in healthy controls.No LD was observed between HFE alleles and other major histocompatibility loci.CONCLUSION A differential HFE association was observed for HH and for diseases associated with acquired IO(HCV,HCC).Since HFE is very distant from other histocompatibility loci,only weak associations were observed with these alleles. | Wagner Narciso de Campos Juliana Doblas Massaro Eduardo Luiz Rachid Can?ado Cláudia Emília Vieira Wiezel Aguinaldo Luiz Sim?es Andreza Correa Teixeira Fernanda Fernandes de Souza Celso Teixeira Mendes-Junior Ana de Lourdes Candolo Martinelli Eduardo Ant?nio Donadi | 2019 | World Journal of Hepatology2019，11，2： | 1 |
| 9 | Staggered extension process (STEP) in vitro recombination显示文摘 | Aguinaldo A M Amold F H | 2003 | Methods Mol Biol2003，231，： | 1 |
| 10 | Atherosclerotic lesions in genetically modified mice quantified in vivo by noninvasive high-resolution magnetic resonance microscopy 显示文摘 | choudhury RP Aguinaldo JG Rong JX | 2002 | Atherosclerosis2002，162，： | 1 |
| 11 | Atherosclerosis and matrix metalloproteinases : experimental molecular MR imaging in viva显示文摘 | Amirbekian V Aguinaldo JG Amirbekian S | 2009 | Radiology2009，251，2： | 1 |
| 12 | Serial,Noninvasive,in vivo magnetic resonance microscopy detects the development of atherosclerosis in apolipoprotein E-deficient mice and its progression by arterial wall remodeling显示文摘 | Choudhury RP Fayad ZA Aguinaldo JG | 2003 | J Magn Reson Imaging2003，17，2： | 1 |
| 13 | Nutritional characteristics of weaning foods prepared from germinated cereals and legumes 显示文摘 | Marero L M Payumo E M Aguinaldo A R | 1988 | Journal of Food Science1988，53，： | 1 |
| 14 | An an- ti-inflammatory role for a phosphoinositide 3-kinase in- hibitor LY294002 in a mouse asthma model 显示文摘 | Duan W Aguinaldo Datiles AM Leung BP | 2005 | Int Im- munopharmacol2005，5，3： | 1 |
| 15 | An anti-inflammatory role for a phosphoinositide 3-kinase inhibitor LY294002 in a mouse asthma model显示文摘 | Duan W Aguinaldo Datiles A M Leung B P Vlahos C J Wong W S | 2005 | Int Immunopharmacol2005，5，： | 1 |
| 16 | Antitubercular constituents from Premna odorata Blanco显示文摘 | Stephen B. Lirio Allan Patrick G. Macabeo Erickson M. Paragas Matthias Knorn Paul Kohls Scott G. Franzblau Yuehong Wang Ma. Alicia M. Aguinaldo | 2014 | Journal of Ethnopharmacology2014，，2： | 1 |
| 17 | Pathologic alteration in the skin component of composite tissue and skin allografts treated with cyclosporine显示文摘 | Black KS Aguinaldo AM | 1988 | Transplant Proc1988，20，3： | 1 |
| 18 | Evolution of the multi-cellular animals显示文摘 | Aguinaldo A M A Lake J A | 1998 | American Zoologist1998，38，6： | 1 |
| 19 | An anti- inflammatory role for a phosphoinositide 3-kinase inhibitor LY294002 in a mouse asthma model 显示文摘 | Duana W Aguinaldo Datilesa AM Letmgb BP | 2005 | Int Immunopharmacol2005，5，3： | 1 |
| 20 | Evidence from 18S Rib osomal DNA that lopophorates are protostome animals显示文摘 | Halanych K M Bacheller J D Aguinaldo A M A | 1995 | Scienc e1995，267，： | 1 |
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